Role of Ca2+and L-Phe in regulating functional cooperativity of disease-associated "toggle" calcium-sensing receptor mutations

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Zhang, Chen ^a   Mulpuri, Nagaraju ^a   Hannan, Fadil M ^b   Nesbit, M Andrew ^b   Thakker, Rajesh V ^b   Hamelberg, Donald ^a   Brown, Edward M ^c   Yang, Jenny J ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALCIUM SENSING RECEPTOR; INOSITOL PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHENYLALANINE; PHOSPHOLIPASE C; CALCIUM; MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; BINDING SITE; CALCIUM BINDING; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; INTERACTIONS WITH NUCLEIC ACID; LOSS OF FUNCTION MUTATION; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; REGULATORY MECHANISM; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HYPERCALCEMIA; HYPOCALCEMIA; METABOLISM; MISSENSE MUTATION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BINDING SITES; BLOTTING, WESTERN; CALCIUM; CALCIUM SIGNALING; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HUMANS; HYPERCALCEMIA; HYPOCALCEMIA; INOSITOL PHOSPHATES; MAP KINASE SIGNALING SYSTEM; MOLECULAR DYNAMICS SIMULATION; MUTATION, MISSENSE; PHENYLALANINE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCIUM-SENSING;

EID: 84912567710     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113622     Document Type: Article

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