Coordinate regulation of cytochrome P450 1a1 expression in mouse liver by the aryl hydrocarbon receptor and the β-catenin pathway

Toxicological Sciences

Volumn 122, Issue 1, 2011, Pages 16-25

  Braeuning, Albert ^a   Köhle, Christoph ^a   Buchmann, Albrecht ^a   Schwarz, Michael ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Dioxin; Drug metabolism; Enzyme induction; Metabolic zonation; Wnt signaling; XRE

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BETA CATENIN; CYTOCHROME P450 1A1; CYTOCHROME P450 ISOENZYME; LIVER ENZYME; T CELL FACTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME INDUCTION; GENE INACTIVATION; IN VITRO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 79961004343     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr080     Document Type: Article

References (36)

1. Anderson, L. M., Ward, J. M., Park, S. S., Rice, J. M. (1989). Immunohistochemical localization of cytochromes P450 with polyclonal and monoclonal antibodies. Pathol. Immunopathol. Res. 8, 61-94.
2. Behrens, J., Lustig, B. (2004). The Wnt connection to tumorigenesis. Int. J. Dev. Biol. 48, 477-487.
3. Benhamouche, S., Decaens, T., Godard, C., Chambrey, R., Rickman, D. S., Moinard, C., Vasseur-Cognet, M., Kuo, C. J., Kahn, A., Perret, C., et al. (2006). Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev. Cell 10, 759-770.
4. Bock, K. W. (1994). Aryl hydrocarbon or dioxin receptor: biologic and toxic responses. Rev. Physiol. Biochem. Pharmacol. 125, 1-42.
5. Braeuning, A., Buchmann, A. (2009). The glycogen synthase kinase inhibitor SB216763 is a partial agonist of the aryl hydrocarbon receptor. Drug Metab. Dispos. 37, 1576-1580.
6. Braeuning, A., Sanna, R., Huelsken, J., Schwarz, M. (2009). Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1. Drug Metab. Dispos. 37, 1138-1145.
7. Braeuning, A., Schwarz, M. (2010a). Beta-catenin as a multilayer modulator of zonal cytochrome P450 expression in mouse liver. Biol. Chem. 391, 139-148.
8. Braeuning, A., Schwarz, M. (2010b). Zonation of heme synthesis enzymes in mouse liver and their regulation by beta-catenin and Ha-ras. Biol. Chem. 391, 1305-1313.
9. Chesire, D. R., Dunn, T. A., Ewing, C. M., Luo, J., Isaacs, W. B. (2004). Identification of aryl hydrocarbon receptor as a putative Wnt/beta-catenin pathway target gene in prostate cancer cells. Cancer Res. 64, 2523-2533.
10. Colletti, M., Cicchini, C., Conigliaro, A., Santangelo, L., Alonzi, T., Pasquini, E., Tripodi, M., Amicone, L. (2009). Convergence of Wnt signaling on the HNF4alpha-driven transcription in controlling liver zonation. Gastroenterology 137, 660-672.
11. Ding, X., Kaminsky, L. S. (2003). Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu. Rev. Pharmacol. Toxicol. 43, 149-173.
12. Giera, S., Braeuning, A., Kohle, C., Bursch, W., Metzger, U., Buchmann, A., Schwarz, M. (2010). Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver. Toxicol. Sci. 115, 22-33.
13. Hailfinger, S., Jaworski, M., Braeuning, A., Buchmann, A., Schwarz, M. (2006). Zonal gene expression in murine liver: lessons from tumors. Hepatology 43, 407-414.
14. Hankinson, O. (2005). Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor. Arch. Biochem. Biophys. 433, 379-386.
15. Kawajiri, K., Kobayashi, Y., Ohtake, F., Ikuta, T., Matsushima, Y., Mimura, J., Pettersson, S., Pollenz, R. S., Sakaki, T., Hirokawa, T., et al. (2009). Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc. Natl. Acad. Sci. U.S.A. 106, 13481-13486.
16. Kress, S., Konig, J., Schweizer, J., Loehrke, H., Bauer-Hofmann, R., Schwarz, M. (1992). p53 mutations are absent from carcinogen-induced mouse liver tumors but occur in cell lines established from these tumors. Mol. Carcinog. 6, 148-158.
