A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry

Journal of Chromatography A

Volumn 1217, Issue 10, 2010, Pages 1616-1625

  Xu, Rongda ^a   Manuel, Melinda ^a   Cramlett, Joshua ^a   Kassel, Daniel B ^a  

^a Takeda San Diego Inc   (United States)

Author keywords

Automation; Cassette analysis; High throughput; Intelligent; Mass spectrometry; Metabolic stability assay; Microsomal stability assay; MS; Sample pooling; UHPLC; UPLC; Workflow

Indexed keywords

CASSETTE ANALYSIS; HIGH THROUGHPUT; METABOLIC STABILITY; METABOLIC STABILITY ASSAY; MS;

ASSAYS; AUTOMATION; CATALYSTS; DATA ACQUISITION; DRUG PRODUCTS PLANTS; ENZYMES; LIQUID CHROMATOGRAPHY; MANAGEMENT; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; STABILITY; THROUGHPUT; TURNAROUND TIME;

QUALITY CONTROL;

ARTICLE; COMPUTER INTERFACE; COMPUTER PREDICTION; COMPUTER PROGRAM; DATA ANALYSIS; DRUG INDUSTRY; HIGH THROUGHPUT SCREENING; INFORMATION PROCESSING; IONIZATION; LIPOPHILICITY; LIQUID CHROMATOGRAPHY; PHASE SEPARATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SEPARATION TECHNIQUE; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG STABILITY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; RATS; TANDEM MASS SPECTROMETRY; WORKFLOW;

EID: 75949109352     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.01.009     Document Type: Article

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