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Volumn 201, Issue 2, 2008, Pages 203-218

Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice

Author keywords

5 hydroxy L tryptophan (5 HTP); 8 hydroxy 2 (di n propylamino)tetralin (8 OH DPAT); Dopamine transporter (DAT); High performance liquid chromatography (HPLC); Serotonin syndrome behaviors; Temperature

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 3,4 DIHYDROXYPHENYLACETIC ACID; 5 CARBAMOYLTRYPTAMINE; 5 HYDROXYINDOLEACETIC ACID; 5 HYDROXYTRYPTOPHAN; CATECHOLAMINE; CLORGYLINE; DOPAMINE; DOPAMINE TRANSPORTER; MONOAMINE OXIDASE INHIBITOR; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NORADRENALIN; SEROTONIN; SEROTONIN 1A ANTAGONIST; SEROTONIN TRANSPORTER; TRANYLCYPROMINE; VANOXERINE;

EID: 56349119282     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-008-1268-7     Document Type: Article
Times cited : (48)

References (83)
  • 1
    • 33745000987 scopus 로고    scopus 로고
    • Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter
    • C Alexandre D Popa V Fabre S Bouali P Venault KP Lesch M Hamon J Adrien 2006 Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter J Neurosci 26 5554 5564
    • (2006) J Neurosci , vol.26 , pp. 5554-5564
    • Alexandre, C.1    Popa, D.2    Fabre, V.3    Bouali, S.4    Venault, P.5    Lesch, K.P.6    Hamon, M.7    Adrien, J.8
  • 2
    • 0027511558 scopus 로고
    • Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2′>- aminophenyl)-1,2,3,6-tetrahydropyridine (2′>-NH2-MPTP): A comparative study with 2′>-CH3-MPTP and MPTP
    • AM Andrews DL Murphy 1993 Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4- (2′>-aminophenyl)-1,2,3,6-tetrahydropyridine (2′>-NH2-MPTP): a comparative study with 2′>-CH3-MPTP and MPTP J Neurochem 60 1167 1170
    • (1993) J Neurochem , vol.60 , pp. 1167-1170
    • Andrews, A.M.1    Murphy, D.L.2
  • 3
    • 7444232259 scopus 로고    scopus 로고
    • Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
    • MS Ansorge M Zhou A Lira R Hen JA Gingrich 2004 Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice Science 306 879 881
    • (2004) Science , vol.306 , pp. 879-881
    • Ansorge, M.S.1    Zhou, M.2    Lira, A.3    Hen, R.4    Gingrich, J.A.5
  • 4
    • 38149041752 scopus 로고    scopus 로고
    • Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice
    • MS Ansorge E Morelli JA Gingrich 2008 Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice J Neurosci 28 199 207
    • (2008) J Neurosci , vol.28 , pp. 199-207
    • Ansorge, M.S.1    Morelli, E.2    Gingrich, J.A.3
  • 5
    • 0021683185 scopus 로고
    • Rat brain concentrations of 5-hydroxytryptamine following acute and chronic administration of MAO-inhibiting antidepressants
    • GB Baker DF LeGatt RT Coutts WG Dewhurst 1984 Rat brain concentrations of 5-hydroxytryptamine following acute and chronic administration of MAO-inhibiting antidepressants Prog Neuro-psychopharmacol Biol Psychiatry 8 653 656
    • (1984) Prog Neuro-psychopharmacol Biol Psychiatry , vol.8 , pp. 653-656
    • Baker, G.B.1    Legatt, D.F.2    Coutts, R.T.3    Dewhurst, W.G.4
  • 6
    • 17444412051 scopus 로고    scopus 로고
    • The dopamine transporter: Potential involvement in neuropsychiatric disorders
    • Watson SJ (ed) Raven Press Ltd., New York, NY., (Available at)
    • Bannon MJ, Sacchetti P, Granneman JG (1998) The dopamine transporter: potential involvement in neuropsychiatric disorders. In: Watson SJ (ed) Psychopharmacology: The fourth generation of progress. Raven Press Ltd., New York, NY., (Available at http://www.acnp.org/G4/toc.htm )
    • (1998) Psychopharmacology: The Fourth Generation of Progress
    • Bannon, M.J.1    Sacchetti, P.2    Granneman, J.G.3
  • 7
    • 0031978809 scopus 로고    scopus 로고
    • Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("ecstasy") in serotonin transporter-deficient mice
