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Volumn 29, Issue 3, 2014, Pages 538-543

Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome

Author keywords

Atherosclerosis; Lipid disorders; Liver X receptor; Proteinuria

Indexed keywords

INDUCIBLE DEGRADER OF THE LOW DENSITY LIPOPROTEIN RECEPTOR; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; PUROMYCIN; SERINE PROTEINASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; MYLIP PROTEIN, RAT; ORPHAN NUCLEAR RECEPTOR; PCSK9 PROTEIN, RAT; UBIQUITIN PROTEIN LIGASE;

EID: 84895749296     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft439     Document Type: Article
Times cited : (57)

References (40)
  • 1
    • 0037406342 scopus 로고    scopus 로고
    • Molecular mechanisms of lipid disorders in nephrotic syndrome
    • Vaziri ND. Molecular mechanisms of lipid disorders in nephrotic syndrome. Kidney Int 2003; 63: 1964-1976
    • (2003) Kidney Int , vol.63 , pp. 1964-1976
    • Vaziri, N.D.1
  • 2
    • 0025150632 scopus 로고
    • Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome
    • Joven J, Villabona C, Vilella E et al. Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome. N Engl J Med 1990; 323: 579-584
    • (1990) N Engl J Med , vol.323 , pp. 579-584
    • Joven, J.1    Villabona, C.2    Vilella, E.3
  • 3
    • 0032974220 scopus 로고    scopus 로고
    • New insights into lipid metabolism in the nephrotic syndrome
    • Kaysen GA, de Sain-van der Velden MG. New insights into lipid metabolism in the nephrotic syndrome. Kidney Int 1999; 71: S18-S21
    • (1999) Kidney Int , vol.71
    • Kaysen, G.A.1    De Sain-Van Der Velden, M.G.2
  • 4
    • 0025783752 scopus 로고
    • Metabolism of apolipoprotein B-containing lipoproteins in subjects with nephrotic-range proteinuria
    • Warwick GL, Packard CJ, Demant T et al. Metabolism of apolipoprotein B-containing lipoproteins in subjects with nephrotic-range proteinuria. Kidney Int 1991; 40: 129-138
    • (1991) Kidney Int , vol.40 , pp. 129-138
    • Warwick, G.L.1    Packard, C.J.2    Demant, T.3
  • 5
    • 0025124528 scopus 로고
    • Boulton-Jones JMet al. Low-density lipoprotein metabolism in the nephrotic syndrome
    • Warwick GL, Caslake MJ, Boulton-Jones JMet al. Low-density lipoprotein metabolism in the nephrotic syndrome. Metabolism 1990; 39: 187-192
    • (1990) Metabolism , vol.39 , pp. 187-192
    • Warwick, G.L.1    Caslake, M.J.2
  • 6
    • 0029785877 scopus 로고    scopus 로고
    • Downregulation of hepatic LDL receptor expression in experimental nephrosis
    • Vaziri ND, Liang K. Downregulation of hepatic LDL receptor expression in experimental nephrosis. Kidney Int 1996; 50: 887-893
    • (1996) Kidney Int , vol.50 , pp. 887-893
    • Vaziri, N.D.1    Liang, K.2
  • 7
    • 0037406315 scopus 로고    scopus 로고
    • Molecular mechanisms of altered cholesterol metabolism in rats with spontaneous focal glomerulosclerosis
    • Vaziri ND, Sato T, Liang K. Molecular mechanisms of altered cholesterol metabolism in rats with spontaneous focal glomerulosclerosis. Kidney Int 2003; 63: 1756-1763
    • (2003) Kidney Int , vol.63 , pp. 1756-1763
    • Vaziri, N.D.1    Sato, T.2    Liang, K.3
  • 8
    • 3342943329 scopus 로고    scopus 로고
    • Acyl-CoA cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, LCAT, SRB-1 and LDL receptor deficiencies in nephrotic syndrome
    • Vaziri ND, Liang K. Acyl-CoA cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, LCAT, SRB-1 and LDL receptor deficiencies in nephrotic syndrome. Circulation 2004; 110: 419-425
    • (2004) Circulation , vol.110 , pp. 419-425
    • Vaziri, N.D.1    Liang, K.2
  • 9
    • 34548659806 scopus 로고    scopus 로고
    • Hepatic tissue sterol regulatory element binding protein 2 and low-density lipoprotein receptor in nephrotic syndrome
