Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4+ T-helper cells by induction of FAS-independent T-cell apoptosis

Immunology

Volumn 109, Issue 1, 2003, Pages 32-40

  Termeer, Christian ^a   Averbeck, Marco ^a   Hara, Hisamichi ^a   Eibel, Herrmann ^a   Herrlich, Peter ^b   Sleeman, Jonathan ^b   Simon, Jan C ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CD4 ANTIGEN; EPITOPE; FAS ANTIBODY; FAS LIGAND; HERMES ANTIGEN; ISOPROTEIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CELL PROLIFERATION; DENDRITIC CELL; DOSE RESPONSE; EXON; FEMALE; MICROSCOPY; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; TIME; TRANSGENIC MOUSE; VIDEORECORDING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD44; ANTIGENS, CD95; APOPTOSIS; CALCIUM; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FAS LIGAND PROTEIN; FEMALE; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0037616163     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2003.01617.x     Document Type: Article

References (35)

1. Guermonprez P, Valladeau J, Zitvogel L et al. Antigen presentation and T-cell stimulation by dendritic cells. Annu Rev Immunol 2002; 20:621-67.
2. Lu L, Qian S, Hershberger PA et al. Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol 1997; 158:5676-84.
3. Galandrini R, Galluzzo E, Albi N et al. Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells. J Immunol 1994; 153:21-31.
4. Arch R, Wirth K, Hofmann M et al. Participation in normal immune responses of a metastasis-inducing splice variant of CD44. Science 1992; 257:682-5.
5. Siegelman MH, DeGrendele HC, Estess P. Activation and interaction of CD44 and hyaluronan in immunological systems. J Leukoc Biol 1999; 66:315-21.
6. Bajorath J. Molecular organization, structural features, and ligand-binding characteristics of CD44, a highly variable cell-surface glycoprotein with multiple functions. Proteins 2000; 39:103-11.
7. Weiss JM, Sleeman J, Renkl AC et al. An essential role for CD44 variant isoforms in epidermal Langerhans' cell and blood dendritic cell function. J Cell Biol 1997; 137:1137-47.
8. Foger N, Marhaba R, Zoller M. CD44 supports T-cell proliferation and apoptosis by apposition of protein kinases. Eur J Immunol 2000; 30:2888-99.
9. Taher TE, Smit L, Griffioen AW et al. Signaling through CD44 is mediated by tyrosine kinases. Association with p561ck in T lymphocytes. J Biol Chem 1996; 271:2863-7.
10. Bates RC, Edwards NS, Burns GF, Fisher DEA. CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-kinase/Akt in colon carcinoma cells. Cancer Res 2001; 61:5275-83.
11. Ayroldi E, Cannarile L, Ricardi C. Modulation of superantigen-induced T-cell deletion by antibody anti-Pgp-1 (CD44). Immunology 1996; 87:191-7.
12. Tian B, Takasu T, Henke C. Functional role of cyclin A on induction of fibroblast apoptosis due to ligation of CD44 matrix receptor by anti-CD44 antibody. Exp Cell Res 2000; 257:135-44.
13. Ayroldi E, Cannarile L, Migliorati G et al. CD44 (Pgp-1) inhibits CD3 and dexamethasone-induced apoptosis. Blood 1995; 86:2672-8.
14. Camp RL, Scheynius A, Johansson C, Pure E. CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation. J Exp Med 1993; 178:497-507.
15. Mikecz K, Brennan FR, Kim JH, Glant TT. Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat Med 1995; 1:558-63.
16. Verdrengh M, Holmdahl R, Tarkowski A. Administration of antibodies to hyaluronan receptor (CD44) delays the start and ameliorates the severity of collagen II arthritis. Scand J Immunol 1995; 42:353-8.
17. Schmits R, Filmus J, Gerwin N et al. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 1997; 90:2217-33.
18. Protin U, Schweighoffer T, Jochum W, Hilberg F. CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets. J Immunol 1999; 163:4917-23.
19. Chen D, McKallip RJ, Zeytun A, et al. CD44-deficient mice exhibit enhanced hepatitis after concanavalin A injection: evidence for involvement of CD44 in activation-induced cell death. J Immunol 2001; 166:5889-97.
20. Sobel ES, Kakkanaiah VN, Cohen PL, Eisenberg RA. Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene. Int Immunol 1993; 5:1275-8.
21. Watanabe-Fukunaga R, Brannan CI, Copeland NG et al. Lympho-proliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356:314-7.
22. + T cells specific for an antigen expressed in Escherichia coli. J Immunol 1998; 160:3462-70.
23. Brandle D, Burki K, Wallace VA et al. Involvement of both T cell receptor V alpha and V beta variable region domains and alpha chain junctional region in viral antigen recognition. Eur J Immunol 1991; 21:2195-202.
24. Inaba K, Inaba M, Romani N et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176:1693-702.
25. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 1995; 184:39-51.
26. Haegel-Kronenberger H, de la Salle H, Bohbot A et al. Adhesive and/or signaling functions of CD44 isoforms in human dendritic cells. J Immunol 1998; 161:3902-11.
27. Galluzzo E, Albi N, Fiorucci S et al. Involvement of CD44 variant isoforms in hyaluronate adhesion by human activated T cells. Eur J Immunol 1995; 25:2932-9.
28. Guo Y, Wu Y, Shinde S, et al. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J Exp Med 1996; 184:955-61.
29. Guo YJ, Ma J, Wong JH et al. Monoclonal anti-CD44 antibody acts in synergy with anti-CD2 but inhibits anti-CD3 or T cell receptor-mediated signaling in murine T-cell hybridomas. Cell Immunol 1993; 152:186-99.
30. Ju ST, Panka DJ, Cui H et al. Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 1995; 373:444-8.
31. Foger N, Marhaba R, Zoller M. Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells. J Cell Sci 2001; 114:1169-78.
32. Al-Alwan MM, Rowden G, Lee TD, West KA. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J Immunol 2001; 166:1452-6.
33. Krummel MF, Davis MM. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr Opin Immunol 2002; 14:66-74.
34. Mikecz K, Dennis K, Shi M, Kim JH. Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis. Arthritis Rheum 1999; 42:659-68.
35. Yonemura S, Hirao M, Doi Y et al. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol 1998; 140:885-95.