    • D Bengel DL Murphy AM Andrews CH Wichems D Feltner A Heils R Mossner H Westphal KP Lesch 1998 Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("ecstasy") in serotonin transporter-deficient mice Mol Pharmacol 53 649 655
    • (1998) Mol Pharmacol , vol.53 , pp. 649-655
    • Bengel, D.1    Murphy, D.L.2    Andrews, A.M.3    Wichems, C.H.4    Feltner, D.5    Heils, A.6    Mossner, R.7    Westphal, H.8    Lesch, K.P.9
  • 8
    • 0025815784 scopus 로고
    • Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia
    • DJ Bill M Knight EA Forster A Fletcher 1991 Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia Br J Pharmacol 103 1857 1864
    • (1991) Br J Pharmacol , vol.103 , pp. 1857-1864
    • Bill, D.J.1    Knight, M.2    Forster, E.A.3    Fletcher, A.4
  • 10
    • 0036087458 scopus 로고    scopus 로고
    • Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino) tetraline: Analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice
    • P Bonaventure D Nepomuceno A Kwok W Chai X Langlois R Hen K Stark N Carruthers TW Lovenberg 2002 Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice J Pharmacol Exp Ther 302 240 248
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 240-248
    • Bonaventure, P.1    Nepomuceno, D.2    Kwok, A.3    Chai, W.4    Langlois, X.5    Hen, R.6    Stark, K.7    Carruthers, N.8    Lovenberg, T.W.9
  • 12
    • 1642463529 scopus 로고    scopus 로고
    • Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter
    • S Bouali A Evrard M Chastanet KP Lesch M Hamon J Adrien 2003 Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter Eur J Neurosci 18 2203 12
    • (2003) Eur J Neurosci , vol.18 , pp. 2203-12
    • Bouali, S.1    Evrard, A.2    Chastanet, M.3    Lesch, K.P.4    Hamon, M.5    Adrien, J.6
  • 15
    • 33745880126 scopus 로고    scopus 로고
    • Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A/7 receptor agonist 8-OH-DPAT
    • C Faure O Mnie-Filali H Scarna G Debonnel N Haddjeri 2006 Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A/7 receptor agonist 8-OH-DPAT Neurosci Lett 404 122 126
    • (2006) Neurosci Lett , vol.404 , pp. 122-126
    • Faure, C.1    Mnie-Filali, O.2    Scarna, H.3    Debonnel, G.4    Haddjeri, N.5
  • 16
    • 34848871368 scopus 로고    scopus 로고
    • Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice
    • M Fox C Jensen P Gallagher D Murphy 2007 Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice Neuropharmacology 53 643 656
    • (2007) Neuropharmacology , vol.53 , pp. 643-656
    • Fox, M.1    Jensen, C.2    Gallagher, P.3    Murphy, D.4
  • 19
    • 0035122950 scopus 로고    scopus 로고
    • Modifications of the serotonergic system in mice lacking serotonin transporters: An in vivo electrophysiological study
    • G Gobbi DL Murphy K Lesch P Blier 2001 Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study J Pharmacol Exp Ther 296 987 995
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 987-995
    • Gobbi, G.1    Murphy, D.L.2    Lesch, K.3    Blier, P.4
  • 21
    • 0022346496 scopus 로고
    • The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). a model of presynaptic 5-HT1 function
    • GM Goodwin RJ De Souza AR Green 1985 The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). A model of presynaptic 5-HT1 function Neuropharmacology 24 1187 1194
    • (1985) Neuropharmacology , vol.24 , pp. 1187-1194
    • Goodwin, G.M.1    De Souza, R.J.2    Green, A.R.3
  • 22
    • 0022991462 scopus 로고
    • The enhancement by lithium of the 5-HT1A mediated serotonin syndrome produced by 8-OH-DPAT in the rat: Evidence for a post-synaptic mechanism
    • GM Goodwin RJ De Souza AJ Wood AR Green 1986 The enhancement by lithium of the 5-HT1A mediated serotonin syndrome produced by 8-OH-DPAT in the rat: evidence for a post-synaptic mechanism Psychopharmacology (Berl) 90 488 493
