Fast synaptic subcortical control of hippocampal circuits

Science

Volumn 326, Issue 5951, 2009, Pages 449-453

  Varga, Viktor ^a   Losonczy, Attila ^b,c   Zemelman, Boris V ^b   Borhegyi, Zsolt ^a   Nyiri, Gábor ^a   Domonkos, Andor ^a   Hangya, Balázs ^a   Holderith, Noémi ^a   Magee, Jeffrey C ^b   Freund, Tamás F ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLOGY; PATHOLOGY; SPATIOTEMPORAL ANALYSIS;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; GABAERGIC TRANSMISSION; HIPPOCAMPUS; INTERNEURON; NERVE CELL NETWORK; NERVE CELL STIMULATION; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; SEROTONINERGIC NERVE CELL; SYNAPTIC TRANSMISSION;

ANIMALS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIALS; INTERNEURONS; MICE; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES; PHOTIC STIMULATION; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SYNAPSES; SYNAPTIC POTENTIALS;

EID: 70350132404     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1178307     Document Type: Article

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22. The efficiency in recruiting inhibitory neuron groups of the fast modulation described herein implies that the pathological alteration of this connection would dramatically shift the inhibitory and excitatory balance leading, ultimately, to the impairment of the target network.
23. We thank A. Lee and B. Kocsis for their comments on the manuscript. We thank L. Acsady and B. K. Andrásfalvy for helping to establish the collaboration between V.V. and A.L. We thank B. Shields, K. Lengyel, and G. Goda for technical assistance. V.V. and G.N. were János Bolyai Research Fellows. This work was supported by grants from the NIH (NIH-MH-54671), Howard Hughes Medical Institute (HHMI55005608), and Hungarian Scientific Research Fund (OTKA K-60927 and NKTH-OTKA CNK 77793). Author contributions V.V., A.L., J.C.M, and T.F.F. conceived the experiments. V.V. conducted the in vivo physiological experiments with the help of A.D. B.V.Z performed the molecular experiments. A.L. performed the in vitro experiments. Z. B. and G.N performed most of the histological experiments. N.H. performed the in vitro experiments for the specificity of the NBQX effect. V.V. and A.L. analyzed most of the physiological data except firing pattern analysis carried out by B.H. A.L., V.V., B.V.Z., J.C.M., and T.F.F. wrote the paper.