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Volumn 58, Issue 7, 2013, Pages 428-433

Clinical application of the CpG island methylator phenotype to prognostic diagnosis in neuroblastomas

Author keywords

CIMP; Neuroblastoma; Poor prognosis

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CYCLOPHOSPHAMIDE; DOXORUBICIN; ISOTRETINOIN;

EID: 84880879970     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2013.64     Document Type: Review
Times cited : (20)

References (50)
  • 1
    • 84891740745 scopus 로고    scopus 로고
    • Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer
    • in press
    • Church, T. R., Wandell, M., Lofton-Day, C., Mongin, S. J., Burger, M., Payne, S. R. et al. Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer. Gut in press (2013
    • (2013) Gut
    • Church, T.R.1    Wandell, M.2    Lofton-Day, C.3    Mongin, S.J.4    Burger, M.5    Payne, S.R.6
  • 4
    • 48549101423 scopus 로고    scopus 로고
    • CpG island methylator phenotype (CIMP) in cancer: Causes and implications
    • Teodoridis, J. M., Hardie, C. & Brown, R. CpG island methylator phenotype (CIMP) in cancer: Causes and implications. Cancer Lett. 268, 177-186 (2008
    • (2008) Cancer Lett , vol.268 , pp. 177-186
    • Teodoridis, J.M.1    Hardie, C.2    Brown, R.3
  • 5
    • 77954122580 scopus 로고    scopus 로고
    • Methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors
    • Cowan, L. A., Talwar, S., Yang, A. S. & Will, D. N. A. Methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors. Epigenomics 2, 71-86 (2010
    • (2010) Epigenomics , vol.2 , pp. 71-86
    • Cowan, L.A.1    Talwar, S.2    Yang, A.S.3    Will, D.N.A.4
  • 7
    • 84655163371 scopus 로고    scopus 로고
    • Combination epigenetic therapy has efficacy in patients with refractory advanced nonsmall cell lung cancer
    • Juergens, R. A., Wrangle, J., Vendetti, F. P., Murphy, S. C., Zhao, M., Coleman, B. et al. Combination epigenetic therapy has efficacy in patients with refractory advanced nonsmall cell lung cancer. Cancer Discov. 1, 598-607 (2011
    • (2011) Cancer Discov , vol.1 , pp. 598-607
    • Juergens, R.A.1    Wrangle, J.2    Vendetti, F.P.3    Murphy, S.C.4    Zhao, M.5    Coleman, B.6
  • 8
    • 46249114389 scopus 로고    scopus 로고
    • Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis
    • Abe, M., Watanabe, N., McDonell, N., Takato, T., Ohira, M., Nakagawara, A. et al. Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis. Oncology 74, 50-60 (2008
    • (2008) Oncology , vol.74 , pp. 50-60
    • Abe, M.1    Watanabe, N.2    McDonell, N.3    Takato, T.4    Ohira, M.5    Nakagawara, A.6
  • 9
    • 84860528199 scopus 로고    scopus 로고
    • Epigenetic resensitization to platinum in ovarian cancer
    • Matei, D., Fang, F., Shen, C., Schilder, J., Arnold, A., Zeng, Y. et al. Epigenetic resensitization to platinum in ovarian cancer. Cancer Res. 72, 2197-2205 (2012
    • (2012) Cancer Res , vol.72 , pp. 2197-2205
    • Matei, D.1    Fang, F.2    Shen, C.3    Schilder, J.4    Arnold, A.5    Zeng, Y.6
  • 11
    • 58249089525 scopus 로고    scopus 로고
    • CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    • Ogino, S., Nosho, K., Kirkner, G. J., Kawasaki, T., Meyerhardt, J. A., Loda, M. et al. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 58, 90-96 (2009
    • (2009) Gut , vol.58 , pp. 90-96
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3    Kawasaki, T.4    Meyerhardt, J.A.5    Loda, M.6
  • 12
    • 36749025213 scopus 로고    scopus 로고
    • Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
    • Shen, L., Toyota, M., Kondo, Y., Lin, E., Zhang, L., Guo, Y. et al. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc. Natl Acad. Sci. USA 104, 18654-18659 (2007
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 18654-18659