    • (1986) Psychopharmacology (Berl) , vol.90 , pp. 488-493
    • Goodwin, G.M.1    De Souza, R.J.2    Wood, A.J.3    Green, A.R.4
  • 23
    • 0023109436 scopus 로고
    • Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat
    • GM Goodwin RJ De Souza AR Green 1987 Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat Psychopharmacology (Berl) 91 500 505
    • (1987) Psychopharmacology (Berl) , vol.91 , pp. 500-505
    • Goodwin, G.M.1    De Souza, R.J.2    Green, A.R.3
  • 24
    • 0023117333 scopus 로고
    • The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
    • GM Goodwin RJ De Souza AR Green DJ Heal 1987 The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) Psychopharmacology (Berl) 91 506 511
    • (1987) Psychopharmacology (Berl) , vol.91 , pp. 506-511
    • Goodwin, G.M.1    De Souza, R.J.2    Green, A.R.3    Heal, D.J.4
  • 28
    • 33645799676 scopus 로고    scopus 로고
    • Genetics of emotional regulation: The role of the serotonin transporter in neural function
    • AR Hariri A Holmes 2006 Genetics of emotional regulation: the role of the serotonin transporter in neural function Trends Cogn Sci 10 182 191
    • (2006) Trends Cogn Sci , vol.10 , pp. 182-191
    • Hariri, A.R.1    Holmes, A.2
  • 31
    • 27944496843 scopus 로고    scopus 로고
    • 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern
    • PB Hedlund S Huitron-Resendiz SJ Henriksen JG Sutcliffe 2005 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern Biol Psychiatry 58 831 837
    • (2005) Biol Psychiatry , vol.58 , pp. 831-837
    • Hedlund, P.B.1    Huitron-Resendiz, S.2    Henriksen, S.J.3    Sutcliffe, J.G.4
  • 32
    • 0032933452 scopus 로고    scopus 로고
    • Paroxetine: A review of its pharmacology, pharmacokinetics and utility in the treatment of a variety of psychiatric disorders
    • WE Heydorn 1999 Paroxetine: a review of its pharmacology, pharmacokinetics and utility in the treatment of a variety of psychiatric disorders Expert Opin Investig Drugs 8 417 441
    • (1999) Expert Opin Investig Drugs , vol.8 , pp. 417-441
    • Heydorn, W.E.1
  • 33
    • 0036897940 scopus 로고    scopus 로고
    • Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter
    • A Holmes RJ Yang DL Murphy JN Crawley 2002 Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter Neuropsychopharmacology 27 914 923
    • (2002) Neuropsychopharmacology , vol.27 , pp. 914-923
    • Holmes, A.1    Yang, R.J.2    Murphy, D.L.3    Crawley, J.N.4
  • 34
    • 0345305849 scopus 로고    scopus 로고
    • Abnormal anxiety-related behavior in serotonin transporter null mutant mice: The influence of genetic background
    • A Holmes Q Li DL Murphy E Gold JN Crawley 2003 Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background Genes Brain Behav 2 365 380
    • (2003) Genes Brain Behav , vol.2 , pp. 365-380
    • Holmes, A.1    Li, Q.2    Murphy, D.L.3    Gold, E.4    Crawley, J.N.5
  • 35
    • 0242600079 scopus 로고    scopus 로고
    • Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior
    • A Holmes RJ Yang KP Lesch JN Crawley DL Murphy 2003 Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior Neuropsychopharmacology 28 2077 2088
    • (2003) Neuropsychopharmacology , vol.28 , pp. 2077-2088
    • Holmes, A.1    Yang, R.J.2    Lesch, K.P.3    Crawley, J.N.4    Murphy, D.L.5
  • 38
    • 33644526575 scopus 로고    scopus 로고
    • Effects of co-administration of a selective serotonin reuptake inhibitor and monoamine oxidase inhibitors on 5-HT-related behavior in rats
    • T Izumi N Iwamoto Y Kitaichi A Kato T Inoue T Koyama 2006 Effects of co-administration of a selective serotonin reuptake inhibitor and monoamine oxidase inhibitors on 5-HT-related behavior in rats Eur J Pharmacol 532 258 264
    • (2006) Eur J Pharmacol , vol.532 , pp. 258-264
