Genetic moderation of CO2-induced fear by 5-HTTLPR genotype

Journal of Psychopharmacology

Volumn 25, Issue 1, 2011, Pages 37-42

  Schruers, Koen ^a   Esquivel, Gabriel ^a   Van Duinen, Marlies ^a   Wichers, Marieke ^a   Kenis, Gunter ^a   Colasanti, Alessandro ^a   Knuts, Inge ^a   Goossens, Lies ^a   Jacobs, Nele ^a   Van Rozendaal, Jalet ^a   Smeets, Hubert ^a   Van Os, Jim ^a   Griez, Eric ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

5 HT transporter gene; anxiety; carbon dioxide; panic disorder; SLC6A4

Indexed keywords

CARBON DIOXIDE; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADULT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEAR; FEMALE; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PANIC; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; ALLELE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; MIDDLE AGED; PSYCHOLOGICAL RATING SCALE; RANDOMIZED CONTROLLED TRIAL;

ADULT; ALLELES; CARBON DIOXIDE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEAR; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PANIC DISORDER; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 78650592681     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881110372543     Document Type: Article

References (43)

1. American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR, 4 th edn. Washington, DC: American Psychiatric Association.
2. 2 challenge in panic disorder: optimization by receiver operating characteristic (ROC) analysis. J Psychiatr Res 29: 111-119.
3. 2-induced anxiety in healthy volunteers with the serotonin antagonist metergoline. Am J Psychiatry 156: 1635-1637.
4. Blaya C., Salum GA, Lima MS, Leistner-Segal S. and Manfro GG (2007) Lack of association between the serotonin transporter promoter polymorphism (5-HTTLPR) and panic disorder: a systematic review and meta-analysis. Behav Brain Funct 3: 41.
5. Graeff FG and Del-Ben CM (2008) Neurobiology of panic disorder: From animal models to brain neuroimaging. Neurosci Biobehav Rev 32: 1326-1335.
6. Graeff FG, Viana MB and Mora PO (1997) Dual role of 5-HT in defense and anxiety. Neurosci Biobehav Rev 21: 791-799.
7. Griez EJ, Colasanti A., van Diest R., Salamon E. and Schruers K. (2007) Carbon dioxide inhalation induces dose-dependent and age-related negative affectivity. PLoS ONE 2: e 987.
8. Hettema JM, Neale MC and Kendler KS (2001) A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158: 1568-1578.
9. Hettema JM, Prescott CA, Myers JM, Neale MC and Kendler KS (2005) The structure of genetic and environmental risk factors for anxiety disorders in men and women. Arch Gen Psychiatry 62: 182-189.
10. Hu XZ, Lipsky RH, Zhu G., et al. (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78: 815-826.
11. Katon WJ, Roy- Byrne P., Russo J. and Cowley D. (2002) Cost-effectiveness and cost offset of a collaborative care intervention for primary care patients with panic disorder. Arch Gen Psychiatry 59: 1098-1104.
12. Kent JM, Coplan JD, Martinez J., Karmally W., Papp LA and Gorman JM (1996) Ventilatory effects of tryptophan depletion in panic disorder: a preliminary report. Psychiatry Res 64: 83-90.
13. Kessler RC, Chiu WT, Jin R., Ruscio AM, Shear K. and Walters EE (2006) The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Arch Gen Psychiatry 63: 415-424.
14. Lesch KP, Bengel D., Heils A., et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531.
15. Maron E. and Shlik J. (2006) Serotonin function in panic disorder: Important, but why? Neuropsychopharmacology 31: 1-11.
16. Maron E., Toru I., Tasa G., et al. (2008) Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers. Neurosci Lett 446: 88-92.
17. Maron E., Toru I., Vasar V. and Shlik J. (2004) The effect of 5-hydroxytryptophan on cholecystokinin-4-induced panic attacks in healthy volunteers. J Psychopharmacol 18: 194-199.
