-
1
-
-
3242778534
-
A physiological model for the estimation of the fraction dose absorbed in humans
-
Willmann S, Schmitt W, Keldenich J, et al. A physiological model for the estimation of the fraction dose absorbed in humans. J Med Chem 2004;47(16):4022-31
-
(2004)
J Med Chem
, vol.47
, Issue.16
, pp. 4022-4031
-
-
Willmann, S.1
Schmitt, W.2
Keldenich, J.3
-
2
-
-
0026823043
-
(D) Routes of delivery: Case studies:(5) Oral absorption of peptides and proteins
-
Smith PL, Wall DA, Gochoco CH, Wilson G. (D) Routes of delivery: case studies:(5) Oral absorption of peptides and proteins. Adv Drug Deliv Rev 1992;8(2):253-90
-
(1992)
Adv Drug Deliv Rev
, vol.8
, Issue.2
, pp. 253-290
-
-
Smith, P.L.1
Wall, D.A.2
Gochoco, C.H.3
Wilson, G.4
-
3
-
-
0027312774
-
Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments
-
Artursson P, Ungell AL, Lofroth JE. Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharm Res 1993;10(8):1123-9
-
(1993)
Pharm Res
, vol.10
, Issue.8
, pp. 1123-1129
-
-
Artursson, P.1
Ungell, A.L.2
Lofroth, J.E.3
-
4
-
-
0025029073
-
Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption
-
Donovan MD, Flynn GL, Amidon GL. Absorption of polyethylene glycols 600 through 2000: the molecular weight dependence of gastrointestinal and nasal absorption. Pharm Res 1990;7(8):863-8
-
(1990)
Pharm Res
, vol.7
, Issue.8
, pp. 863-868
-
-
Donovan, M.D.1
Flynn, G.L.2
Amidon, G.L.3
-
5
-
-
0032189375
-
Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight
-
Camenisch G, Alsenz J, van de Waterbeemd H, Folkers G. Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight. Eur J Pharm Sci 1998;6(4):317-24
-
(1998)
Eur J Pharm Sci
, vol.6
, Issue.4
, pp. 317-324
-
-
Camenisch, G.1
Alsenz, J.2
Van De Waterbeemd, H.3
Folkers, G.4
-
6
-
-
0028657017
-
Enzymatic barriers for GI peptide and protein delivery
-
Woodley JF. Enzymatic barriers for GI peptide and protein delivery. Crit Rev Ther Drug Carrier Syst 1994;11(2-3):61-95
-
(1994)
Crit Rev Ther Drug Carrier Syst
, vol.11
, Issue.2-3
, pp. 61-95
-
-
Woodley, J.F.1
-
7
-
-
80054061227
-
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery
-
Chen MC, Sonaje K, Chen KJ, Sung HW. A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials 2011;32(36):9826-38
-
(2011)
Biomaterials
, vol.32
, Issue.36
, pp. 9826-9838
-
-
Chen, M.C.1
Sonaje, K.2
Chen, K.J.3
Sung, H.W.4
-
8
-
-
0030460690
-
Oral controlled release technology for peptides: Status and future prospects
-
Fix JA. Oral controlled release technology for peptides: status and future prospects. Pharm Res 1996;13(12):1760-4
-
(1996)
Pharm Res
, vol.13
, Issue.12
, pp. 1760-1764
-
-
Fix, J.A.1
-
9
-
-
84874945035
-
Approaches for enhancing oral bioavailability of peptides and proteins
-
Renukuntla J, Vadlapudi AD, Patel A, et al. Approaches for enhancing oral bioavailability of peptides and proteins. Int J Pharm 2013;447(1):75-93
-
(2013)
Int J Pharm
, vol.447
, Issue.1
, pp. 75-93
-
-
Renukuntla, J.1
Vadlapudi, A.D.2
Patel, A.3
-
10
-
-
33646492929
-
Tight junction modulation and its relationship to drug delivery
-
Salama NN, Eddington ND, Fasano A. Tight junction modulation and its relationship to drug delivery. Adv Drug Deliv Rev 2006;58(1):15-28
-
(2006)
Adv Drug Deliv Rev
, vol.58
, Issue.1
, pp. 15-28
-
-
Salama, N.N.1
Eddington, N.D.2
Fasano, A.3
-
11
-
-
0031943571
-
Regulation of the movement of solutes across tight junctions
-
Madara JL. Regulation of the movement of solutes across tight junctions. Annu Rev Physiol 1998;60:143-59
-
(1998)
Annu Rev Physiol
, vol.60
, pp. 143-159
-
-
Madara, J.L.1
-
12
-
-
19444373410
-
theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: A novel mechanism for regulation of permeability
-
Banan A, Zhang LJ, Shaikh M, et al. theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability. J Pharmacol Exp Ther 2005;313(3):962-82
-
(2005)
J Pharmacol Exp Ther
, vol.313
, Issue.3
, pp. 962-982
-
-
Banan, A.1