    • Izumi, T.1    Iwamoto, N.2    Kitaichi, Y.3    Kato, A.4    Inoue, T.5    Koyama, T.6
  • 39
    • 0017086367 scopus 로고
    • An animal behavior model for studying central serotonergic synapses
    • BL Jacobs 1976 An animal behavior model for studying central serotonergic synapses Life Sci 19 777 785
    • (1976) Life Sci , vol.19 , pp. 777-785
    • Jacobs, B.L.1
  • 41
    • 34249065202 scopus 로고    scopus 로고
    • Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice
    • AV Kalueff MA Fox PS Gallagher DL Murphy 2007 Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice Genes Brain Behav 6 389 400
    • (2007) Genes Brain Behav , vol.6 , pp. 389-400
    • Kalueff, A.V.1    Fox, M.A.2    Gallagher, P.S.3    Murphy, D.L.4
  • 42
    • 0022359434 scopus 로고
    • Central serotonergic responses and behavioural adaptation to repeated immobilisation: The effect of the corticosterone synthesis inhibitor metyrapone
    • GA Kennett SL Dickinson G Curzon 1985 Central serotonergic responses and behavioural adaptation to repeated immobilisation: the effect of the corticosterone synthesis inhibitor metyrapone Eur J Pharmacol 119 143 152
    • (1985) Eur J Pharmacol , vol.119 , pp. 143-152
    • Kennett, G.A.1    Dickinson, S.L.2    Curzon, G.3
  • 45
    • 0032706095 scopus 로고    scopus 로고
    • Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice
    • Q Li C Wichems A Heils LD Van De Kar KP Lesch DL Murphy 1999 Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice J Pharmacol Exp Ther 291 999 1007
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 999-1007
    • Li, Q.1    Wichems, C.2    Heils, A.3    Van De Kar, L.D.4    Lesch, K.P.5    Murphy, D.L.6
  • 46
    • 0034331195 scopus 로고    scopus 로고
    • Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: Gender and brain region differences
    • Q Li C Wichems A Heils KP Lesch DL Murphy 2000 Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences J Neurosci 20 7888 7895
    • (2000) J Neurosci , vol.20 , pp. 7888-7895
    • Li, Q.1    Wichems, C.2    Heils, A.3    Lesch, K.P.4    Murphy, D.L.5
  • 47
    • 0021336087 scopus 로고
    • Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat
    • I Lucki MS Nobler A Frazer 1984 Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat J Pharmacol Exp Ther 228 133 139
    • (1984) J Pharmacol Exp Ther , vol.228 , pp. 133-139
    • Lucki, I.1    Nobler, M.S.2    Frazer, A.3
  • 48
    • 0026784676 scopus 로고
    • Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants
    • KF Martin I Phillips M Hearson MR Prow DJ Heal 1992 Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants Br J Pharmacol 107 15 21
    • (1992) Br J Pharmacol , vol.107 , pp. 15-21
    • Martin, K.F.1    Phillips, I.2    Hearson, M.3    Prow, M.R.4    Heal, D.J.5
  • 49
    • 10344221595 scopus 로고    scopus 로고
    • Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression
    • TA Mathews DE Fedele FM Coppelli AM Avila DL Murphy AM Andrews 2004 Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression J Neurosci Methods 140 169 181
    • (2004) J Neurosci Methods , vol.140 , pp. 169-181
    • Mathews, T.A.1    Fedele, D.E.2    Coppelli, F.M.3    Avila, A.M.4    Murphy, D.L.5    Andrews, A.M.6
  • 51
    • 17144466384 scopus 로고    scopus 로고
    • Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice
    • S Montanez WA Owens GG Gould DL Murphy LC Daws 2003 Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice J Neurochem 86 210 219
    • (2003) J Neurochem , vol.86 , pp. 210-219
    • Montanez, S.1    Owens, W.A.2    Gould, G.G.3    Murphy, D.L.4    Daws, L.C.5
  • 53
  • 54
    • 38649099407 scopus 로고    scopus 로고
    • Targeting the murine serotonin transporter: Insights into human neurobiology
    • DL Murphy KP Lesch 2008 Targeting the murine serotonin transporter: insights into human neurobiology Nat Rev Neurosci 9 85 96
