Heart rate and blood pressure changes during autonomic nervous system challenge in panic disorder patients

Psychosomatic Medicine

Volumn 72, Issue 5, 2010, Pages 442-449

  Martinez, Jose M ^a   Garakani, Amir ^a   Kaufmann, Horacio ^b   Aaronson, Cindy J ^a   Gorman, Jack M ^c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Univ S Carolina Sch Med Vice P   (United States)

Author keywords

Autonomic nervous system; Blood pressure variability; Heart rate variability; Panic disorder; Severity of illness.; Tilt test

Indexed keywords

AGORAPHOBIA; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD PRESSURE MEASUREMENT; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; FEMALE; HEART RATE VARIABILITY; HUMAN; MALE; ORTHOSTATIC BLOOD PRESSURE; PANIC; PRIORITY JOURNAL; SCORING SYSTEM; SPECTROSCOPY; SYSTOLIC BLOOD PRESSURE;

ADOLESCENT; ADULT; AGED; AGORAPHOBIA; AROUSAL; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; PANIC DISORDER; PERSONALITY INVENTORY; SEVERITY OF ILLNESS INDEX; SYMPATHETIC NERVOUS SYSTEM; TILT-TABLE TEST; VAGUS NERVE;

EID: 77953357512     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e3181d972c2     Document Type: Article

