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Volumn 22, Issue 8, 2013, Pages 955-963

Investigational therapies for acromegaly

Author keywords

Acromegaly; Cabergoline; Medical therapy; Pasireotide; Pegvisomant; Somatostatin analogs

Indexed keywords

ANGIOPEPTIN; CABERGOLINE; OCTREOLIN; OCTREOTIDE; PASIREOTIDE; PEGVISOMANT; PIOGLITAZONE; ROSIGLITAZONE; SOMATOSTATIN DERIVATIVE; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

EID: 84880191515     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2013.805201     Document Type: Review
Times cited : (13)

References (58)
  • 1
    • 33845491265 scopus 로고    scopus 로고
    • Acromegaly
    • Melmed S. Acromegaly. N Engl J Med 2006;355:2558-73
    • (2006) N Engl J Med , vol.355 , pp. 2558-2573
    • Melmed, S.1
  • 2
    • 1442326975 scopus 로고    scopus 로고
    • Systemic complications of acromegaly: Epidemiology, pathogenesis, and management
    • Colao A, Ferone D, Marzullo P, et al. Systemic complications of acromegaly: Epidemiology, pathogenesis, and management. Endocr Rev 2004;25(1):102-52
    • (2004) Endocr Rev , vol.25 , Issue.1 , pp. 102-152
    • Colao, A.1    Ferone, D.2    Marzullo, P.3
  • 3
    • 66149130384 scopus 로고    scopus 로고
    • Acromegaly Consensus Group. Guidelines for acromegaly management: An update
    • Melmed S, Colao A, Barkan A, et al. Acromegaly Consensus Group. Guidelines for acromegaly management: An update. J Clin Endocrinol Metab 2009;94(5):1509-17
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.5 , pp. 1509-1517
    • Melmed, S.1    Colao, A.2    Barkan, A.3
  • 4
    • 79955577752 scopus 로고    scopus 로고
    • Resistance to somatostatin analogs in acromegaly
    • Colao A, Auriemma RS, Lombardi G, et al. Resistance to somatostatin analogs in acromegaly. Endocr Rev 2011;32(2):247-71
    • (2011) Endocr Rev , vol.32 , Issue.2 , pp. 247-271
    • Colao, A.1    Auriemma, R.S.2    Lombardi, G.3
  • 5
    • 77955768701 scopus 로고    scopus 로고
    • New formulations and approaches in the medical treatment of acromegaly
    • Debono M, Newell-Price J. New formulations and approaches in the medical treatment of acromegaly. Curr Opin Endocrinol Diabetes Obes 2010;17(4):350-5
    • (2010) Curr Opin Endocrinol Diabetes Obes , vol.17 , Issue.4 , pp. 350-355
    • Debono, M.1    Newell-Price, J.2
  • 6
    • 80053923341 scopus 로고    scopus 로고
    • Clinical quality of life and economic value of acromegaly disease control
    • Ben-Shlomo A, Sheppard MC, Stephens JM, et al. Clinical, quality of life, and economic value of acromegaly disease control. Pituitary 2011;14(3):284-94
    • (2011) Pituitary , vol.14 , Issue.3 , pp. 284-294
    • Ben-Shlomo, A.1    Sheppard, M.C.2    Stephens, J.M.3
  • 7
    • 57349198830 scopus 로고    scopus 로고
    • Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults
    • Pituitary Society; European Neuroendocrine Association.
    • Giustina A, Barkan A, Chanson P, et al. Pituitary Society; European Neuroendocrine Association. Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults. J Endocrinol Invest 2008;31(9):820-38
    • (2008) J Endocrinol Invest , vol.31 , Issue.9 , pp. 820-838
    • Giustina, A.1    Barkan, A.2    Chanson, P.3
  • 8
    • 84864583427 scopus 로고    scopus 로고
    • Somatostatin analogs as a first-line treatment in acromegaly: When is it appropriate?