    • (2008) Nat Rev Neurosci , vol.9 , pp. 85-96
    • Murphy, D.L.1    Lesch, K.P.2
  • 55
    • 0031671214 scopus 로고    scopus 로고
    • Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs
    • Suppl 15
    • DL Murphy AM Andrews CH Wichems Q Li M Tohda B Greenberg 1998 Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs J Clin Psychiatry 59 Suppl 15 4 12
    • (1998) J Clin Psychiatry , vol.59 , pp. 4-12
    • Murphy, D.L.1    Andrews, A.M.2    Wichems, C.H.3    Li, Q.4    Tohda, M.5    Greenberg, B.6
  • 56
    • 2342629856 scopus 로고    scopus 로고
    • Serotonin transporter: Gene, genetic disorders, and pharmacogenetics
    • DL Murphy A Lerner G Rudnick KP Lesch 2004 Serotonin transporter: gene, genetic disorders, and pharmacogenetics Mol Interv 4 109 123
    • (2004) Mol Interv , vol.4 , pp. 109-123
    • Murphy, D.L.1    Lerner, A.2    Rudnick, G.3    Lesch, K.P.4
  • 57
    • 0031727557 scopus 로고    scopus 로고
    • The serotonin transporter and depression
    • Suppl 1
    • MJ Owens CB Nemeroff 1998 The serotonin transporter and depression Depress Anxiety 8 Suppl 1 5 12
    • (1998) Depress Anxiety , vol.8 , pp. 5-12
    • Owens, M.J.1    Nemeroff, C.B.2
  • 58
    • 0035977577 scopus 로고    scopus 로고
    • Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice
    • Y Pan E Gembom W Peng KP Lesch R Mossner R Simantov 2001 Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice Brain Res Dev Brain Res 126 125 129
    • (2001) Brain Res Dev Brain Res , vol.126 , pp. 125-129
    • Pan, Y.1    Gembom, E.2    Peng, W.3    Lesch, K.P.4    Mossner, R.5    Simantov, R.6
  • 60
    • 43649087841 scopus 로고    scopus 로고
    • Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: Evidence from sleep, stress, and behavior
    • D Popa C Lena C Alexandre J Adrien 2008 Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior J Neurosci 28 3546 3554
    • (2008) J Neurosci , vol.28 , pp. 3546-3554
    • Popa, D.1    Lena, C.2    Alexandre, C.3    Adrien, J.4
  • 62
    • 21244500509 scopus 로고    scopus 로고
    • 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter
    • Y Qu N Villacreses DL Murphy SI Rapoport 2005 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter Psychopharmacology (Berl) 180 12 20
    • (2005) Psychopharmacology (Berl) , vol.180 , pp. 12-20
    • Qu, Y.1    Villacreses, N.2    Murphy, D.L.3    Rapoport, S.I.4
  • 63
    • 0035059877 scopus 로고    scopus 로고
    • Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein
    • A Ravary A Muzerelle M Darmon DL Murphy R Moessner KP Lesch P Gaspar 2001 Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein Eur J Neurosci 13 1349 1362
    • (2001) Eur J Neurosci , vol.13 , pp. 1349-1362
    • Ravary, A.1    Muzerelle, A.2    Darmon, M.3    Murphy, D.L.4    Moessner, R.5    Lesch, K.P.6    Gaspar, P.7
  • 65
    • 23144436298 scopus 로고    scopus 로고
    • The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments
    • A Serretti F Benedetti R Zanardi E Smeraldi 2005 The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments Prog Neuro-psychopharmacol Biol Psychiatry 29 1074 1084
    • (2005) Prog Neuro-psychopharmacol Biol Psychiatry , vol.29 , pp. 1074-1084
    • Serretti, A.1    Benedetti, F.2    Zanardi, R.3    Smeraldi, E.4
  • 66
    • 36448980625 scopus 로고    scopus 로고
    • Important messages in the 'post': Recent discoveries in 5-HT neurone feedback control
    • T Sharp L Boothman J Raley P Queree 2007 Important messages in the 'post': recent discoveries in 5-HT neurone feedback control Trends Pharmacol Sci 28 629 636
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 629-636
    • Sharp, T.1    Boothman, L.2    Raley, J.3    Queree, P.4
  • 69
    • 0022457933 scopus 로고
    • Differential effects of 5-hydroxytryptamine1a selective drugs on the 5-HT behavioral syndrome
