Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways

Toxicology and Applied Pharmacology

Volumn 281, Issue 2, 2014, Pages 230-241

  Pratheeshkumar, Poyil ^a   Son, Young Ok ^a   Divya, Sasidharan Padmaja ^a   Roy, Ram Vinod ^a   Hitron, John Andrew ^a   Wang, Lei ^a   Kim, Donghern ^a   Dai, Jin ^a   Asha, Padmaja ^b   Zhang, Zhuo ^a   Wang, Yitao ^c   Shi, Xianglin ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Department of Physics   (India)

^c University of Macau   (Macao)

Author keywords

Angiogenesis; Carcinogenesis; Hexavalent chromium; Inflammation; Luteolin

Indexed keywords

CATALASE; CHROMIUM; CYCLOOXYGENASE 2; FOCAL ADHESION KINASE; GELATINASE B; GLUTATHIONE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LUTEOLIN; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STAT3 PROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; ANGIOGENIC PROTEIN; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; AUTACOID; CHROMIUM HEXAVALENT ION; DICHROMATE POTASSIUM; SCAVENGER;

ANGIOGENESIS; ARTICLE; BRONCHUS MUCOSA; CELL VIABILITY ASSAY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LUNG CARCINOGENESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BRONCHUS; CELL LINE; CELL PROTECTION; CELL SURVIVAL; CELL TRANSFORMATION; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; EPITHELIUM CELL; GENETIC TRANSFECTION; GENETICS; LUNG NEOPLASMS; METABOLISM; NUDE MOUSE; OXIDATIVE STRESS; PATHOLOGY; TOXICITY;

ANGIOGENIC PROTEINS; ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS REGULATORY PROTEINS; BRONCHI; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CHROMIUM; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FREE RADICAL SCAVENGERS; HUMANS; INFLAMMATION MEDIATORS; LUNG NEOPLASMS; LUTEOLIN; MICE, NUDE; OXIDATIVE STRESS; POTASSIUM DICHROMATE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84912123899     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.10.008     Document Type: Article

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