Consequences of domain insertion on sequence-structure divergence in a superfold

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages

  Pandya, Chetanya ^a   Brown, Shoshana ^b   Pieper, Ursula ^b   Sali, Andrej ^b,c   Dunaway Mariano, Debra ^d   Babbitt, Patricia C ^b,c   Xia, Yu ^a,e,f   Allen, Karen N ^e  

^a BOSTON UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF NEW MEXICO   (United States)

^e USA   (United States)

^f MCGILL UNIVERSITY   (Canada)

Author keywords

Directed evolution; HAD superfamily; Phosphoryl transferase; Protein evolution; Structural bioinformatics

Indexed keywords

HALOALKANOATE DEHALOGENASE SUPERFAMILY; MULTIPROTEIN COMPLEX; PROTEIN; UNCLASSIFIED DRUG; HALOALKANE DEHALOGENASE; HYDROLASE;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; COEVOLUTION; CONFORMATIONAL TRANSITION; MOLECULAR EVOLUTION; MUTATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; SEQUENCE ALIGNMENT; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; GENETICS; PHYLOGENY; PRINCIPAL COMPONENT ANALYSIS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

EVOLUTION, MOLECULAR; GENETIC VARIATION; HYDROLASES; MODELS, MOLECULAR; MUTAGENESIS, INSERTIONAL; PHYLOGENY; PRINCIPAL COMPONENT ANALYSIS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84883419423     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1305519110     Document Type: Article

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