Association study of 90 candidate gene polymorphisms in panic disorder

Psychiatric Genetics

Volumn 15, Issue 1, 2005, Pages 17-24

  Maron, Eduard ^a   Nikopensius, Tiit ^b   Kõks, Sulev ^a,c   Altmäe, Signe ^b   Heinaste, Evelin ^b   Vabrit, Kristel ^b   Tammekivi, Veronika ^b   Hallast, Pille ^b   Koido, Kati ^a   Kurg, Ants ^b   Metspalu, Andres ^b,d   Vasar, Eero ^a   Vasar, Veiko ^a   Shlik, Jakov ^a,e  

^a UNIVERSITY OF TARTU   (Estonia)

^b UNIVERSITY OF TARTU   (Estonia)

^c Visgenyx Ltd   (Estonia)

^d Asper Biotech Ltd   (Estonia)

^e UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Association analysis; Cholecystokinin; Dopamine; Genetics; Haplotype analysis; Major depressive disorder; Neurotransmitter; Opioid peptides; Panic disorder; Serotonin; Single nucleotide polymorphisms

Indexed keywords

CHOLECYSTOKININ; DOPAMINE; OPIATE; SEROTONIN;

ADULT; ARTICLE; COMORBIDITY; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; FEMALE; GENOTYPE; HAPLOTYPE; HUMAN; MALE; PANIC; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

CHOLECYSTOKININ; COMORBIDITY; DEPRESSIVE DISORDER; DNA; DNA PRIMERS; GENOTYPE; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANIC DISORDER; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE; RECEPTORS, SEROTONIN; REFERENCE VALUES;

EID: 20144386110     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-200503000-00004     Document Type: Article

References (57)