    • Shen, L.1    Toyota, M.2    Kondo, Y.3    Lin, E.4    Zhang, L.5    Guo, Y.6
  • 14
    • 77950900898 scopus 로고    scopus 로고
    • IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype
    • Suzuki, H., Igarashi, S., Nojima, M., Maruyama, R., Yamamoto, E., Kai, M. et al. IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. Carcinogenesis 31, 342-349 (2010
    • (2010) Carcinogenesis , vol.31 , pp. 342-349
    • Suzuki, H.1    Igarashi, S.2    Nojima, M.3    Maruyama, R.4    Yamamoto, E.5    Kai, M.6
  • 15
    • 77249141762 scopus 로고    scopus 로고
    • Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling
    • Hinoue, T., Weisenberger, D. J., Pan, F., Campan, M., Kim, M., Young, J. et al. Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PLoS One 4, e8357 (2009
    • (2009) PLoS One , vol.4
    • Hinoue, T.1    Weisenberger, D.J.2    Pan, F.3    Campan, M.4    Kim, M.5    Young, J.6
  • 16
    • 0038325528 scopus 로고    scopus 로고
    • Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability
    • Kim, H., Kim, Y. H., Kim, S. E., Kim, N. G. & Noh, S. H. Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability. J. Pathol. 200, 23-31 (2003
    • (2003) J. Pathol , vol.200 , pp. 23-31
    • Kim, H.1    Kim, Y.H.2    Kim, S.E.3    Kim, N.G.4    Noh, S.H.5
  • 17
    • 0033229890 scopus 로고    scopus 로고
    • Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
    • Toyota, M., Ahuja, N., Suzuki, H., Itoh, F., Ohe-Toyota, M., Imai, K. et al. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res. 59, 5438-5442 (1999
    • (1999) Cancer Res , vol.59 , pp. 5438-5442
    • Toyota, M.1    Ahuja, N.2    Suzuki, H.3    Itoh, F.4    Ohe-Toyota, M.5    Imai, K.6
  • 18
    • 33751275546 scopus 로고    scopus 로고
    • Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors
    • Marsit, C. J., Houseman, E. A., Christensen, B. C., Eddy, K., Bueno, R., Sugarbaker, D. J. et al. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Res. 66, 10621-10629 (2006
    • (2006) Cancer Res , vol.66 , pp. 10621-10629
    • Marsit, C.J.1    Houseman, E.A.2    Christensen, B.C.3    Eddy, K.4    Bueno, R.5    Sugarbaker, D.J.6
  • 19
    • 0037094189 scopus 로고    scopus 로고
    • DNA methylation and environmental exposures in human hepatocellular carcinoma
    • Shen, L., Ahuja, N., Shen, Y., Habib, N. A., Toyota, M., Rashid, A. et al. DNA methylation and environmental exposures in human hepatocellular carcinoma. J. Natl Cancer Inst. 94, 755-761 (2002
    • (2002) J. Natl Cancer Inst , vol.94 , pp. 755-761
    • Shen, L.1    Ahuja, N.2    Shen, Y.3    Habib, N.A.4    Toyota, M.5    Rashid, A.6
  • 20
    • 0035099160 scopus 로고    scopus 로고
    • Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes
    • Strathdee, G., Appleton, K., Illand, M., Millan, D. W., Sargent, J., Paul, J. et al. Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes. Am. J. Pathol. 158, 1121-1127 (2001
    • (2001) Am. J. Pathol , vol.158 , pp. 1121-1127
    • Strathdee, G.1    Appleton, K.2    Illand, M.3    Millan, D.W.4    Sargent, J.5    Paul, J.6
  • 21
    • 33745123035 scopus 로고    scopus 로고
    • CpG island methylator phenotype redefines the prognostic effect of t(12;21) in childhood acute lymphoblastic leukemia
    • Roman-Gomez, J., Jimenez-Velasco, A., Agirre, X., Castillejo, J. A., Navarro, G., Calasanz, M. J. et al. CpG island methylator phenotype redefines the prognostic effect of t(12;21) in childhood acute lymphoblastic leukemia. Clin. Cancer Res. 12, 4845-4850 (2006
    • (2006) Clin. Cancer Res , vol.12 , pp. 4845-4850
    • Roman-Gomez, J.1    Jimenez-Velasco, A.2    Agirre, X.3    Castillejo, J.A.4    Navarro, G.5    Calasanz, M.J.6
  • 22
    • 0035893756 scopus 로고    scopus 로고
    • Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features