Zhang, L.J.2
Shaikh, M.3
-
14
-
-
0024310227
-
Ionic permeation mechanisms in epithelia: Biionic potentials, dilution potentials, conductances, and streaming potentials
-
Barry PH. Ionic permeation mechanisms in epithelia: biionic potentials, dilution potentials, conductances, and streaming potentials. Methods Enzymol 1989;171:678-715
-
(1989)
Methods Enzymol
, vol.171
, pp. 678-715
-
-
Barry, P.H.1
-
15
-
-
0019631483
-
Barrier function of epithelia
-
Powell DW. Barrier function of epithelia. Am J Physiol 1981;241(4):G275-88
-
(1981)
Am J Physiol
, vol.241
, Issue.4
, pp. G275-G288
-
-
Powell, D.W.1
-
16
-
-
14544286414
-
Particle uptake by Peyer's patches: A pathway for drug and vaccine delivery
-
Shakweh M, Ponchel G, Fattal E. Particle uptake by Peyer's patches: a pathway for drug and vaccine delivery. Expert Opin Drug Deliv 2004;1(1):141-63
-
(2004)
Expert Opin Drug Deliv
, vol.1
, Issue.1
, pp. 141-163
-
-
Shakweh, M.1
Ponchel, G.2
Fattal, E.3
-
17
-
-
0016358918
-
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell
-
Cheng H, Leblond CP. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. Am J Anat 1974;141(4):461-79
-
(1974)
Am J Anat
, vol.141
, Issue.4
, pp. 461-479
-
-
Cheng, H.1
Leblond, C.P.2
-
19
-
-
0026758261
-
Structural specificity of mucosal-cell transport and metabolism of peptide drugs: Implication for oral peptide drug delivery
-
Bai JP, Amidon GL. Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery. Pharm Res 1992;9(8):969-78
-
(1992)
Pharm Res
, vol.9
, Issue.8
, pp. 969-978
-
-
Bai, J.P.1
Amidon, G.L.2
-
20
-
-
0035286685
-
The potential use of receptor-mediated endocytosis for oral drug delivery
-
Russell-Jones GJ. The potential use of receptor-mediated endocytosis for oral drug delivery. Adv Drug Deliv Rev 2001;46(1-3):59-73
-
(2001)
Adv Drug Deliv Rev
, vol.46
, Issue.1-3
, pp. 59-73
-
-
Russell-Jones, G.J.1
-
21
-
-
0031777867
-
Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways
-
Swaan PW. Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways. Pharm Res 1998;15(6):826-34
-
(1998)
Pharm Res
, vol.15
, Issue.6
, pp. 826-834
-
-
Swaan, P.W.1
-
22
-
-
0030457349
-
Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells
-
Shah D, Shen WC. Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells. J Pharm Sci 1996;85(12):1306-11
-
(1996)
J Pharm Sci
, vol.85
, Issue.12
, pp. 1306-1311
-
-
Shah, D.1
Shen, W.C.2
-
23
-
-
0033254582
-
Drug transport and targeting. Intestinal transport
-
Oh DM, Han HK, Amidon GL. Drug transport and targeting. Intestinal transport. Pharm Biotechnol 1999;12:59-88
-
(1999)
Pharm Biotechnol
, vol.12
, pp. 59-88
-
-
Oh, D.M.1
Han, H.K.2
Amidon, G.L.3
-
24
-
-
0031193858
-
Enhanced transepithelial transport of peptides by conjugation to cholic acid
-
Swaan PW, Hillgren KM, Szoka FC Jr, Oie S. Enhanced transepithelial transport of peptides by conjugation to cholic acid. Bioconjug Chem 1997;8(4):520-5
-
(1997)
Bioconjug Chem
, vol.8
, Issue.4
, pp. 520-525
-
-
Swaan, P.W.1
Hillgren, K.M.2
Szoka, F.C.3
Oie, S.4
-
25
-
-
0029334731
-
Vitamin B12 mediated oral delivery systems for granulocytecolony stimulating factor and erythropoietin
-
Russell-Jones GJ, Westwood SW, Habberfield AD. Vitamin B12 mediated oral delivery systems for granulocytecolony stimulating factor and erythropoietin. Bioconjug Chem 1995;6(4):459-65
-
(1995)
Bioconjug Chem
, vol.6
, Issue.4
, pp. 459-465
-
-
Russell-Jones, G.J.1
Westwood, S.W.2
Habberfield, A.D.3
-
26
-
-
0032217158
-
Use of vitamin B12 conjugates to deliver protein drugs by the oral route
-
Russell-Jones GJ. Use of vitamin B12 conjugates to deliver protein drugs by the oral route. Crit Rev Ther Drug Carrier Syst 1998;15(6):557-86
-
(1998)
Crit Rev Ther Drug Carrier Syst
, vol.15
, Issue.6
, pp. 557-586
-
-
Russell-Jones, G.J.1
-
27
-
-
0035910004
-
Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent
-
