Etiology, triggers and neurochemical circuits associated with unexpected, expected, and laboratory-induced panic attacks

Neuroscience and Biobehavioral Reviews

Volumn 46, Issue P3, 2014, Pages 429-454

  Johnson, Philip L ^a   Federici, Lauren M ^a   Shekhar, Anantha ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amygdala; Anxiety; CO2; Insula; Lactate; Panic; Periaqueductal gray; Perifornical hypothalamus

Indexed keywords

ANTIPANIC AGENT; CARBON DIOXIDE; LACTATE SODIUM;

AGORAPHOBIA; AMYGDALOID NUCLEUS; ASSOCIATION; AUTONOMIC NERVOUS SYSTEM FUNCTION; BRAIN FUNCTION; CLINICAL EFFECTIVENESS; CLINICAL FEATURE; COGNITIVE THERAPY; COPING BEHAVIOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE ASSOCIATION; DISEASE MODEL; DISTRESS SYNDROME; DSM-5; DSM-II; DSM-III; EARLY LIFE STRESS; EXPERIMENTAL DISEASE; FEAR; GABAERGIC SYSTEM; GENDER; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE ENVIRONMENT INTERACTION; HEART DISEASE; HEART PALPITATION; HERITABILITY; HORMONE RESPONSE; HUMAN; HYPERVENTILATION; HYPOTHALAMUS; HYPOVENTILATION; NERVE POTENTIAL; NEUROANATOMY; NEUROCHEMISTRY; NONHUMAN; NORADRENERGIC SYSTEM; ONSET AGE; PANIC; PARASYMPATHETIC NERVE; PATHOPHYSIOLOGY; PERIAQUEDUCTAL GRAY MATTER; PREFRONTAL CORTEX; RECURRENT DISEASE; RESPIRATORY TRACT DISEASE; REVIEW; RISK FACTOR; SENSORY DYSFUNCTION; SEROTONINERGIC SYSTEM; SUFFOCATION; SWEATING; SYMPATHETIC NERVE; SYMPTOM; TEMPERATURE SENSITIVITY; TRANSCRANIAL MAGNETIC STIMULATION; AGE; ANIMAL; ANXIETY; BRAIN; FEMALE; MALE; METABOLISM; NERVE TRACT; PANIC DISORDER; PATHOLOGY;

AGE FACTORS; ANIMALS; ANXIETY; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; NEURAL PATHWAYS; NEUROCHEMISTRY; PANIC DISORDER;

EID: 84911433504     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2014.07.027     Document Type: Review

References (256)

1. Abelson J.L., Nesse R.M., Weg J.G., Curtis G.C. Respiratory psychophysiology and anxiety: cognitive intervention in the doxapram model of panic. Psychosom. Med. 1996, 58:302-313.
2. Abelson J.L., Khan S., Liberzon I., Young E.A. HPA axis activity in patients with panic disorder: review and synthesis of four studies. Depress. Anxiety 2007, 24:66-76.
3. Adolphs R., Tranel D., Damasio H., Damasio A. Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala. Nature 1994, 372:669-672.
4. Adolphs R., Tranel D., Damasio H., Damasio A.R. Fear and the human amygdala. J. Neurosci. 1995, 15:5879-5891.
5. Anderson J.J., DiMicco J.A. Effect of local inhibition of gamma-aminobutyric acid uptake in the dorsomedial hypothalamus on extracellular levels of gamma-aminobutyric acid and on stress-induced tachycardia: a study using microdialysis. J. Pharmacol. Exp. Ther. 1990, 255:1399-1407.
6. Andreatini R., Blanchard C., Blanchard R., Brandao M.L., Carobrez A.P., Griebel G., et al. The brain decade in debate: II. Panic or anxiety? From animal models to a neurobiological basis. Braz. J. Med. Biol. Res. 2001, 34:145-154.
7. 2 inhalation of subjects with types of specific phobia, panic disorder, or no mental disorder. Am. J. Psychiatry 1997, 154:1089-1095.
8. Asami T., Yamasue H., Hayano F., Nakamura M., Uehara K., Otsuka T., et al. Sexually dimorphic gray matter volume reduction in patients with panic disorder. Psychiatry Res. 2009, 173:128-134.
9. Austin D.W., Richards J.C. The catastrophic misinterpretation model of panic disorder. Behav. Res. Ther. 2001, 39:1277-1291.
10. 2 in human volunteers. Depress. Anxiety 2005, 21:18-25.
11. Bakker A., van Balkom A.J., Spinhoven P. SSRIs vs. TCAs in the treatment of panic disorder: a meta-analysis. Acta Psychiatr. Scand. 2002, 106:163-167.
12. Baldwin D.S., Anderson I.M., Nutt D.J., Bandelow B., Bond A., Davidson J.R., et al. Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology. J. Psychopharmacol. 2005, 19:567-596.
13. Ballenger J.C., Burrows G.D., DuPont R.L., Lesser I.M., Noyes R., Pecknold J.C., et al. Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. I. Efficacy in short-term treatment. Arch. Gen. Psychiatry 1988, 45:413-422.
14. Balon R., Yeragani V.K., Pohl R., Muench J., Berchou R. Somatic and psychological symptoms during isoproterenol-induced panic attacks. Psychiatry Res. 1990, 32:103-112.
15. Bandelow B., et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision. World J. Biol. Psychiatry 2008, 9:248-312.
16. Bandler R., Carrive P. Integrated defence reaction elicited by excitatory amino acid microinjection in the midbrain periaqueductal grey region of the unrestrained cat. Brain Res. 1988, 439:95-106.
17. Bar-Haim Y., Lamy D., Pergamin L., Bakermans-Kranenburg M.J., van I.M.H. Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychol. Bull. 2007, 133:1-24.
18. Bard P. A diencephalic mechanism for the expression of rage with special reference to the sympathetic nervous system. Am. J. Physiol. 1928, 84:490-515.
19. Bard P., Mountcastle V.B. Some forebrain mechanisms involved in the expression of rage with special reference to suppression of angry behavior. Res. Publ. Assoc. Res. Nerv. Ment. Dis. 1948, 27:362-404.
20. Barr Taylor C., Telch M.J., Havvik D. Ambulatory heart rate changes during panic attacks. J. Psychiatr. Res. 1982, 17:261-266.
21. Bechara A., Tranel D., Damasio H., Adolphs R., Rockland C., Damasio A.R. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 1995, 269:1115-1118.
22. Beitman B.D., Kushner M., Lamberti J.W., Mukerji V. Panic disorder without fear in patients with angiographically normal coronary arteries. J. Nerv. Ment. Dis. 1990, 178:307-312.
