Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: A post-mortem study

Journal of Psychiatric Research

Volumn 41, Issue 1-2, 2007, Pages 168-173

  Zill, Peter ^a   Büttner, Andreas ^a   Eisenmenger, Wolfgang ^a   Möller, Hans Jürgen ^a   Ackenheil, Manfred ^a   Bondy, Brigitta ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Brain; Gene expression; mRNA; Post mortem; Quantification; Tryptophan hydroxylase

Indexed keywords

MESSENGER RNA; TRYPTOPHAN HYDROXYLASE;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; AUTOPSY; BRAIN; BRAIN CORTEX; BRAIN REGION; CENTRAL NERVOUS SYSTEM DISEASE; CEREBELLUM; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAPHE NUCLEUS; SUDDEN DEATH; THALAMUS;

ADULT; AMYGDALA; BRAIN; CELL CULTURE TECHNIQUES; CEREBELLUM; CEREBRAL CORTEX; DNA PRIMERS; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HUMANS; HYPOTHALAMUS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RAPHE NUCLEI; RNA, MESSENGER; SEROTONIN; THALAMUS; TRYPTOPHAN HYDROXYLASE;

EID: 33750725388     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2005.05.004     Document Type: Article

References (36)

1. Berenguer P., Soulage C., Perrin D., Pequignot J.M., and Abraini J.H. Behavioral and neurochemical effects induced by subchronic exposure to 40 ppm toluene in rats. Pharmacology Biochemistry and Behavior 74 (2003) 997-1003
2. Brambilla P., Perez J., Barale F., Schettini G., and Soares J.C. GABAergic dysfunction in mood disorders. Molecular Psychiatry 8 (2003) 721-737 715
3. Chamas F., and Sabban E.L. Role of the 5′ untranslated region (UTR) in the tissue-specific regulation of rat tryptophan hydroxylase gene expression by stress. Journal of Neurochemistry 82 (2002) 645-654
4. Chamas F., Serova L., and Sabban E.L. Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland. Neuroscience Letters 267 (1999) 157-160
5. Chamas F.M., Underwood M.D., Arango V., Serova L., Kassir S.A., Mann J.J., et al. Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei. Biological Psychiatry 55 (2004) 278-283
6. Clark M.S., and Russo A.F. Tissue-specific glucocorticoid regulation of tryptophan hydroxylase mRNA levels. Brain Research and Molecular Brain Research 48 (1997) 346-354
7. Clark M.S., and Russo A.F. Measurement of tryptophan hydroxylase mRNA levels by competitive RT-PCR. Brain Research and Brain Research Protocols 2 (1998) 273-285
8. Dahltroem A., and Fuxe K. Evidence for the existence of maonoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiologica Scandinavica 62 Suppl 55 (1964)
9. Dumas S., Darmon M.C., Delort J., and Mallet J. Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: evidence for a role of translation efficiency. Journal of Neuroscience Research 24 (1989) 537-547
10. Hamon M., Bourgoin S., Artaud F., and Nelson D. Regulatory properties of neuronal tryptophan hydroxylase. Advances in Experimental Medicine and Biology 133 (1981) 231-251
11. Harvey M., Shink E., Tremblay M., Gagne B., Raymond C., Labbe M., et al. Support for the involvement of TPH2 gene in affective disorders. Molecular Psychiatry 9 (2004) 980-981
12. Hornung J.P. The human raphe nuclei and the serotonergic system. Journal of Chemical Neuroanatomy 26 (2003) 331-343
13. Kamali M., Oquendo M.A., and Mann J.J. Understanding the neurobiology of suicidal behavior. Depression and Anxiety 14 (2001) 164-176
14. Khan I.A., and Thomas P. Aroclor 1254 inhibits tryptophan hydroxylase activity in rat brain. Archives of Toxicology 78 (2004) 316-320
15. Lalovic A., and Turecki G. Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior. American Journal of Medical Genetics 114 (2002) 533-540
