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Volumn 11, Issue 12, 2014, Pages 1955-1967

Advances in oral macromolecular drug delivery

Author keywords

Absorption enhancer; Chemical conjugation; Macromolecular drug; Oral delivery; Particle

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; DNA; EXENDIN 4; GASTRIN; GLUCAGON LIKE PEPTIDE 1; GROWTH HORMONE; HEPARIN; INSULIN; NANOPARTICLE; OCTREOTIDE; PACLITAXEL; MACROMOLECULE;

EID: 84911467916     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2014.945420     Document Type: Review
Times cited : (51)

References (105)
  • 1
    • 3242778534 scopus 로고    scopus 로고
    • A physiological model for the estimation of the fraction dose absorbed in humans
    • Willmann S, Schmitt W, Keldenich J, et al. A physiological model for the estimation of the fraction dose absorbed in humans. J Med Chem 2004;47(16):4022-31
    • (2004) J Med Chem , vol.47 , Issue.16 , pp. 4022-4031
    • Willmann, S.1    Schmitt, W.2    Keldenich, J.3
  • 2
    • 0026823043 scopus 로고
    • (D) Routes of delivery: Case studies:(5) Oral absorption of peptides and proteins
    • Smith PL, Wall DA, Gochoco CH, Wilson G. (D) Routes of delivery: case studies:(5) Oral absorption of peptides and proteins. Adv Drug Deliv Rev 1992;8(2):253-90
    • (1992) Adv Drug Deliv Rev , vol.8 , Issue.2 , pp. 253-290
    • Smith, P.L.1    Wall, D.A.2    Gochoco, C.H.3    Wilson, G.4
  • 3
    • 0027312774 scopus 로고
    • Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments
    • Artursson P, Ungell AL, Lofroth JE. Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharm Res 1993;10(8):1123-9
    • (1993) Pharm Res , vol.10 , Issue.8 , pp. 1123-1129
    • Artursson, P.1    Ungell, A.L.2    Lofroth, J.E.3
  • 4
    • 0025029073 scopus 로고
    • Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption
    • Donovan MD, Flynn GL, Amidon GL. Absorption of polyethylene glycols 600 through 2000: the molecular weight dependence of gastrointestinal and nasal absorption. Pharm Res 1990;7(8):863-8
    • (1990) Pharm Res , vol.7 , Issue.8 , pp. 863-868
    • Donovan, M.D.1    Flynn, G.L.2    Amidon, G.L.3
  • 5
    • 0032189375 scopus 로고    scopus 로고
    • Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight
    • Camenisch G, Alsenz J, van de Waterbeemd H, Folkers G. Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight. Eur J Pharm Sci 1998;6(4):317-24
    • (1998) Eur J Pharm Sci , vol.6 , Issue.4 , pp. 317-324
    • Camenisch, G.1    Alsenz, J.2    Van De Waterbeemd, H.3    Folkers, G.4
  • 6
    • 0028657017 scopus 로고
    • Enzymatic barriers for GI peptide and protein delivery
    • Woodley JF. Enzymatic barriers for GI peptide and protein delivery. Crit Rev Ther Drug Carrier Syst 1994;11(2-3):61-95
    • (1994) Crit Rev Ther Drug Carrier Syst , vol.11 , Issue.2-3 , pp. 61-95
    • Woodley, J.F.1
  • 7
    • 80054061227 scopus 로고    scopus 로고
    • A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery
    • Chen MC, Sonaje K, Chen KJ, Sung HW. A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials 2011;32(36):9826-38
    • (2011) Biomaterials , vol.32 , Issue.36 , pp. 9826-9838
    • Chen, M.C.1    Sonaje, K.2    Chen, K.J.3    Sung, H.W.4
  • 8
    • 0030460690 scopus 로고    scopus 로고
    • Oral controlled release technology for peptides: Status and future prospects
    • Fix JA. Oral controlled release technology for peptides: status and future prospects. Pharm Res 1996;13(12):1760-4
    • (1996) Pharm Res , vol.13 , Issue.12 , pp. 1760-1764
    • Fix, J.A.1
  • 9
    • 84874945035 scopus 로고    scopus 로고
    • Approaches for enhancing oral bioavailability of peptides and proteins
    • Renukuntla J, Vadlapudi AD, Patel A, et al. Approaches for enhancing oral bioavailability of peptides and proteins. Int J Pharm 2013;447(1):75-93
    • (2013) Int J Pharm , vol.447 , Issue.1 , pp. 75-93
    • Renukuntla, J.1    Vadlapudi, A.D.2    Patel, A.3
  • 10
    • 33646492929 scopus 로고    scopus 로고
    • Tight junction modulation and its relationship to drug delivery
    • Salama NN, Eddington ND, Fasano A. Tight junction modulation and its relationship to drug delivery. Adv Drug Deliv Rev 2006;58(1):15-28
    • (2006) Adv Drug Deliv Rev , vol.58 , Issue.1 , pp. 15-28
    • Salama, N.N.1    Eddington, N.D.2    Fasano, A.3
  • 11
    • 0031943571 scopus 로고    scopus 로고
    • Regulation of the movement of solutes across tight junctions
    • Madara JL. Regulation of the movement of solutes across tight junctions. Annu Rev Physiol 1998;60:143-59
    • (1998) Annu Rev Physiol , vol.60 , pp. 143-159
    • Madara, J.L.1
  • 12
