CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: A possible metabolic link to blackwater fever

Malaria Journal

Volumn 12, Issue 1, 2013, Pages

  Marcsisin, Sean R ^a   Jin, Xiannu ^a   Bettger, Theresa ^a   McCulley, Nicholas ^a   Sousa, Jason C ^a   Shanks, G Dennis ^b   Tekwani, Babu L ^c   Sahu, Rajnish ^c   Reichard, Gregory A ^a   Sciotti, Richard J ^a   Melendez, Victor ^a   Pybus, Brandon S ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b AUSTRALIAN ARMY MALARIA INSTITUTE   (Australia)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Blackwater fever; CYP450; Metabolism; Metabolite identification; Quinine

Indexed keywords

2' OXOQUININONE; 3 HYDROXYQUININE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; O DESMETHYLQUININE; QUININE; QUININE DERIVATIVE; QUINUCLIDINE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; DOSE RESPONSE; ERYTHROCYTE; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROXYLATION; MALARIA FALCIPARUM; METABOLISM; METABOLITE; MICROSOME; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE;

BLACKWATER FEVER; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ERYTHROCYTES; HUMANS; MALARIA; MASS SPECTROMETRY; MICROSOMES; QUININE; REACTIVE OXYGEN SPECIES;

EID: 84879085913     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-12-214     Document Type: Article

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