    • Maruyama, R., Toyooka, S., Toyooka, K. O., Harada, K., Virmani, A. K., Zochbauer-Muller, S. et al. Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features. Cancer Res. 61, 8659-8663 (2001
    • (2001) Cancer Res , vol.61 , pp. 8659-8663
    • Maruyama, R.1    Toyooka, S.2    Toyooka, K.O.3    Harada, K.4    Virmani, A.K.5    Zochbauer-Muller, S.6
  • 23
    • 12444268993 scopus 로고    scopus 로고
    • Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma
    • Brock, M. V., Gou, M., Akiyama, Y., Muller, A., Wu, T. T., Montgomery, E. et al. Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin. Cancer Res. 9, 2912-2919 (2003
    • (2003) Clin. Cancer Res , vol.9 , pp. 2912-2919
    • Brock, M.V.1    Gou, M.2    Akiyama, Y.3    Muller, A.4    Wu, T.T.5    Montgomery, E.6
  • 24
    • 0035992386 scopus 로고    scopus 로고
    • Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers
    • Wei, S. H., Chen, C. M., Strathdee, G., Harnsomburana, J., Shyu, C. R., Rahmatpanah, F. et al. Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers. Clin. Cancer Res. 8, 2246-2252 (2002
    • (2002) Clin. Cancer Res , vol.8 , pp. 2246-2252
    • Wei, S.H.1    Chen, C.M.2    Strathdee, G.3    Harnsomburana, J.4    Shyu, C.R.5    Rahmatpanah, F.6
  • 25
    • 33645801603 scopus 로고    scopus 로고
    • Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus
    • Kusano, M., Toyota, M., Suzuki, H., Akino, K., Aoki, F., Fujita, M. et al. Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus. Cancer 106, 1467-1479 (2006
    • (2006) Cancer , vol.106 , pp. 1467-1479
    • Kusano, M.1    Toyota, M.2    Suzuki, H.3    Akino, K.4    Aoki, F.5    Fujita, M.6
  • 26
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr, H., Weisenberger, D. J., Diefes, K., Phillips, H. S., Pujara, K., Berman, B. P. et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17, 510-522 (2010
    • (2010) Cancer Cell , vol.17 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3    Phillips, H.S.4    Pujara, K.5    Berman, B.P.6
  • 27
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan, S., Rohle, D., Goenka, A., Walsh, L. A., Fang, F., Yilmaz, E. et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483, 479-483 (2012
    • (2012) Nature , vol.483 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3    Walsh, L.A.4    Fang, F.5    Yilmaz, E.6
  • 29
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S. H. et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17-30 (2011
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.H.6
  • 30
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A. et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553-567 (2010
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6
  • 31
    • 77953523121 scopus 로고    scopus 로고
    • Recent advances in neuroblastoma
    • Maris, J. M. Recent advances in neuroblastoma. N. Engl. J. Med. 362, 2202-2211 (2010
    • (2010) N. Engl. J. Med , vol.362 , pp. 2202-2211
    • Maris, J.M.1
  • 32
    • 58249093955 scopus 로고    scopus 로고
    • The International Neuroblastoma Risk Group (INRG) classification system: An INRG Task Force report
    • Cohn, S. L., Pearson, A. D., London, W. B., Monclair, T., Ambros, P. F., Brodeur, G. M. et al. The International Neuroblastoma Risk Group (INRG) classification system: An INRG Task Force report. J. Clin. Oncol. 27, 289-297 (2009
    • (2009) J. Clin. Oncol , vol.27 , pp. 289-297
    • Cohn, S.L.1    Pearson, A.D.2    London, W.B.3    Monclair, T.4    Ambros, P.F.5    Brodeur, G.M.6
  • 33
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Suppl
    • Jaenisch, R. & Bird, A. Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat. Genet. 33 (Suppl), 245-254 (2003
    • (2003) Nat. Genet , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 34
    • 0036733675 scopus 로고    scopus 로고
    • Chromatin modification and epigenetic reprogramming in mammalian development