23. Bittencourt A.S., Carobrez A.P., Zamprogno L.P., Tufik S., Schenberg L.C. Organization of single components of defensive behaviors within distinct columns of periaqueductal gray matter of the rat: role of N-methyl-d-aspartic acid glutamate receptors. Neuroscience 2004, 125:71-89.
24. Breier A., Charney D.S., Heninger G.R. Agoraphobia with panic attacks. Development, diagnostic stability, and course of illness. Arch. Gen. Psychiatry 1986, 43:1029-1036.
25. Cannon W.B., Britton S.W. Studies on conditions of activity in endocrine glands. XV. Pseudoaffective medulliadrenal secretion. Am. J. Physiol. 1925, 72:283-294.
26. Carrive P., Dampney R.A., Bandler R. Excitation of neurones in a restricted portion of the midbrain periaqueductal grey elicits both behavioural and cardiovascular components of the defence reaction in the unanaesthetised decerebrate cat. Neurosci. Lett. 1987, 81:273-278.
27. Carrive P., Bandler R., Dampney R.A. Anatomical evidence that hypertension associated with the defence reaction in the cat is mediated by a direct projection from a restricted portion of the midbrain periaqueductal grey to the subretrofacial nucleus of the medulla. Brain Res. 1988, 460:339-345.
28. Casey L.M., Oei T.P., Newcombe P.A., Kenardy J. The role of catastrophic misinterpretation of bodily sensations and panic self-efficacy in predicting panic severity. J. Anxiety Disord. 2004, 18:325-340.
29. Chapman W.P., Singh M.M., Schroeder H.R., Fager C. Temporal lobe epilepsy: brief review; responses on electrical stimulation of the amygdaloid region in six patients. Am. J. Med. 1957, 23:107-119.
30. Charney D.S., Heninger G.R. Noradrenergic function and the mechanism of action of antianxiety treatment. II. The effect of long-term imipramine treatment. Arch. Gen. Psychiatry 1985, 42:473-481.
31. Charney D.S., Woods S.W., Goodman W.K., Heninger G.R. Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbine-induced panic attacks. Am. J. Psychiatry 1987, 144:1030-1036.
32. Charney D.S., Woods S.W., Goodman W.K., Heninger G.R. Serotonin function in anxiety, II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects. Psychopharmacology (Berl.) 1987, 92:14-24.
33. Chen P., Smith M.S. Suckling-induced activation of neuronal input to the dorsomedial nucleus of the hypothalamus: possible candidates for mediating the activation of DMH neuropeptide Y neurons during lactation. Brain Res. 2003, 984:11-20.
34. Chen J., Tsuchiya M., Kawakami N., Furukawa T.A. Non-fearful vs. fearful panic attacks: a general population study from the National Comorbidity Survey. J. Affect. Disord. 2009, 112:273-278.
35. Clark D.M. A cognitive approach to panic. Behav. Res. Ther. 1986, 24:461-470.
36. Cloos J.M., Ferreira V. Current use of benzodiazepines in anxiety disorders. Curr. Opin. Psychiatry 2009, 22:90-95.
37. Cohen A.S., Barlow D.H., Blanchard E.B. Psychophysiology of relaxation-associated panic attacks. J. Abnorm. Psychol. 1985, 94:96-101.
38. Condie B.G., Bain G., Gottlieb D.I., Capecchi M.R. Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:11451-11455.
39. Coupland N.J., Wilson S.J., Potokar J.P., Bell C., Nutt D.J. Increased sympathetic response to standing in panic disorder. Psychiatry Res. 2003, 118:69-79.
40. Cowley D.S., Dager S.R., Dunner D.L. Lactate infusions in major depression without panic attacks. J. Psychiatr. Res. 1987, 21:243-248.
41. Cox B.J., Swinson R.P., Endler N.S., Norton G.R. The symptom structure of panic attacks. Compr. Psychiatry 1994, 35:349-353.
42. Craig A.D., Chen K., Bandy D., Reiman E.M. Thermosensory activation of insular cortex. Nat. Neurosci. 2000, 3:184-190.
43. Craske M.G., Kircanski K., Epstein A., Wittchen H.U., Pine D.S., Lewis-Fernandez R., et al. Panic disorder: a review of DSM-IV panic disorder and proposals for DSM-V. Depress. Anxiety 2010, 27:93-112.
44. Critchley H.D., Wiens S., Rotshtein P., Ohman A., Dolan R.J. Neural systems supporting interoceptive awareness. Nat. Neurosci. 2004, 7:189-195.
45. Dager S.R., Marro K.I., Richards T.L., Metzger G.D. Preliminary application of magnetic resonance spectroscopy to investigate lactate-induced panic. Am. J. Psychiatry 1994, 151:57-63.
46. Dager S.R., Richards T., Strauss W., Artru A. Single-voxel 1H-MRS investigation of brain metabolic changes during lactate-induced panic. Psychiatry Res. 1997, 76:89-99.
47. Davies S.J., Ghahramani P., Jackson P.R., Noble T.W., Hardy P.G., Hippisley-Cox J., et al. Association of panic disorder and panic attacks with hypertension. Am. J. Med. 1999, 107:310-316.
48. de Beurs E., Garssen B., Buikhuisen M., Lange A., van Balkom A., Van Dyck R. Continuous monitoring of panic. Acta Psychiatr. Scand. 1994, 90:38-45.
49. De Cort K., Hermans D., Spruyt A., Griez E., Schruers K. A specific attentional bias in panic disorder?. Depress. Anxiety 2008, 25:951-955.
50. Dielenberg R.A., Hunt G.E., McGregor I.S. "When a rat smells a cat": the distribution of Fos immunoreactivity in rat brain following exposure to a predatory odor. Neuroscience 2001, 104:1085-1097.
51. Domschke K., Deckert J., O'Donovan M.C., Glatt S.J. Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2007, 144B:667-673.
52. Domschke K., Ohrmann P., Braun M., Suslow T., Bauer J., Hohoff C., et al. Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder. Psychiatry Res. 2008, 163:13-20.
53. Dorow R., Horowski R., Paschelke G., Amin M. Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors. Lancet 1983, 2:98-99.
54. Dresler T., Hahn T., Plichta M.M., Ernst L.H., Tupak S.V., Ehlis A.C., et al. Neural correlates of spontaneous panic attacks. J. Neural Transm. 2011, 118:263-269.
55. Dresler T., Guhn A., Tupak S.V., Ehlis A.C., Herrmann M.J., Fallgatter A.J., et al. Revise the revised? New dimensions of the neuroanatomical hypothesis of panic disorder. J. Neural Transm. 2013, 120:3-29.