Lee Y, Nam JH, Shin HC, Byun Y. Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent. Circulation 2001;104(25):3116-20
-
(2001)
Circulation
, vol.104
, Issue.25
, pp. 3116-3120
-
-
Lee, Y.1
Nam, J.H.2
Shin, H.C.3
Byun, Y.4
-
28
-
-
33645227760
-
Efficacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys
-
Lee YK, Kim SK, Lee DY, et al. Efficacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys. J Control Release 2006;111(3):290-8
-
(2006)
J Control Release
, vol.111
, Issue.3
, pp. 290-298
-
-
Lee, Y.K.1
Kim, S.K.2
Lee, D.Y.3
-
29
-
-
77953268983
-
Anticoagulant efficacy of solid oral formulations containing a new heparin derivative
-
Park JW, Jeon OC, Kim SK, et al. Anticoagulant efficacy of solid oral formulations containing a new heparin derivative. Mol Pharm 2010;7(3):836-43
-
(2010)
Mol Pharm
, vol.7
, Issue.3
, pp. 836-843
-
-
Park, J.W.1
Jeon, O.C.2
Kim, S.K.3
-
30
-
-
84891528616
-
Oligomeric bile acid-mediated oral delivery of low molecular weight heparin
-
Al-Hilal TA, Park J, Alam F, et al. Oligomeric bile acid-mediated oral delivery of low molecular weight heparin. J Control Release 2014;175:17-24
-
(2014)
J Control Release
, vol.175
, pp. 17-24
-
-
Al-Hilal, T.A.1
Park, J.2
Alam, F.3
-
32
-
-
0031467883
-
Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter
-
Lazaridis KN, Pham L, Tietz P, et al. Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. J Clin Invest 1997;100(11):2714-21
-
(1997)
J Clin Invest
, vol.100
, Issue.11
, pp. 2714-2721
-
-
Lazaridis, K.N.1
Pham, L.2
Tietz, P.3
-
33
-
-
84894816912
-
Functional transformations of bile acid transporters induced by high-affinity macromolecules
-
Al-Hilal TA, Chung SW, Alam F, et al. Functional transformations of bile acid transporters induced by high-affinity macromolecules. Sci Rep 2014;4:4163
-
(2014)
Sci Rep
, vol.4
, pp. 4163
-
-
Al-Hilal, T.A.1
Chung, S.W.2
Alam, F.3
-
34
-
-
0033978710
-
Gene transfer facilitated by a cellular targeting molecule, reovirus protein sigma1
-
Wu Y, Boysun MJ, Csencsits KL, Pascual DW. Gene transfer facilitated by a cellular targeting molecule, reovirus protein sigma1. Gene Ther 2000;7(1):61-9
-
(2000)
Gene Ther
, vol.7
, Issue.1
, pp. 61-69
-
-
Wu, Y.1
Boysun, M.J.2
Csencsits, K.L.3
Pascual, D.W.4
-
35
-
-
48849088009
-
Vitamin B12 as a carrier for the oral delivery of insulin
-
Petrus AK, Vortherms AR, Fairchild TJ, Doyle RP. Vitamin B12 as a carrier for the oral delivery of insulin. ChemMedChem 2007;2(12):1717-21
-
(2007)
ChemMedChem
, vol.2
, Issue.12
, pp. 1717-1721
-
-
Petrus, A.K.1
Vortherms, A.R.2
Fairchild, T.J.3
Doyle, R.P.4
-
36
-
-
84859720244
-
Oral biodrug delivery using cell-penetrating peptide
-
Khafagy E-S, Morishita M. Oral biodrug delivery using cell-penetrating peptide. Adv Drug Deliv Rev 2012;64(6):531-9
-
(2012)
Adv Drug Deliv Rev
, vol.64
, Issue.6
, pp. 531-539
-
-
Khafagy, E.-S.1
Morishita, M.2
-
37
-
-
67349268446
-
Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides
-
Kamei N, Morishita M, Takayama K. Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides. J Control Release 2009;136(3):179-86
-
(2009)
J Control Release
, vol.136
, Issue.3
, pp. 179-186
-
-
Kamei, N.1
Morishita, M.2
Takayama, K.3
-
38
-
-
39049130647
-
Cell-penetrating peptides for drug delivery across membrane barriers
-
Foged C, Nielsen HM. Cell-penetrating peptides for drug delivery across membrane barriers. Expert Opin Drug Deliv 2008;5(1):105-17
-
(2008)
Expert Opin Drug Deliv
, vol.5
, Issue.1
, pp. 105-117
-
-
Foged, C.1
Nielsen, H.M.2
-
39
-
-
23944512155
-
Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency
-
Liang JF, Yang VC. Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency. Biochem Biophys Res Commun 2005;335(3):734-8
-
(2005)
Biochem Biophys Res Commun
, vol.335
, Issue.3
, pp. 734-738
-
-
Liang, J.F.1
Yang, V.C.2
-
40
-
-
54549097056
-
Conjugated chitosan as a novel platform for oral delivery of paclitaxel
-
