Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 9666-9673

  Kourimate, Sanae ^a,d   Le May, Cédric ^a   Langhi, Cédric ^a   Jarnoux, Anne Laure ^a   Ouguerram, Khadija ^a,c   Zaïr, Yassine ^a,b   Nguyen, Patrick ^e   Krempf, Michel ^a,b,c   Cariou, Bertrand ^a,b   Costet, Philippe ^a,d,f  

^a INSERM   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d CRNH AUVERGNE   (France)

^e LUNAM UNIVERSITÉ   (France)

^f HÔTEL DIEU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOSOMAL DOMINANTS; BENEFICIAL EFFECTS; CELLULAR SECRETIONS; COMBINED THERAPIES; CONVERTASES; DUAL MECHANISMS; FIBRATES; FUNCTIONAL RELEVANCES; FUNCTIONAL TESTS; HUMAN HEPATOCYTES; HYPERCHOLESTEROLEMIA; IN VITRO; LDL RECEPTORS; LIPID HOMEOSTASISES; LIVER X RECEPTORS; NATURAL INHIBITORS; PRAVASTATIN; PROMOTER ACTIVITIES; PROMOTER LEVELS; PROTEIN CONTENTS; PROTEIN LEVELS; STATINS;

PHYSIOLOGY;

CLOFIBRATE; FENOFIBRIC ACID; FURIN; GEMFIBROZIL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MEVINOLIN; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PRAVASTATIN; PROPROTEIN CONVERTASE 5; PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9; SERINE PROTEINASE; UNCLASSIFIED DRUG; CELL RECEPTOR; CLOFIBRIC ACID; DNA BINDING PROTEIN; DRUG DERIVATIVE; FENOFIBRATE; FURIN PROTEIN, HUMAN; HYPOCHOLESTEROLEMIC AGENT; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PCSK9 PROTEIN, HUMAN; SULFONAMIDE;

ARTICLE; CELL SECRETION; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME REPRESSION; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; UPREGULATION; BIOSYNTHESIS; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HYPERLIPOPROTEINEMIA TYPE 2; LIPID METABOLISM; METABOLISM; PROMOTER REGION; TUMOR CELL LINE;

ANTICHOLESTEREMIC AGENTS; CELL LINE, TUMOR; CLOFIBRIC ACID; DNA-BINDING PROTEINS; FURIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; LIPID METABOLISM; PPAR ALPHA; PRAVASTATIN; PROCETOFEN; PROMOTER REGIONS (GENETICS); PROPROTEIN CONVERTASE 5; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, LDL; SERINE ENDOPEPTIDASES; SULFONAMIDES; UP-REGULATION;

EID: 44349177547     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705831200     Document Type: Article

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