NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium

Toxicological Sciences

Volumn 123, Issue 2, 2011, Pages 399-410

  Wang, Xin ^a   Son, Young Ok ^a   Chang, Qingshan ^a   Sun, Lijuan ^a   Hitron, J Andrew ^a   Budhraja, Amit ^a   Zhang, Zhuo ^a   Ke, Zunji ^b   Chen, Fei ^a   Luo, Jia ^c   Shi, Xianglin ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Carcinogenesis; Hexavalent chromium; NADPH oxidase; ROS generation

Indexed keywords

CATALASE; CHROMIUM DERIVATIVE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE; HEXAVALENT CHROMIUM; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN P22; PROTEIN P40; PROTEIN P47; PROTEIN P67; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION;

ANIMALS; BRONCHI; CARCINOGENS; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CHROMATES; CHROMIUM; ENZYME ACTIVATION; EPITHELIAL CELLS; GENE SILENCING; HUMANS; MICE; MICE, NUDE; NADPH OXIDASE; NEOPLASM TRANSPLANTATION; NEOPLASMS; OXIDATIVE STRESS; OXIDOREDUCTASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 80053439911     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr180     Document Type: Article

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