    • LM Smith SJ Peroutka 1986 Differential effects of 5-hydroxytryptamine1a selective drugs on the 5-HT behavioral syndrome Pharmacol Biochem Behav 24 1513 1519
    • (1986) Pharmacol Biochem Behav , vol.24 , pp. 1513-1519
    • Smith, L.M.1    Peroutka, S.J.2
  • 71
    • 0036892142 scopus 로고    scopus 로고
    • Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene
    • OA Tjurmina I Armando JM Saavedra DS Goldstein DL Murphy 2002 Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene Endocrinology 143 4520 4526
    • (2002) Endocrinology , vol.143 , pp. 4520-4526
    • Tjurmina, O.A.1    Armando, I.2    Saavedra, J.M.3    Goldstein, D.S.4    Murphy, D.L.5
  • 72
    • 38349150151 scopus 로고    scopus 로고
    • The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis
    • R Uher P McGuffin 2008 The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis Mol Psychiatry 13 131 146
    • (2008) Mol Psychiatry , vol.13 , pp. 131-146
    • Uher, R.1    McGuffin, P.2
  • 75
    • 33751175401 scopus 로고    scopus 로고
    • Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats
    • A Wesolowska A Nikiforuk K Stachowicz 2006 Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats Eur J Pharmacol 553 185 190
    • (2006) Eur J Pharmacol , vol.553 , pp. 185-190
    • Wesolowska, A.1    Nikiforuk, A.2    Stachowicz, K.3
  • 76
    • 33747075753 scopus 로고    scopus 로고
    • Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression
    • A Wesolowska A Nikiforuk K Stachowicz E Tatarczynska 2006 Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression Neuropharmacology 51 578 586
    • (2006) Neuropharmacology , vol.51 , pp. 578-586
    • Wesolowska, A.1    Nikiforuk, A.2    Stachowicz, K.3    Tatarczynska, E.4
  • 77
    • 33845741592 scopus 로고    scopus 로고
    • Enhancement of the anti-immobility action of antidepressants by a selective 5-HT(7) receptor antagonist in the forced swimming test in mice
    • A Wesolowska E Tatarczynska A Nikiforuk E Chojnacka-Wojcik 2007 Enhancement of the anti-immobility action of antidepressants by a selective 5-HT(7) receptor antagonist in the forced swimming test in mice Eur J Pharmacol 555 43 47
    • (2007) Eur J Pharmacol , vol.555 , pp. 43-47
    • Wesolowska, A.1    Tatarczynska, E.2    Nikiforuk, A.3    Chojnacka-Wojcik, E.4
  • 78
    • 0030752477 scopus 로고    scopus 로고
    • Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats
    • DL Willins HY Meltzer 1997 Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats J Pharmacol Exp Ther 282 699 706
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 699-706
    • Willins, D.L.1    Meltzer, H.Y.2
  • 80
    • 2442437811 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitor disrupts organization of thalamocortical somatosensory barrels during development
    • Y Xu Y Sari FC Zhou 2004 Selective serotonin reuptake inhibitor disrupts organization of thalamocortical somatosensory barrels during development Brain Res Dev Brain Res 150 151 161
    • (2004) Brain Res Dev Brain Res , vol.150 , pp. 151-161
    • Xu, Y.1    Sari, Y.2    Zhou, F.C.3
  • 81
    • 0023788434 scopus 로고
    • The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice
    • J Yamada Y Sugimoto K Horisaka 1988 The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice Eur J Pharmacol 154 299 304
    • (1988) Eur J Pharmacol , vol.154 , pp. 299-304
    • Yamada, J.1    Sugimoto, Y.2    Horisaka, K.3
  • 83
    • 0037189057 scopus 로고    scopus 로고
    • Serotonin uptake into dopamine neurons via dopamine transporters: A compensatory alternative
    • FC Zhou KP Lesch DL Murphy 2002 Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative Brain Res 942 109 119
    • (2002) Brain Res , vol.942 , pp. 109-119
    • Zhou, F.C.1    Lesch, K.P.2    Murphy, D.L.3


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