Coupling ultra-high-pressure liquid chromatography with mass spectrometry for in-vitro drug-metabolism studies

TrAC - Trends in Analytical Chemistry

Volumn 63, Issue , 2014, Pages 129-139

  Spaggiari, Dany ^a   Geiser, Laurent ^a   Rudaz, Serge ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Drug drug interaction; In vitro drug metabolism; Mass spectrometry (MS); Metabolic stability; Metabolite identification; Metabolite profiling; Reactive metabolite; Sub 2 m particle; UHPLC MS; Ultra high pressure liquid chromatography (UHPLC)

Indexed keywords

BIOMOLECULES; DRUG INTERACTIONS; DRUG PRODUCTS; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PHYSIOLOGY;

DRUG-DRUG INTERACTIONS; IN-VITRO; METABOLIC STABILITY; METABOLITE IDENTIFICATION; METABOLITE PROFILING; REACTIVE METABOLITES; U-HPLC-MS; ULTRA-HIGH-PRESSURE LIQUID CHROMATOGRAPHY;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

CYTOCHROME P450; DRUG;

DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME ANALYSIS; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PARTICLE SIZE; QUADRUPOLE MASS SPECTROMETRY; RELIABILITY; REVIEW; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84912001149     PISSN: 01659936     EISSN: 18793142     Source Type: Journal    
DOI: 10.1016/j.trac.2014.06.021     Document Type: Review

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