    • Grasso LF, Pivonello R, Colao A. Somatostatin analogs as a first-line treatment in acromegaly: When is it appropriate? Curr Opin Endocrinol Diabetes Obes 2012;19(4):288-94
    • (2012) Curr Opin Endocrinol Diabetes Obes , vol.19 , Issue.4 , pp. 288-294
    • Grasso, L.F.1    Pivonello, R.2    Colao, A.3
  • 9
    • 34548665710 scopus 로고    scopus 로고
    • Efficacy of a slow-release formulation of lanreotide (autogel 120 mg) in patients with acromegaly previously treated with octreotide long acting release (LAR): An open,multicenter longitudinal study
    • Ronchi CL, Boschetti M, Degli Uberti EC, et al. Efficacy of a slow-release formulation of lanreotide (autogel 120 mg) in patients with acromegaly previously treated with octreotide long acting release (LAR): An open,multicenter longitudinal study. Clin Endocrinol (Oxf) 2007;67:512-19
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 512-519
    • Ronchi, C.L.1    Boschetti, M.2    Degli Uberti, E.C.3
  • 10
    • 0036319414 scopus 로고    scopus 로고
    • Somatostatin analogs in acromegaly
    • Freda PU. Somatostatin analogs in acromegaly. J Clin Endocrinol Metab 2002;87:3013-18
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3013-3018
    • Freda, P.U.1
  • 11
    • 0034974291 scopus 로고    scopus 로고
    • Long-term effects of depot long-acting somatostatin analog octreotide on hormone levels and tumor mass in acromegaly
    • Colao A, Ferone D, Marzullo P, et al. Long-term effects of depot long-acting somatostatin analog octreotide on hormone levels and tumor mass in acromegaly. J Clin Endocrinol Metab 2001;86:2779-86
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2779-2786
    • Colao, A.1    Ferone, D.2    Marzullo, P.3
  • 12
    • 70349900717 scopus 로고    scopus 로고
    • Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-I levels, tumor shrinkage, and cardiovascular disease: A prospective study
    • Colao A, Auriemma RS, Galdiero M, et al. Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-I levels, tumor shrinkage, and cardiovascular disease: A prospective study. J Clin Endocrinol Metab 2009;94(10):3746-56
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.10 , pp. 3746-3756
    • Colao, A.1    Auriemma, R.S.2    Galdiero, M.3
  • 13
    • 67650317928 scopus 로고    scopus 로고
    • Significant tumour shrinkage after 12 months of lanreotide Autogel-120 mg treatment given first-line in acromegaly
    • Colao A, Auriemma RS, Rebora A, et al. Significant tumour shrinkage after 12 months of lanreotide Autogel-120 mg treatment given first-line in acromegaly. Clin Endocrinol (Oxf) 2009;71(2):237-45
    • (2009) Clin Endocrinol (Oxf) , vol.71 , Issue.2 , pp. 237-245
    • Colao, A.1    Auriemma, R.S.2    Rebora, A.3
  • 14
    • 64749112299 scopus 로고    scopus 로고
    • Effects of lanreotide Autogel on growth hormone, insulin-like growth factor 1, and tumor size in acromegaly: A 1-year prospective multicenter study
    • Attanasio R, Lanzi R, Losa M, et al. Effects of lanreotide Autogel on growth hormone, insulin-like growth factor 1, and tumor size in acromegaly: A 1-year prospective multicenter study. Endocr Pract 2008;14(7):846-55
    • (2008) Endocr Pract , vol.14 , Issue.7 , pp. 846-855
    • Attanasio, R.1    Lanzi, R.2    Losa, M.3
  • 15
    • 33845491265 scopus 로고    scopus 로고
    • Medical progress: Acromegaly
    • Melmed S. Medical progress: Acromegaly. N Engl J Med 2006;355(24):2558-73
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2558-2573