56. DSM-V Diagnostic and Statistical Manual (DSM-V) 2013, American Psychiatric Association, Washington, DC. 5th ed.
57. Duan Y.F., Winters R., McCabe P.M., Green E.J., Huang Y., Schneiderman N. Behavioral characteristics of defense and vigilance reactions elicited by electrical stimulation of the hypothalamus in rabbits. Behav. Brain Res. 1996, 81:33-41.
58. Ehlers A., Breuer P. How good are patients with panic disorder at perceiving their heartbeats?. Biol. Psychol. 1996, 42:165-182.
59. Eren I., Tukel R., Polat A., Karaman R., Unal S. Evaluation of regional cerebral blood flow changes in panic disorder with Tc99m-HMPAO SPECT. Psychiatry Res. 2003, 123:135-143.
60. Feinstein J.S., Buzza C., Hurlemann R., Follmer R.L., Dahdaleh N.S., Coryell W.H., et al. Fear and panic in humans with bilateral amygdala damage. Nat. Neurosci. 2013, 16:270-272.
61. Ferguson A.V., Samson W.K. The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function. Front. Neuroendocrinol. 2003, 24:141-150.
62. Folkow B., Di Bona G.F., Hjemdahl P., Toren P.H., Wallin B.G. Measurements of plasma norepinephrine concentrations in human primary hypertension. A word of caution on their applicability for assessing neurogenic contributions. Hypertension 1983, 5:399-403.
63. 2-enriched air as unconditioned stimuli. J. Abnorm. Psychol. 1998, 107:291-304.
64. Forsyth J.P., Eifert G.H., Canna M.A. Evoking analogue subtypes of panic attacks in a nonclinical population using carbon dioxide-enriched air. Behav. Res. Ther. 2000, 38:559-572.
65. 2-enriched air: stability within sessions and habituation across time. J. Behav. Ther. Exp. Psychiatry 2000, 31:103-121.
66. Friedman S.D., Mathis C.M., Hayes C., Renshaw P., Dager S.R. Brain pH response to hyperventilation in panic disorder: preliminary evidence for altered acid-base regulation. Am. J. Psychiatry 2006, 163:710-715.
67. Fyer A.J., Liebowitz M.R., Gorman J.M., Campeas R., Levin A., Davies S.O., et al. Discontinuation of alprazolam treatment in panic patients. Am. J. Psychiatry 1987, 144:303-308.
68. Fyer A.J., Hamilton S.P., Durner M., Haghighi F., Heiman G.A., Costa R., et al. A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci. Biol. Psychiatry 2006, 60:388-401.
69. Garpenstrand H., Annas P., Ekblom J., Oreland L., Fredrikson M. Human fear conditioning is related to dopaminergic and serotonergic biological markers. Behav. Neurosci. 2001, 115:358-364.
70. Gee D.G., Karlsgodt K.H., van Erp T.G., Bearden C.E., Lieberman M.D., Belger A., et al. Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study. Schizophr. Res. 2012, 134:1-9.
71. Gee D.G., Gabard-Durnam L.J., Flannery J., Goff B., Humphreys K.L., Telzer E.H., et al. Early developmental emergence of human amygdala-prefrontal connectivity after maternal deprivation. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:15638-15643.
72. Gee D.G., Humphreys K.L., Flannery J., Goff B., Telzer E.H., Shapiro M., et al. A developmental shift from positive to negative connectivity in human amygdala-prefrontal circuitry. J. Neurosci. 2013, 33:4584-4593.
73. George D.T., Lindquist T., Nutt D.J., Ragan P.W., Alim T., McFarlane V., et al. Effect of chloride or glucose on the incidence of lactate-induced panic attacks. Am. J. Psychiatry 1995, 152:692-697.
74. Gittelman R., Klein D.F. Relationship between separation anxiety and panic and agoraphobic disorders. Psychopathology 1984, 17(Suppl. 1):56-65.
75. Goddard A.W., Brouette T., Almai A., Jetty P., Woods S.W., Charney D. Early coadministration of clonazepam with sertraline for panic disorder. Arch. Gen. Psychiatry 2001, 58:681-686.
76. Goddard A.W., Mason G.F., Almai A., Rothman D.L., Behar K.L., Petroff O.A., et al. Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Arch. Gen. Psychiatry 2001, 58:556-561.
77. Goddard A.W., Mason G.F., Appel M., Rothman D.L., Gueorguieva R., Behar K.L., et al. Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. Am. J. Psychiatry 2004, 161:2186-2193.
78. Goetz R.R., Gorman J.M., Dillon D.J., Papp L.A., Hollander E., Fyer A.J., et al. Do panic disorder patients indiscriminately endorse somatic complaints?. Psychiatry Res. 1989, 29:207-213.
79. Gogos J.A., Morgan M., Luine V., Santha M., Ogawa S., Pfaff D., et al. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:9991-9996.
80. Goldin P.R., McRae K., Ramel W., Gross J.J. The neural bases of emotion regulation: reappraisal and suppression of negative emotion. Biol. Psychiatry 2008, 63:577-586.
81. Goldstein D.S. Plasma catecholamines and essential hypertension. An analytical review. Hypertension 1983, 5:86-99.
82. Goldstein D.S., Horwitz D., Keiser H.R., Polinsky R.J., Kopin I.J. Plasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension. J. Clin. Invest. 1983, 72:1748-1758.
83. Goodwin R.D., Faravelli C., Rosi S., Cosci F., Truglia E., de Graaf R., et al. The epidemiology of panic disorder and agoraphobia in Europe. Eur. Neuropsychopharmacol. 2005, 15:435-443.
84. Gorman J.M., Askanazi J., Liebowitz M.R., Fyer A.J., Stein J., Kinney J.M., et al. Response to hyperventilation in a group of patients with panic disorder. Am. J. Psychiatry 1984, 141:857-861.
85. Gorman J.M., Liebowitz M.R., Fyer A.J., Dillon D., Davies S.O., Stein J., et al. Lactate infusions in obsessive-compulsive disorder. Am. J. Psychiatry 1985, 142:864-866.
86. Gorman J.M., Cohen B.S., Liebowitz M.R., Fyer A.J., Ross D., Davies S.O., et al. Blood gas changes and hypophosphatemia in lactate-induced panic. Arch. Gen. Psychiatry 1986, 43:1067-1071.
87. Gorman J.M., Battista D., Goetz R.R., Dillon D.J., Liebowitz M.R., Fyer A.J., et al. A comparison of sodium bicarbonate and sodium lactate infusion in the induction of panic attacks. Arch. Gen. Psychiatry 1989, 46:145-150.
88. 2 and hyperventilation in patients with panic disorder. Am. J. Psychiatry 1994, 151:547-553.