Lee E, Lee J, Lee IH, et al. Conjugated chitosan as a novel platform for oral delivery of paclitaxel. J Med Chem 2008;51(20):6442-9
-
(2008)
J Med Chem
, vol.51
, Issue.20
, pp. 6442-6449
-
-
Lee, E.1
Lee, J.2
Lee, I.H.3
-
41
-
-
70350622459
-
In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration
-
Lee E, Kim H, Lee IH, Jon S. In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration. J Control Release 2009;140(2):79-85
-
(2009)
J Control Release
, vol.140
, Issue.2
, pp. 79-85
-
-
Lee, E.1
Kim, H.2
Lee, I.H.3
Jon, S.4
-
42
-
-
75149183537
-
Chitosan-based delivery systems for protein therapeutics and antigens
-
Amidi M, Mastrobattista E, Jiskoot W, Hennink WE. Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev 2010;62(1):59-82
-
(2010)
Adv Drug Deliv Rev
, vol.62
, Issue.1
, pp. 59-82
-
-
Amidi, M.1
Mastrobattista, E.2
Jiskoot, W.3
Hennink, W.E.4
-
43
-
-
70249139516
-
Chitosan and its salts for mucosal and transmucosal delivery
-
Bonferoni MC, Sandri G, Rossi S, et al. Chitosan and its salts for mucosal and transmucosal delivery. Expert Opin Drug Deliv 2009;6(9):923-39
-
(2009)
Expert Opin Drug Deliv
, vol.6
, Issue.9
, pp. 923-939
-
-
Bonferoni, M.C.1
Sandri, G.2
Rossi, S.3
-
45
-
-
0036379293
-
Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus: The glucose stabilization effects of HIM2
-
Clement S, Still JG, Kosutic G, McAllister RG. Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus: the glucose stabilization effects of HIM2. Diabetes Technol Ther 2002;4(4):459-66
-
(2002)
Diabetes Technol Ther
, vol.4
, Issue.4
, pp. 459-466
-
-
Clement, S.1
Still, J.G.2
Kosutic, G.3
McAllister, R.G.4
-
46
-
-
9444230519
-
Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects
-
Wajcberg E, Miyazaki Y, Triplitt C, et al. Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects. Diabetes Care 2004;27(12):2868-73
-
(2004)
Diabetes Care
, vol.27
, Issue.12
, pp. 2868-2873
-
-
Wajcberg, E.1
Miyazaki, Y.2
Triplitt, C.3
-
47
-
-
33645470970
-
Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: In vitro activity screening
-
Miller MA, Malkar NB, Severynse-Stevens D, et al. Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: in vitro activity screening. Bioconjug Chem 2006;17(2):267-74
-
(2006)
Bioconjug Chem
, vol.17
, Issue.2
, pp. 267-274
-
-
Miller, M.A.1
Malkar, N.B.2
Severynse-Stevens, D.3
-
48
-
-
55449094132
-
Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension
-
Cataliotti A, Chen HH, Schirger JA, et al. Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension. Circulation 2008;118(17):1729-36
-
(2008)
Circulation
, vol.118
, Issue.17
, pp. 1729-1736
-
-
Cataliotti, A.1
Chen, H.H.2
Schirger, J.A.3
-
49
-
-
23844481859
-
Oral human brain natriuretic peptide activates cyclic guanosine 3′,5′-monophosphate and decreases mean arterial pressure
-
Cataliotti A, Schirger JA, Martin FL, et al. Oral human brain natriuretic peptide activates cyclic guanosine 3′,5′-monophosphate and decreases mean arterial pressure. Circulation 2005;112(6):836-40
-
(2005)
Circulation
, vol.112
, Issue.6
, pp. 836-840
-
-
Cataliotti, A.1
Schirger, J.A.2
Martin, F.L.3
-
50
-
-
0037124466
-
PEGylated antibodies and antibody fragments for improved therapy: A review
-
Chapman AP. PEGylated antibodies and antibody fragments for improved therapy: a review. Adv Drug Deliv Rev 2002;54(4):531-45
-
(2002)
Adv Drug Deliv Rev
, vol.54
, Issue.4
, pp. 531-545
-
-
Chapman, A.P.1
-
51
-
-
0029056705
-
Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine
-
Asada H, Douen T, Waki M, et al. Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine. J Pharm Sci 1995;84(6):682-7
-
(1995)
J Pharm Sci
, vol.84
, Issue.6
, pp. 682-687
-
-
Asada, H.1
Douen, T.2
Waki, M.3
-
52
-
-
0026720001
-
Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid in rats
-
Hashizume M, Douen T, Murakami M, et al. Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid in rats. J Pharm Pharmacol 1992;44(7):555-9
-
(1992)
J Pharm Pharmacol