17. Kress, S., Reichert, J., Schwarz, M. (1998). Functional analysis of the human cytochrome P4501A1 (CYP1A1) gene enhancer. Eur. J. Biochem. 258, 803-812.
18. Lindros, K. O. (1997). Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver. Gen. Pharmacol. 28, 191-196.
19. Loeppen, S., Koehle, C., Buchmann, A., Schwarz, M. (2005). A beta-catenindependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors. Carcinogenesis 26, 239-248.
20. Luckert, K., Götschel, F., Sorger, P. K., Hecht, A., Joos, T. O., Pötz, O. Snapshots of protein dynamics and posttranslational modifications in one experiment-b-catenin and its functions. Mol. Cell. Proteomics Forthcoming.
21. Mulholland, D. J., Dedhar, S., Coetzee, G. A., Nelson, C. C. (2005). Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr. Rev. 26, 898-915.
22. Munzel, P. A., Schmohl, S., Buckler, F., Jaehrling, J., Raschko, F. T., Kohle, C., Bock, K. W. (2003). Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDPglucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells. Biochem. Pharmacol. 66, 841-847.
23. Ohtake, F., Takeyama, K., Matsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., Tohyama, C., Krust, A., Mimura, J., Chambon, P., et al. (2003). Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature 423, 545-550.
24. Pasquali, L., Busceti, C. L., Fulceri, F., Paparelli, A., Fornai, F. (2010). Intracellular pathways underlying the effects of lithium. Behav. Pharmacol. 21, 473-492.
25. Pollenz, R. S. (1996). The aryl-hydrocarbon receptor, but not the arylhydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzop-dioxin. Mol. Pharmacol. 49, 391-398.
26. Schreiber, T. D., Kohle, C., Buckler, F., Schmohl, S., Braeuning, A., Schmiechen, A., Schwarz, M., Munzel, P. A. (2006). Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone. Drug Metab. Dispos. 34, 1096-1101.
27. Schrem, H., Klempnauer, J., Borlak, J. (2004). Liver-enriched transcription factors in liver function and development. Part II: the C/EBPs and D sitebinding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Pharmacol. Rev. 56, 291-330.
28. Sekine, S., Gutierrez, P. J., Lan, B. Y., Feng, S., Hebrok, M. (2007). Liverspecific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. Hepatology 45, 361-368.
29. Sekine, S., Lan, B. Y., Bedolli, M., Feng, S., Hebrok, M. (2006). Liver-specific loss of ß-catenin blocks glutamine synthetis pathway activity and cytochrome P450 expression in mice. Hepatology 43, 817-825.
30. Stahl, S., Ittrich, C., Marx-Stoelting, P., Kohle, C., Altug-Teber, O., Riess, O., Bonin, M., Jobst, J., Kaiser, S., Buchmann, A., et al. (2005). Genotypephenotype relationships in hepatocellular tumors from mice and man. Hepatology 42, 353-361.
31. Stambolic, V., Ruel, L., Woodgett, J. R. (1996). Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr. Biol. 6, 1664-1668.
32. Tan, X., Behari, J., Cieply, B., Michalopoulos, G. K., Monga, S. P. (2006). Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 131, 1561-1572.
33. Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., Speleman, F. (2002). Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol.3, RESEARCH0034.
34. Weiss, C., Kolluri, S. K., Kiefer, F., Goettlicher, M. (1996). Complementation of Ah receptor deficiency in hepatoma cells: negative feedback regulation and cell cycle control by the Ah receptor. Exp. Cell Res. 226, 154-163.
35. Willert, K., Nusse, R. (1998). Beta-catenin: a key mediator of Wnt signaling. Curr. Opin. Genet. Dev. 8, 95-102.
36. Xu, C., Li, C. Y., Kong, A. N. (2005). Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch. Pharm. Res. 28, 249-268.