Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 5296-5309

  Zhang, Chen ^a   Huang, Yun ^a   Jiang, Yusheng ^a   Mulpuri, Nagaraju ^a   Wei, Ling ^a   Hamelberg, Donald ^a   Brown, Edward M ^b   Yang, Jenny J ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES;

CALCIUM-SENSING RECEPTORS; COOPERATIVE RESPONSE; COOPERATIVITY; IN-VIVO; L-PHENYLALANINE; MOLECULAR BASIS;

CALCIUM;

CALCIUM ION; CALCIUM SENSING RECEPTOR; PHENYLALANINE;

ARTICLE; CALCIUM BINDING; CONTROLLED STUDY; ENZYME ACTIVATION; HETEROTROPHY; HUMAN; HUMAN CELL; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID; CALCIUM IMAGING; CALCIUM OSCILLATION; CALCIUM SIGNALING; CALCIUM-SENSING RECEPTOR; COOPERATIVITY; G PROTEIN-COUPLED RECEPTORS (GPCR);

AMINO ACID SEQUENCE; BINDING SITES; CALCIUM; HEK293 CELLS; HUMANS; INTRACELLULAR SPACE; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PHENYLALANINE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCIUM-SENSING; SEQUENCE ALIGNMENT; THERMODYNAMICS;

EID: 84894420817     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.537357     Document Type: Article

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