In the Multi-domain Protein Adenylate Kinase, Domain Insertion Facilitates Cooperative Folding while Accommodating Function at Domain Interfaces

PLoS Computational Biology

Volumn 10, Issue 11, 2014, Pages

  Giri Rao, V V Hemanth ^a   Gosavi, Shachi ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

COARSE-GRAINED MODELING; ENZYMES;

ADENYLATE KINASE; ALL OR NOTHINGS; COOPERATIVITY; DOMAIN INSERTION; DOMAIN INTERFACES; FOLDINGS; INTER-DOMAIN; KINASE DOMAINS; MULTI-DOMAINS; MULTIPLE DOMAINS;

ESCHERICHIA COLI;

ADENYLATE KINASE; ESCHERICHIA COLI PROTEIN;

ARTICLE; CALORIMETRY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENTHALPY; ENTROPY; ENZYME CONFORMATION; ENZYME STABILITY; ESCHERICHIA COLI; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; STRUCTURAL BIOINFORMATICS; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS;

ADENYLATE KINASE; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MUTATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS;

EID: 84912084325     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003938     Document Type: Article

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