Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test

Neuropharmacology

Volumn 63, Issue 6, 2012, Pages 1051-1063

  Clark, J A ^a,b   Alves, S ^a   Gundlah, C ^a   Rocha, B ^a   Birzin, E T ^a   Cai, S J ^a   Flick, R ^a   Hayes, E ^a   Ho, K ^a   Warrier, S ^a   Pai, L ^a   Yudkovitz, J ^a   Fleischer, R ^a   Colwell, L ^a   Li, S ^a   Wilkinson, H ^a   Schaeffer, J ^a   Wilkening, R ^a   Mattingly, E ^a   Hammond, M ^a   Rohrer, S P ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Antidepressant activity; ER ; Neurogenesis; Progesterone receptor; Selective estrogen receptor beta modulator; TPH1

Indexed keywords

ESTROGEN RECEPTOR BETA; PROGESTERONE RECEPTOR; SELECTIVE ESTROGEN RECEPTOR BETA1 MODULATOR; SELECTIVE ESTROGEN RECEPTOR BETA2 MODULATOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN DEVELOPMENT; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; DEPRESSION; DORSAL RAPHE NUCLEUS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG PENETRATION; ESTROGEN RESPONSIVE ELEMENT; FEMALE; FORCED SWIMMING TEST; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; UTERUS WEIGHT;

ANIMALS; ANTIDEPRESSIVE AGENTS; BLOOD-BRAIN BARRIER; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NEUROGENESIS; ORGAN SIZE; PLASMIDS; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; RECEPTORS, PROGESTERONE; RNA, MESSENGER; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SWIMMING; TRANSCRIPTIONAL ACTIVATION; TRYPTOPHAN HYDROXYLASE; UTERUS;

EID: 84865274050     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.07.004     Document Type: Article

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