Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 47, 2014, Pages 16820-16825

  Wagner, Koen ^a   Kwakkenbos, Mark J ^a   Claassena, Yvonne B ^a   Maijoor, Kelly ^a   Böhne, Martino ^a   Van Der Sluijs, Koenraad F ^b   Witte, Martin D ^c   Van Zoelen, Diana J ^d   Cornelissen, Lisette A ^d   Beaumont, Tim ^a   Bakker, Arjen Q ^a   Ploegh, Hidde L ^c   Spits, Hergen ^a  

^a AIMM Therapeutics   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Antibody engineering; Immunotherapy; Influenza

Indexed keywords

AT 10 002; AT 10 005; BISPECIFIC ANTIBODY; DIMER; HETERODIMER; HYBRID PROTEIN; IMMUNOGLOBULIN G ANTIBODY; NEUTRALIZING ANTIBODY; RITUXIMAB; SORTASE; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY ENGINEERING; ANTIVIRAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL REACTION; CLICK CHEMISTRY; CONTROLLED STUDY; COVALENT BOND; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG SYNTHESIS; ENZYME MECHANISM; HUMAN; HUMAN CELL; INFLUENZA; INFLUENZA A; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN MODIFICATION; TRANSPEPTIDATION; B LYMPHOCYTE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CLASSIFICATION; DIMERIZATION; IMMUNOLOGY; INFLUENZA A VIRUS; POLYACRYLAMIDE GEL ELECTROPHORESIS; SURFACE PLASMON RESONANCE; VIROLOGY; WESTERN BLOTTING;

ANTIBODIES, BISPECIFIC; B-LYMPHOCYTES; BLOTTING, WESTERN; CELLS, CULTURED; CLICK CHEMISTRY; DIMERIZATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INFLUENZA A VIRUS; SURFACE PLASMON RESONANCE;

EID: 84913550613     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1408605111     Document Type: Article

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