    • 19444373410 scopus 로고    scopus 로고
    • theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: A novel mechanism for regulation of permeability
    • Banan A, Zhang LJ, Shaikh M, et al. theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability. J Pharmacol Exp Ther 2005;313(3):962-82
    • (2005) J Pharmacol Exp Ther , vol.313 , Issue.3 , pp. 962-982
    • Banan, A.1    Zhang, L.J.2    Shaikh, M.3
  • 13
    • 0035320037 scopus 로고    scopus 로고
    • Multifunctional strands in tight junctions
    • Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2001;2(4):285-93
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.4 , pp. 285-293
    • Tsukita, S.1    Furuse, M.2    Itoh, M.3
  • 14
    • 0024310227 scopus 로고
    • Ionic permeation mechanisms in epithelia: Biionic potentials, dilution potentials, conductances, and streaming potentials
    • Barry PH. Ionic permeation mechanisms in epithelia: biionic potentials, dilution potentials, conductances, and streaming potentials. Methods Enzymol 1989;171:678-715
    • (1989) Methods Enzymol , vol.171 , pp. 678-715
    • Barry, P.H.1
  • 15
    • 0019631483 scopus 로고
    • Barrier function of epithelia
    • Powell DW. Barrier function of epithelia. Am J Physiol 1981;241(4):G275-88
    • (1981) Am J Physiol , vol.241 , Issue.4 , pp. G275-G288
    • Powell, D.W.1
  • 16
    • 14544286414 scopus 로고    scopus 로고
    • Particle uptake by Peyer's patches: A pathway for drug and vaccine delivery
    • Shakweh M, Ponchel G, Fattal E. Particle uptake by Peyer's patches: a pathway for drug and vaccine delivery. Expert Opin Drug Deliv 2004;1(1):141-63
    • (2004) Expert Opin Drug Deliv , vol.1 , Issue.1 , pp. 141-163
    • Shakweh, M.1    Ponchel, G.2    Fattal, E.3
  • 17
    • 0016358918 scopus 로고
    • Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell
    • Cheng H, Leblond CP. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. Am J Anat 1974;141(4):461-79
    • (1974) Am J Anat , vol.141 , Issue.4 , pp. 461-479
    • Cheng, H.1    Leblond, C.P.2
  • 18
    • 0029841664 scopus 로고    scopus 로고
    • M cells in Peyer's patches of the intestine
    • Gebert A, Rothkotter HJ, Pabst R. M cells in Peyer's patches of the intestine. Int Rev Cytol 1996;167:91-159
    • (1996) Int Rev Cytol , vol.167 , pp. 91-159
    • Gebert, A.1    Rothkotter, H.J.2    Pabst, R.3
  • 19
    • 0026758261 scopus 로고
    • Structural specificity of mucosal-cell transport and metabolism of peptide drugs: Implication for oral peptide drug delivery
    • Bai JP, Amidon GL. Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery. Pharm Res 1992;9(8):969-78
    • (1992) Pharm Res , vol.9 , Issue.8 , pp. 969-978
    • Bai, J.P.1    Amidon, G.L.2
  • 20
    • 0035286685 scopus 로고    scopus 로고
    • The potential use of receptor-mediated endocytosis for oral drug delivery
    • Russell-Jones GJ. The potential use of receptor-mediated endocytosis for oral drug delivery. Adv Drug Deliv Rev 2001;46(1-3):59-73
    • (2001) Adv Drug Deliv Rev , vol.46 , Issue.1-3 , pp. 59-73
    • Russell-Jones, G.J.1
  • 21
    • 0031777867 scopus 로고    scopus 로고
    • Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways
    • Swaan PW. Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways. Pharm Res 1998;15(6):826-34
    • (1998) Pharm Res , vol.15 , Issue.6 , pp. 826-834
    • Swaan, P.W.1
  • 22
    • 0030457349 scopus 로고    scopus 로고
    • Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells
    • Shah D, Shen WC. Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells. J Pharm Sci 1996;85(12):1306-11
    • (1996) J Pharm Sci , vol.85 , Issue.12 , pp. 1306-1311
    • Shah, D.1    Shen, W.C.2
  • 23
    • 0033254582 scopus 로고    scopus 로고
    • Drug transport and targeting. Intestinal transport
    • Oh DM, Han HK, Amidon GL. Drug transport and targeting. Intestinal transport. Pharm Biotechnol 1999;12:59-88
    • (1999) Pharm Biotechnol , vol.12 , pp. 59-88
    • Oh, D.M.1    Han, H.K.2    Amidon, G.L.3
  • 24
    • 0031193858 scopus 로고    scopus 로고
    • Enhanced transepithelial transport of peptides by conjugation to cholic acid
    • Swaan PW, Hillgren KM, Szoka FC Jr, Oie S. Enhanced transepithelial transport of peptides by conjugation to cholic acid. Bioconjug Chem 1997;8(4):520-5
    • (1997) Bioconjug Chem , vol.8 , Issue.4 , pp. 520-525
    • Swaan, P.W.1    Hillgren, K.M.2    Szoka, F.C.3    Oie, S.4
  • 25
    • 0029334731 scopus 로고
    • Vitamin B12 mediated oral delivery systems for granulocytecolony stimulating factor and erythropoietin
