Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca2+ sensing receptor

Trends in Pharmacological Sciences

Volumn 21, Issue 10, 2000, Pages 401-407

  Conigrave, Arthur D ^a   Quinn, Stephen J ^a   Brown, Edward M ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 METHOXYPHENYL) N (3 PHENYLPROPYL)ETHYLAMINE; AMINO ACID; CALCIUM; CATION; G PROTEIN COUPLED RECEPTOR; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; PHENYLALANINE; SPERMINE;

ALLOSTERISM; ANIMAL CELL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CHO CELL; CONTROLLED STUDY; IONIC STRENGTH; NONHUMAN; PH; PRIORITY JOURNAL; REVIEW; STEREOSPECIFICITY; TISSUE DISTRIBUTION;

AMINO ACIDS; ANIMAL; CALCIUM; HOMEOSTASIS; HUMAN; HYDROGEN-ION CONCENTRATION; OSMOLAR CONCENTRATION; PARATHYROID DISEASES; RECEPTORS, CELL SURFACE;

EID: 0034306491     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01546-7     Document Type: Review

References (70)

1. 2+ in bovine parathyroid cells evoked by extracellular divalent cations
2. 2+ stimulate accumulation of inositol phosphates in bovine parathyroid cells
3. High calcium and other divalent cations increase inositol trisphosphate in bovine parathyroid cells
4. 2+-sensing receptor from bovine parathyroid
5. The calcium-sensing receptor; insights into extracellular calcium homeostasis in health and disease
6. 2+(o)-sensing receptor
7. Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells
8. 2+ (o))-sensing receptor (CaR): roles in cell signaling and control of diverse cellular functions
9. 2+ activation of the human calcium sensing receptor. A study with receptor-green fluorescent protein fusions
10. Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells
11. Dimerization of the calcium-sensing receptor occurs within the extracellular domain and is eliminated by Cys→Ser mutations at Cys101 and Cys236
12. 2+ receptor
13. Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function
14. 2+-sensing receptor gene cause familial hypocalciuric hyper calcemia and neonatal severe hyperparathyroidism
15. Two novel missense mutations in calcium-sensing receptor gene associated with neonatal severe hyperparathyroidism
16. Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism
17. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
18. 2+-sensing receptor gene mutation
19. 2+-sensing receptor gene cause autosomal dominant and sporadic hypoparathyroidism
20. A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations
21. The extracellular calcium-sensing receptor: its role in health and disease
22. 2+ sensing receptor in cytotrophoblasts from human term placenta
23. Calcium-sensing receptor: molecular cloning in rat and localization to nerve terminals
24. Localization of calcium receptor mRNA in the adult rat central nervous system by in situ hybridization
25. Calcium-sensing receptor in the rat hippocampus: a developmental study
26. Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells
27. Identification and localization of the extracellular calcium-sensing receptor in human breast
28. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation
29. Expression of extracellular calcium-sensing receptor by human lens epithelial cells
30. Expression of the calcium-sensing receptor on human antral gastrin cells in culture
31. Expression of an extracellular calcium-sensing receptor in rat stomach
32. 2+-sensing receptor in normal human gastric mucous epithelial cells
33. 2+ (polyvalent cation)-sensing receptor in rat pancreas
34. Distribution of calcium sensing receptor in rats: an immunohistochemical study
35. 2+-sensing receptor; expression in pancreatic islet B-cells and possible role in the regulation of insulin release
36. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation
37. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor
38. Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium
39. 2+ (o))-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells
40. 2+ and channel blockers
41. 2+-sensing receptor (CaR) activate nonselective cation channels in HEK293 cells stably transfected with the human CaR
42. Cytosolic calcium responses of single rMTC 44-2 cells to stimulation with external calcium and potassium
43. 2+ receptor-stimulated hormone release from sheep thyroid parafollicular cells
44. 2 action and arachidonic acid metabolism in calcium-mediated parathyroid hormone secretion
45. 2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells
46. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
47. 2+-sensing receptor: a target for polyamines
48. Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells
49. Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells
50. 2+ receptors
51. The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
52. Sodium and ionic strength sensing by the calcium receptor
53. Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet
54. Effect of level of protein intake on urinary and fecal calcium and calcium retention of young adult males
55. Protein-induced hypercalciuria: a longer term study
56. Calcimimetics with potent and selective activity on the parathyroid calcium receptor
57. 2+-sensing receptor
58. Stimulation of gastrin release in dogs by individual amino acids
59. Intravenous infusion of amino acids stimulates gastric acid secretion in man
60. 2+-sensing receptor in rat intestine
61. + channel
62. + channel in a human astrocytoma cell line (U87)
63. Developmental and adult expression of rat calcium-sensing receptor transcripts in neurons and oligodendrocytes
64. Extracellular pH sensing by the calcium-sensing receptor
65. NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium
66. NPS R-568 halts or reverses osteitis fibrosa in uremic rats
67. Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism
68. Stimulation of parathyroid hormone secretion by a small molecule antagonist of the calcium receptor
69. An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis
70. Suppression of parathyroid hormone by therapy with a mixture of keto analogues/amino acids in hemodialysis patients