Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening

British Journal of Pharmacology

Volumn 171, Issue 22, 2014, Pages 5093-5112

  Kowalski, M ^a   Hausmann, R ^b   Dopychai, A ^b   Grohmann, M ^a,b   Franke, H ^a   Nieber, K ^a   Schmalzing, G ^b   Illes, P ^a   Riedel, T ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; PURINERGIC P2X3 RECEPTOR; ALPHA,BETA-METHYLENEADENOSINE 5'-TRIPHOSPHATE; PURINERGIC P2X RECEPTOR AGONIST;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MIGRATION; CELL SURFACE; CHANNEL GATING; CONTROLLED STUDY; CROSS LINKING; DISULFIDE BOND; HUMAN; HUMAN CELL; JAW; MOLECULAR DYNAMICS; NONHUMAN; OOCYTE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; XENOPUS LAEVIS; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HEK293 CELL LINE; MUTATION; PHYSIOLOGY; PROTEIN CONFORMATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; MUTATION; OOCYTES; PROTEIN CONFORMATION; PURINERGIC P2X RECEPTOR AGONISTS; RECEPTORS, PURINERGIC P2X3; XENOPUS LAEVIS;

EID: 84911929423     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12830     Document Type: Article

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