    • Russell-Jones GJ, Westwood SW, Habberfield AD. Vitamin B12 mediated oral delivery systems for granulocytecolony stimulating factor and erythropoietin. Bioconjug Chem 1995;6(4):459-65
    • (1995) Bioconjug Chem , vol.6 , Issue.4 , pp. 459-465
    • Russell-Jones, G.J.1    Westwood, S.W.2    Habberfield, A.D.3
  • 26
    • 0032217158 scopus 로고    scopus 로고
    • Use of vitamin B12 conjugates to deliver protein drugs by the oral route
    • Russell-Jones GJ. Use of vitamin B12 conjugates to deliver protein drugs by the oral route. Crit Rev Ther Drug Carrier Syst 1998;15(6):557-86
    • (1998) Crit Rev Ther Drug Carrier Syst , vol.15 , Issue.6 , pp. 557-586
    • Russell-Jones, G.J.1
  • 27
    • 0035910004 scopus 로고    scopus 로고
    • Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent
    • Lee Y, Nam JH, Shin HC, Byun Y. Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent. Circulation 2001;104(25):3116-20
    • (2001) Circulation , vol.104 , Issue.25 , pp. 3116-3120
    • Lee, Y.1    Nam, J.H.2    Shin, H.C.3    Byun, Y.4
  • 28
    • 33645227760 scopus 로고    scopus 로고
    • Efficacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys
    • Lee YK, Kim SK, Lee DY, et al. Efficacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys. J Control Release 2006;111(3):290-8
    • (2006) J Control Release , vol.111 , Issue.3 , pp. 290-298
    • Lee, Y.K.1    Kim, S.K.2    Lee, D.Y.3
  • 29
    • 77953268983 scopus 로고    scopus 로고
    • Anticoagulant efficacy of solid oral formulations containing a new heparin derivative
    • Park JW, Jeon OC, Kim SK, et al. Anticoagulant efficacy of solid oral formulations containing a new heparin derivative. Mol Pharm 2010;7(3):836-43
    • (2010) Mol Pharm , vol.7 , Issue.3 , pp. 836-843
    • Park, J.W.1    Jeon, O.C.2    Kim, S.K.3
  • 30
    • 84891528616 scopus 로고    scopus 로고
    • Oligomeric bile acid-mediated oral delivery of low molecular weight heparin
    • Al-Hilal TA, Park J, Alam F, et al. Oligomeric bile acid-mediated oral delivery of low molecular weight heparin. J Control Release 2014;175:17-24
    • (2014) J Control Release , vol.175 , pp. 17-24
    • Al-Hilal, T.A.1    Park, J.2    Alam, F.3
  • 32
    • 0031467883 scopus 로고    scopus 로고
    • Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter
    • Lazaridis KN, Pham L, Tietz P, et al. Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. J Clin Invest 1997;100(11):2714-21
    • (1997) J Clin Invest , vol.100 , Issue.11 , pp. 2714-2721
    • Lazaridis, K.N.1    Pham, L.2    Tietz, P.3
  • 33
    • 84894816912 scopus 로고    scopus 로고
    • Functional transformations of bile acid transporters induced by high-affinity macromolecules
    • Al-Hilal TA, Chung SW, Alam F, et al. Functional transformations of bile acid transporters induced by high-affinity macromolecules. Sci Rep 2014;4:4163
    • (2014) Sci Rep , vol.4 , pp. 4163
    • Al-Hilal, T.A.1    Chung, S.W.2    Alam, F.3
  • 34
    • 0033978710 scopus 로고    scopus 로고
    • Gene transfer facilitated by a cellular targeting molecule, reovirus protein sigma1
    • Wu Y, Boysun MJ, Csencsits KL, Pascual DW. Gene transfer facilitated by a cellular targeting molecule, reovirus protein sigma1. Gene Ther 2000;7(1):61-9
    • (2000) Gene Ther , vol.7 , Issue.1 , pp. 61-69
    • Wu, Y.1    Boysun, M.J.2    Csencsits, K.L.3    Pascual, D.W.4
  • 36
    • 84859720244 scopus 로고    scopus 로고
    • Oral biodrug delivery using cell-penetrating peptide
    • Khafagy E-S, Morishita M. Oral biodrug delivery using cell-penetrating peptide. Adv Drug Deliv Rev 2012;64(6):531-9
    • (2012) Adv Drug Deliv Rev , vol.64 , Issue.6 , pp. 531-539
    • Khafagy, E.-S.1    Morishita, M.2
  • 37
    • 67349268446 scopus 로고    scopus 로고
    • Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides
    • Kamei N, Morishita M, Takayama K. Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides. J Control Release 2009;136(3):179-86
    • (2009) J Control Release , vol.136 , Issue.3 , pp. 179-186
    • Kamei, N.1    Morishita, M.2    Takayama, K.3
  • 38
    • 39049130647 scopus 로고    scopus 로고
    • Cell-penetrating peptides for drug delivery across membrane barriers
    • Foged C, Nielsen HM. Cell-penetrating peptides for drug delivery across membrane barriers. Expert Opin Drug Deliv 2008;5(1):105-17
    • (2008) Expert Opin Drug Deliv , vol.5 , Issue.1 , pp. 105-117
    • Foged, C.1    Nielsen, H.M.2
  • 39
    • 23944512155 scopus 로고    scopus 로고
    • Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency
    • Liang JF, Yang VC. Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency. Biochem Biophys Res Commun 2005;335(3):734-8
    • (2005) Biochem Biophys Res Commun , vol.335 , Issue.3 , pp. 734-738