1. Arias B, Arranz MJ, Gasto C, Catalan R, Pintor L, Gutierrez B, et al. (2002). Analysis of structural polymorphisms and C-1018G promoter variant of the 5-HT(1A) receptor gene as putative risk factors in major depression. Mol Psychiatry 7:930-932.
2. Arranz MJ, Munro J, Sham P, Kirov G, Murray RM, Collier DA, et al. (1998). Metaanalysis of studies on genetic variation in 5-HT2A receptors and clozapine response. Schizophr Res 32:93-99.
3. Bishop C, Walker PD (2003). Combined intrastriatal dopamine d1 and serotonin 5-ht2 receptor stimulation reveals a mechanism for hyperlocomotion in 6-hydroxydopamine-lesioned rats. Neuroscience 121:649-657.
4. Bourin M, Baker GB, Bradwejn J (1998). Neurobiology of panic disorder. J Psychosom Res 44:163-180.
5. Bowen T, Norton N, Jacobsen NJ, Guy C, Daniels JK, Sanders RD, et al. (1998). Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder. Mol Psychiatry 3:67-71.
6. Chen YW, Dilsaver SC (1995). Comorbidity of panic disorder in bipolar illness: evidence from the Epidemiologic Catchment Area Survey. Am J Psychiatry 152:280-282.
7. Cichon S, Nothen MM, Stober G, Schroers R, Albus M, Maier W, et al. (1996). Systematic screening for mutations in the 5′-regulatory region of the human dopamine D1 receptor (DRD1) gene in patients with schizophrenia and bipolar affective disorder. Am J Med Genet 67:424-428.
8. Cusin C, Serretti A, Zanardi R, Lattuada E, Rossini D, Lilli R, et al. (2002). Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity. Int J Neuropsychopharmacol 5:27-35.
9. Deckert J, Catalano M, Heils A, Di Bella D, Friess F, Politi E, et al. (1997). Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder. Psychiatr Genet 7:45-47.
10. Deckert J, Nothen MM, Franke P, Delmo C, Fritze J, Knapp M, et al. (1998). Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease. Mol Psychiatry 3:81-85.
11. Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, et al. (1999). Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 8:621-624.
12. Deckert J, Meyer J, Catalano M, Bosi M, Sand P, Di Bella D, et al. (2000). Novel 5′-regulatory region polymorphisms of the 5-HT2C receptor gene: association study with panic disorder. Int J Neuropsychopharmacol 4:321-325.
13. Eaton WW, Kessler RC, Wittchen HU, Magee WJ (1994). Panic and panic disorder in the United States. Am J Psychiatry 151:413-420.
14. Fehr C, Szegedi A, Anghelescu I, Klawe C, Hiemke C, Dahmen N (2000a). Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study. Psychiatr Genet 10:59-65.
15. Fehr C, Grintschuk N, Szegedi A, Anghelescu I, Klawe C, Singer P, et al. (2000b). The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. Psychiatry Res 97:1-10.
16. Fehr C, Schleicher A, Szegedi A, Anghelescu I, Klawe C, Hiemke C, et al. (2001). Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. Prog Neuropsychopharmacol Biol Psychiatry 25:965-982.
17. Finn CT, Smoller JW (2001). The genetics of panic disorder. Curr Psychiatry Rep 2:131-137.
18. Geijer T, Frisch A, Persson ML, Wasserman D, Rockah R, Michaelovsky E, et al. (2000). Search for association between suicide attempt and serotonergic polymorphisms. Psychiatr Genet 10:19-26.
19. Goisman RM, Warshaw MG, Peterson LG, Rogers MP, Cuneo P, Hunt MF, et al. (1994). Panic, agoraphobia, and panic disorder with agoraphobia. Data from a multicenter anxiety disorders study. J Nerv Ment Dis 182:72-79.
20. Goldman-Rakic PS, Muly III, Williams GV (2000). D1 receptors in prefrontal cells and circuits. Brain Res Rev 31:295-301.
21. German JM, Kent JM, Sullivan GM, Coplan JD (2000). Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 157:493-505.
22. Hamilton SP, Heiman GA, Haghighi F, Mick S, Klein DF, Hodge SE, et al. (1999). Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder. Psychiatr Genet 9:1-6.
23. Hamilton SP, Haghighi F, Heiman GA, Klein DF, Hodge SE, Fyer AJ, et al. (2000). Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder. Am J Med Genet 96:324-330.
24. Hamilton SP, Slager SL, Helleby L, Heiman GA, Klein DF, Hodge SE, et al. (2001). No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. Mol Psychiatry 6:59-65.
25. Han L, Nielsen DA, Rosenthal NE, Jefferson K, Kaye W, Murphy D, et al. (1999). No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biol Psychiatry 45:615-619.
26. Hattori E, Yamada K, Toyota T, Yoshitsugu K, Toru M, Shibuya H, et al. (2001). Association studies of the CT repeat polymorphism in the 5′ upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects. Am J Med Genet 105:779-782.
27. Hösing VG, Schirmacher A, Kuhlenbaumer G, Freitag C, Sand P, Schlesiger C, et al. (2004). Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder. J Neural Transm Suppl 68:147-156.
28. Inada Y, Yoneda H, Koh J, Sakai J, Himei A, Kinoshita Y, et al. (2003). Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene. Psychiatry Res 118:25-31.