    • Li, E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat. Rev. Genet. 3, 662-673 (2002
    • (2002) Nat. Rev. Genet , vol.3 , pp. 662-673
    • Li, E.1
  • 35
    • 13444270332 scopus 로고    scopus 로고
    • CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas
    • Abe, M., Ohira, M., Kaneda, A., Yagi, Y., Yamamoto, S., Kitano, Y. et al. CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res. 65, 828-834 (2005
    • (2005) Cancer Res , vol.65 , pp. 828-834
    • Abe, M.1    Ohira, M.2    Kaneda, A.3    Yagi, Y.4    Yamamoto, S.5    Kitano, Y.6
  • 36
    • 33846922849 scopus 로고    scopus 로고
    • Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas
    • Abe, M., Westermann, F., Nakagawara, A., Takato, T., Schwab, M. & Ushijima, T. Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas. Cancer Lett. 247, 253-258 (2007
    • (2007) Cancer Lett , vol.247 , pp. 253-258
    • Abe, M.1    Westermann, F.2    Nakagawara, A.3    Takato, T.4    Schwab, M.5    Ushijima, T.6
  • 37
    • 84857740783 scopus 로고    scopus 로고
    • A pyrosequencing assay for the quantitative methylation analysis of the PCDHB gene cluster, the major factor in neuroblastoma methylator phenotype
    • Banelli, B., Brigati, C., Di Vinci, A., Casciano, I., Forlani, A., Borzi, L. et al. A pyrosequencing assay for the quantitative methylation analysis of the PCDHB gene cluster, the major factor in neuroblastoma methylator phenotype. Lab. Invest. 92, 458-465 (2011
    • (2011) Lab. Invest , vol.92 , pp. 458-465
    • Banelli, B.1    Brigati, C.2    Di Vinci, A.3    Casciano, I.4    Forlani, A.5    Borzi, L.6
  • 38
    • 84866165031 scopus 로고    scopus 로고
    • Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas
    • Kiss, N. B., Kogner, P., Johnsen, J. I., Martinsson, T., Larsson, C. & Geli, J. Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas. BMC Med. Genet. 13, 83 (2012
    • (2012) BMC Med. Genet , vol.13 , Issue.83
    • Kiss, N.B.1    Kogner, P.2    Johnsen, J.I.3    Martinsson, T.4    Larsson, C.5    Geli, J.6
  • 39
    • 0021063273 scopus 로고
    • Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
    • Schwab, M., Alitalo, K., Klempnauer, K. H., Varmus, H. E., Bishop, J. M., Gilbert, F. et al. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature 305, 245-248 (1983
    • (1983) Nature , vol.305 , pp. 245-248
    • Schwab, M.1    Alitalo, K.2    Klempnauer, K.H.3    Varmus, H.E.4    Bishop, J.M.5    Gilbert, F.6
  • 40
    • 0021261878 scopus 로고
    • Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage
    • Brodeur, G. M., Seeger, R. C., Schwab, M., Varmus, H. E. & Bishop, J. M. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224, 1121-1124 (1984
    • (1984) Science , vol.224 , pp. 1121-1124
    • Brodeur, G.M.1    Seeger, R.C.2    Schwab, M.3    Varmus, H.E.4    Bishop, J.M.5
  • 41
    • 0022388606 scopus 로고
    • Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas
    • Seeger, R. C., Brodeur, G. M., Sather, H., Dalton, A., Siegel, S. E., Wong, K. Y. et al. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N. Engl. J. Med. 313, 1111-1116 (1985
    • (1985) N. Engl. J. Med , vol.313 , pp. 1111-1116
    • Seeger, R.C.1    Brodeur, G.M.2    Sather, H.3    Dalton, A.4    Siegel, S.E.5    Wong, K.Y.6
  • 42
    • 79951840043 scopus 로고    scopus 로고
    • Hypermethylation of apoptotic genes as independent prognostic factor in neuroblastoma disease
    • Grau, E., Martinez, F., Orellana, C., Canete, A., Yanez, Y., Oltra, S. et al. Hypermethylation of apoptotic genes as independent prognostic factor in neuroblastoma disease. Mol. Carcinog. 50, 153-162 (2011
    • (2011) Mol. Carcinog , vol.50 , pp. 153-162
    • Grau, E.1    Martinez, F.2    Orellana, C.3    Canete, A.4    Yanez, Y.5    Oltra, S.6
  • 43
    • 20144387913 scopus 로고    scopus 로고
    • EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma
    • Alaminos, M., Davalos, V., Ropero, S., Setien, F., Paz, M. F., Herranz, M. et al. EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma. Cancer Res. 65, 2565-2571 (2005
    • (2005) Cancer Res , vol.65 , pp. 2565-2571
    • Alaminos, M.1    Davalos, V.2    Ropero, S.3    Setien, F.4    Paz, M.F.5    Herranz, M.6
  • 44
    • 4344688973 scopus 로고    scopus 로고
    • Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma
    • Alaminos, M., Davalos, V., Cheung, N. K., Gerald, W. L. & Esteller, M. Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma. J. Natl Cancer Inst. 96, 1208-1219 (2004
    • (2004) J. Natl Cancer Inst , vol.96 , pp. 1208-1219
    • Alaminos, M.1    Davalos, V.2    Cheung, N.K.3    Gerald, W.L.4    Esteller, M.5
  • 45
    • 28544444942 scopus 로고    scopus 로고
    • Methylation-Associated silencing of the nuclear receptor 1I2 gene in advanced-Type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification
    • Misawa, A., Inoue, J., Sugino, Y., Hosoi, H., Sugimoto, T., Hosoda, F. et al. Methylation-Associated silencing of the nuclear receptor 1I2 gene in advanced-Type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification. Cancer Res. 65, 10233-10242 (2005
    • (2005) Cancer Res , vol.65 , pp. 10233-10242
    • Misawa, A.1    Inoue, J.2    Sugino, Y.3    Hosoi, H.4    Sugimoto, T.5    Hosoda, F.6
  • 46
    • 84878642565 scopus 로고    scopus 로고
    • Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas
    • in press
    • Asada, K., Watanabe, N., Nakamura, Y., Ohira, M., Westermann, F., Scwab, M. et al. Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas. Jpn J. Clin. Oncol. in press (2013
    • (2013) Jpn J. Clin. Oncol
    • Asada, K.1    Watanabe, N.2    Nakamura, Y.3    Ohira, M.4    Westermann, F.5    Scwab, M.6
  • 47
    • 62449197931 scopus 로고    scopus 로고
    • Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: Implications for therapy
    • Schulte, J. H., Lim, S., Schramm, A., Friedrichs, N., Koster, J., Versteeg, R. et al. Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: Implications for therapy. Cancer Res. 69, 2065-2071 (2009
    • (2009) Cancer Res , vol.69 , pp. 2065-2071
    • Schulte, J.H.1    Lim, S.2    Schramm, A.3    Friedrichs, N.4    Koster, J.5    Versteeg, R.6
  • 48
    • 72249117352 scopus 로고    scopus 로고
    • Identification of cell-Active lysine specific demethylase 1-selective inhibitors
    • Ueda, R., Suzuki, T., Mino, K., Tsumoto, H., Nakagawa, H., Hasegawa, M. et al. Identification of cell-Active lysine specific demethylase 1-selective inhibitors. J. Am. Chem. Soc. 131, 17536-17537 (2009
    • (2009) J. Am. Chem. Soc , vol.131 , pp. 17536-17537
    • Ueda, R.1    Suzuki, T.2    Mino, K.3    Tsumoto, H.4    Nakagawa, H.5    Hasegawa, M.6
  • 49
    • 77957039745 scopus 로고    scopus 로고
    • Phase i study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors: A children's oncology group study
    • George, R. E., Lahti, J. M., Adamson, P. C., Zhu, K., Finkelstein, D., Ingle, A. M. et al. Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors: A Children's Oncology Group study. Pediatr. Blood Cancer 55, 629-638 (2010
    • (2010) Pediatr. Blood Cancer , vol.55 , pp. 629-638
    • George, R.E.1    Lahti, J.M.2    Adamson, P.C.3    Zhu, K.4    Finkelstein, D.5    Ingle, A.M.6
  • 50
    • 33745541234 scopus 로고    scopus 로고
    • CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    • Weisenberger, D. J., Siegmund, K. D., Campan, M., Young, J., Long, T. I., Faasse, M. A. et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat. Genet. 38, 787-793 (2006
    • (2006) Nat. Genet , vol.38 , pp. 787-793
    • Weisenberger, D.J.1    Siegmund, K.D.2    Campan, M.3    Young, J.4    Long, T.I.5    Faasse, M.A.6


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