89. Gorman J.M., Kent J.M., Sullivan G.M., Coplan J.D. Neuroanatomical hypothesis of panic disorder, revised. Am. J. Psychiatry 2000, 157:493-505.
90. Grassi M., Caldirola D., Vanni G., Guerriero G., Piccinni M., Valchera A., et al. Baseline respiratory parameters in panic disorder: a meta-analysis. J. Affect. Disord. 2013, 146:158-173.
91. Griebel G., Holmes A. 50 years of hurdles and hope in anxiolytic drug discovery. Nat. Rev. 2013, 12:667-687.
92. Gutman D.A., Coplan J., Papp L., Martinez J., Gorman J. Doxapram-induced panic attacks and cortisol elevation. Psychiatry Res. 2005, 133:253-261.
93. 2 chemoreception and integrated neural mechanisms of cardiovascular and respiratory control. J. Appl. Physiol. 2010, 108:995-1002.
94. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002, 297:400-403.
95. Hayano F., Nakamura M., Asami T., Uehara K., Yoshida T., Roppongi T., et al. Smaller amygdala is associated with anxiety in patients with panic disorder. Psychiatry Clin. Neurosci. 2009, 63:266-276.
96. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., et al. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 1996, 66:2621-2624.
97. Heinz A., Smolka M.N., Braus D.F., Wrase J., Beck A., Flor H., et al. Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation. Biol. Psychiatry 2007, 61:1011-1014.
98. Hess W.R., Akert K. Experimental data on role of hypothalamus in mechanism of emotional behavior. AMA Arch. Neurol. Psychiatry 1955, 73:127-129.
99. Hess W.R., Brugger M. Das subkortikake Zenrrumder affektriven Abwehrreaktion. Helv. Physiol. Acta 1943, 1:33-52.
100. Hettema J.M., Neale M.C., Kendler K.S. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am. J. Psychiatry 2001, 158:1568-1578.
101. Hettema J.M., Prescott C.A., Myers J.M., Neale M.C., Kendler K.S. The structure of genetic and environmental risk factors for anxiety disorders in men and women. Arch. Gen. Psychiatry 2005, 62:182-189.
102. Hettema J.M., An S.S., Neale M.C., Bukszar J., van den Oord E.J., Kendler K.S., et al. Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. Mol. Psychiatry 2006, 11:752-762.
103. Hoehn-Saric R., McLeod D.R., Funderburk F., Kowalski P. Somatic symptoms and physiologic responses in generalized anxiety disorder and panic disorder: an ambulatory monitor study. Arch. Gen. Psychiatry 2004, 61:913-921.
104. Hofmann S.G., Sawyer A.T., Korte K.J., Smits J.A. Is it beneficial to add pharmacotherapy to cognitive-behavioral therapy when treating anxiety disorders? A meta-analytic review. Int. J. Cogn. Ther. 2009, 2:160-175.
105. Hofmann S.G., Sawyer A.T., Asnaani A. d-Cycloserine as an augmentation strategy for cognitive behavioral therapy for anxiety disorders: an update. Curr. Pharm. Des. 2012, 18:5659-5662.
106. Hofmann S.G., Asnaani A., Vonk I.J., Sawyer A.T., Fang A. The efficacy of cognitive behavioral therapy: a review of meta-analyses. Cogn. Ther. Res. 2012, 36:427-440.
107. Homberg J.R., Olivier J.D., Smits B.M., Mul J.D., Mudde J., Verheul M., et al. Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience 2007, 146:1662-1676.
108. 2 chemosensitivity - towards a better understanding of mechanism. J. Physiol. 2011, 589:5561-5579.
109. Huttenlocher P.R. Synaptic density in human frontal cortex - developmental changes and effects of aging. Brain Res. 1979, 163:195-205.
110. Huttenlocher P.R. Synapse elimination and plasticity in developing human cerebral cortex. Am. J. Ment. Defic. 1984, 88:488-496.
111. Insel T.R. Rethinking schizophrenia. Nature 2010, 468:187-193.
112. Ito T., Inoue Y., Sugihara T., Yamada H., Katayama S., Kawahara R. Autonomic function in the early stage of panic disorder: power spectral analysis of heart rate variability. Psychiatry Clin. Neurosci. 1999, 53:667-672.
113. Jansen A.S., Wessendorf M.W., Loewy A.D. Transneuronal labeling of CNS neuropeptide and monoamine neurons after pseudorabies virus injections into the stellate ganglion. Brain Res. 1995, 683:1-24.
114. Jensen C.F., Peskind E.R., Keller T.W., McFall M.E., Raskind M.A. Comparison of sodium lactate-induced panic symptoms between panic disorder and posttraumatic stress disorder. Depress. Anxiety 1998, 7:122-125.
115. Joeyen-Waldorf J., Edgar N., Sibille E. The roles of sex and serotonin transporter levels in age- and stress-related emotionality in mice. Brain Res. 2009, 1286:84-93.
116. Johnson P.L., Shekhar A. Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors. J. Neurosci. 2006, 26:7093-7104.
117. Johnson P.L., Shekhar A. An animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamus. Physiol. Behav. 2012, 107:686-698.
118. Johnson P.L., Hollis J.H., Moratalla R., Lightman S.L., Lowry C.A. Acute hypercarbic gas exposure reveals functionally distinct subpopulations of serotonergic neurons in rats. J. Psychopharmacol. 2005, 19:327-341.
119. Johnson P., Lowry C., Truitt W., Shekhar A. Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic. J. Psychopharmacol. 2008, 22:642-652.
120. Johnson P.L., Truitt W.A., Fitz S.D., Lowry C.A., Shekhar A. Neural pathways underlying lactate-induced panic. Neuropsychopharmacology 2008, 33:2093-2107.
121. Johnson P.L., Truitt W., Fitz S.D., Minick P.E., Dietrich A., Sanghani S., et al. A key role for orexin in panic anxiety. Nat. Med. 2010, 16:111-115.
122. Johnson P.L., Fitz S.D., Hollis J.H., Moratalla R., Lightman S.L., Shekhar A., et al. Induction of c-Fos in 'panic/defence'-related brain circuits following brief hypercarbic gas exposure. J. Psychopharmacol. 2011, 25:26-36.
123. Johnson P.J., Samuels B.C., Fitz S.D., Federici L.M., Hammes N., Early M.C., et al. Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Physiol. Behav. 2012, 107:733-742.
124. Johnson P.L., Molosh A., Fitz S.D., Truitt W.A., Shekhar A. Orexin, stress, and anxiety/panic states. Prog. Brain Res. 2012, 198:133-161.
