Liphophilic complexation of heparin based on bile acid for oral delivery

Journal of Controlled Release

Volumn 123, Issue 1, 2007, Pages 39-45

  Lee, Dong Yun ^a   Lee, Jisook ^b   Lee, Seulki ^b   Kim, Sang Kyoon ^a   Byun, Youngro ^a  

^a Seoul National University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

Deoxycholylethylamine; Heparin; Ionic complex; Lipophilicity; Oral delivery

Indexed keywords

AMINES; COMPLEXATION; DRUG DELIVERY; MOLECULAR WEIGHT; PROPYLENE; TISSUE;

DEOXYCHOLYLETHYLAMINE; HEPARIN; PHYSICOCHEMICAL PROPERTIES; PROPYLENE GLYCOL; THROMBOSIS;

PROTEINS;

BILE ACID; LOW MOLECULAR WEIGHT HEPARIN; PROPYLENE GLYCOL;

ARTICLE; COMPLEX FORMATION; DRUG ABSORPTION; HUMAN; INTESTINE ABSORPTION; LIPOPHILICITY; MAXIMUM PLASMA CONCENTRATION; PRIORITY JOURNAL; SYNTHESIS;

ADMINISTRATION, ORAL; ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL AVAILABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; HEPARIN; LIPIDS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34548830808     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.07.013     Document Type: Article

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