    • Melmed, S.1
  • 16
    • 36549040940 scopus 로고    scopus 로고
    • Beneficial effect of dose escalation of octreotide-LAR as first-line therapy in patients with acromegaly
    • Colao A, Pivonello R, Auriemma RS, et al. Beneficial effect of dose escalation of octreotide-LAR as first-line therapy in patients with acromegaly. Eur J Endocrinol 2007;157(5):579-87
    • (2007) Eur J Endocrinol , vol.157 , Issue.5 , pp. 579-587
    • Colao, A.1    Pivonello, R.2    Auriemma, R.S.3
  • 17
    • 68349141978 scopus 로고    scopus 로고
    • High-dose intramuscular octreotide in patients with acromegaly inadequately controlled on conventional somatostatin analogue therapy: A randomised controlled trial
    • Giustina A, Bonadonna S, Bugari G, et al. High-dose intramuscular octreotide in patients with acromegaly inadequately controlled on conventional somatostatin analogue therapy: A randomised controlled trial. Eur J Endocrinol 2009;161(2):331-8
    • (2009) Eur J Endocrinol , vol.161 , Issue.2 , pp. 331-338
    • Giustina, A.1    Bonadonna, S.2    Bugari, G.3
  • 18
    • 84877651825 scopus 로고    scopus 로고
    • Octreolin- pharmacodynamics: An oral octreotide formulation to treat acromegaly suppresses growth hormone in healthy volunteers
    • (03-MeetingAbstracts)
    • Teichman SL, Tuvia S, Atsmon J, et al. Octreolin- pharmacodynamics: An oral octreotide formulation to treat acromegaly suppresses growth hormone in healthy volunteers. Endocr Rev 33 (03-MeetingAbstracts) 2012:OR49-4
    • (2012) Endocr Rev , vol.33
    • Teichman, S.L.1    Tuvia, S.2    Atsmon, J.3
  • 19
    • 84863588864 scopus 로고    scopus 로고
    • Oral octreotide absorption in human subjects: Comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression
    • Tuvia S, Atsmon J, Teichman SL, et al. Oral octreotide absorption in human subjects: Comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression. J Clin Endocrinol Metab 2012;97(7):2362-9
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.7 , pp. 2362-2369
    • Tuvia, S.1    Atsmon, J.2    Teichman, S.L.3
  • 22
    • 84880238584 scopus 로고    scopus 로고
    • March 2010. Available from
    • March 2010. Available from: http://www.fiercebiotech.com/press-releases/ ambrilia-biopharma-inc-reports-positivefinal-phase-iii-results-its-octreotide- formul
  • 24
    • 43549111835 scopus 로고    scopus 로고
    • Pasireotide (SOM230): Development, mechanism of action and potential applications
    • Schmid HA. Pasireotide (SOM230): Development, mechanism of action and potential applications. Mol Cell Endocrinol 2008;286(1-2):69-74
    • (2008) Mol Cell Endocrinol , vol.286 , Issue.1-2 , pp. 69-74
    • Schmid, H.A.1
  • 25
    • 77954484928 scopus 로고    scopus 로고
    • Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: A randomized, multicenter, phase II trial
    • Pasireotide Acromegaly Study Group
    • Petersenn S, Schopohl J, Barkan A, et al. Pasireotide Acromegaly Study Group. Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: A randomized, multicenter, phase II trial. J Clin Endocrinol Metab 2010;95(6):2781-9
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.6 , pp. 2781-2789
    • Petersenn, S.1    Schopohl, J.2    Barkan, A.3
  • 26
    • 0036111856 scopus 로고    scopus 로고
    • SOM230: A novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile
    • Bruns C, Lewis I, Briner U, et al. SOM230: A novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile. Eur J Endocrinol 2002;146(5):707-16