125. 2-mediated anxiety and hypertension but not bradycardia. Neuropsychopharmacology 2012, 37:1911-1922.
126. Johnson P.L., Federici L.M., Fitz S.D., Molosh A.I., Truitt W., Lowry C.A., et al. Serotonin transporter deficient rats exhibit enhanced acquisition and disrupted extinction of conditioned fear. 52nd American College of Neuropsychopharmacology Meeting 2012.
127. Jones M., Mellersh V. A comparison of the exercise response in anxiety states and normal controls. Psychosom. Med. 1946, 8:180-187.
128. Kash S.F., Tecott L.H., Hodge C., Baekkeskov S. Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:1698-1703.
129. Kellner M., Muhtz C., Stark K., Yassouridis A., Arlt J., Wiedemann K. Effects of a metabotropic glutamate (2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results. Psychopharmacology (Berl.) 2005, 179:310-315.
130. Kelly D., Mitchell-Heggs N., Sherman D. Anxiety and the effects of sodium lactate assessed clinically and physiologically. Br. J. Psychiatry 1971, 119:129-141.
131. Kessler R.C., Chiu W.T., Jin R., Ruscio A.M., Shear K., Walters E.E. The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 2006, 63:415-424.
132. Kessler R.C., Ruscio A.M., Shear K., Wittchen H.U. Epidemiology of anxiety disorders. Curr. Top. Behav. Neurosci. 2010, 2:21-35.
133. Kheirbek M.A., Klemenhagen K.C., Sahay A., Hen R. Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat. Neurosci. 2012, 15:1613-1620.
134. Kim B., Yoo E., Lee J.Y., Lee K.S., Choe A.Y., Lee J.E., et al. The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity in patients with panic disorder. J. Affect. Disord. 2013, 147:64-71.
135. Klein D.F. False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis. Arch. Gen. Psychiatry 1993, 50:306-317.
136. Klumpers F., Heitland I., Oosting R.S., Kenemans J.L., Baas J.M. Genetic variation in serotonin transporter function affects human fear expression indexed by fear-potentiated startle. Biol. Psychol. 2012, 89:277-282.
137. Knight D.C., Nguyen H.T., Bandettini P.A. The role of the human amygdala in the production of conditioned fear responses. Neuroimage 2005, 26:1193-1200.
138. LaBar K.S., LeDoux J.E., Spencer D.D., Phelps E.A. Impaired fear conditioning following unilateral temporal lobectomy in humans. J. Neurosci. 1995, 15:6846-6855.
139. Lai C.H., Hsu Y.Y., Wu Y.T. First episode drug-naive major depressive disorder with panic disorder: gray matter deficits in limbic and default network structures. Eur. Neuropsychopharmacol. 2010, 20:676-682.
140. Layton M.E., Friedman S.D., Dager S.R. Brain metabolic changes during lactate-induced panic: effects of gabapentin treatment. Depress. Anxiety 2001, 14:251-254.
141. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-1531.
142. Ley R. The "suffocation alarm" theory of panic attacks: a critical commentary. J. Behav. Ther. Exp. Psychiatry 1994, 25:269-273.
143. Li B.H., Rowland N.E. Dexfenfluramine induces Fos-like immunoreactivity in discrete brain regions in rats. Brain Res. Bull. 1993, 31:43-48.
144. Liebowitz M.R., Fyer A.J., Gorman J.M., Dillon D., Appleby I.L., Levy G., et al. Lactate provocation of panic attacks. I. Clinical and behavioral findings. Arch. Gen. Psychiatry 1984, 41:764-770.
145. Liebowitz M.R., Fyer A.J., Gorman J.M., Dillon D., Davies S., Stein J.M., et al. Specificity of lactate infusions in social phobia versus panic disorders. Am. J. Psychiatry 1985, 142:947-950.
146. Liebowitz M.R., Gorman J.M., Fyer A.J., Levitt M., Dillon D., Levy G., et al. Lactate provocation of panic attacks. II. Biochemical and physiological findings. Arch. Gen. Psychiatry 1985, 42:709-719.
147. Line S.J., Barkus C., Coyle C., Jennings K.A., Deacon R.M., Lesch K.P., et al. Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice. Eur. Neuropsychopharmacol. 2011, 21:108-116.
148. Little K.Y., McLaughlin D.P., Zhang L., Livermore C.S., Dalack G.W., McFinton P.R., et al. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am. J. Psychiatry 1998, 155:207-213.
149. Lonsdorf T.B., Ruck C., Bergstrom J., Andersson G., Ohman A., Schalling M., et al. The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009, 33:1479-1483.
150. Lundh L.G., Wikstrom J., Westerlund J., Ost L.G. Preattentive bias for emotional information in panic disorder with agoraphobia. J. Abnorm. Psychol. 1999, 108:222-232.
151. Lynn R. National rates of economic growth, anxiety and suicide. Nature 1969, 222:494.
152. Margraf J., Taylor B., Ehlers A., Roth W.T., Agras W.S. Panic attacks in the natural environment. J. Nerv. Ment. Dis. 1987, 175:558-565.
153. Markgraf C.G., Winters R.W., Liskowsky D.R., McCabe P.M., Green E.J., Schneiderman N. Hypothalamic, midbrain and bulbar areas involved in the defense reaction in rabbits. Physiol. Behav. 1991, 49:493-500.
154. Maron E., Nikopensius T., Koks S., Altmae S., Heinaste E., Vabrit K., et al. Association study of 90 candidate gene polymorphisms in panic disorder. Psychiatr. Genet. 2005, 15:17-24.
155. Maron E., Hettema J.M., Shlik J. Advances in molecular genetics of panic disorder. Mol. Psychiatry 2010, 15:681-701.
156. Martinez J.M., Garakani A., Kaufmann H., Aaronson C.J., Gorman J.M. Heart rate and blood pressure changes during autonomic nervous system challenge in panic disorder patients. Psychosom. Med. 2010, 72:442-449.
157. Massana G., Serra-Grabulosa J.M., Salgado-Pineda P., Gasto C., Junque C., Massana J., et al. Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging. Neuroimage 2003, 19:80-90.
158. Matsuura S., Kakizaki H., Mitsui T., Shiga T., Tamaki N., Koyanagi T. Human brain region response to distention or cold stimulation of the bladder: a positron emission tomography study. J. Urol. 2002, 168:2035-2039.
159. McCabe P.M., Duan Y.F., Winters R.W., Green E.J., Huang Y., Schneiderman N. Comparison of peripheral blood flow patterns associated with the defense reaction and the vigilance reaction in rabbits. Physiol. Behav. 1994, 56:1101-1106.