    • Liang, J.F.1    Yang, V.C.2
  • 40
    • 54549097056 scopus 로고    scopus 로고
    • Conjugated chitosan as a novel platform for oral delivery of paclitaxel
    • Lee E, Lee J, Lee IH, et al. Conjugated chitosan as a novel platform for oral delivery of paclitaxel. J Med Chem 2008;51(20):6442-9
    • (2008) J Med Chem , vol.51 , Issue.20 , pp. 6442-6449
    • Lee, E.1    Lee, J.2    Lee, I.H.3
  • 41
    • 70350622459 scopus 로고    scopus 로고
    • In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration
    • Lee E, Kim H, Lee IH, Jon S. In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration. J Control Release 2009;140(2):79-85
    • (2009) J Control Release , vol.140 , Issue.2 , pp. 79-85
    • Lee, E.1    Kim, H.2    Lee, I.H.3    Jon, S.4
  • 42
    • 75149183537 scopus 로고    scopus 로고
    • Chitosan-based delivery systems for protein therapeutics and antigens
    • Amidi M, Mastrobattista E, Jiskoot W, Hennink WE. Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev 2010;62(1):59-82
    • (2010) Adv Drug Deliv Rev , vol.62 , Issue.1 , pp. 59-82
    • Amidi, M.1    Mastrobattista, E.2    Jiskoot, W.3    Hennink, W.E.4
  • 43
    • 70249139516 scopus 로고    scopus 로고
    • Chitosan and its salts for mucosal and transmucosal delivery
    • Bonferoni MC, Sandri G, Rossi S, et al. Chitosan and its salts for mucosal and transmucosal delivery. Expert Opin Drug Deliv 2009;6(9):923-39
    • (2009) Expert Opin Drug Deliv , vol.6 , Issue.9 , pp. 923-939
    • Bonferoni, M.C.1    Sandri, G.2    Rossi, S.3
  • 44
    • 65949092552 scopus 로고    scopus 로고
    • Modified chitosans for oral drug delivery
    • Werle M, Takeuchi H, Bernkop-Schnurch A. Modified chitosans for oral drug delivery. J Pharm Sci 2009;98(5):1643-56
    • (2009) J Pharm Sci , vol.98 , Issue.5 , pp. 1643-1656
    • Werle, M.1    Takeuchi, H.2    Bernkop-Schnurch, A.3
  • 45
    • 0036379293 scopus 로고    scopus 로고
    • Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus: The glucose stabilization effects of HIM2
    • Clement S, Still JG, Kosutic G, McAllister RG. Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus: the glucose stabilization effects of HIM2. Diabetes Technol Ther 2002;4(4):459-66
    • (2002) Diabetes Technol Ther , vol.4 , Issue.4 , pp. 459-466
    • Clement, S.1    Still, J.G.2    Kosutic, G.3    McAllister, R.G.4
  • 46
    • 9444230519 scopus 로고    scopus 로고
    • Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects
    • Wajcberg E, Miyazaki Y, Triplitt C, et al. Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects. Diabetes Care 2004;27(12):2868-73
    • (2004) Diabetes Care , vol.27 , Issue.12 , pp. 2868-2873
    • Wajcberg, E.1    Miyazaki, Y.2    Triplitt, C.3
  • 47
    • 33645470970 scopus 로고    scopus 로고
    • Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: In vitro activity screening
    • Miller MA, Malkar NB, Severynse-Stevens D, et al. Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: in vitro activity screening. Bioconjug Chem 2006;17(2):267-74
    • (2006) Bioconjug Chem , vol.17 , Issue.2 , pp. 267-274
    • Miller, M.A.1    Malkar, N.B.2    Severynse-Stevens, D.3
  • 48
    • 55449094132 scopus 로고    scopus 로고
    • Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension
    • Cataliotti A, Chen HH, Schirger JA, et al. Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension. Circulation 2008;118(17):1729-36
    • (2008) Circulation , vol.118 , Issue.17 , pp. 1729-1736
    • Cataliotti, A.1    Chen, H.H.2    Schirger, J.A.3
  • 49
    • 23844481859 scopus 로고    scopus 로고
    • Oral human brain natriuretic peptide activates cyclic guanosine 3′,5′-monophosphate and decreases mean arterial pressure
    • Cataliotti A, Schirger JA, Martin FL, et al. Oral human brain natriuretic peptide activates cyclic guanosine 3′,5′-monophosphate and decreases mean arterial pressure. Circulation 2005;112(6):836-40
    • (2005) Circulation , vol.112 , Issue.6 , pp. 836-840
    • Cataliotti, A.1    Schirger, J.A.2    Martin, F.L.3
  • 50
    • 0037124466 scopus 로고    scopus 로고
    • PEGylated antibodies and antibody fragments for improved therapy: A review
    • Chapman AP. PEGylated antibodies and antibody fragments for improved therapy: a review. Adv Drug Deliv Rev 2002;54(4):531-45
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.4 , pp. 531-545
    • Chapman, A.P.1
  • 51
    • 0029056705 scopus 로고
    • Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine
    • Asada H, Douen T, Waki M, et al. Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine. J Pharm Sci 1995;84(6):682-7