16. Liang J., Wessel III J.H., Iuvone P.M., Tosini G., and Fukuhara C. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Neuroreport 15 (2004) 1497-1500
17. Lucki I. The spectrum of behaviors influenced by serotonin. Biological Psychiatry 44 (1998) 151-162
18. Malek Z.S., Pevet P., and Raison S. Circadian change in tryptophan hydroxylase protein levels within the rat intergeniculate leaflets and raphe nuclei. Neuroscience 125 (2004) 749-758
19. Miguez J., Martin F., and Aldegunde M. Differential effects of pinealectomy on amygdala and hippocampus serotonin metabolism. Journal of Pineal Research 10 (1991) 100-103
20. Nielsen D.A., Virkkunen M., Lappalainen J., Eggert M., Brown G.L., Long J.C., et al. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Archives of General Psychiatry 55 (1998) 593-602
21. Patel P.D., Pontrello C., and Burke S. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biological Psychiatry 55 (2004) 428-433
22. Popova N.K., Gilinsky M.A., Amstislavskaya T.G., Morosova E.A., Seif I., and De Maeyer E. Regional serotonin metabolism in the brain of transgenic mice lacking monoamine oxidase A. Journal of Neuroscience Research 66 (2001) 423-427
23. Popova N.K., Naumenko K.S., Maslova L.N., Amstislavskaya T.G., Melidi N.N., Bulygina V.V., et al. Hypothalamic tryptophan hydroxylase and the hypothalamic-pituitary-adrenocortical response to water deprivation and hydration in vassopressin-deficient and normal rats. Plugers Archives 444 (2002) 372-377
24. Preece P., and Cairns N.J. Quantifying mRNA in post-mortem human brain: influence of gender, age at death, post-mortem interval, brain pH, agonal state and inter-lobe mRNA variance. Brain Research and Molecular Brain Research 118 (2003) 60-71
25. Preece P., Virley D.J., Costandi M., Coombes R., Moss S.J., Mudge A.W., et al. An optimistic view for quantifying mRNA in post-mortem human brain. Brain Research and Molecular Brain Research 116 (2003) 7-16
26. Ressler K.J., and Nemeroff C.B. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depression and Anxiety 12 Suppl 1 (2000) 2-19
27. Scheibel A.B. The thalamus and neuropsychiatric illness. Journal of Neuropsychiatry Clinical Neuroscience 9 (1997) 342-353
28. Schweighofer N., Doya K., and Kuroda S. Cerebellar aminergic neuromodulation: towards a functional understanding. Brain Research and Brain Research Review 44 (2004) 103-116
29. Serretti A., Lilli R., Lorenzi C., Lattuada E., Cusin C., and Smeraldi E. Tryptophan hydroxylase gene and major psychoses. Psychiatry Research 103 (2001) 79-86
30. Sugden D. Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real-time PCR. Journal of Neurochemistry 86 (2003) 1308-1311
31. Walther D.J., and Bader M. A unique central tryptophan hydroxylase isoform. Biochemical Pharmacology 66 (2003) 1673-1680
32. Walther D.J., Peter J.U., Bashammakh S., Hortnagl H., Voits M., Fink H., et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 (2003) 76
33. Zhang X., Beaulieu J.M., Sotnikova T.D., Gainetdinov R.R., and Caron M.G. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305 (2004) 217
34. Zill P., Buttner A., Eisenmenger W., Bondy B., and Ackenheil M. Regional mRNA expression of a second tryptophan hydroxylase isoform in post-mortem tissue samples of two human brains. European Neuropsychopharmacology 14 (2004) 282-284
35. Zill P., Buttner A., Eisenmenger W., Moller H.J., Bondy B., and Ackenheil M. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biological Psychiatry 56 (2004) 581-586
36. Zill P., Baghai T.C., Zwanzger P., Schule C., Eser D., Rupprecht R., et al. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Molecular Psychiatry 9 (2004) 1030-1036