2,3,7,8-tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: Aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription

American Journal of Respiratory Cell and Molecular Biology

Volumn 45, Issue 2, 2011, Pages 270-276

  Lee, Yong C ^a   Oslund, Karen L ^a,b   Thai, Philip ^a   Velichko, Sharlene ^a   Fujisawa, Tomoyuki ^a   Duong, Trang ^a   Denison, Michael S ^a   Wu, Reen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Airways; Aryl hydrocarbon receptor; Mucin; Signaling

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; MITHRAMYCIN; MITHRAMYCIN A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MUCIN 5AC; MUTANT PROTEIN; RECEPTOR BLOCKING AGENT; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; EXPOSURE; GENE ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME; TRANSIENT TRANSFECTION; WESTERN BLOTTING;

BLOTTING, WESTERN; BRONCHI; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; ENVIRONMENTAL POLLUTANTS; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MUCIN 5AC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 80051635707     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0313OC     Document Type: Article

References (45)

1. Van den Berg M, Birnbaum L, Bosveld AT, Brunström B, Cook P, Feeley M, Giesy JP, Hanberg A, Hasegawa R, Kennedy SW, et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 1998;106:775-792. (Pubitemid 29073822)
2. Birnbaum LS. The mechanism of dioxin toxicity: relationship to risk assessment. Environ Health Perspect 1994;102:157-167.
3. Bertazzi PA, Consonni D, Bachetti S, Rubagotti M, Baccarelli A, Zocchetti C, Pesatori AC. Health effects of dioxin exposure: a 20-year mortality study. Am J Epidemiol 2001;153:1031-1044. (Pubitemid 32493249)
4. Steenland K, Piacitelli L, Deddens J, Fingerhut M, Chang LI. Cancer, heart disease, and diabetes in workers exposed to 2,3,7,8-tetrachlorodibenzo-p- dioxin. J Natl Cancer Inst 1999;91:779-786. (Pubitemid 29239057)
5. Pesatori AC, Zocchetti C, Guercilena S, Consonni D, Turrini D, Bertazzi PA. Dioxin exposure and non-malignant health effects: a mortality study. Occup Environ Med 1998;55:126-131. (Pubitemid 28179991)
6. Consonni D, Pesatori AC, Zocchetti C, Sindaco R, D'Oro LC, Rubagotti M, Bertazzi PA. Mortality in a population exposed to dioxin after theSeveso, Italy accident in 1976: 25 years of follow up. Am J Epidemiol 2008;167:847-858. (Pubitemid 351451742)
7. Perdew GH. Association of the Ah receptor with the 90-kDa heat shock protein. J Biol Chem 1988;263:13802-13805.
8. Denis M, Cuthill S, Wikstrom AC, Poellinger L, Gustafsson JA. Association of the dioxin receptor with the Mr 90,000 heat shock protein: a structural kinship with the glucocorticoid receptor. Biochem Biophys Res Commun 1988;155:801-807.
9. Meyer BK, Pray-Grant MG, Vanden Heuvel JP, Perdew GH. Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol Cell Biol 1998;18:978-988. (Pubitemid 28063432)
10. Kazlauskas A, Poellinger L, Pongratz I. Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (aryl hydrocarbon) receptor. J Biol Chem 1999;274:13519-13524.
11. Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 2003;43:309-334. (Pubitemid 37372644)
12. Sun YV, Boverhof DR, Burgoon LD, Fielden MR, Sacharewski TR. Comparative analysis of dioxin response elements in human, mouse, and rat genomic sequences. Nucleic Acids Res 2004;32:4512-4523. (Pubitemid 39317729)
13. Schmidt JV, Bradfield CA. Ah receptor signaling pathways. Annu Rev Cell Dev Biol 1996;12:55-89. (Pubitemid 26422709)
14. Madhukar BV, Brewster DW, Matsumura F. Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster. Proc Natl Acad Sci USA 1984;81:7407-7411. (Pubitemid 15196191)
15. Park SJ, Yoon WK, Kim HJ, Son HY, Cho SW, Jeong KS, Kim TH, Kim SH, Kim SR, Ryu SY. 2,3,7,8-Tetrachlorodibenzo-p-dioxin activates ERK and p38 mitogen-activated protein kinases in RAW 264.7 cells. Anticancer Res 2005;25:2831-2836.
16. Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 2006;86:245-278.
17. Voynow JA, Gendler SJ, Rose MC. Regulation of mucin genes in chronic inflammatory airway diseases. Am J Respir Cell Mol Biol 2006;34:661-665. (Pubitemid 43825329)
18. Thai P, Loukoianov A, Wachi S, Wu R. Regulation of airway mucin gene expression. Annu Rev Physiol 2008;70:405-429. (Pubitemid 351738186)
19. Wu DY, Wu R, Chen Y, Tarasova N, Chang MM. PMA stimulates MUC5B gene expression through an Sp1-based mechanism in airway epithelial cells. Am J Respir Cell Mol Biol 2007;37:589-597. (Pubitemid 350058190)
20. Wu YCD, Wu R, Reddy SP, Lee YC, Chang MM. Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate. Am J Pathol 2007;170:20-32. (Pubitemid 47339186)