    • (1995) J Pharm Sci , vol.84 , Issue.6 , pp. 682-687
    • Asada, H.1    Douen, T.2    Waki, M.3
  • 52
    • 0026720001 scopus 로고
    • Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid in rats
    • Hashizume M, Douen T, Murakami M, et al. Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid in rats. J Pharm Pharmacol 1992;44(7):555-9
    • (1992) J Pharm Pharmacol , vol.44 , Issue.7 , pp. 555-559
    • Hashizume, M.1    Douen, T.2    Murakami, M.3
  • 53
    • 0027941981 scopus 로고
    • Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids
    • Yodoya E, Uemura K, Tenma T, et al. Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids. J Pharmacol Exp Ther 1994;271(3):1509-13
    • (1994) J Pharmacol Exp Ther , vol.271 , Issue.3 , pp. 1509-1513
    • Yodoya, E.1    Uemura, K.2    Tenma, T.3
  • 54
    • 0027538539 scopus 로고
    • Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin
    • Morishita M, Morishita I, Takayama K, et al. Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin. Biol Pharm Bull 1993;16(1):68-72
    • (1993) Biol Pharm Bull , vol.16 , Issue.1 , pp. 68-72
    • Morishita, M.1    Morishita, I.2    Takayama, K.3
  • 55
    • 0035813752 scopus 로고    scopus 로고
    • Oral drug absorption enhancement by chitosan and its derivatives
    • Thanou M, Verhoef JC, Junginger HE. Oral drug absorption enhancement by chitosan and its derivatives. Adv Drug Deliv Rev 2001;52(2):117-26
    • (2001) Adv Drug Deliv Rev , vol.52 , Issue.2 , pp. 117-126
    • Thanou, M.1    Verhoef, J.C.2    Junginger, H.E.3
  • 56
    • 1142309794 scopus 로고    scopus 로고
    • In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer
    • Rama Prasad YV, Minamimoto T, Yoshikawa Y, et al. In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer. Int J Pharm 2004;271(1-2):225-32
    • (2004) Int J Pharm , vol.271 , Issue.1-2 , pp. 225-232
    • Rama Prasad, Y.V.1    Minamimoto, T.2    Yoshikawa, Y.3
  • 58
    • 0026571249 scopus 로고
    • (C) Means to enhance penetration:(2) Intestinal permeability enhancement for proteins, peptides and other polar drugs: Mechanisms and potential toxicity
    • Scott Swenson E, Curatolo WJ. (C) Means to enhance penetration:(2) Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity. Adv Drug Deliv Rev 1992;8(1):39-92
    • (1992) Adv Drug Deliv Rev , vol.8 , Issue.1 , pp. 39-92
    • Scott Swenson, E.1    Curatolo, W.J.2
  • 59
    • 84876055612 scopus 로고    scopus 로고
    • Permeability enhancement techniques for poorly permeable drugs: A review
    • MS I S, Derle ND, Bhamber R. Permeability enhancement techniques for poorly permeable drugs: a review. J Appl Pharm Sci 2012;2(7):1-6
    • (2012) J Appl Pharm Sci , vol.2 , Issue.7 , pp. 1-6
    • Ms, I.S.1    Derle, N.D.2    Bhamber, R.3
  • 60
    • 0037027858 scopus 로고    scopus 로고
    • Oral absorption of insulin encapsulated in artificial chyles of bile salts, palmitic acid and alphatocopherol dispersions
    • Mesiha MS, Ponnapula S, Plakogiannis F. Oral absorption of insulin encapsulated in artificial chyles of bile salts, palmitic acid and alphatocopherol dispersions. Int J Pharm 2002;249(1-2):1-5
    • (2002) Int J Pharm , vol.249 , Issue.1-2 , pp. 1-5
    • Mesiha, M.S.1    Ponnapula, S.2    Plakogiannis, F.3
  • 61
    • 0027941106 scopus 로고
    • The effect of mixed micellar systems, bile salt/fatty acids, on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat
    • O'Reilly JR, Corrigan OI, O'Driscoll CM. The effect of mixed micellar systems, bile salt/fatty acids, on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat. Int J Pharm 1994;109(2):147-54
    • (1994) Int J Pharm , vol.109 , Issue.2 , pp. 147-154
    • O'Reilly, J.R.1    Corrigan, O.I.2    O'Driscoll, C.M.3
  • 62
    • 70849133150 scopus 로고    scopus 로고
    • Bile acid transporters
    • Dawson PA, Lan T, Rao A. Bile acid transporters. J Lipid Res 2009;50(12):2340-57
    • (2009) J Lipid Res , vol.50 , Issue.12 , pp. 2340-2357
    • Dawson, P.A.1    Lan, T.2    Rao, A.3
  • 63
    • 33745769730 scopus 로고    scopus 로고
    • Apical sodium dependent bile acid transporter (ASBT, SLC10A2): A potential prodrug target
    • Balakrishnan A, Polli JE. Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target. Mol Pharm 2006;3(3):223-30
    • (2006) Mol Pharm , vol.3 , Issue.3 , pp. 223-230
    • Balakrishnan, A.1    Polli, J.E.2
  • 64
    • 16844365876 scopus 로고    scopus 로고
    • A new drug carrier, Nalpha-deoxycholyl-L: -lysylmethylester, for enhancing insulin absorption in the intestine
    • Lee S, Lee J, Lee DY, et al. A new drug carrier, Nalpha-deoxycholyl-L: -lysylmethylester, for enhancing insulin absorption in the intestine. Diabetologia 2005;48(3):405-11
