The WNT/b-catenin pathway is a transcriptional regulator of CYP2E1, CYP1A2, and aryl hydrocarbon receptor gene expression in primary human hepatocytes

Molecular Pharmacology

Volumn 86, Issue 6, 2014, Pages 624-634

  Gerbal Chaloin, Sabine ^a,b   Dumé, Anne Sophie ^a,b   Briolotti, Philippe ^a,b   Klieber, Sylvie ^c   Raulet, Edith ^a,b   Duret, Cédric ^a,b   Fabre, Jean Michel ^d   Ramos, Jeanne ^e   Maurel, Patrick ^a,b   Daujat Chavanieu, Martine ^a,b,f  

^a HÔPITAL SAINT ELOI   (France)

^b UNIV MONTPELLIER   (France)

^c Drug Disposition Domain   (India)

^d Medical Oncology Unit   (France)

^e GUI DE CHAULIAC HOSPITAL   (France)

^f MONTPELLIER UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; AROMATIC HYDROCARBON RECEPTOR; BETA CATENIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 5; GLUTATHIONE; GLYCOGEN SYNTHASE KINASE 3BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PREGNANE X RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN; CTNNB1 PROTEIN, HUMAN; CYP1A2 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLON POLYPOSIS; DRUG METABOLISM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER CELL; MALE; MIDDLE AGED; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSIENT TRANSFECTION; VERY ELDERLY; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; WNT SIGNALING PATHWAY;

ADULT; AGED; BETA CATENIN; CELL LINE; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; RECEPTORS, ARYL HYDROCARBON; WNT SIGNALING PATHWAY;

EID: 84912041758     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.094797     Document Type: Article

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