    • (2002) Eur J Endocrinol , vol.146 , Issue.5 , pp. 707-716
    • Bruns, C.1    Lewis, I.2    Briner, U.3
  • 27
    • 2942657529 scopus 로고    scopus 로고
    • The novel somatostatin ligand (SOM230) regulates human and rat anterior pituitary hormone secretion
    • Murray RD, Kim K, Ren SG, et al. The novel somatostatin ligand (SOM230) regulates human and rat anterior pituitary hormone secretion. J Clin Endocrinol Metab 2004;89(6):3027-32
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.6 , pp. 3027-3032
    • Murray, R.D.1    Kim, K.2    Ren, S.G.3
  • 28
    • 34249111192 scopus 로고    scopus 로고
    • SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin-secreting pituitary adenomas
    • Fedele M, De Martino I, Pivonello R, et al. SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin- secreting pituitary adenomas. Clin Cancer Res 2007;13(9):2738-44
    • (2007) Clin Cancer Res , vol.13 , Issue.9 , pp. 2738-2744
    • Fedele, M.1    De Martino, I.2    Pivonello, R.3
  • 29
    • 85015926038 scopus 로고    scopus 로고
    • Pasireotide LAR is significantly more effective than octreotide LAR at inducing biochemical control in patients with acromegaly: Results of a 12-month randomized, double-blind, multicenter, Phase III study [abstracts]
    • OC1.1
    • Colao A, Bronstein M, Freda P, et al. Pasireotide LAR is significantly more effective than octreotide LAR at inducing biochemical control in patients with acromegaly: Results of a 12-month randomized, double-blind, multicenter, Phase III study [abstracts]. Endocrine 2012;29:OC1.1
    • (2012) Endocrine , vol.29
    • Colao, A.1    Bronstein, M.2    Freda, P.3
  • 30
    • 84880215762 scopus 로고    scopus 로고
    • Pasireotide lar and octreotide lar maintain gh and igf-i suppression in patients with acromegaly: Extension of a 12-month randomized, double-blind, multicenter, phase-iii study
    • (Special 3)OC31
    • Sheppard M, Gadelha M, Bronstein MD, et al. Pasireotide LAR and Octreotide LAR maintain GH and IGF-I suppression in patients with acromegaly: Extension of a 12-month randomized, double-blind, multicenter, Phase-III study. J Klin Endokrinol Stoffe 2012;5(Special Issue 3):OC31
    • (2012) J Klin Endokrinol Stoffe , vol.5
    • Sheppard, M.1    Gadelha, M.2    Bronstein, M.D.3
  • 31
    • 84894893928 scopus 로고    scopus 로고
    • Pasireotide LAR vs octreotide LAR in patients with acromegaly: Double-blind, crossover, extension period to a randomized, double-blind, multicenter, phase III study [abstracts]
    • Fleseriu M, Sheppard M, Bronstein M, et al. Pasireotide LAR vs octreotide LAR in patients with acromegaly: Double-blind, crossover, extension period to a randomized, double-blind, multicenter, phase III study [abstracts]. Endocrine 2012;29:P1404
    • (2012) Endocrine , vol.29
    • Fleseriu, M.1    Sheppard, M.2    Bronstein, M.3
  • 34
    • 84860134423 scopus 로고    scopus 로고
    • Pituitary carcinomas and aggressive pituitary tumours: Merits and pitfalls of temozolomide treatment
    • Raverot G, Castinetti F, Jouanneau E, et al. Pituitary carcinomas and aggressive pituitary tumours: Merits and pitfalls of temozolomide treatment. Clin Endocrinol (Oxf) 2012;76(6):769-75
    • (2012) Clin Endocrinol (Oxf) , vol.76 , Issue.6 , pp. 769-775
    • Raverot, G.1    Castinetti, F.2    Jouanneau, E.3
  • 35
    • 70349771361 scopus 로고    scopus 로고
    • Temozolomide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy
    • Hagen C, Schroeder HD, Hansen S, et al. Temozolomide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy. Eur J Endocrinol 2009;161(4):631-7
    • (2009) Eur J Endocrinol , vol.161 , Issue.4 , pp. 631-637
    • Hagen, C.1    Schroeder, H.D.2    Hansen, S.3
  • 36
    • 79959922097 scopus 로고    scopus 로고
    • Failure of temozolomide and conventional doses of pegvisomant to attain biochemical control in a severe case of acromegaly
    • Morin E, Berthelet F, Weisnagel J, et al. Failure of temozolomide and conventional doses of pegvisomant to attain biochemical control in a severe case of acromegaly. Pituitary 2012;15(1):97-100
    • (2012) Pituitary , vol.15 , Issue.1 , pp. 97-100
    • Morin, E.1    Berthelet, F.2    Weisnagel, J.3
  • 37
    • 33646061363 scopus 로고    scopus 로고
    • Progressive low-grade oligodendrogliomas: Response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression
    • Levin N, Lavon I, Zelikovitsh B, et al. Progressive low-grade oligodendrogliomas: Response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression. Cancer 2006;106:1759-65
    • (2006) Cancer , vol.106 , pp. 1759-1765
    • Levin, N.1    Lavon, I.2    Zelikovitsh, B.3
  • 38
    • 12144291692 scopus 로고    scopus 로고
    • Clinical trial substantiates the predictive value of O-6-methylguanine- DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
    • Hegi ME, Diserens AC, Godard S, et al. Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res 2004;10:1871-4
    • (2004) Clin Cancer Res , vol.10 , pp. 1871-1874
    • Hegi, M.E.1    Diserens, A.C.2    Godard, S.3
  • 39
    • 84855195096 scopus 로고    scopus 로고
    • MGMT immunoexpression in growth hormone-secreting pituitary adenomas and its correlation with ki-67 labeling index and cytokeratin distribution pattern
    • Zuhur SS, Tanik C, Karaman O, et al. MGMT immunoexpression in growth hormone-secreting pituitary adenomas and its correlation with Ki-67 labeling index and cytokeratin distribution pattern. Endocrine 2011;40(2):222-7
    • (2011) Endocrine , vol.40 , Issue.2 , pp. 222-227
    • Zuhur, S.S.1    Tanik, C.2    Karaman, O.3
  • 40
    • 3242675176 scopus 로고    scopus 로고
    • PPARgamma inhibits GH synthesis and secretion and increases apoptosis of pituitary GH-secreting adenomas
    • Bogazzi F, Ultimieri F, Raggi F, et al. PPARgamma inhibits GH synthesis and secretion and increases apoptosis of pituitary GH-secreting adenomas. Eur J Endocrinol 2004;150(6):863-75
    • (2004) Eur J Endocrinol , vol.150 , Issue.6 , pp. 863-875
    • Bogazzi, F.1    Ultimieri, F.2    Raggi, F.3
  • 41
    • 33846412672 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo
    • Lecka-Czernik B, Ackert-Bicknell C, Adamo ML, et al. Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo. Endocrinology 2007;148(2):903-11
    • (2007) Endocrinology , vol.148 , Issue.2 , pp. 903-911
    • Lecka-Czernik, B.1    Ackert-Bicknell, C.2    Adamo, M.L.3
  • 42
    • 34848851961 scopus 로고    scopus 로고
    • The PPAR-gamma activator rosiglitazone fails to lower plasma growth hormone and insulin-like growth factor-1 levels in patients with acromegaly
    • Bastemir M, Akin F, Yaylali GF. The PPAR-gamma activator rosiglitazone fails to lower plasma growth hormone and insulin-like growth factor-1 levels in patients with acromegaly. Neuroendocrinology 2007;86(2):119-23
    • (2007) Neuroendocrinology , vol.86 , Issue.2 , pp. 119-123
    • Bastemir, M.1    Akin, F.2    Yaylali, G.F.3
  • 43
    • 80053099505 scopus 로고    scopus 로고