    • (2005) Diabetologia , vol.48 , Issue.3 , pp. 405-411
    • Lee, S.1    Lee, J.2    Lee, D.Y.3
  • 65
    • 34548830808 scopus 로고    scopus 로고
    • Liphophilic complexation of heparin based on bile acid for oral delivery
    • Lee DY, Lee J, Lee S, et al. Liphophilic complexation of heparin based on bile acid for oral delivery. J Control Release 2007;123(1):39-45
    • (2007) J Control Release , vol.123 , Issue.1 , pp. 39-45
    • Lee, D.Y.1    Lee, J.2    Lee, S.3
  • 66
    • 30844439844 scopus 로고    scopus 로고
    • Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels
    • Motlekar NA, Srivenugopal KS, Wachtel MS, Youan B-BC. Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels. J Drug Target 2005;13(10):573-83
    • (2005) J Drug Target , vol.13 , Issue.10 , pp. 573-583
    • Motlekar, N.A.1    Srivenugopal, K.S.2    Wachtel, M.S.3    Youan, B.-B.C.4
  • 67
    • 0035171635 scopus 로고    scopus 로고
    • Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo
    • Thanou M, Nihot M, Jansen M, et al. Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo. J Pharm Sci 2001;90(1):38-46
    • (2001) J Pharm Sci , vol.90 , Issue.1 , pp. 38-46
    • Thanou, M.1    Nihot, M.2    Jansen, M.3
  • 68
    • 33846550081 scopus 로고    scopus 로고
    • N-sulfonato-N,O-carboxymethylchitosan: A novel polymeric absorption enhancer for the oral delivery of macromolecules
    • Thanou M, Henderson S, Kydonieus A, Elson C. N-sulfonato-N,O-carboxymethylchitosan: A novel polymeric absorption enhancer for the oral delivery of macromolecules. J Control Release 2007;117(2):171-8
    • (2007) J Control Release , vol.117 , Issue.2 , pp. 171-178
    • Thanou, M.1    Henderson, S.2    Kydonieus, A.3    Elson, C.4
  • 69
    • 0141551200 scopus 로고    scopus 로고
    • Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: Thiomer/GSH systems
    • Bernkop-Schnurch A, Kast CE, Guggi D. Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems. J Control Release 2003;93(2):95-103
    • (2003) J Control Release , vol.93 , Issue.2 , pp. 95-103
    • Bernkop-Schnurch, A.1    Kast, C.E.2    Guggi, D.3
  • 70
    • 0031723043 scopus 로고    scopus 로고
    • Beta cyclodextrins enhance adenoviral-mediated gene delivery to the intestine
    • Croyle MA, Roessler BJ, Hsu CP, et al. Beta cyclodextrins enhance adenoviral-mediated gene delivery to the intestine. Pharm Res 1998;15(9):1348-55
    • (1998) Pharm Res , vol.15 , Issue.9 , pp. 1348-1355
    • Croyle, M.A.1    Roessler, B.J.2    Hsu, C.P.3
  • 71
    • 71549130146 scopus 로고    scopus 로고
    • Safety and efficacy of sodium caprate in promoting oral drug absorption: From in vitro to the clinic
    • Maher S, Leonard TW, Jacobsen J, Brayden DJ. Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic. Adv Drug Deliv Rev 2009;61(15):1427-49
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.15 , pp. 1427-1449
    • Maher, S.1    Leonard, T.W.2    Jacobsen, J.3    Brayden, D.J.4
  • 72
    • 72749107757 scopus 로고    scopus 로고
    • Oral insulin: The rationale for this approach and current developments
    • Arbit E, Kidron M. Oral insulin: the rationale for this approach and current developments. J Diabetes Sci Technol 2009;3(3):562-7
    • (2009) J Diabetes Sci Technol , vol.3 , Issue.3 , pp. 562-567
    • Arbit, E.1    Kidron, M.2
  • 73
    • 68849115881 scopus 로고    scopus 로고
    • Oral protein delivery: A patent review of academic and industrial approaches
    • Werle M, Makhlof A, Takeuchi H. Oral protein delivery: a patent review of academic and industrial approaches. Recent Pat Drug Deliv Formul 2009;3(2):94-104
    • (2009) Recent Pat Drug Deliv Formul , vol.3 , Issue.2 , pp. 94-104
    • Werle, M.1    Makhlof, A.2    Takeuchi, H.3
  • 74
    • 79551683531 scopus 로고    scopus 로고
    • Oral protein delivery: Current status and future prospect
    • Park K, Kwon IC, Park K. Oral protein delivery: current status and future prospect. React Funct Polym 2011;71(3):280-7
    • (2011) React Funct Polym , vol.71 , Issue.3 , pp. 280-287
    • Park, K.1    Kwon, I.C.2    Park, K.3
  • 75
    • 78049440734 scopus 로고    scopus 로고
    • Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects
    • Steinert RE, Poller B, Castelli MC, et al. Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects. Am J Clin Nutr 2010;92(4):810-17
    • (2010) Am J Clin Nutr , vol.92 , Issue.4 , pp. 810-817
    • Steinert, R.E.1    Poller, B.2    Castelli, M.C.3
  • 76
    • 84862122167 scopus 로고    scopus 로고
    • Gut hormones: The future of obesity treatment?