29. Ise K, Akiyoshi J, Horinouchi Y, Tsutsumi T, Isogawa K, Nagayama H (2003). Association between the CCK-A receptor gene and panic disorder. Am J Med Genet 118B:29-31.
30. Ishiguro H, Saito T, Shibuya H, Toru M, Arinami T (1999). No association between C-45T polymorphism in the Sp1 binding site of the promoter region of the cholecystokinin gene and alcoholism. Psychiatry Res 85:209-213.
31. Kato T, Wang ZW, Zoega T, Crowe RR (1996). Missense mutation of the cholecystokinin B receptor gene: lack of association with panic disorder. Am J Med Genet 67:401-405.
32. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ (1993). Panic disorder in women: a population-based twin study. Psychol Med 23:397-406.
33. Kennedy JL, Bradwejn J, Koszycki D, King N, Crowe R, Vincent J, et al. (1999). Investigation of cholecystokinin system genes in panic disorder. Mol Psychiatry 4:284-285.
34. Kennedy JL, Neves-Pereira M, King N, Lizak MV, Basile VS, Chartier MJ, et al. (2001). Dopamine system genes not linked to social phobia. Psychiatr Genet 11:213-217.
35. Kessler RC, Stang PE, Wittchen HU, Ustun TB, Roy-Burne PP, Walters EE (1998). Lifetime panic-depression comorbidity in the National Comorbidity Survey. Arch Gen Psychiatry 55:801-808.
36. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, et al. (2003). Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 23:8788-8799.
37. Lerer B, Macciardi F, Segman RH, Adolfsson R, Blackwood D, Blairy S, et al. (2001). Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Mol Psychiatry 6:579-585.
38. Maier W, Lichtermann D, Minges J, Oehrlein A, Franke P (1993). A controlled family study in panic disorder. J Psychiatr Res 27:79-87.
39. Massat I, Souery D, Lipp O, Blairy S, Papadimitriou G, Dikeos D, et al. (2000). A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder. Am J Med Genet 96:136-140.
40. Moldin SO (2000). Neurobiology of anxiety and fear: challenges for genomic science of the new millennium. Biol Psychiatry 48:1144-1146.
41. Noyes R, Jr, Crowe RR, Harris EL, Hamra BJ, McChesney CM, Chaudhry DR (1986). Relationship between panic disorder and agoraphobia. A family study. Arch Gen Psychiatry 43:227-232.
42. Ohara K, Nagai M, Suzuki Y, Ochiai M, Ohara K (1998). No association between anxiety disorders and catechol-O-methyltransferase polymorphism. Psychiatry Res 80:145-148.
43. Oswald P, Souery D, Massat I, Del Favero J, Linotte S, Papadimitriou G, et al. (2003). Lack of association between the 5HT2A receptor polymorphism (T102C) and unipolar affective disorder in a mutlicentric European study. Eur Neuropsychopharmacol 13:365-368.
44. Raymond M, Rousset F (1995). GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Hered 86:284-295.
45. Roth BL, Willins DL, Kristiansen K, Kroeze WK (1998). 5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function. Pharmacol Ther 79:231-257.
46. Rothe C, Gutknecht L, Freitag C, Tauber R, Mossner R, Franke P, et al. (2004). Association of a functional -1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia. Int J Neuropsychopharmacol 7:189-192.
47. Salvador-Carulla L, Segui J, Fernandez-Cano P, Canet J (1995). Costs and offset effect in panic disorders. Br J Psychiatry 166 (suppl 27):23-28.
48. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59:22-33.
49. Tachikawa H, Harada S, Kawanishi Y, Okubo T, Suzuki T (2001). Linked polymorphisms (-333G>T and -286A>G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia. Psychiatry Res 103:147-155.
50. Tadic A, Rujescu D, Szegedi A, Giegling I, Singer P, Moller HJ, et al. (2003). Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. Am J Med Genet 117B:1-6.
51. Tregouet DA, Barbaux S, Escolano S, Tahri N, Golmard JL, Tiret L, et al. (2002). Specific haplotypes of the P-selectin gene are associated with myocardial infarction. Hum Mol Genet 11:2015-2023.
52. Tonisson N, Zemant J, Kurg A, Pavel H, Slavin G, Roomere H, et al. (2002). Evaluating the arrayed primer extension resequencing assay of TP53 tumor suppressor gene. Proc Natl Acad Sci USA 99:5503-5508.
53. Wang Z, Valdes J, Noyes R, Zoega T, Crowe RR (1998). Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder. Am J Med Genet 81:228-234.
54. Williams J, Spulock G, McGuffin P, Mallet J, Nöthen MM, Aschauer H, et al. (1996). Association between schizophrenia and T102C polymorphism of the 5 hydroxytryptamine type 2a-receptor. Lancet 347:1294-1296.
55. Woo JM, Yoon KS, Yu BH (2002). Catechol O-methyltransferase genetic polymorphism in panic disorder. Am J Psychiatry 159:1785-1787.
56. Yamada K, Hattori E, Shimizu M, Sugaya A, Shibuya H, Yoshikawa T (2001). Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder. J Neural Transm Genet Sec 108:837-848.
57. Zaubler TS, Katon W (1998). Panic disorder in the general medical setting. J Psychosom Res 44:25-42.