18. Meyer-Lindenberg A. and Weinberger DR (2006) Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 7: 818-827.
19. 2-induced anxiety in patients with panic disorder and normal volunteers. Br J Psychiatry 176: 182-188.
20. Moreno FA, Rowe DC, Kaiser B., et al. (2002) Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Mol Psychiatry 7: 213-216.
21. Mortimore C. and Anderson IM (2000) d-Fenfluramine in panic disorder: a dual role for 5-hydroxytryptamine. Psychopharmacology (Berl) 149: 251-258.
22. Munafo MR, Durrant C., Lewis G and Flint J (2009) Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry 65: 211-219.
23. Nakamura M., Ueno S., Sano A. and Tanabe H. (2000) The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 5: 32-38.
24. Neumeister A., Hu XZ, Luckenbaugh DA, et al. (2006) Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry 63: 978-986.
25. Park JW, Kim JS, Lee HK, Kim YI and Lee KS (2004) Serotonin transporter polymorphism and harm avoidance personality in chronic tension-type headache. Headache 44: 1005-1009.
26. 2 reactivity and serotonin transporter gene regulatory region polymorphism in panic disorder. Am J Med Genet B Neuropsychiatr Genet 129B: 41-43.
27. Perna G., Favaron E., Di Bella D., Bussi R. and Bellodi L. (2005) Antipanic efficacy of paroxetine and polymorphism within the promoter of the serotonin transporter gene. Neuropsychopharmacology 30: 2230-2235.
28. Richerson GB (2004) Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci 5: 449-461.
29. Sanjuan J., Martin-Santos R., Garcia-Esteve L., et al. (2008) Mood changes after delivery: role of the serotonin transporter gene. Br J Psychiatry 193: 383-388.
30. Schmidt NB, Storey J., Greenberg BD, Santiago HT, Li Q. and Murphy DL (2000) Evaluating gene x psychological risk factor effects in the pathogenesis of anxiety: a new model approach. J Abnorm Psychol 109: 308-320.
31. 2 provoked panic in panic disorder. J Psychopharmacol 18: 553-558.
32. Schruers K., Klaassen T., Pols H., Overbeek T., Deutz NE and Griez E. (2000) Effects of tryptophan depletion on carbon dioxide provoked panic in panic disorder patients. Psychiatry Res 93: 179-187.
33. Schruers K., van Diest R., Overbeek T. and Griez E. (2002) Acute L-5hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res 113: 237-243.
34. Severson CA, Wang W., Pieribone VA, Dohle CI and Richerson GB (2003) Midbrain serotonergic neurons are central pH chemoreceptors. Nat Neurosci 6: 1139-1140.
35. Snijders TAB and Bosker RJ (1999) Multilevel Analysis: An Introduction to Basic and Advanced Multilevel Modeling. London: Sage.
36. StataCorp (2007) Stata Statistical Software: Release 10. College Station, TX: StataCorp LP.
37. Strug LJ, Suresh R., Fyer AJ, et al. (2010) Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Mol Psychiatry 15: 166-176.
38. Sullivan PF (2007) Spurious genetic associations. Biol Psychiatry 61: 1121-1126.
39. van Duinen M., Rickelt J. and Griez E. (2008) Validation of the electronic Visual Analogue Scale of Anxiety. Prog Neuropsychopharmacol Biol Psychiatry 32: 1045-1047.
40. Van Os J. and Sham P. (2003) Gene-environment interactions. In: Murray RM, Jones PB, Susser E, Van Os J and Cannon M (eds) The Epidemiology of Schizophrenia. Cambridge: Cambridge University Press, 235-254.
41. 2 challenge. In: Griez EJL, Faravelli C, Nutt D and Zohar J (eds) Anxiety Disorders, an Introduction to Clinical Management and Research. Chichester: Wiley, 341-357.
42. Verburg K., Pols H., de Leeuw M. and Griez E. (1998) Reliability of the 35% carbon dioxide panic provocation challenge. Psychiatry Res 78: 207-214.
43. Wendland JR, Martin BJ, Kruse MR, Lesch KP and Murphy DL (2006) Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 11: 224-226.