The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C

Cell Biology and Toxicology

Volumn 16, Issue 4, 2000, Pages 221-233

  Lagadic Gossmann, D ^a   Lerche, C ^a   Rissel, M ^a   Joannard, F ^a   Galisteo, M ^a   Guillouzo, A ^a   Corcos, L ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

CYP2E1; Interleukin 4; PKC; Transcription; Tyrosine kinase

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; BUCLADESINE; CALPHOSTIN C; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYTOCHROME P450 2E1; FORSKOLIN; GENISTEIN; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT INTERLEUKIN 4; TYRPHOSTIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIVER METABOLISM; PRIORITY JOURNAL;

1-METHYL-3-ISOBUTYLXANTHINE; BUCLADESINE; CARCINOMA, HEPATOCELLULAR; CYTOCHROME P-450 CYP2E1; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; INTERLEUKIN-4; KINETICS; LIVER; LIVER NEOPLASMS; PROTEIN BIOSYNTHESIS; PROTEIN KINASE C; RNA, MESSENGER; STAT6 TRANSCRIPTION FACTOR; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0033773692     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007625925095     Document Type: Article

References (36)

1. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture
2. Fatty acids and fibrates are potent inducers of transcription of the phosphoenolpyruvate carboxykinase gene in adipocytes
3. The acute phase response
4. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
5. Signal transduction pathways for interleukin 4 and insulin in human hepatoma cells
6. Genomic sequencing
7. Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats
8. Differential expression of five protein kinase C isoenzymes in Fao and HepG2 hepatoma cell lines compared with normal rat hepatocytes
9. Transmembrane and intracellular signalling by interleukin-4: Receptor dimerization and beyond
10. Ligand dependent maintenance of ethanol inducible cytochrome P-450 in primary rat hepatocyte cell cultures
11. Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation
12. Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption
13. Expression of a multidrug resistance-adenosine deaminase fusion gene
14. Cell cycle gene regulation in reversibly differentiated new human hepatoma cell lines
15. Potential antiinflammatory effects of interleukin 4: Suppression of human monocyte tumor necrosis factor α, interleukin 1, and prostaglandin E2
16. Induction mechanisms of cytochrome P450 2E1 in liver: Interplay between ethanol treatment and starvation
17. Transcriptional regulation of CYP2E1 in human B16A2 hepatoma cells: Identification of an IL-4 responsive element
18. Evidence for a role of phosphatidylinositol 3-kinase in IL-4 induced germline Cε transcription
19. Cytokines and STATs: How can signals achieve specificity?
20. Induction of rat hepatic P-450IIE1 (CYP 2E1) by pyridine: Evidence for a role of protein synthesis in the absence of transcriptional activation
21. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
22. Up-regulation of glutathione S-transferases alpha by interleukin 4 in human hepatocytes in primary culture
23. Trans-Acting factors, detoxication enzymes and hepatitis B virus replication in a novel set of human hepatoma cell lines
24. Rat liver epithelial cells express functional cytochrome P450 2E1
25. Cytochrome P-4502E1: Its physiological and pathological role
26. Interleukin 4 inhibits the production of some acute-phase proteins by human hepatocytes in primary culture
27. Modulation of glutathione S-transferase subunits A2, M1, and P1 expression by interleukin-1 beta in rat hepatocytes in primary culture
28. Expression of cytochrome P-450 enzymes in cultured human hepatocytes
29. Factors affecting drug biotransformation
30. A high-efficiency HeLa cell nuclear transcription extract
31. Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women
32. Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme
33. Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization
34. Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes
35. Possible role of nuclear factor-kappa B activity in germline C epsilon transcription in a human Burkitt lymphoma B cell line
36. Cytochrome P450IIE1: Roles in nitrosamine metabolism and mechanisms of regulation