160. McDowall L.M., Horiuchi J., Killinger S., Dampney R.A. Modulation of the baroreceptor reflex by the dorsomedial hypothalamic nucleus and perifornical area. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R1020-R1026.
161. McNally R.J., Lukach B.M. Are panic attacks traumatic stressors?. Am. J. Psychiatry 1992, 149:824-826.
162. McNally R.J., Riemann B.C., Kim E. Selective processing of threat cues in panic disorder. Behav. Res. Ther. 1990, 28:407-412.
163. McNally R.J., Riemann B.C., Louro C.E., Lukach B.M., Kim E. Cognitive processing of emotional information in panic disorder. Behav. Res. Ther. 1992, 30:143-149.
164. McNally R.J., Amir N., Louro C.E., Lukach B.M., Riemann B.C., Calamari J.E. Cognitive processing of idiographic emotional information in panic disorder. Behav. Res. Ther. 1994, 32:119-122.
165. Meletti S., Tassi L., Mai R., Fini N., Tassinari C.A., Russo G.L. Emotions induced by intracerebral electrical stimulation of the temporal lobe. Epilepsia 2006, 47(Suppl. 5):47-51.
166. Meuret A.E., White K.S., Ritz T., Roth W.T., Hofmann S.G., Brown T.A. Panic attack symptom dimensions and their relationship to illness characteristics in panic disorder. J. Psychiatr. Res. 2006, 40:520-527.
167. Milad M.R., Quirk G.J. Fear extinction as a model for translational neuroscience: ten years of progress. Annu. Rev. Psychol. 2012, 63:129-151.
168. Milad M.R., Quinn B.T., Pitman R.K., Orr S.P., Fischl B., Rauch S.L. Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:10706-10711.
169. Milad M.R., Zeidan M.A., Contero A., Pitman R.K., Klibanski A., Rauch S.L., et al. The influence of gonadal hormones on conditioned fear extinction in healthy humans. Neuroscience 2010, 168:652-658.
170. Mitte K. A meta-analysis of the efficacy of psycho- and pharmacotherapy in panic disorder with and without agoraphobia. J. Affect. Disord. 2005, 88:27-45.
171. Molosh A.I., Johnson P.L., Fitz S.D., Dimicco J.A., Herman J.P., Shekhar A. Changes in central sodium and not osmolarity or lactate induce panic-like responses in a model of panic disorder. Neuropsychopharmacology 2010, 35:1333-1347.
172. Nardi A.E., Valenca A.M., Nascimento I., Mezzasalma M.A., Zin W. Panic disorder and hyperventilation. Arq. Neuropsiquiatr. 1999, 57:932-936.
173. Nardi A.E., Valenca A.M., Nascimento I., Zin W.A. Hyperventilation challenge test in panic disorder and depression with panic attacks. Psychiatry Res. 2001, 105:57-65.
174. Nashold B.S., Wilson W.P., Slaughter D.G. Sensations evoked by stimulation in the midbrain of man. J. Neurosurg. 1969, 30:14-24.
175. Nikolaus S., Antke C., Beu M., Muller H.W. Cortical GABA, striatal dopamine and midbrain serotonin as the key players in compulsive and anxiety disorders - results from in vivo imaging studies. Rev. Neurosci. 2010, 21:119-139.
176. Nillni Y.I., Toufexis D.J., Rohan K.J. Anxiety sensitivity, the menstrual cycle, and panic disorder: a putative neuroendocrine and psychological interaction. Clin. Psychol. Rev. 2011, 31:1183-1191.
177. Nutt D.J., Ballenger J.C., Sheehan D., Wittchen H.U. Generalized anxiety disorder: comorbidity, comparative biology and treatment. Int. J. Neuropsychopharmacol. 2002, 5:315-325.
178. Olivier J.D., Van Der Hart M.G., Van Swelm R.P., Dederen P.J., Homberg J.R., Cremers T., et al. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience 2008, 152:573-584.
179. Ost L.G. Cognitive behavior therapy for anxiety disorders: 40 years of progress. Nord. J. Psychiatry 2008, 62(Suppl. 47):5-10.
180. Otte C. Cognitive behavioral therapy in anxiety disorders: current state of the evidence. Dialogues Clin. Neurosci. 2011, 13:413-421.
181. Otto M.W., Tolin D.F., Simon N.M., Pearlson G.D., Basden S., Meunier S.A., et al. Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder. Biol. Psychiatry 2010, 67:365-370.
182. Palkovits M. Insula, a "mysterious" island in our brain - minireview. Orv. Hetil. 2010, 151:1924-1929.
183. Penfield W. Memory mechanisms. AMA Arch. Neurol. Psychiatry 1952, 67:178-198.
184. Perez J.A., Otowa T., Roberson-Nay R., Hettema J.M. Genetics of anxiety disorders. Neurobiology of Mental Illness 2013, Oxford University Press, New York. 4th ed. D. Charney, P. Sklar, J.D. Buxbaum, E.J. Nestler (Eds.).
185. Perna G., Guerriero G., Caldirola D. Emerging drugs for panic disorder. Expert Opin. Emerg. Drugs 2011, 16:631-645.
186. Peskind E.R., Jensen C.F., Pascualy M., Tsuang D., Cowley D., Martin D.C., et al. Sodium lactate and hypertonic sodium chloride induce equivalent panic incidence, panic symptoms, and hypernatremia in panic disorder. Biol. Psychiatry 1998, 44:1007-1016.
187. Pfleiderer B., Zinkirciran S., Arolt V., Heindel W., Deckert J., Domschke K. fMRI amygdala activation during a spontaneous panic attack in a patient with panic disorder. World J. Biol. Psychiatry 2007, 8:269-272.
188. Phelps E.A., Delgado M.R., Nearing K.I., LeDoux J.E. Extinction learning in humans: role of the amygdala and vmPFC. Neuron 2004, 43:897-905.
189. Pitts F.N., McClure J.N. Lactate metabolism in anxiety neurosis. N. Engl. J. Med. 1967, 277:1329-1336.
190. Pollack M., Mangano R., Entsuah R., Tzanis E., Simon N.M., Zhang Y. A randomized controlled trial of venlafaxine ER and paroxetine in the treatment of outpatients with panic disorder. Psychopharmacology (Berl.) 2007, 194:233-242.
191. Pollack M.H., Lepola U., Koponen H., Simon N.M., Worthington J.J., Emilien G., et al. A double-blind study of the efficacy of venlafaxine extended-release, paroxetine, and placebo in the treatment of panic disorder. Depress. Anxiety 2007, 24:1-14.
192. Pollock R.A., Carter A.S., Amir N., Marks L.E. Anxiety sensitivity and auditory perception of heartbeat. Behav. Res. Ther. 2006, 44:1739-1756.