    • Kim CH, Kim HJ, Mitsuhashi M et al. Hepatic tissue sterol regulatory element binding protein 2 and low-density lipoprotein receptor in nephrotic syndrome. Metabolism 2007; 56: 1377-1382
    • (2007) Metabolism , vol.56 , pp. 1377-1382
    • Kim, C.H.1    Kim, H.J.2    Mitsuhashi, M.3
  • 10
    • 67650092919 scopus 로고    scopus 로고
    • LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    • Zelcer N, Hong C, Boyadjian R et al. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 2009; 325: 100-104
    • (2009) Science , vol.325 , pp. 100-104
    • Zelcer, N.1    Hong, C.2    Boyadjian, R.3
  • 11
    • 2342451128 scopus 로고    scopus 로고
    • Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
    • Maxwell KN, Breslow JL. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc Natl Acad Sci USA 2004; 101: 7100-7105
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7100-7105
    • Maxwell, K.N.1    Breslow, J.L.2
  • 12
    • 33750597734 scopus 로고    scopus 로고
    • Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and livers of parabiotic mice
    • Lagace TA, Curtis DE, Garuti R et al. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and livers of parabiotic mice. J Clin Invest 2006; 116: 2995-3005
    • (2006) J Clin Invest , vol.116 , pp. 2995-3005
    • Lagace, T.A.1    Curtis, D.E.2    Garuti, R.3
  • 13
    • 34548163845 scopus 로고    scopus 로고
    • Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity
    • Li J, Tumanut C, Gavigan JA et al. Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity. Biochem J 2007; 406: 203-207
    • (2007) Biochem J , vol.406 , pp. 203-207
    • Li, J.1    Tumanut, C.2    Gavigan, J.A.3
  • 14
    • 34547137377 scopus 로고    scopus 로고
    • Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells
    • McNutt MC, Lagace TA, Horton JD. Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells. J Biol Chem 2007; 282: 20799-20803
    • (2007) J Biol Chem , vol.282 , pp. 20799-20803
    • McNutt, M.C.1    Lagace, T.A.2    Horton, J.D.3
  • 15
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH, Jr et al. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006; 354: 1264-1272
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley Jr., T.H.3
  • 16
    • 84871871419 scopus 로고    scopus 로고
    • Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis
    • Zhang L, Reue K, Fong LG et al. Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arterioscler Thromb Vasc Biol 2012; 32: 2541-2546
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2541-2546
    • Zhang, L.1    Reue, K.2    Fong, L.G.3
  • 17
    • 34548659806 scopus 로고    scopus 로고
    • Hepatic tissue sterol regulatory element-binding protein-2 (SREBP-2) and LDL receptor in nephrotic syndrome
    • Kim CH, Kim HJ, Mitsuhashi M et al. Hepatic tissue sterol regulatory element-binding protein-2 (SREBP-2) and LDL receptor in nephrotic syndrome. Metabolism 2007; 56: 1377-1382
    • (2007) Metabolism , vol.56 , pp. 1377-1382
    • Kim, C.H.1    Kim, H.J.2    Mitsuhashi, M.3
  • 18
    • 0028876322 scopus 로고
    • Hepatic HMG-CoA reductase gene expression during the course of puromycin-induced nephrosis
    • Vaziri ND, Liang KH. Hepatic HMG-CoA reductase gene expression during the course of puromycin-induced nephrosis. Kidney Int 1995; 48: 1979-1985
    • (1995) Kidney Int , vol.48 , pp. 1979-1985
    • Vaziri, N.D.1    Liang, K.H.2
  • 19
    • 34848861377 scopus 로고    scopus 로고
    • Serum proprotein convertase subtilisin kexin type 9 is correlated directly with serum LDL cholesterol
    • Alborn WE, Cao G, Careskey HE et al. Serum proprotein convertase subtilisin kexin type 9 is correlated directly with serum LDL cholesterol. Clin Chem 2007; 53: 1814-1819
    • (2007) Clin Chem , vol.53 , pp. 1814-1819
    • Alborn, W.E.1    Cao, G.2    Careskey, H.E.3
  • 20
    • 44849086762 scopus 로고    scopus 로고
    • Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment
    • Lambert G, Ancellin N, Charlton F et al. Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment. Clin Chem 2008; 54: 1038-1045
    • (2008) Clin Chem , vol.54 , pp. 1038-1045
    • Lambert, G.1    Ancellin, N.2    Charlton, F.3
  • 21
    • 70449732531 scopus 로고    scopus 로고
    • Plasma proprotein convertase subtilisin/kexin type 9: A marker of LDL apolipoprotein B-100 catabolism?
    • Chan DC, Lambert G, Barrett PH et al. Plasma proprotein convertase subtilisin/kexin type 9: a marker of LDL apolipoprotein B-100 catabolism? Clin Chem 2009; 55: 2049-2052
    • (2009) Clin Chem , vol.55 , pp. 2049-2052
    • Chan, D.C.1    Lambert, G.2    Barrett, P.H.3
  • 22
    • 84860735288 scopus 로고    scopus 로고
    • Plasma PCSK9 levels and clinical outcomes in the treating to new targets trial: A nested case-control study
    • Huijgen R, Boekholdt SM, Arsenault BJ et al. Plasma PCSK9 levels and clinical outcomes in the treating to new targets trial: a nested case-control study. J Am Coll Cardiol 2012; 59: 1778-1784
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1778-1784
    • Huijgen, R.1    Boekholdt, S.M.2    Arsenault, B.J.3
  • 23
    • 38949137409 scopus 로고    scopus 로고
    • Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2
    • Jeong HJ, Lee HS, Kim KS et al. Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2. J Lipid Res 2008; 49: 399-409
    • (2008) J Lipid Res , vol.49 , pp. 399-409
    • Jeong, H.J.1    Lee, H.S.2    Kim, K.S.3
  • 24
    • 77952684555 scopus 로고    scopus 로고
    • Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: Mechanism for the resistance to LDLcholesterol lowering effect of statins in dyslipidemic hamsters
    • Dong B, Wu M, Li H et al. Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDLcholesterol lowering effect of statins in dyslipidemic hamsters. J Lipid Res 2010; 51: 1486-1495
    • (2010) J Lipid Res , vol.51 , pp. 1486-1495
    • Dong, B.1    Wu, M.2    Li, H.3
  • 25
    • 38949109659 scopus 로고    scopus 로고
    • Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
    • Careskey HE, Davis RA, Alborn WE et al. Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9. J Lipid Res 2008; 49: 394-398
    • (2008) J Lipid Res , vol.49 , pp. 394-398
    • Careskey, H.E.1    Davis, R.A.2    Alborn, W.E.3
  • 26
    • 45549096493 scopus 로고    scopus 로고
    • Plasma PCSK9 levels are significantly modified by statins and fibrates in humans
    • Mayne J, Dewpura T, Raymond A et al. Plasma PCSK9 levels are significantly modified by statins and fibrates in humans. Lipids Health Dis 2008; 7: 22
    • (2008) Lipids Health Dis , vol.7 , pp. 22
    • Mayne, J.1    Dewpura, T.2    Raymond, A.3
  • 27
    • 17244377696 scopus 로고    scopus 로고
    • Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
    • Rashid S, Curtis DE, Garuti R et al. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci USA 2005; 102: 5374-5379
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5374-5379
    • Rashid, S.1    Curtis, D.E.2    Garuti, R.3
  • 28
    • 0036233724 scopus 로고    scopus 로고
    • Upregulation of Acyl-Coenzyme A: Cholesterol acyltransferase (ACAT) in nephrotic syndrome
    • Vaziri ND, Liang KH. Upregulation of Acyl-Coenzyme A: cholesterol acyltransferase (ACAT) in nephrotic syndrome. Kidney Int 2002; 61: 1769-1775
    • (2002) Kidney Int , vol.61 , pp. 1769-1775
    • Vaziri, N.D.1    Liang, K.H.2
  • 29
    • 41149133845 scopus 로고    scopus 로고
    • Molecular basis for LDL receptor recognition by PCSK9
    • Kwon HJ, Lagace TA, McNutt MC et al. Molecular basis for LDL receptor recognition by PCSK9. Proc Natl Acad Sci USA 2008; 105: 1820-1825
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 1820-1825
    • Kwon, H.J.1    Lagace, T.A.2    McNutt, M.C.3
  • 30
    • 34547108600 scopus 로고    scopus 로고
    • Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
