Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity

GLIA

Volumn 58, Issue 4, 2010, Pages 446-457

  Tang, Kim San ^a,b   Suh, Sang Won ^c,d,e   Alano, Conrad C ^d,e   Shao, Zongjun ^a,b   Hunt, Waylon T ^a,b   Swanson, Raymond A ^d,e   Anderson, Christopher M ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b ST BONIFACE GENERAL HOSPITAL   (Canada)

^c Hallym University   (South Korea)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Astrocyte neuron communication; ATP depletion; DNA damage; Excitotoxicity; NAD+

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALKYLATING AGENT; GLUTAMIC ACID; METHYLNITRONITROSOGUANIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1;

ANIMAL CELL; ARTICLE; ASTROCYTE; BIOENERGY; CELL COMMUNICATION; CELL DEATH; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME ACTIVATION; EXCITOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NERVE CELL; NEUROPROTECTION; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALKYLATING AGENTS; ANIMALS; ASTROCYTES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; COCULTURE TECHNIQUES; GLUTAMIC ACID; METHYLNITRONITROSOGUANIDINE; MICE; MICE, KNOCKOUT; NAD; NEURONS; POLY(ADP-RIBOSE) POLYMERASES; TIME FACTORS;

EID: 76549098903     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20936     Document Type: Article

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