193. Prasko J., Horacek J., Zalesky R., Kopecek M., Novak T., Paskova B., et al. The change of regional brain metabolism (18FDG PET) in panic disorder during the treatment with cognitive behavioral therapy or antidepressants. Neuro Endocrinol. Lett. 2004, 25:340-348.
194. Protopopescu X., Pan H., Tuescher O., Cloitre M., Goldstein M., Engelien A., et al. Increased brainstem volume in panic disorder: a voxel-based morphometric study. Neuroreport 2006, 17:361-363.
195. Rasche D., Foethke D., Gliemroth J., Tronnier V.M. Deep brain stimulation in the posterior hypothalamus for chronic cluster headache. Case report and review of the literature. Schmerz 2006, 20:439-444.
196. Rauch S.L., Milad M.R., Orr S.P., Quinn B.T., Fischl B., Pitman R.K. Orbitofrontal thickness, retention of fear extinction, and extraversion. Neuroreport 2005, 16:1909-1912.
197. Reed V., Wittchen H.U. DSM-IV panic attacks and panic disorder in a community sample of adolescents and young adults: how specific are panic attacks?. J. Psychiatr. Res. 1998, 32:335-345.
198. Reiman E.M., Raichle M.E., Robins E., Mintun M.A., Fusselman M.J., Fox P.T., et al. Neuroanatomical correlates of a lactate-induced anxiety attack. Arch. Gen. Psychiatry 1989, 46:493-500.
199. Rifkin A., Klein D.F., Dillon D., Levitt M. Blockade by imipramine or desipramine of panic induced by sodium lactate. Am. J. Psychiatry 1981, 138:676-677.
200. Rupprecht R., et al. Translocator protein (18kD) as target for anxiolytics without benzodiazepine-like side effects. Science 2009, 325:490-493.
201. Sakai Y., Kumano H., Nishikawa M., Sakano Y., Kaiya H., Imabayashi E., et al. Cerebral glucose metabolism associated with a fear network in panic disorder. Neuroreport 2005, 16:927-931.
202. Sakai Y., Kumano H., Nishikawa M., Sakano Y., Kaiya H., Imabayashi E., et al. Changes in cerebral glucose utilization in patients with panic disorder treated with cognitive-behavioral therapy. Neuroimage 2006, 33:218-226.
203. Samuels B.C., Zaretsky D.V., DiMicco J.A. Tachycardia evoked by disinhibition of the dorsomedial hypothalamus in rats is mediated through medullary raphe. J. Physiol. 2002, 538:941-946.
204. Sanchez-Meca J., Rosa-Alcazar A.I., Marin-Martinez F., Gomez-Conesa A. Psychological treatment of panic disorder with or without agoraphobia: a meta-analysis. Clin. Psychol. Rev. 2010, 30:37-50.
205. 2 enriched air: a single subject analysis of psychological and physiological effects. Behav. Res. Ther. 1988, 26:333-335.
206. Schenberg L.C., Lovick T.A. Neurones in the medullary raphe nuclei attenuate the cardiovascular responses evoked from the dorsolateral periaqueductal grey matter. Brain Res. 1994, 651:236-240.
207. 2 challenge reactivity as unique and interactive prospective predictors of anxiety pathology. Depress. Anxiety 2007, 24:527-536.
208. Schoepp D.D., Wright R.A., Levine L.R., Gaydos B., Potter W.Z. LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress. Stress 2003, 6:189-197.
209. 2-induced fear by 5-HTTLPR genotype. J. Psychopharmacol. 2011, 25:37-42.
210. Schumacher J., Kristensen A.S., Wendland J.R., Nothen M.M., Mors O., McMahon F.J. The genetics of panic disorder. J. Med. Genet. 2011, 48:361-368.
211. Sheikh J.I., Leskin G.A., Klein D.F. Gender differences in panic disorder: findings from the National Cormobidity Survey. Am. J. Psychiatry 2002, 159:55-58.
212. Shekhar A., DiMicco J.A. Defense reaction elicited by injection of GABA antagonists and synthesis inhibitors into the posterior hypothalamus in rats. Neuropharmacology 1987, 26:407-417.
213. Shekhar A., Keim S.R. The circumventricular organs form a potential neural pathway for lactate sensitivity: implications for panic disorder. J. Neurosci. 1997, 17:9726-9735.
214. Shekhar A., Keim S.R. LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats. Neuropharmacology 2000, 39:1139-1146.
215. Shekhar A., Hingtgen J.N., DiMicco J.A. GABA receptors in the posterior hypothalamus regulate experimental anxiety in rats. Brain Res. 1990, 512:81-88.
216. Shekhar A., Keim S.R., Simon J.R., McBride W.J. Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions. Pharmacol. Biochem. Behav. 1996, 55:249-256.
217. Shekhar A., McCann U.D., Meaney M.J., Blanchard D.C., Davis M., Frey K.A., et al. Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders. Psychopharmacology (Berl.) 2001, 157:327-339.
218. Shekhar A., Johnson P.L., Sajdyk T.J., Fitz S.D., Keim S.R., Kelley P.E., et al. Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus. J. Neurosci. 2006, 26:9205-9215.
219. Shekhar A., Johnson P.L., Fitz S.D., Nakazato A., Chaki S., Steckler T., et al. A selective, non-peptide CRF receptor 1 antagonist prevents sodium lactate-induced acute panic-like responses. Int. J. Neuropsychopharmacol. 2011, 14:355-365.
220. Shin L.M., Liberzon I. The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology 2010, 35:169-191.
221. Shulman I.D., Cox B.J., Swinson R.P., Kuch K., Reichman J.T. Precipitating events, locations and reactions associated with initial unexpected panic attacks. Behav. Res. Ther. 1994, 32:17-20.
222. Singewald N., Sharp T. Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry. Neuroscience 2000, 98:759-770.
223. Singewald N., Salchner P., Sharp T. Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biol. Psychiatry 2003, 53:275-283.
224. Smith J.E., Jansen A.S., Gilbey M.P., Loewy A.D. CNS cell groups projecting to sympathetic outflow of tail artery: neural circuits involved in heat loss in the rat. Brain Res. 1998, 786:153-164.
225. Sobanski T., Wagner G., Peikert G., Gruhn U., Schluttig K., Sauer H., et al. Temporal and right frontal lobe alterations in panic disorder: a quantitative volumetric and voxel-based morphometric MRI study. Psychol. Med. 2010, 40:1879-1886.
226. Soltis R.P., DiMicco J.A. Hypothalamic excitatory amino acid receptors mediate stress-induced tachycardia in rats. Am. J. Physiol. 1992, 262:R689-R697.
