Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors

Journal of Biological Chemistry

Volumn 283, Issue 29, 2008, Pages 20126-20136

  Roberts, Jonathan A ^a   Digby, Helen R ^a   Kara, Madina ^a   El Ajouz, Sam ^a   Sutcliffe, Michael J ^a,b   Evans, Richard J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; MAMMALS; MUTAGENESIS; RADIOACTIVE MATERIALS;

AGONIST BINDING SITES; ARGININE RESIDUES; BINDING PROTEINS; COMMON MODES; CONSERVED RESIDUES; CYSTEINE SUBSTITUTIONS; EXTRACELLULAR LOOPS; LYSINE RESIDUES; METHANETHIOSULFONATE; METHANETHIOSULFONATE REAGENTS; MUTANT RECEPTORS; NON-CONSERVED RESIDUES; P2X RECEPTORS; POSITIVE CHARGES;

AMINO ACIDS;

ADENOSINE TRIPHOSPHATE; ARGININE; ASPARAGINE; CYSTEINE; LYSINE; METHANETHIOSULFONATE; PHENYLALANINE; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X4 RECEPTOR; SULFONIC ACID DERIVATIVE; THREONINE; UNCLASSIFIED DRUG; MESYLIC ACID DERIVATIVE; PURINERGIC P2 RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; HUMAN; MUTAGENESIS; MUTANT; MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MOTIF; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG EFFECT; ELECTROPHYSIOLOGY; FEMALE; GENETICS; METABOLISM; MOLECULAR GENETICS; OOCYTE; PATCH CLAMP; SEQUENCE ALIGNMENT; XENOPUS LAEVIS;

MAMMALIA;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; CYSTEINE; ELECTROPHYSIOLOGY; FEMALE; HUMANS; MESYLATES; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, PURINERGIC P2; SEQUENCE ALIGNMENT; XENOPUS LAEVIS;

EID: 50649117149     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800294200     Document Type: Article

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