    • Zhang DW, Lagace TA, Garuti R et al. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J Biol Chem 2007; 282: 18602-18612
    • (2007) J Biol Chem , vol.282 , pp. 18602-18612
    • Zhang, D.W.1    Lagace, T.A.2    Garuti, R.3
  • 31
    • 79955378862 scopus 로고    scopus 로고
    • Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists
    • Scotti E, Hong C, Yoshinaga Y et al. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol 2011; 31: 1885-1893
    • (2011) Mol Cell Biol , vol.31 , pp. 1885-1893
    • Scotti, E.1    Hong, C.2    Yoshinaga, Y.3
  • 32
    • 77953767546 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2
    • Hong C, Duit S, Jalonen P et al. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. J Biol Chem 2010; 285: 19720-19726
    • (2010) J Biol Chem , vol.285 , pp. 19720-19726
    • Hong, C.1    Duit, S.2    Jalonen, P.3
  • 33
    • 0036147318 scopus 로고    scopus 로고
    • Down-regulation of lipoprotein lipase and VLDL receptor in rats with focal glomerulosclerosis
    • Sato T, Liang K, Vaziri ND. Down-regulation of lipoprotein lipase and VLDL receptor in rats with focal glomerulosclerosis. Kidney Int 2002; 61: 157-162
    • (2002) Kidney Int , vol.61 , pp. 157-162
    • Sato, T.1    Liang, K.2    Vaziri, N.D.3
  • 34
    • 0030964202 scopus 로고    scopus 로고
    • Acquired VLDL receptor deficiency in experimental nephrosis
    • Liang K, Vaziri ND. Acquired VLDL receptor deficiency in experimental nephrosis. Kidney Int 1997; 51: 1761-1765
    • (1997) Kidney Int , vol.51 , pp. 1761-1765
    • Liang, K.1    Vaziri, N.D.2
  • 35
    • 84867571866 scopus 로고    scopus 로고
    • Proteinuria decreases tissue lipoprotein receptor levels resulting in altered lipoprotein structure and increasing lipid levels
    • Wang L, Shearer GC, Budamagunta MS et al. Proteinuria decreases tissue lipoprotein receptor levels resulting in altered lipoprotein structure and increasing lipid levels. Kidney Int 2012; 82: 990-999
    • (2012) Kidney Int , vol.82 , pp. 990-999
    • Wang, L.1    Shearer, G.C.2    Budamagunta, M.S.3
  • 36
    • 0023948210 scopus 로고
    • Lovastatin therapy in nephrotic hyperlipidemia: Effects on lipoprotein metabolism
    • Vega GL, Grundy SM. Lovastatin therapy in nephrotic hyperlipidemia: effects on lipoprotein metabolism. Kidney Int 1988; 33: 1160-1168
    • (1988) Kidney Int , vol.33 , pp. 1160-1168
    • Vega, G.L.1    Grundy, S.M.2
  • 37
    • 0028861338 scopus 로고
    • Physiologic mechanisms of action of lovastatin in nephrotic syndrome
    • Aguilar-Salinas CA, Barrett PH, Kelber J et al. Physiologic mechanisms of action of lovastatin in nephrotic syndrome. J Lipid Res 1995; 36: 188-199
    • (1995) J Lipid Res , vol.36 , pp. 188-199
    • Aguilar-Salinas, C.A.1    Barrett, P.H.2    Kelber, J.3
  • 38
    • 0031979035 scopus 로고    scopus 로고
    • Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis
    • de Sain-van der Velden MG, Kaysen GA, Barrett HA et al. Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis. Kidney Int 1998; 4: 994-1001
    • (1998) Kidney Int , vol.4 , pp. 994-1001
    • De Sain-Van Der Velden, M.G.1    Kaysen, G.A.2    Barrett, H.A.3
  • 39
    • 78650419609 scopus 로고    scopus 로고
    • Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans
    • Persson L, Cao G, Ståhle L et al. Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans. Arterioscler Thromb Vasc Biol 2010; 30: 2666-2672
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2666-2672
    • Persson, L.1    Cao, G.2    Ståhle, L.3
  • 40
    • 78149300891 scopus 로고    scopus 로고
    • Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans
    • Browning JD, Horton JD. Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans. J Lipid Res 2010; 51: 3359-3363
    • (2010) J Lipid Res , vol.51 , pp. 3359-3363
    • Browning, J.D.1    Horton, J.D.2


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