227. Spear L.P. The adolescent brain and age-related behavioral manifestations. Neurosci. Biobehav. Rev. 2000, 24:417-463.
228. Spiegelhalder K., Hornyak M., Kyle S.D., Paul D., Blechert J., Seifritz E., et al. Cerebral correlates of heart rate variations during a spontaneous panic attack in the fMRI scanner. Neurocase 2009, 15:527-534.
229. Stein M.B., Asmundson G.J. Autonomic function in panic disorder: cardiorespiratory and plasma catecholamine responsivity to multiple challenges of the autonomic nervous system. Biol. Psychiatry 1994, 36:548-558.
230. Stein D.J., Bouwer C. A neuro-evolutionary approach to the anxiety disorders. J. Anxiety Disord. 1997, 11:409-429.
231. Stein M.B., Tancer M.E., Uhde T.W. Heart rate and plasma norepinephrine responsivity to orthostatic challenge in anxiety disorders. Comparison of patients with panic disorder and social phobia and normal control subjects. Arch. Gen. Psychiatry 1992, 49:311-317.
232. Street L.L., Craske M.G., Barlow D.H. Sensations, cognitions and the perception of cues associated with expected and unexpected panic attacks. Behav. Res. Ther. 1989, 27:189-198.
233. Targum S.D. Panic attack frequency and vulnerability to anxiogenic challenge studies. Psychiatry Res. 1991, 36:75-83.
234. Targum S.D. Cortisol response during different anxiogenic challenges in panic disorder patients. Psychoneuroendocrinology 1992, 17:453-458.
235. Taylor C.B., Sheikh J., Agras W.S., Roth W.T., Margraf J., Ehlers A., et al. Ambulatory heart rate changes in patients with panic attacks. Am. J. Psychiatry 1986, 143:478-482.
236. Tesar G.E., Rosenbaum J.F. Successful use of clonazepam in patients with treatment-resistant panic disorder. J. Nerv. Ment. Dis. 1986, 174:477-482.
237. Van Buren J.M. Sensory, motor and autonomic effects of mesial temporal stimulation in man. J. Neurosurg. 1961, 18:273-288.
238. van den Heuvel O.A., Veltman D.J., Groenewegen H.J., Witter M.P., Merkelbach J., Cath D.C., et al. Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Arch. Gen. Psychiatry 2005, 62:922-933.
239. Vickers K., McNally R.J. Respiratory symptoms and panic in the National Comorbidity Survey: a test of Klein's suffocation false alarm theory. Behav. Res. Ther. 2005, 43:1011-1018.
240. von Leupoldt A., Sommer T., Kegat S., Baumann H.J., Klose H., Dahme B., et al. The unpleasantness of perceived dyspnea is processed in the anterior insula and amygdala. Am. J. Respir. Crit. Care Med. 2008, 177:1026-1032.
241. Weissman N.J., Shear M.K., Kramer-Fox R., Devereux R.B. Contrasting patterns of autonomic dysfunction in patients with mitral valve prolapse and panic attacks. Am. J. Med. 1987, 82:880-888.
242. Wellman C.L., Izquierdo A., Garrett J.E., Martin K.P., Carroll J., Millstein R., et al. Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J. Neurosci. 2007, 27:684-691.
243. Westerhaus M.J., Loewy A.D. Central representation of the sympathetic nervous system in the cerebral cortex. Brain Res. 2001, 903:117-127.
244. Wiest G., Lehner-Baumgartner E., Baumgartner C. Panic attacks in an individual with bilateral selective lesions of the amygdala. Arch. Neurol. 2006, 63:1798-1801.
245. Wilent W.B., Oh M.Y., Buetefisch C.M., Bailes J.E., Cantella D., Angle C., et al. Induction of panic attack by stimulation of the ventromedial hypothalamus. J. Neurosurg. 2010, 112:1295-1298.
246. Wilent W.B., Oh M.Y., Buetefisch C., Bailes J.E., Cantella D., Angle C., et al. Mapping of microstimulation evoked responses and unit activity patterns in the lateral hypothalamic area recorded in awake humans. Technical note. J. Neurosurg. 2011, 115:295-300.
247. Wilkinson D.J., Thompson J.M., Lambert G.W., Jennings G.L., Schwarz R.G., Jefferys D., et al. Sympathetic activity in patients with panic disorder at rest, under laboratory mental stress, and during panic attacks. Arch. Gen. Psychiatry 1998, 55:511-520.
248. Wilson K.A., Hayward C. A prospective evaluation of agoraphobia and depression symptoms following panic attacks in a community sample of adolescents. J. Anxiety Disord. 2005, 19:87-103.
249. Wittchen H.U., Gloster A.T., Beesdo-Baum K., Fava G.A., Craske M.G. Agoraphobia: a review of the diagnostic classificatory position and criteria. Depress. Anxiety 2010, 27:113-133.
250. Woods S.W., Charney D.S., Loke J., Goodman W.K., Redmond D.E., Heninger G.R. Carbon dioxide sensitivity in panic anxiety. Ventilatory and anxiogenic response to carbon dioxide in healthy subjects and patients with panic anxiety before and after alprazolam treatment. Arch. Gen. Psychiatry 1986, 43:900-909.
251. Woods S.W., Charney D.S., McPherson C.A., Gradman A.H., Heninger G.R. Situational panic attacks. Behavioral, physiologic, and biochemical characterization. Arch. Gen. Psychiatry 1987, 44:365-375.
252. Woods S.W., Charney D.S., Goodman W.K., Heninger G.R. Carbon dioxide-induced anxiety. Behavioral, physiologic, and biochemical effects of carbon dioxide in patients with panic disorders and healthy subjects. Arch. Gen. Psychiatry 1988, 45:43-52.
253. Yeragani V.K., Pohl R., Balon R., Weinberg P., Berchou R., Rainey J.M. Preinfusion anxiety predicts lactate-induced panic attacks in normal controls. Psychosom. Med. 1987, 49:383-389.
254. Yeragani V.K., Meiri P.C., Pohl R., Balon R., Desai N., Golec S. Heart rate and blood pressure changes during postural change and isometric handgrip exercise in patients with panic disorder and normal controls. Acta Psychiatr. Scand. 1990, 81:9-13.
255. Young R.F. Brain and spinal stimulation: how and to whom!. Clin. Neurosurg. 1989, 35:429-447.
256. Zeidan M.A., Igoe S.A., Linnman C., Vitalo A., Levine J.B., Klibanski A., et al. Estradiol modulates medial prefrontal cortex and amygdala activity during fear extinction in women and female rats. Biol. Psychiatry 2011, 70:920-927.