21. Wu R, Martin WR, Robinson CB, St George JA, Plopper CG, Kurland G, Last JA, Cross CE, McDonald RJ, Boucher R. Expression of mucin synthesis and secretion in human tracheobronchial epithelial cells grown in culture. Am J Respir Cell Mol Biol 1990;3:467-478.
22. Wu R, Zhao YH, Chang MM. Growth and differentiation of conducting airway epithelial cells in culture. Eur Respir J 1997;10:2398-2403. (Pubitemid 27479567)
23. Fujisawa T, Velichko S, Thai P, Hung L-Y, Huang F, Wu R. Regulation of airway MUC5AC expression by IL-1β and IL-17A; the NF-κB paradigm. J Immunol 2009;183:6236-6243.
24. Yankaskas JR, Haizlip JE, Conrad M, Koval D, Lazarowski E, Paradiso AM, Rinehart CA Jr, Sarkadi B, Schlegel R, Boucher RC. Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype. Am J Physiol 1993;264:C1219-C1230. (Pubitemid 23158828)
25. Vuong H, Patterson T, Shapiro P, Kalvakolanu DV, Wu R, Ma WY, Dong Z, Kleeberger SR, Reddy SP. Phorbol ester-induced expression of airway squamous cell differentiation marker, SPRR1B, is regulated by protein kinase Cdelta /Ras/MEKK1/MKK1-dependent/AP-1 signal transduction pathway. J Biol Chem 2000;275:32250-32259.
26. Li D, Gallup M, Fan N, Szymkowski DE, Basbaum CB. Cloning of the amino-terminal and 5′-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts. J Biol Chem 1998;273:6812-6820. (Pubitemid 28160344)
27. Ha U, Lim JH, Jono H, Koga T, Srivastava A, Malley R, Pages G, Pouyssegur J, Li JD. A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol 2007;178:1736-1747. (Pubitemid 46154645)
28. Hewson CA, Edbrooke MR, Johnston SL. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. J Mol Biol 2004;344:683-695. (Pubitemid 39469213)
29. Shao MX, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol 2004;287:L420-L427. (Pubitemid 38943925)
30. Borchers MT, Wert SE, Leikauf GD. Acrolein-induced MUC5ac expression in rat airways. Am J Physiol 1998;274:L573-L581.
31. Wong PS, Vogel CF, Kokosinksi K, Matsumura F.Arylhydrocarbon receptor activation in NCI-H441 cells and C57/BL6 mice: possible mechanisms for lung dysfunction. Am J Respir CellMol Biol 2010;42:210-217.
32. Cheon H, Woo YS, Lee JY, Kim HS, Kim HJ, Cho S, Won NH, Sohn J. Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages. Exp Mol Med 2007;39:524-534. (Pubitemid 47443867)
33. Kim SH, Henry EC, Kim DK, Kim YH, Shin KJ, Han MS, Lee TG, Kang JK, Gasiewicz TA, Ryu SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol 2006;69: 1871-1878. (Pubitemid 43894303)
34. Wang B, Lim DJ, Han J, Kim YS, Basbaum CB, Li JD. Novel cytoplasmic proteins of nontypeable Haemophilus influenzae upregulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway. J Biol Chem 2002;277:949-957. (Pubitemid 34968839)
35. Song KS, Lee WJ, Chung KC, Koo JS, Yang EJ, Choi JY, Yoon JH. Interleukin-1b and tumor necrosis factor-a induce MUC5AC over-expression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem 2003;278:23243-23250. (Pubitemid 36830137)
36. Fujisawa T, Ide K, Holtzman MJ, Suda T, Suzuki K, Kuroishi S, Chida K, Nakamura H. Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells. Respirology 2008;13:191-202. (Pubitemid 351388781)
37. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M. TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway. Oncogene 2005;24:4975-4983. (Pubitemid 41129101)
38. Vogel CF, Zhao Y, Wong P, Young NF, Matsumura F. The use of c-src knockout mice for the identification of the main toxic signaling pathway of TCDD to induce wasting syndrome. J Biochem Mol Toxicol 2003;17:305-315. (Pubitemid 38072278)
39. Knerr S, Schaefer J, Both S, Mally A, Dekant W, Schrenk D. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cytochrome P450s alter the formation of reactive oxygen species in liver cells. Mol Nutr Food Res 2006;50:378-384.
40. Park JY, Shigenaga MK, Ames BN. Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage. Proc Natl Acad Sci USA 1996;93:2322-2327. (Pubitemid 26104348)
41. Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol 2005;175:4009-4016. (Pubitemid 41292063)
42. Puppala D, Gairola CG, Swanson HI. Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation. Carcinogenesis 2007;28:639-647. (Pubitemid 46523359)
43. Joiakim A, Matieu PA, Palermo C, Gasiewicz TA, Reiners JJ Jr. The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor. Drug Metab Dispos 2003;31:1279-1282. (Pubitemid 37310311)
44. Reiners JJ Jr, Lee JY, Clift RE, Dudley DT, Myrand SP. PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.MolPharmacol 1998;53:438-445. (Pubitemid 28162865)
45. Chen S, Operaña T, Bonzo J, Nguyen N, Tukey RH. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem 2005;280:4350-4359. (Pubitemid 41741355)