, vol.44
, Issue.7
, pp. 555-559
-
-
Hashizume, M.1
Douen, T.2
Murakami, M.3
-
53
-
-
0027941981
-
Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids
-
Yodoya E, Uemura K, Tenma T, et al. Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids. J Pharmacol Exp Ther 1994;271(3):1509-13
-
(1994)
J Pharmacol Exp Ther
, vol.271
, Issue.3
, pp. 1509-1513
-
-
Yodoya, E.1
Uemura, K.2
Tenma, T.3
-
54
-
-
0027538539
-
Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin
-
Morishita M, Morishita I, Takayama K, et al. Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin. Biol Pharm Bull 1993;16(1):68-72
-
(1993)
Biol Pharm Bull
, vol.16
, Issue.1
, pp. 68-72
-
-
Morishita, M.1
Morishita, I.2
Takayama, K.3
-
55
-
-
0035813752
-
Oral drug absorption enhancement by chitosan and its derivatives
-
Thanou M, Verhoef JC, Junginger HE. Oral drug absorption enhancement by chitosan and its derivatives. Adv Drug Deliv Rev 2001;52(2):117-26
-
(2001)
Adv Drug Deliv Rev
, vol.52
, Issue.2
, pp. 117-126
-
-
Thanou, M.1
Verhoef, J.C.2
Junginger, H.E.3
-
56
-
-
1142309794
-
In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer
-
Rama Prasad YV, Minamimoto T, Yoshikawa Y, et al. In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer. Int J Pharm 2004;271(1-2):225-32
-
(2004)
Int J Pharm
, vol.271
, Issue.1-2
, pp. 225-232
-
-
Rama Prasad, Y.V.1
Minamimoto, T.2
Yoshikawa, Y.3
-
58
-
-
0026571249
-
(C) Means to enhance penetration:(2) Intestinal permeability enhancement for proteins, peptides and other polar drugs: Mechanisms and potential toxicity
-
Scott Swenson E, Curatolo WJ. (C) Means to enhance penetration:(2) Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity. Adv Drug Deliv Rev 1992;8(1):39-92
-
(1992)
Adv Drug Deliv Rev
, vol.8
, Issue.1
, pp. 39-92
-
-
Scott Swenson, E.1
Curatolo, W.J.2
-
59
-
-
84876055612
-
Permeability enhancement techniques for poorly permeable drugs: A review
-
MS I S, Derle ND, Bhamber R. Permeability enhancement techniques for poorly permeable drugs: a review. J Appl Pharm Sci 2012;2(7):1-6
-
(2012)
J Appl Pharm Sci
, vol.2
, Issue.7
, pp. 1-6
-
-
Ms, I.S.1
Derle, N.D.2
Bhamber, R.3
-
60
-
-
0037027858
-
Oral absorption of insulin encapsulated in artificial chyles of bile salts, palmitic acid and alphatocopherol dispersions
-
Mesiha MS, Ponnapula S, Plakogiannis F. Oral absorption of insulin encapsulated in artificial chyles of bile salts, palmitic acid and alphatocopherol dispersions. Int J Pharm 2002;249(1-2):1-5
-
(2002)
Int J Pharm
, vol.249
, Issue.1-2
, pp. 1-5
-
-
Mesiha, M.S.1
Ponnapula, S.2
Plakogiannis, F.3
-
61
-
-
0027941106
-
The effect of mixed micellar systems, bile salt/fatty acids, on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat
-
O'Reilly JR, Corrigan OI, O'Driscoll CM. The effect of mixed micellar systems, bile salt/fatty acids, on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat. Int J Pharm 1994;109(2):147-54
-
(1994)
Int J Pharm
, vol.109
, Issue.2
, pp. 147-154
-
-
O'Reilly, J.R.1
Corrigan, O.I.2
O'Driscoll, C.M.3
-
62
-
-
70849133150
-
Bile acid transporters
-
Dawson PA, Lan T, Rao A. Bile acid transporters. J Lipid Res 2009;50(12):2340-57
-
(2009)
J Lipid Res
, vol.50
, Issue.12
, pp. 2340-2357
-
-
Dawson, P.A.1
Lan, T.2
Rao, A.3
-
63
-
-
33745769730
-
Apical sodium dependent bile acid transporter (ASBT, SLC10A2): A potential prodrug target
-
Balakrishnan A, Polli JE. Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target. Mol Pharm 2006;3(3):223-30
-
(2006)
Mol Pharm
, vol.3
, Issue.3
, pp. 223-230
-
-
Balakrishnan, A.1
Polli, J.E.2
-
64
-
-
16844365876
-
A new drug carrier, Nalpha-deoxycholyl-L: -lysylmethylester, for enhancing insulin absorption in the intestine
-
Lee S, Lee J, Lee DY, et al. A new drug carrier, Nalpha-deoxycholyl-L: -lysylmethylester, for enhancing insulin absorption in the intestine. Diabetologia 2005;48(3):405-11
-
(2005)
Diabetologia
, vol.48
, Issue.3
