Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity

Carcinogenesis

Volumn 21, Issue 8, 2000, Pages 1491-1500

  Chuang, Show Mei ^a   Liou, Geou Yarh ^a   Yang, Jia Ling ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMITROLE; CHROMIUM; HYDROGEN PEROXIDE; MANNITOL; MITOGEN ACTIVATED PROTEIN KINASE; POTASSIUM CHROMATE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ADULT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; FLUORESCENCE; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MALE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; WESTERN BLOTTING;

EID: 0033867513     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.5.491     Document Type: Article

References (85)

1. Chromium
2. Genotoxicity of chromium compounds. A review
3. Mechanism of chromium(VI) carcinogenesis: Reactive intermediates and effect on gene expression
4. Reaction of chromium(VI) with glutathione or with hydrogen peroxide: Identification of reactive intermediates and their role in chromium(VI)-induced DNA damage
5. Mechanism of DNA cleavage induced by sodium chromium(VI) in the presence of hydrogen peroxide
6. The DNA cleavage induced by a chromium(V) complex and by chromate and glutathione is mediated by activated oxygen species
7. Prominent role of DT-diaphorase as a cellular mechanism reducing chromium(VI) and reverting its mutagenicity
8. Mechanisms of chromium toxicity in mitochondria
9. Reductive metabolism and protein binding of chromium(VI) by P450 protein enzymes
10. Generation of hydroxyl radical by chromate in biologically relevant systems: Role of Cr(V) complexes versus tetraperoxochromate(V)
11. Chromium-induced cross-linking of nuclear proteins and DNA
12. Comparison of DNA lesions and cytotoxicity induced by calcium chromate in human, mouse, and hamster cell lines
13. Analysis of the binding sites of chromium to DNA and protein in vitro and in intact cells
14. Two pathways for chromium(VI)-induced DNA damage in 14 day chick embryos: Cr-DNA binding in liver and 8-oxo-2'-deoxyguanosine in red blood cells
15. Mechanisms of the carcinogenic chromium(VI)-induced DNA-protein cross-linking and their characterization in cultured intact human cells
16. Incidence and localization of sister chromatid exchanges induced by nickel and chromium compounds
17. Comparison of the localization of chromosome damage induced by calcium chromate and nickel compounds
18. Mutational specificity of chromium(VI) compounds in the hprt locus of Chinese hamster ovary-K1 cells
19. Mutational spectrum of chromium(VI) in human cells
20. Chromium(VI)-induced nuclear factor-KB activation in intact cells via free radical reactions
21. Chromium induces a persistent activation of mitogen-activated protein kinases by a redox-sensitive mechanism in H4 rat hepatoma cells
22. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
23. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
24. Protein kinase cascades activated by stress and inflammatory cytokines
25. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development
26. Mitogen-activated protein kinase phosphatase: A negative regulator of the mitogen-activated protein kinase cascade
27. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
28. Regulation of JNK signaling by GSTp
29. Transcriptional regulation by extracellular signals: Mechanisms and specificity
30. Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-α in rat mesangial cells
31. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor α
32. Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases
33. The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells
34. Activation of MAPKs in human bronchial epithelial cells exposed to metals
35. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival
36. Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts
37. Effects of mannitol or catalase on the generation of reactive oxygen species leading to DNA damage by chromium(VI) reduction with ascorbate
38. Hypervalent chromium mimics reactive oxygen species as measured by the oxidant-sensitive dyes 2',7'-dichlorofluorescein and dihydrorhodamine
39. Reactive oxygen species may participate in the mutagenicity and mutational spectrum of cadmium in Chinese hamster ovary-K1 cells
40. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
41. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
42. Characterization of the mucin differentiation in human lung adenocarcinoma cell lines
43. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
44. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
45. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
46. Fluorescence detection of enzymatically formed hydrogen peroxide in aqueous solution and in reversed micelles
47. SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)
48. 2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38
49. A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses
50. 2-terminal kinase
51. 2-terminal Kinase-specific kinase
52. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
53. Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway
54. Hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
55. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
56. A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
57. Three distinct signalling responses by murine fibroblasts to genotoxic stress
58. Selective activation of JNK1 is necessary for the anti-apoptotic activity of h1LP
59. T cell proliferation in response to interleukins 2 and 7 requires p38 MAP kinase activation
60. Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase
61. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors
62. The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs)
63. Organization and regulation of mitogen-activated protein kinase signaling pathways
64. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
65. The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases
66. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase
67. Thioredoxin redox control of cell growth and death and the effects of inhibitors
68. Glutathione S-transferases-a review