Modulation of a pre-existing conformational equilibrium tunes adenylate kinase activity

Journal of the American Chemical Society

Volumn 134, Issue 40, 2012, Pages 16562-16570

  Ådén, Jörgen ^a   Verma, Abhinav ^b   Schug, Alexander ^b   Wolf Watz, Magnus ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; CONFORMATIONAL EQUILIBRIUM; ENZYMATIC CATALYSIS; ENZYMATIC REACTION CYCLE; ENZYMATIC TURNOVER; EVOLUTIONARY PERSPECTIVE; MICHAELIS CONSTANTS; MOLECULAR DYNAMICS SIMULATIONS; OPEN CONFORMATION; OSMOLYTES; SELECTIVE PRESSURE; SUB-DOMAINS; SUBSTRATE BINDING; TURNOVER NUMBER; TURNOVER RATE;

BINDING ENERGY; ENZYMES; EQUILIBRIUM CONSTANTS; ESCHERICHIA COLI; HYDROGEN BONDS; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CONFORMATIONS;

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; HYDROGEN;

ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME METABOLISM; ENZYME STRUCTURE; EQUILIBRIUM CONSTANT; ESCHERICHIA COLI; HYDROGEN BOND; MICHAELIS CONSTANT; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN DOMAIN;

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; BINDING SITES; ESCHERICHIA COLI; HYDROGEN BONDING; METHYLAMINES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION;

EID: 84867375354     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3032482     Document Type: Article

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