, pp. 405-411
-
-
Lee, S.1
Lee, J.2
Lee, D.Y.3
-
65
-
-
34548830808
-
Liphophilic complexation of heparin based on bile acid for oral delivery
-
Lee DY, Lee J, Lee S, et al. Liphophilic complexation of heparin based on bile acid for oral delivery. J Control Release 2007;123(1):39-45
-
(2007)
J Control Release
, vol.123
, Issue.1
, pp. 39-45
-
-
Lee, D.Y.1
Lee, J.2
Lee, S.3
-
66
-
-
30844439844
-
Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels
-
Motlekar NA, Srivenugopal KS, Wachtel MS, Youan B-BC. Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels. J Drug Target 2005;13(10):573-83
-
(2005)
J Drug Target
, vol.13
, Issue.10
, pp. 573-583
-
-
Motlekar, N.A.1
Srivenugopal, K.S.2
Wachtel, M.S.3
Youan, B.-B.C.4
-
67
-
-
0035171635
-
Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo
-
Thanou M, Nihot M, Jansen M, et al. Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo. J Pharm Sci 2001;90(1):38-46
-
(2001)
J Pharm Sci
, vol.90
, Issue.1
, pp. 38-46
-
-
Thanou, M.1
Nihot, M.2
Jansen, M.3
-
68
-
-
33846550081
-
N-sulfonato-N,O-carboxymethylchitosan: A novel polymeric absorption enhancer for the oral delivery of macromolecules
-
Thanou M, Henderson S, Kydonieus A, Elson C. N-sulfonato-N,O-carboxymethylchitosan: A novel polymeric absorption enhancer for the oral delivery of macromolecules. J Control Release 2007;117(2):171-8
-
(2007)
J Control Release
, vol.117
, Issue.2
, pp. 171-178
-
-
Thanou, M.1
Henderson, S.2
Kydonieus, A.3
Elson, C.4
-
69
-
-
0141551200
-
Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: Thiomer/GSH systems
-
Bernkop-Schnurch A, Kast CE, Guggi D. Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems. J Control Release 2003;93(2):95-103
-
(2003)
J Control Release
, vol.93
, Issue.2
, pp. 95-103
-
-
Bernkop-Schnurch, A.1
Kast, C.E.2
Guggi, D.3
-
70
-
-
0031723043
-
Beta cyclodextrins enhance adenoviral-mediated gene delivery to the intestine
-
Croyle MA, Roessler BJ, Hsu CP, et al. Beta cyclodextrins enhance adenoviral-mediated gene delivery to the intestine. Pharm Res 1998;15(9):1348-55
-
(1998)
Pharm Res
, vol.15
, Issue.9
, pp. 1348-1355
-
-
Croyle, M.A.1
Roessler, B.J.2
Hsu, C.P.3
-
71
-
-
71549130146
-
Safety and efficacy of sodium caprate in promoting oral drug absorption: From in vitro to the clinic
-
Maher S, Leonard TW, Jacobsen J, Brayden DJ. Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic. Adv Drug Deliv Rev 2009;61(15):1427-49
-
(2009)
Adv Drug Deliv Rev
, vol.61
, Issue.15
, pp. 1427-1449
-
-
Maher, S.1
Leonard, T.W.2
Jacobsen, J.3
Brayden, D.J.4
-
72
-
-
72749107757
-
Oral insulin: The rationale for this approach and current developments
-
Arbit E, Kidron M. Oral insulin: the rationale for this approach and current developments. J Diabetes Sci Technol 2009;3(3):562-7
-
(2009)
J Diabetes Sci Technol
, vol.3
, Issue.3
, pp. 562-567
-
-
Arbit, E.1
Kidron, M.2
-
73
-
-
68849115881
-
Oral protein delivery: A patent review of academic and industrial approaches
-
Werle M, Makhlof A, Takeuchi H. Oral protein delivery: a patent review of academic and industrial approaches. Recent Pat Drug Deliv Formul 2009;3(2):94-104
-
(2009)
Recent Pat Drug Deliv Formul
, vol.3
, Issue.2
, pp. 94-104
-
-
Werle, M.1
Makhlof, A.2
Takeuchi, H.3
-
74
-
-
79551683531
-
Oral protein delivery: Current status and future prospect
-
Park K, Kwon IC, Park K. Oral protein delivery: current status and future prospect. React Funct Polym 2011;71(3):280-7
-
(2011)
React Funct Polym
, vol.71
, Issue.3
, pp. 280-287
-
-
Park, K.1
Kwon, I.C.2
Park, K.3
-
75
-
-
78049440734
-
Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects
-
Steinert RE, Poller B, Castelli MC, et al. Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects. Am J Clin Nutr 2010;92(4):810-17
-
(2010)
Am J Clin Nutr
, vol.92
, Issue.4
, pp. 810-817
-
-
Steinert, R.E.1
Poller, B.2
Castelli, M.C.3
-
76
-
-
84862122167
-
Gut hormones: The future of obesity treatment?
