Poly(ADP-ribose) polymerase-1 causes mitochondrial damage and neuron death mediated by Bnip3

Journal of Neuroscience

Volumn 34, Issue 48, 2014, Pages 15975-15987

  Lu, Ping ^a   Kamboj, Amit ^a   Gibson, Spencer B ^b   Anderson, Christopher M ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Apoptosis inducing factor; Bnip3; Ischemia; Mitochondrial permeability; PARP; Sirtuin

Indexed keywords

APOPTOSIS INDUCING FACTOR; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BNIP3; SHORT HAIRPIN RNA; SIRTUIN 1; SURVIVAL MOTOR NEURON PROTEIN; TRANSCRIPTION FACTOR FKHRL1; BNIP3 PROTEIN, MOUSE; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DAMAGE; CELL FRACTIONATION; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; GENE SILENCING; GENE TRANSLOCATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MEMBRANE PERMEABILITY; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PROMOTER REGION; PROTEIN ACETYLATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; WESTERN BLOTTING; 129 MOUSE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL DEATH; FEMALE; KNOCKOUT MOUSE; MALE; METABOLISM; MITOCHONDRION; NERVE CELL; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CELL DEATH; CELLS, CULTURED; FEMALE; MALE; MEMBRANE PROTEINS; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEURONS; POLY(ADP-RIBOSE) POLYMERASES;

EID: 84911923161     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2499-14.2014     Document Type: Article

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