    • McGavigan AK, Murphy KG. Gut hormones: the future of obesity treatment? Br J Clin Pharmacol 2012;74(6):911-19
    • (2012) Br J Clin Pharmacol , vol.74 , Issue.6 , pp. 911-919
    • McGavigan, A.K.1    Murphy, K.G.2
  • 77
    • 0020363575 scopus 로고
    • SMS 201-995: A very potent and selective octapeptide analogue of somatostatin with prolonged action
    • Bauer W, Briner U, Doepfner W, et al. SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action. Life Sci 1982;31(11):1133-40
    • (1982) Life Sci , vol.31 , Issue.11 , pp. 1133-1140
    • Bauer, W.1    Briner, U.2    Doepfner, W.3
  • 78
    • 84863588864 scopus 로고    scopus 로고
    • Oral octreotide absorption in human subjects: Comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression
    • Tuvia S, Atsmon J, Teichman SL, et al. Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression. J Clin Endocrinol Metab 2012;97(7):2362-9
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.7 , pp. 2362-2369
    • Tuvia, S.1    Atsmon, J.2    Teichman, S.L.3
  • 79
    • 17844406157 scopus 로고    scopus 로고
    • Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: A target for drug delivery
    • Cano-Cebrian MJ, Zornoza T, Granero L, Polache A. Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery. Curr Drug Deliv 2005;2(1):9-22
    • (2005) Curr Drug Deliv , vol.2 , Issue.1 , pp. 9-22
    • Cano-Cebrian, M.J.1    Zornoza, T.2    Granero, L.3    Polache, A.4
  • 81
    • 0023856501 scopus 로고
    • New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier
    • Damge C, Michel C, Aprahamian M, Couvreur P. New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes 1988;37(2):246-51
    • (1988) Diabetes , vol.37 , Issue.2 , pp. 246-251
    • Damge, C.1    Michel, C.2    Aprahamian, M.3    Couvreur, P.4
  • 82
    • 0027869836 scopus 로고
    • Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells
    • Jepson MA, Simmons NL, O'Hagan DT, Hirst BH. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J Drug Target 1993;1(3):245-9
    • (1993) J Drug Target , vol.1 , Issue.3 , pp. 245-249
    • Jepson, M.A.1    Simmons, N.L.2    O'Hagan, D.T.3    Hirst, B.H.4
  • 84
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • Desai MP, Labhasetwar V, Amidon GL, Levy RJ. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res 1996;13(12):1838-45
    • (1996) Pharm Res , vol.13 , Issue.12 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 85
    • 0032055177 scopus 로고    scopus 로고
    • Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia
    • McClean S, Prosser E, Meehan E, et al. Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia. Eur J Pharm Sci 1998;6(2):153-63
    • (1998) Eur J Pharm Sci , vol.6 , Issue.2 , pp. 153-163
    • McClean, S.1    Prosser, E.2    Meehan, E.3
  • 86
    • 0034601281 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for oral delivery of peptides: Is there a role for polymers to affect mucosal uptake?
    • Jung T, Kamm W, Breitenbach A, et al. Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur J Pharm Biopharm 2000;50(1):147-60
    • (2000) Eur J Pharm Biopharm , vol.50 , Issue.1 , pp. 147-160
    • Jung, T.1    Kamm, W.2    Breitenbach, A.3
  • 87
    • 76749103819 scopus 로고    scopus 로고
    • Enteric-coated capsules filled with freeze-dried chitosan/poly(gammaglutamic acid) nanoparticles for oral insulin delivery
    • Sonaje K, Chen YJ, Chen HL, et al. Enteric-coated capsules filled with freeze-dried chitosan/poly(gammaglutamic acid) nanoparticles for oral insulin delivery. Biomaterials 2010;31(12):3384-94
    • (2010) Biomaterials , vol.31 , Issue.12 , pp. 3384-3394
    • Sonaje, K.1    Chen, Y.J.2    Chen, H.L.3
  • 88
    • 60849130683 scopus 로고    scopus 로고
    • In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery
    • Sonaje K, Lin YH, Juang JH, et al. In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 2009;30(12):2329-39
    • (2009) Biomaterials , vol.30 , Issue.12 , pp. 2329-2339
    • Sonaje, K.1    Lin, Y.H.2    Juang, J.H.3
  • 89
    • 77954385916 scopus 로고    scopus 로고
    • Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-responsive nanoparticles vs. Subcutaneous injection
    • Sonaje K, Lin KJ, Wey SP, et al. Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-responsive nanoparticles vs. subcutaneous injection. Biomaterials 2010;31(26):6849-58
    • (2010) Biomaterials , vol.31 , Issue.26 , pp. 6849-6858
    • Sonaje, K.1    Lin, K.J.2    Wey, S.P.3
  • 90
    • 79251593382 scopus 로고    scopus 로고
    • The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo
    • Nguyen HN, Wey SP, Juang JH, et al. The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo. Biomaterials 2011;32(10):2673-82
    • (2011) Biomaterials , vol.32 , Issue.10 , pp. 2673-2682
    • Nguyen, H.N.1    Wey, S.P.2    Juang, J.H.3
  • 91
    • 35549012407 scopus 로고    scopus 로고
    • Oral bioavailability of insulin contained in polysaccharide nanoparticles
