Development of a bioartificial pancreas: II. Effects of oxygen on long- term entrapped βTC3 cell cultures

Biotechnology and Bioengineering

Volumn 66, Issue 4, 1999, Pages 231-237

  Papas, K K ^a,c   Long Jr , R C ^b   Sambanis, A ^a   Constantinidis, I ^b  

^a Georgia Institute of Technology   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Bioartificial pancreas; Bioenergetics; Cell encapsulation; Insulin secretion; Nuclear magnetic resonance (NMR) spectroscopy; Oxygen effects; TC3 cells

Indexed keywords

BIOMEDICAL ENGINEERING; CELL CULTURE; GLUCOSE; INSULIN; METABOLISM; NONINVASIVE MEDICAL PROCEDURES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN; TISSUE;

BIOARTIFICIAL PANCREAS; BIOENERGETICS;

IMPLANTS (SURGICAL);

LACTIC ACID; PHOSPHATE; PHOSPHORYLCHOLINE;

ANIMAL CELL; ARTICLE; CELL HYPOXIA; CELL VIABILITY; GLYCOLYSIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TENSION; PANCREAS;

ANIMALIA;

EID: 0033376083     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(1999)66:4<231::AID-BIT4>3.0.CO;2-U     Document Type: Article

References (35)

1. Benson JP, Papas KK, Constantinidis I, Sambanis A. 1997. Towards the development of a bioartificial pancreas: effects of poly-L-lysine on alginate beads with βTC3 cells. Cell Transplant 6:395-402.
2. Chen C-F, Chera H-T, Leu F-J, Chang T-M, Shian L-R, Sun AM. 1994. Xenotransplantation of microencapsulated canine islets into diabetic rats. Artif Org 18:193-197.
3. 13C NMR study of the effects of alginate/poly-L-lysine/alginate entrapment on glucose metabolism by βTC3 mouse insulinoma cells. Cell Molec Biol 43: 721-729.
4. 31P nuclear magnetic resonance study of a human colon adenocarcinoma cultured cell line. Cancer Res 46:3768-3774.
5. Dionne KE, Colton CK, Yarmush ML. 1989. Effect of oxygen on isolated pancreatic tissue. Trans Am Soc Artif Intern Organs 35:739-741.
6. Dionne KE, Colton CK, Yarmush ML. 1991. A microperifusion system with environmental control for studying insulin secretion by pancreatic tissue. Biotechnol Prog 7:359-368.
7. Efrat S, Linde S, Kofod H, Spector D, Delannoy M, Grant S, Hanahan D, Baekkeskov S. 1988. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc Natl Acad Sci USA 85:9037-9041.
8. Erecinska M, Bryla J, Michalik M, Meglasson MD, Nelson D. 1992. Energy metabolism in islets of Langerhans. Biochim Biophys Acta 1101: 273-295.
9. Fernandez EJ, Mancuso A, Murphy MK, Blanch HW, Clark DS. 1990. Nuclear magnetic resonance methods for observing the intracellular environment of mammalian cells. Ann NY Acad Sci 589:458-475.
10. Kriat M, Fantini J, Viom-Dury J, Confort-Gouny S, Galons JP, Cozzonne PJ. 1992. Energetic metabolism of glucose, mannose and galactose in glucose starved rat insulinoma cells anchored on microcarrier beads. A phosphorous-31 NMR study. Biochimie 74:949-955.
11. Lacy PE, Hegre OD, Gerasimidi-Vazeou A, Gentile FT, Dionne KE. 1991. Maintenance of normoglycemia in diabetic mice by subcateneous xenografts of encapsulated islets. Science 254:1782-1784.
12. Lanza RP, Bulter DH, Borland KM, Staruk JE, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, Chick WL. 1991. Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. Proc Natl Acad Sci USA 88:11100.
13. Lanza RP, Lodge P, Borland KM, Carretta M, Sullivan SJ, Beyer AM, Muller TE, Solomon BA, Maki T, Monaco AP, Chick WL. 1993. Tranplantation of islet allografts using a diffusion-based biohybrid artificial pancreas: long-term studies in diabetic, pancreatectomized dogs. Transplant Proc 25:978-980.
