Serum components and activated Ha-ras antagonize expression of perivenous marker genes stimulated by β-catenin signaling in mouse hepatocytes

FEBS Journal

Volumn 274, Issue 18, 2007, Pages 4766-4777

  Braeuning, Albert ^a   Menzel, Moritz ^a   Kleinschnitz, Eva Maria ^a   Harada, Naomoto ^b   Tamai, Yoshitaka ^b   Köhle, Christoph ^a   Buchmann, Albrecht ^a   Schwarz, Michael ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

catenin; Gene expression; Ha ras; Liver tumor; Metabolic zonation

Indexed keywords

BETA CATENIN; BIOLOGICAL MARKER; CYTOCHROME P450; EPIDERMAL GROWTH FACTOR; GLUTAMATE AMMONIA LIGASE; HA RAS PROTEIN; ISOPROTEIN; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN DERIVATIVE; RAS PROTEIN; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CENTRAL VEIN; COMPARATIVE STUDY; CONCENTRATION RESPONSE; DRUG INHIBITION; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATOMA CELL; LIVER; LIVER CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STIMULATION; TRANSGENIC MOUSE;

ANIMALS; BETA CATENIN; BIOLOGICAL MARKERS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSKELETAL PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GLUTAMATE-AMMONIA LIGASE; HEPATOCYTES; MICE; MICE, TRANSGENIC; ONCOGENE PROTEIN P21(RAS); SERUM; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

MUS MUSCULUS;

EID: 34548458190     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.06002.x     Document Type: Article

References (36)