    • Sarmento B, Ribeiro A, Veiga F, et al. Oral bioavailability of insulin contained in polysaccharide nanoparticles. Biomacromolecules 2007;8(10):3054-60
    • (2007) Biomacromolecules , vol.8 , Issue.10 , pp. 3054-3060
    • Sarmento, B.1    Ribeiro, A.2    Veiga, F.3
  • 92
    • 35848959714 scopus 로고    scopus 로고
    • Alginate/chitosan nanoparticles are effective for oral insulin delivery
    • Sarmento B, Ribeiro A, Veiga F, et al. Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm Res 2007;24(12):2198-206
    • (2007) Pharm Res , vol.24 , Issue.12 , pp. 2198-2206
    • Sarmento, B.1    Ribeiro, A.2    Veiga, F.3
  • 93
    • 0036692366 scopus 로고    scopus 로고
    • Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport
    • Behrens I, Pena AI, Alonso MJ, Kissel T. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm Res 2002;19(8):1185-93
    • (2002) Pharm Res , vol.19 , Issue.8 , pp. 1185-1193
    • Behrens, I.1    Pena, A.I.2    Alonso, M.J.3    Kissel, T.4
  • 94
    • 33751253462 scopus 로고    scopus 로고
    • Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
    • des Rieux A, Fievez V, Garinot M, et al. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release 2006;116(1):1-27
    • (2006) J Control Release , vol.116 , Issue.1 , pp. 1-27
    • Des Rieux, A.1    Fievez, V.2    Garinot, M.3
  • 95
    • 0030993565 scopus 로고    scopus 로고
    • The oral absorption of micro- and nanoparticulates: Neither exceptional nor unusual
    • Florence AT. The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm Res 1997;14(3):259-66
    • (1997) Pharm Res , vol.14 , Issue.3 , pp. 259-266
    • Florence, A.T.1
  • 96
    • 77957309983 scopus 로고    scopus 로고
    • Hepatic-directed vesicle insulin: A review of formulation development and preclinical evaluation
    • Geho WB, Geho HC, Lau JR, Gana TJ. Hepatic-directed vesicle insulin: a review of formulation development and preclinical evaluation. J Diabetes Sci Technol 2009;3(6):1451-9
    • (2009) J Diabetes Sci Technol , vol.3 , Issue.6 , pp. 1451-1459
    • Geho, W.B.1    Geho, H.C.2    Lau, J.R.3    Gana, T.J.4
  • 98
    • 34447577190 scopus 로고    scopus 로고
    • Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
    • Chalasani KB, Russell-Jones GJ, Jain AK, et al. Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J Control Release 2007;122(2):141-50
    • (2007) J Control Release , vol.122 , Issue.2 , pp. 141-150
    • Chalasani, K.B.1    Russell-Jones, G.J.2    Jain, A.K.3
  • 100
    • 84867422454 scopus 로고    scopus 로고
    • Proof of concept for next-generation nanoparticle drugs in humans
    • Sheridan C. Proof of concept for next-generation nanoparticle drugs in humans. Nat Biotechnol 2012;30(6):471-3
    • (2012) Nat Biotechnol , vol.30 , Issue.6 , pp. 471-473
    • Sheridan, C.1
  • 101
    • 0037080913 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits
    • Jiao Y, Ubrich N, Marchand-Arvier M, et al. In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation 2002;105(2):230-5
    • (2002) Circulation , vol.105 , Issue.2 , pp. 230-235
    • Jiao, Y.1    Ubrich, N.2    Marchand-Arvier, M.3
  • 102
    • 84892198202 scopus 로고    scopus 로고
    • Delivering biotherapeutics - technical opportunities and strategic trends
    • Shohet S, Wood G. Delivering biotherapeutics - technical opportunities and strategic trends. J Commercial Biotechnol 2002;9(1):59-66
    • (2002) J Commercial Biotechnol , vol.9 , Issue.1 , pp. 59-66
    • Shohet, S.1    Wood, G.2
  • 103
    • 77950519662 scopus 로고    scopus 로고
    • Novel fibrillar insulin formulations for oral administration: Formulation and in vivo studies in diabetic mice
    • Dekel Y, Glucksam Y, Mar galit R. Novel fibrillar insulin formulations for oral administration: formulation and in vivo studies in diabetic mice. J Control Release 2010;143(1):128-35
    • (2010) J Control Release , vol.143 , Issue.1 , pp. 128-135
    • Dekel, Y.1    Glucksam, Y.2    Margalit, R.3
  • 104
    • 4444339112 scopus 로고    scopus 로고
    • Mucoadhesive and penetration enhancement properties of three grades of hyaluronic acid using porcine buccal and vaginal tissue, Caco-2 cell lines, and rat jejunum
    • Sandri G, Rossi S, Ferrari F, et al. Mucoadhesive and penetration enhancement properties of three grades of hyaluronic acid using porcine buccal and vaginal tissue, Caco-2 cell lines, and rat jejunum. J Pharm Pharmacol 2004;56(9):1083-90
    • (2004) J Pharm Pharmacol , vol.56 , Issue.9 , pp. 1083-1090
    • Sandri, G.1    Rossi, S.2    Ferrari, F.3
  • 105
    • 35348863173 scopus 로고    scopus 로고
    • Oral low molecular weight heparin delivery by microparticles from complex coacervation
    • Lamprecht A, Ubrich N, Maincent P. Oral low molecular weight heparin delivery by microparticles from complex coacervation. Eur J Pharm Biopharm 2007;67(3):632-8
    • (2007) Eur J Pharm Biopharm , vol.67 , Issue.3 , pp. 632-638
    • Lamprecht, A.1    Ubrich, N.2    Maincent, P.3


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