14. Lanza RP, Kühtreiber DM, Ecker JP, Marsh JE, Chick WL. 1996. Xenotransplantation of bovine islets into dogs using biodegradable, injectable microreactors. Transplant Proc 28:820.
15. Lim F, Sun AM, 1980. Microencapsulated islets as bioartificial endocrine pancreas. Science 210:908-910.
16. 31P NMR spectroscopy studies of phospholipid metabolism in human melanoma xenograft lines differing in rate of tumour cell proliferation. NMR Biomed 8:65-71.
17. Malaisse WJ, Best L, Kawazu S, Malaisse-Lagaae F, Sener A. 1983. The stimulus-secretion coupling of glucose-induced insulin release: fuel metabolism in islets deprived of nutrients. Arch Biochem Biophys 224:102-110.
18. Matschinsky FM. 1996. Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45:223-241.
19. Miller WM, Wilke CR, Blanch HW. 1987. Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture. J Cell Physiol 132:524-530.
20. Ohta M, Nelson D, Nelson J, Meglasson MD, Erecinska M. 1990. Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans. J Biol Chem 265:17525-17532.
21. O'Shea GM, Goosen MFA, Sun AM. 1984. Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane. Biochim Biophys Acta 804:133-136.
22. Ozturk SS, Palsson BO. 1990. Effects of dissolved oxygen on hybridoma cell growth, metabolism and antibody production kinetics in continuous culture. Biotechnol Prog 6:437-446.
23. Papas KK, Long RC Jr, Sambanis A, Constantinidis I. 1999. Towards the development of a bioartificial pancreas: I. Long-term propagation and basal and induced secretion from entrapped βTC3 cell cultures. Biotechnol Bioeng 66:219-230.
24. i in the mechanism of insulin secretion in the mouse insulinoma βTC3 cell line. Biochem J 326:807-814.
25. Papas KK, Long RC Jr, Constantinidis I, Sambanis A. 1996. Effects of oxygen on the metabolic and secretory activities of βTC3 cells. Biochim Biophys Acta 1291:163-166.
26. Papas KK. 1996. Bioenergetics, metabolism and secretion of immunoisolated endocrine cell preparations. PhD thesis, Georgia Institute of Technology, Atlanta, GA, USA.
27. 13C NMR studies of choline and ethanolamine uptake. Biochim Biophys Acta 1138:203-212.
28. Ruiz-Cabello J, Cohen JS. 1992. Phospholipid metabolites as indicators of cancer cell function. NMR Biomed 5:226-233.
29. Sener A, Giroix MH, Hellestrom C, Malaisse WJ. 1987a. Influence of D-glucose upon the respiratory and secretory response of insulin-producing tumor cells to 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid. Cancer Res 47:5905-5907.
30. Sener A, Leclercq-Meyer V. Giroix MH, Malaisse WJ, Hellestrom C. 1987b. Opposite effects of D-glucose and a nonmetabolized analogue of L-leucine on respiration and secretion in insulin-producing tumoral cells (RINm5F). Diabetes 36:187-192.
31. Soon-Shiong P, Heintz RE, Merideth N, Yao QX, Yao Z, Zheng T, Murphy M, Moloney MK, Schmehl M, Harris M, Mendez R, Mendex R, Sandford PA. 1994. Insulin independence in a type I diabetic patient after encapsulated islet transplantation. Lancet 343:950-951.
32. Soon-Shiong P, Feldman E, Nelson R, Komtebedde J, Smidsrod O, Skjak-Braek G, Espevik T, Heintz R, Lee M. 1992. Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets. Transplantation 54:769-774.
33. Sun AM, O'Shea GM. 1985. Microencapsulation of living cells - a long-term delivery system. J Controlled Rel 2:137-141.
34. Sullivan SJ, Maki T, Carretta M, Ozato H, Borland K, Mahoney MD, Muller TE, Solomon BA, Monaco AP, Chick WL. 1992. Evaluation of the hybrid artificial pancreas in diabetic dogs. ASAIO J 38:29-33.
35. Tziampazis E, Sambanis A. 1995. Tissue engineering of a bioartificial pancreas: modeling the cell environment and device function. Biotechnol Prog 11:115-126.