Development and validation of a fast and sensitive UPLC-MS/MS method for the quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity

Talanta

Volumn 89, Issue , 2012, Pages 209-216

  De Bock, Lies ^a   Boussery, Koen ^a   Colin, Pieter ^a   De Smet, Julie ^a   T'Jollyn, Huybrecht ^a   Van Bocxlaer, Jan ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Cytochrome P450; Drug metabolism; Human liver microsomes; Ultra high performance liquid chromatography mass spectrometry; Validation

Indexed keywords

FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PARTICLE SIZE; PROBES;

CYTOCHROME P450; DRUG METABOLISMS; HUMAN LIVER MICROSOMES; ULTRA HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIES; VALIDATION;

BIOMOLECULES;

EID: 84856356243     PISSN: 00399140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.talanta.2011.11.083     Document Type: Article

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