    • Effect of rosiglitazone on serum IGF-I concentrations in uncontrolled acromegalic patients under conventional medical therapy: Results from a pilot phase 2 study
    • Bogazzi F, Rossi G, Lombardi M, et al. Effect of rosiglitazone on serum IGF-I concentrations in uncontrolled acromegalic patients under conventional medical therapy: Results from a pilot phase 2 study. J Endocrinol Invest 2011;34(2):e43-51
    • (2011) J Endocrinol Invest , vol.34 , Issue.2
    • Bogazzi, F.1    Rossi, G.2    Lombardi, M.3
  • 44
    • 84867288293 scopus 로고    scopus 로고
    • Pioglitazone in acromegaly - an open-label, prospective study
    • Kim DD, Goh J, Panossian Z, et al. Pioglitazone in acromegaly - an open-label, prospective study. Clin Endocrinol (Oxf) 2012;77(4):575-8
    • (2012) Clin Endocrinol (Oxf) , vol.77 , Issue.4 , pp. 575-578
    • Kim, D.D.1    Goh, J.2    Panossian, Z.3
  • 45
    • 33645221483 scopus 로고    scopus 로고
    • Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: Effect on IGF-I levels, tumor mass, hypertension and glucose tolerance
    • Colao A, Pivonello R, Auriemma RS, et al. Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: Effect on IGF-I levels, tumor mass, hypertension and glucose tolerance. Eur J Endocrinol 2006;154(3):467-77
    • (2006) Eur J Endocrinol , vol.154 , Issue.3 , pp. 467-477
    • Colao, A.1    Pivonello, R.2    Auriemma, R.S.3
  • 46
  • 47
    • 70450207331 scopus 로고    scopus 로고
    • German pegvisomant observational study the german acrostudy: Past and present
    • Suppl
    • Buchfelder M, Schlaffer S, Droste M, et al. German pegvisomant observational study the german ACROSTUDY: Past and present. Eur J Endocrinol 2009;161(Suppl):S3-S10
    • (2009) Eur J Endocrinol , vol.161
    • Buchfelder, M.1    Schlaffer, S.2    Droste, M.3
  • 48
    • 84860764307 scopus 로고    scopus 로고
    • Long-term safety of pegvisomant in patients with acromegaly: Comprehensive review of 1288 subjects in Acrostudy
    • van der Lely AJ, Biller BM, Brue T, et al. Long-term safety of pegvisomant in patients with acromegaly: Comprehensive review of 1288 subjects in ACROSTUDY. J Clin Endocrinol Metab 2012;97(5):1589-97
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.5 , pp. 1589-1597
    • Van Der Lely, A.J.1    Biller, B.M.2    Brue, T.3
  • 49
    • 36849041110 scopus 로고    scopus 로고
    • Long-term efficacy and safety of combined treatment of somatostatin analogs and pegvisomant in acromegaly
    • Neggers SJ, van Aken MO, Janssen JA, et al. Long-term efficacy and safety of combined treatment of somatostatin analogs and pegvisomant in acromegaly. J Clin Endocrinol Metab 2007;92(12):4598-601
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.12 , pp. 4598-4601
    • Neggers, S.J.1    Van Aken, M.O.2    Janssen, J.A.3
  • 50
    • 69949142355 scopus 로고    scopus 로고
    • A randomized, controlled, multicentre trial comparing pegvisomant alone with combination therapy of pegvisomant and long-acting octreotide in patients with acromegaly
    • Trainer PJ, Ezzat S, D'Souza GA, et al. A randomized, controlled, multicentre trial comparing pegvisomant alone with combination therapy of pegvisomant and long-acting octreotide in patients with acromegaly. Clin Endocrinol (Oxf) 2009;71(4):549-57
    • (2009) Clin Endocrinol (Oxf) , vol.71 , Issue.4 , pp. 549-557
    • Trainer, P.J.1    Ezzat, S.2    D'Souza, G.A.3
  • 51
    • 79951996841 scopus 로고    scopus 로고
    • Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone
    • van der Lely AJ, Bernabeu I, Cap J, et al. Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone. Eur J Endocrinol 2011;164(3):325-33
    • (2011) Eur J Endocrinol , vol.164 , Issue.3 , pp. 325-3333
    • Van Der Lely, A.J.1    Bernabeu, I.2    Cap, J.3
  • 52
    • 26244434860 scopus 로고    scopus 로고
    • Cotreatment of acromegaly with a somatostatin analog and a growth hormone receptor antagonist
    • Jørgensen JO, Feldt-Rasmussen U, Frystyk J, et al. Cotreatment of acromegaly with a somatostatin analog and a growth hormone receptor antagonist. J Clin Endocrinol Metab 2005;90(10):5627-31
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.10 , pp. 5627-5631
    • Jørgensen, J.O.1    Feldt-Rasmussen, U.2    Frystyk, J.3
  • 53
    • 18744389775 scopus 로고    scopus 로고
    • Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly
    • Feenstra J, de Herder WW, ten Have SM, et al. Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly. Lancet 2005;365(9471):1644-6
    • (2005) Lancet , vol.365 , Issue.9471 , pp. 1644-1646
    • Feenstra, J.1    De Herder, W.W.2    Ten Have, S.M.3
  • 54
    • 80053921557 scopus 로고    scopus 로고
    • Conversion of daily pegvisomant to weekly pegvisomant combined with long-acting somatostatin analogs in controlled acromegaly patients
    • Neggers SJ, de Herder WW, Feelders RA, et al. Conversion of daily pegvisomant to weekly pegvisomant combined with long-acting somatostatin analogs, in controlled acromegaly patients. Pituitary 2011;14(3):253-8
    • (2011) Pituitary , vol.14 , Issue.3 , pp. 253-258
    • Neggers, S.J.1    De Herder, W.W.2    Feelders, R.A.3
  • 55
    • 67650755038 scopus 로고    scopus 로고
    • Successful use of weekly pegvisomant administration in patients with acromegaly
    • Higham CE, Thomas JD, Bidlingmaier M, et al. Successful use of weekly pegvisomant administration in patients with acromegaly. Eur J Endocrinol 2009;161(1):21-5
    • (2009) Eur J Endocrinol , vol.161 , Issue.1 , pp. 21-25
    • Higham, C.E.1    Thomas, J.D.2    Bidlingmaier, M.3
  • 56
    • 53749104459 scopus 로고    scopus 로고
    • Quality of life in acromegalic patients during long-term somatostatin analog treatment with and without pegvisomant
    • Neggers SJ, van Aken MO, de Herder WW, et al. Quality of life in acromegalic patients during long-term somatostatin analog treatment with and without pegvisomant. J Clin Endocrinol Metab 2008;93(10):3853-9
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.10 , pp. 3853-3859
    • Neggers, S.J.1    Van Aken, M.O.2    De Herder, W.W.3
  • 57
    • 77957119638 scopus 로고    scopus 로고
    • The acute effect of a single application of cabergoline on endogenous gh levels in patients with acromegaly on pegvisomant treatment
    • Roemmler J, Steffin B, Gutt B, et al. The acute effect of a single application of cabergoline on endogenous GH levels in patients with acromegaly on pegvisomant treatment. Growth Horm IGF Res 2010;20(5):338-44
    • (2010) Growth Horm IGF Res , vol.20 , Issue.5 , pp. 338-344
    • Roemmler, J.1    Steffin, B.2    Gutt, B.3
  • 58
    • 84877673454 scopus 로고    scopus 로고
    • Pegvisomant and cabergoline combination therapy in acromegaly
    • Epub ahead of print]
    • Bernabeu I, Alvarez-Escolá C, Paniagua AE, et al. Pegvisomant and cabergoline combination therapy in acromegaly. Pituitary 2012;[Epub ahead of print]
    • (2012) Pituitary
    • Bernabeu, I.1    Alvarez-Escolá, C.2    Paniagua, A.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.