1. Jungermann K Katz N (1989) Functional specialization of different hepatocyte populations. Physiol Rev 69, 708 764.
2. Gebhardt R (1992) Metabolic zonation of the liver: regulation and implications for liver function. Pharmacol Ther 53, 275 354.
3. Jungermann K Kietzmann T (1996) Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr 16, 179 203.
4. Lindros KO (1997) Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver. Gen Pharmacol 28, 191 196.
5. Jungermann K (1995) Zonation of metabolism and gene expression in liver. Histochem Cell Biol 103, 81 91.
6. Hailfinger S, Jaworski M, Braeuning A, Buchmann A Schwarz M (2006) Zonal gene expression in murine liver: lessons from tumors. Hepatology 43, 407 414.
7. Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman DS, Moinard C, Vasseur-Cognet M, Kuo CJ, Kahn A, Perret C et al. (2006) Apc tumor suppressor gene is the 'zonation-keeper' of mouse liver. Dev Cell 10, 759 770.
8. Sekine S, Lan BYA, Bedolli M, Feng S Hebrok M (2006) Liver-specific loss of β-catenin blocks glutamine synthesis pathway activity and cytochrome P450 expression in mice. Hepatology 43, 817 825.
9. Tan X, Behari J, Cieply B, Michalopoulos GK Monga SP (2006) Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 131, 1561 1572.
10. Braeuning A, Ittrich C, Koehle C, Buchmann A Schwarz M (2007) Zonal gene expression in mouse liver resembles expression patterns of Ha-ras and {beta}-catenin mutated hepatomas. Drug Metab Disp 35, 503 507.
11. Harada N, Oshima H, Katoh M, Tamai Y, Oshima M Taketo MM (2004) Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res 64, 48 54.
12. Harada N, Miyoshi H, Murai N, Oshima H, Tamai Y, Oshima M Taketo MM (2002) Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer Res 62, 1971 1977.
13. Braeuning A, Ittrich C, Kohle C, Hailfinger S, Bonin M, Buchmann A Schwarz M (2006) Differential gene expression in periportal and perivenous mouse hepatocytes. FEBS J 273, 5051 5061.
14. Stahl S, Ittrich C, Marx-Stoelting P, Kohle C, Altug-Teber O, Riess O, Bonin M, Jobst J, Kaiser S, Buchmann A et al. (2005) Genotype-phenotype relationships in hepatocellular tumors from mice and man. Hepatology 42, 353 361.
15. Lustig B, Jerchow B, Sachs M, Weiler S, Pietsch T, Karsten U, van de Wetering M, Clevers H, Schlag PM, Birchmeier W et al. (2002) Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22, 1184 1193.
16. Yamamoto Y, Sakamoto M, Fujii G, Tsuiji H, Kenetaka K, Asaka M Hirohashi S (2003) Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. Hepatology 37, 528 533.
17. Reiners JJ Jr., Jones CL, Hong N, Clift RE Elferink C (1997) Downregulation of aryl hydrocarbon receptor function and cytochrome P450 1A1 induction by expression of Ha-ras oncogenes. Mol Carcinog 19, 91 100.
18. Jaworski M, Ittrich C, Hailfinger S, Bonin M, Buchmann A, Schwarz M Köhle C (2007) Global gene expression in Ha-ras and B-raf mutated mouse liver tumors. Int J Cancer 121, 1382 1385.
19. Aydinlik H, Nguyen TD, Moennikes O, Buchmann A Schwarz M (2001) Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. Oncogene 20, 7812 7816.
20. Devereux TR, Anna CH, Foley JF, White CM, Sills RC Barrett JC (1999) Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis. Oncogene 18, 4726 4733.
21. Chabot JG, Walker P Pelletier G (1986) Distribution of epidermal growth factor binding sites in the adult rat liver. Am J Physiol 250, G760 G764.
22. Marti U Gebhardt R (1991) Acinar heterogeneity of the epidermal growth factor receptor in the liver of male rats. Eur J Cell Biol 55, 158 164.
23. Gebhardt R Jonitza D (1991) Different proliferative responses of periportal and perivenous hepatocytes to EGF. Biochem Biophys Res Commun 181, 1201 1207.
24. Gebhardt R Marti U (1992) Heterogeneous distribution of the epidermal growth factor receptor in rat liver parenchyma. Prog Histochem Cytochem 26, 164 168.
25. Imai K, Mine T, Tagami M, Hanaoka K Fujita T (1998) Zonal differences in effects of HGF/SF and EGF on DNA synthesis in hepatocytes under fed or starved conditions. Am J Physiol 275, G1394 G1401.
26. Kietzmann T, Hirsch-Ernst KI, Kahl GF Jungermann K (1999) Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension. Mol Pharmacol 56, 46 53.
27. Garcia MC, Thangavel C Shapiro BH (2001) Epidermal growth factor regulation of female-dependent CYP2A1 and CYP2C12 in primary rat hepatocyte culture. Drug Metab Dispos 29, 111 120.
28. De Smet K, Loyer P, Gilot D, Vercruysse A, Rogiers V Guguen-Guillouzo C (2001) Effects of epidermal growth factor on CYP inducibility by xenobiotics, DNA replication, and caspase activations in collagen I gel sandwich cultures of rat hepatocytes. Biochem Pharmacol 61, 1293 1303.
29. Vanhaecke T, Lindros KO, Oinonen T, Vercruysse A Rogiers V (2001) Triiodothyronine downregulates the periportal expression of alpha class glutathione S-transferase in rat liver. FEBS Lett 487, 356 360.
30. Schuetz EG, Schuetz JD, May B Guzelian PS (1990) Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. J Biol Chem 265, 1188 1192.
31. Oinonen T, Nikkola E Lindros KO (1993) Growth hormone mediates zone-specific gene expression in liver. FEBS Lett 327, 237 240.
32. Oinonen T, Ronis M, Wigell T, Tohmo K, Badger T Lindros KO (2000) Growth hormone-regulated periportal expression of CYP2C7 in rat liver. Biochem Pharmacol 59, 583 589.
33. Bauer D, Wolfram N, Kahl GF Hirsch-Ernst KI (2004) Transcriptional regulation of CYP2B1 induction in primary rat hepatocyte cultures: repression by epidermal growth factor is mediated via a distal enhancer region. Mol Pharmacol 65, 172 180.
34. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H et al. (2000) Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev 14, 1741 1749.
35. Jaworski M, Buchmann A, Bauer P, Riess O Schwarz M (2005) B-raf and Ha-ras mutations in chemically induced mouse liver tumors. Oncogene 24, 1290 1295.
36. Kress SK, Koenig J, Schweizer J, Loehrke H, Bauer-Hofmann R Schwarz M (1992) p53 mutations are absent from carcinogen-induced mouse liver tumors but occur in cell lines established from these tumors. Mol Carcinogenesis 6, 148 158.