-
McGavigan AK, Murphy KG. Gut hormones: the future of obesity treatment? Br J Clin Pharmacol 2012;74(6):911-19
-
(2012)
Br J Clin Pharmacol
, vol.74
, Issue.6
, pp. 911-919
-
-
McGavigan, A.K.1
Murphy, K.G.2
-
77
-
-
0020363575
-
SMS 201-995: A very potent and selective octapeptide analogue of somatostatin with prolonged action
-
Bauer W, Briner U, Doepfner W, et al. SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action. Life Sci 1982;31(11):1133-40
-
(1982)
Life Sci
, vol.31
, Issue.11
, pp. 1133-1140
-
-
Bauer, W.1
Briner, U.2
Doepfner, W.3
-
78
-
-
84863588864
-
Oral octreotide absorption in human subjects: Comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression
-
Tuvia S, Atsmon J, Teichman SL, et al. Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression. J Clin Endocrinol Metab 2012;97(7):2362-9
-
(2012)
J Clin Endocrinol Metab
, vol.97
, Issue.7
, pp. 2362-2369
-
-
Tuvia, S.1
Atsmon, J.2
Teichman, S.L.3
-
79
-
-
17844406157
-
Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: A target for drug delivery
-
Cano-Cebrian MJ, Zornoza T, Granero L, Polache A. Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery. Curr Drug Deliv 2005;2(1):9-22
-
(2005)
Curr Drug Deliv
, vol.2
, Issue.1
, pp. 9-22
-
-
Cano-Cebrian, M.J.1
Zornoza, T.2
Granero, L.3
Polache, A.4
-
81
-
-
0023856501
-
New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier
-
Damge C, Michel C, Aprahamian M, Couvreur P. New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes 1988;37(2):246-51
-
(1988)
Diabetes
, vol.37
, Issue.2
, pp. 246-251
-
-
Damge, C.1
Michel, C.2
Aprahamian, M.3
Couvreur, P.4
-
82
-
-
0027869836
-
Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells
-
Jepson MA, Simmons NL, O'Hagan DT, Hirst BH. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J Drug Target 1993;1(3):245-9
-
(1993)
J Drug Target
, vol.1
, Issue.3
, pp. 245-249
-
-
Jepson, M.A.1
Simmons, N.L.2
O'Hagan, D.T.3
Hirst, B.H.4
-
84
-
-
0030471901
-
Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
-
Desai MP, Labhasetwar V, Amidon GL, Levy RJ. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res 1996;13(12):1838-45
-
(1996)
Pharm Res
, vol.13
, Issue.12
, pp. 1838-1845
-
-
Desai, M.P.1
Labhasetwar, V.2
Amidon, G.L.3
Levy, R.J.4
-
85
-
-
0032055177
-
Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia
-
McClean S, Prosser E, Meehan E, et al. Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia. Eur J Pharm Sci 1998;6(2):153-63
-
(1998)
Eur J Pharm Sci
, vol.6
, Issue.2
, pp. 153-163
-
-
McClean, S.1
Prosser, E.2
Meehan, E.3
-
86
-
-
0034601281
-
Biodegradable nanoparticles for oral delivery of peptides: Is there a role for polymers to affect mucosal uptake?
-
Jung T, Kamm W, Breitenbach A, et al. Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur J Pharm Biopharm 2000;50(1):147-60
-
(2000)
Eur J Pharm Biopharm
, vol.50
, Issue.1
, pp. 147-160
-
-
Jung, T.1
Kamm, W.2
Breitenbach, A.3
-
87
-
-
76749103819
-
Enteric-coated capsules filled with freeze-dried chitosan/poly(gammaglutamic acid) nanoparticles for oral insulin delivery
-
Sonaje K, Chen YJ, Chen HL, et al. Enteric-coated capsules filled with freeze-dried chitosan/poly(gammaglutamic acid) nanoparticles for oral insulin delivery. Biomaterials 2010;31(12):3384-94
-
(2010)
Biomaterials
, vol.31
, Issue.12
, pp. 3384-3394
-
-
Sonaje, K.1
Chen, Y.J.2
Chen, H.L.3
-
88
-
-
60849130683
-
In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery
-
Sonaje K, Lin YH, Juang JH, et al. In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 2009;30(12):2329-39
-
(2009)
Biomaterials
, vol.30
, Issue.12
, pp. 2329-2339
-
-
Sonaje, K.1
Lin, Y.H.2
Juang, J.H.3
-
89
-
-
77954385916
-
Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-responsive nanoparticles vs. Subcutaneous injection
-
Sonaje K, Lin KJ, Wey SP, et al. Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-responsive nanoparticles vs. subcutaneous injection. Biomaterials 2010;31(26):6849-58
-
(2010)
Biomaterials
, vol.31
, Issue.26
, pp. 6849-6858
-
-
Sonaje, K.1
Lin, K.J.2
Wey, S.P.3
-
90
-
-
79251593382
-
The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo
-
Nguyen HN, Wey SP, Juang JH, et al. The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo. Biomaterials 2011;32(10):2673-82
-
(2011)
Biomaterials
, vol.32
, Issue.10
, pp. 2673-2682
-
-
Nguyen, H.N.1
Wey, S.P.2
Juang, J.H.3
-
91
-
-
35549012407
-
Oral bioavailability of insulin contained in polysaccharide nanoparticles
-
Sarmento B, Ribeiro A, Veiga F, et al. Oral bioavailability of insulin contained in polysaccharide nanoparticles. Biomacromolecules 2007;8(10):3054-60
-
(2007)
Biomacromolecules
, vol.8
, Issue.10
, pp. 3054-3060
-
-
Sarmento, B.1
Ribeiro, A.2
Veiga, F.3
-
92
-
-
35848959714
-
Alginate/chitosan nanoparticles are effective for oral insulin delivery
-
Sarmento B, Ribeiro A, Veiga F, et al. Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm Res 2007;24(12):2198-206
-
(2007)
Pharm Res
, vol.24
, Issue.12
, pp. 2198-2206
-
-
Sarmento, B.1
Ribeiro, A.2
Veiga, F.3
-
93
-
-
0036692366
-
Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport
-
Behrens I, Pena AI, Alonso MJ, Kissel T. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm Res 2002;19(8):1185-93
-
(2002)
Pharm Res
, vol.19
, Issue.8
, pp. 1185-1193
-
-
Behrens, I.1
Pena, A.I.2
Alonso, M.J.3
Kissel, T.4
-
94
-
-
33751253462
-
Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
-
des Rieux A, Fievez V, Garinot M, et al. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release 2006;116(1):1-27
-
(2006)
J Control Release
, vol.116
, Issue.1
, pp. 1-27
-
-
Des Rieux, A.1
Fievez, V.2
Garinot, M.3
-
95
-
-
0030993565
-
The oral absorption of micro- and nanoparticulates: Neither exceptional nor unusual
-
Florence AT. The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm Res 1997;14(3):259-66
-
(1997)
Pharm Res
, vol.14
, Issue.3
, pp. 259-266
-
-
Florence, A.T.1
-
96
-
-
77957309983
-
Hepatic-directed vesicle insulin: A review of formulation development and preclinical evaluation
-
Geho WB, Geho HC, Lau JR, Gana TJ. Hepatic-directed vesicle insulin: a review of formulation development and preclinical evaluation. J Diabetes Sci Technol 2009;3(6):1451-9
-
(2009)
J Diabetes Sci Technol
, vol.3
, Issue.6
, pp. 1451-1459
-
-
Geho, W.B.1
Geho, H.C.2
Lau, J.R.3
Gana, T.J.4
-
97
-
-
79955974608
-
Fate of polymeric nanocarriers for oral drug delivery
-
Plapied L, Duhem N, des Rieux A, Preat V. Fate of polymeric nanocarriers for oral drug delivery. Curr Opin Colloid In 2011;16(3):228-37
-
(2011)
Curr Opin Colloid In
, vol.16
, Issue.3
, pp. 228-237
-
-
Plapied, L.1
Duhem, N.2
Des Rieux, A.3
Preat, V.4
-
98
-
-
34447577190
-
Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
-
Chalasani KB, Russell-Jones GJ, Jain AK, et al. Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J Control Release 2007;122(2):141-50
-
(2007)
J Control Release
, vol.122
, Issue.2
, pp. 141-150
-
-
Chalasani, K.B.1
Russell-Jones, G.J.2
Jain, A.K.3
-
100
-
-
84867422454
-
Proof of concept for next-generation nanoparticle drugs in humans
-
Sheridan C. Proof of concept for next-generation nanoparticle drugs in humans. Nat Biotechnol 2012;30(6):471-3
-
(2012)
Nat Biotechnol
, vol.30
, Issue.6
, pp. 471-473
-
-
Sheridan, C.1
-
101
-
-
0037080913
-
In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits
-
Jiao Y, Ubrich N, Marchand-Arvier M, et al. In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation 2002;105(2):230-5
-
(2002)
Circulation
, vol.105
, Issue.2
, pp. 230-235
-
-
Jiao, Y.1
Ubrich, N.2
Marchand-Arvier, M.3
-
102
-
-
84892198202
-
Delivering biotherapeutics - technical opportunities and strategic trends
-
Shohet S, Wood G. Delivering biotherapeutics - technical opportunities and strategic trends. J Commercial Biotechnol 2002;9(1):59-66
-
(2002)
J Commercial Biotechnol
, vol.9
, Issue.1
, pp. 59-66
-
-
Shohet, S.1
Wood, G.2
-
103
-
-
77950519662
-
Novel fibrillar insulin formulations for oral administration: Formulation and in vivo studies in diabetic mice
-
Dekel Y, Glucksam Y, Mar galit R. Novel fibrillar insulin formulations for oral administration: formulation and in vivo studies in diabetic mice. J Control Release 2010;143(1):128-35
-
(2010)
J Control Release
, vol.143
, Issue.1
, pp. 128-135
-
-
Dekel, Y.1
Glucksam, Y.2
Margalit, R.3
-
104
-
-
4444339112
-
Mucoadhesive and penetration enhancement properties of three grades of hyaluronic acid using porcine buccal and vaginal tissue, Caco-2 cell lines, and rat jejunum
-
Sandri G, Rossi S, Ferrari F, et al. Mucoadhesive and penetration enhancement properties of three grades of hyaluronic acid using porcine buccal and vaginal tissue, Caco-2 cell lines, and rat jejunum. J Pharm Pharmacol 2004;56(9):1083-90
-
(2004)
J Pharm Pharmacol
, vol.56
, Issue.9
, pp. 1083-1090
-
-
Sandri, G.1
Rossi, S.2
Ferrari, F.3
-
105
-
-
35348863173
-
Oral low molecular weight heparin delivery by microparticles from complex coacervation
-
Lamprecht A, Ubrich N, Maincent P. Oral low molecular weight heparin delivery by microparticles from complex coacervation. Eur J Pharm Biopharm 2007;67(3):632-8
-
(2007)
Eur J Pharm Biopharm
, vol.67
, Issue.3
, pp. 632-638
-
-
Lamprecht, A.1
Ubrich, N.2
Maincent, P.3
|