References (67)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington DC: American Psychiatric Association; 2000.
2. Korczak DJ, Goldstein BI, Levitt AJ. Panic disorder, cardiac diagnosis and emergency department utilization in an epidemiologic community sample. Gen Hosp Psychiatry 2007;29:335-339
3. Chen YH, Tsai SY, Lee HC, Lin HC. Increased risk of acute myocardial infarction for patients with panic disorder: a nationwide population-based study. Psychosom Med 2009;71:798-804.
4. Bystritsky A, Craske M, Maidenberg E, Vapnik T, Shapiro D. Ambulatory monitoring of panic patients during regular activity: a preliminary report. Biol Psychiatry 1995;38:684-689
5. Coplan JD, Goetz R, Klein DF, Papp LA, Fyer AJ, Liebowitz MR, Davies SO, Gorman JM. Plasma cortisol concentrations preceding lactate-induced panic. Psychological, biochemical, and physiological correlates. Arch Gen Psychiatry 1998;55:130-136
6. Martinez JM, Coplan JD, Browne ST, Goetz R, Welkowitz LA, Papp LA, Klein DF, Gorman JM. Hemodynamic response to respiratory challenges in panic disorder. J Psychosom Res 1998;44:153-161
7. Bystritsky A, Craske M, Maidenberg E, Vapnik T, Shapiro D. Autonomic reactivity of panic patients during a CO2 inhalation procedure. Depress Anxiety 2000;11:15-26.
8. Shear MK, Brown TA, Barlow DH, Sholomskas DE, Woods SW, Gorman JM, Papp LA. Multicenter collaborative panic disorder severity scale. Am J Psychiatry 1997;154:1571-1575
9. Stein MB, Asmundson GJ. Autonomic function in panic disorder: cardiore-spiratory and plasma catecholamine responsivity to multiple challenges of the autonomic nervous system. Biol Psychiatry 1994;36:548-558
10. Roy-Byrne P, Cowley DS, Stein MB, Wingerson D, Veith R. Cardiovascular and catecholamine response to orthostasis in panic and obsessive-compulsive disorder and normal controls: effects of anxiety and novelty. Depress Anxiety 1997;6:159-164
11. Cohen H, Benjamin J, Geva AB, Matar MA, Kaplan Z, Kotler M. Autonomic dysregulation in panic disorder and in post-traumatic stress disorder: application of power spectrum analysis of heart rate variability at rest and in response to recollection of trauma or panic attacks. Psychiatry Res 2000;96:1-13.
12. Blechert J, Michael T, Grossman P, Lajtman M, Wilhelm FH. Autonomic and respiratory characteristics of posttraumatic stress disorder and panic disorder. Psychosom Med 2007;69:935-943
13. Woodward SH, Arsenault NJ, Voelker K, Nguyen T, Lynch J, Skultety K, Mozer E, Leskin GA, Sheikh JI. Autonomic activation during sleep in posttraumatic stress disorder and panic: a mattress actigraphic study. Biol Psychiatry 2009;66:41-46
14. Parati G, Saul JP, Di Rienzo M, Mancia G. Spectral analysis of blood pressure and heart rate variability in evaluating cardiovascular regulation. A critical appraisal. Hypertension 1995;25:1276-1286
15. Kleiger RE, Miller JP, Bigger JT, Moss AJ. Decreased heart variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987;59:256-262
16. Tsuji H, Larson MG, Venditti FJ Jr, Manders ES, Evans JC, Feldman CL, Levy D. Impact of reduced heart rate variability on risk for cardiac events: the Framingham heart study. Circulation 1996;94:2850-2855
17. Liao D, Cai J, Rosamond WD, Barnes RW, Hutchinson RG, Whitsel EA, Rautaharju P, Heiss G. Cardiac autonomic function and incident coronary heart disease a population-based case-cohort study. The ARIC study. Atherosclerosis Risk in Communities Study. Am J Epidemiol 1997;145: 696-706.
18. Evrengul H, Tanriverdi H, Kose S, Amasyali B, Kilic A, Celik T, Turhan H. The relationship between heart rate recovery and heart rate variability in coronary artery disease. Ann Noninvasive Electrocardiol 2006;21:154-162
19. Klein E, Cnaani E, Harel T, Braun S, Ben-Haim SA. Altered heart rate variability in panic disorder patients. Biol Psychiatry 1995;37:18-24.
20. McCraty R, Atkinson M, Tomasino D, Stuppy WP. Analysis of twenty-four hour heart rate variability in patients with panic disorder. Biol Psychology 2001;56:131-150
21. Yeragani VK, Pohl R, Berger R, Balon R, Ramesh C, Glitz D, Srinivasan K, Weinberg P. Decreased heart rate variability in panic disorder patients: a study of power-spectral analysis of heart rate. Psychiatry Res 1993;46: 89-103.
22. Yeragani VK, Tancer M, Uhde T. Heart rate and QT interval variability: abnormal alpha-2 adrenergic function in patients with panic disorder. Psychiatry Res 2003;121:185-196
23. Gorman JM, Sloan RP. Heart rate variability in depressive and anxiety disorders. Am Heart J 2000;140:77-83.
24. Sullivan GM, Kent JM, Kleber M, Martinez JM, Yeragani VK, Gorman JM. Effects of hyperventilation on heart rate and QT variability in panic disorder pre and post-treatment. Psychiatry Res 2004;125:29-39.
25. Garakani A, Martinez JM, Aaronson CJ, Voustianiouk A, Kaufmann H, Gorman JM. Effect of medication and psychotherapy on heart rate variability in panic disorder. Depress Anxiety 2009;26:251-258
26. Akselrod S, Gordon D, Ubel FA, Shannon DC, Berger AC, Cohen RJ. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science 1981;213:220-222
27. Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E, et al. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res 1986; 59:178-193.
28. Lavoie KL, Fleet RP, Laurin C, Arsenault A, Miller SB, Bacon SL. Heart rate variability in coronary artery disease patients with and without panic disorder. Psychiatry Res 2004;128:289-299
29. Yeragani VK, Berger R, Pohl R, Srinivasan K, Balon R, Ramesh C, Weinberg P, Berchou R. Effects of yohimbine on heart rate variability in panic disorder patients and normal controls: a study of power spectral analysis of heart rate. J Cardiovasc Pharmacol 1992;20:609-618
30. Yeragani VK, Pohl R, Srinivasan K, Balon R, Ramesh C, Berchou R. Effects of isoproterenol infusions on heart rate variability in patients with panic disorder. Psychiatry Res 1995;56:289-293
31. Seier FE, Kellner M, Yassouridis A, Heese R, Strian F, Wiedemann K. Autonomic reactivity and hormonal secretion in lactate-induced panic attacks. Am J Physiol 1997;272:H2630-8.
32. Stein MB, Asmundson GJ. Autonomic function in panic disorder: cardiore-spiratory and plasma catecholamine responsivity to multiple challenges of the autonomic nervous system. Biol Psychiatry 1994;36:548-558
33. Alvarenga ME, Richards JC, Lambert G, Esler MD. Psychophysiological mechanisms in panic disorder: a correlative analysis of noradrenaline spillover, neuronal noradrenaline reuptake, power spectral analysis of heart rate variability, and psychological variables. Psychosom Med 2006;68:8-16.
34. Wilkinson DJ, Thompson JM, Lambert GW, Jennings GL, Schwarz RG, Jefferys D, Turner AG, Esler MD. Sympathetic activity in patients with panic disorder at rest, under laboratory mental stress, and during panic attacks. Arch Gen Psychiatry 1998;55:511-520
35. Grippo AJ, Johnson AK. Biological mechanisms in the relationship between depression and heart disease. Neurosci Biobehav Rev 2002;26:941-962
36. Smyth HS, Sleight P, Pickering GW. Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity. Circ Res 1969;24:109-121
37. Japundzic N, Grichois ML, Zitoun P, Laude D, Elghozi JL. Spectral analysis of blood pressure and heart rate in conscious rats: effects of autonomic blockers. J Auton Nerv Syst 1990;30:91-100.
38. Pagani M, Montano N, Porta A, Malliani A, Abboud FM, Birkett C, Somers VK. Relationship between spectral components of cardiovascular and direct measures of muscle sympathetic nerve activity in humans. Circulation 1997;95:1441-1448 (Pubitemid 27142801)
39. Cottin F, Papelier Y, Escourrou P. Effects of exercise load and breathing frequency on heart rate and blood pressure variability during dynamic exercise. Int J Sports Med 1999;20:232-238
40. Kouakam C, Lacroix D, Klug D, Baux P, Marquié C, Kacet S. Prevalence and prognostic significance of psychiatric disorders in patients evaluated for recurrent unexplained syncope. Am J Cardiol 2002;89:530-535
41. Piccirillo G, Elvira S, Bucca C, Viola E, Cacciafesta M, Marigliano V. Abnormal passive head-up tilt test in participants with symptoms of anxiety power spectral analysis study of heart rate and blood pressure. Int J Cardiol 1997;60:121-131
42. Ito T, Inoue Y, Sugihara T, Yamada H, Katayama S, Kawahara R. Autonomic function in the early stage of panic disorder: power spectral analysis of heart rate variability. Psychiatry Clin Neurosci 1999;53:667-672.
43. Virtanen R, Jula A, Salminen JK, Voipio-Pulkki LM, Helenius H, Kuu-sela T, Airaksinen J. Anxiety and hostility are associated with reduced baroreflex sensitivity and increased beat-to-beat blood pressure variability. Psychosom Med 2003;65:751-756
44. Coupland NJ, Wilson SJ, Potokar JP, Bell C, Nutt DJ. Increased sympathetic response to standing in panic disorder. Psychiatry Res 2003;118:69-79.
45. Shioiri T, Kojima-Maruyama M, Hosoki T, Kitamura H, Tanaka A, Yoshizawa M, Bando T, Someya T. Dysfunctional baroreflex regulation of sympathetic nerve activity in remitted patients with panic disorder. A new methodological approach. Eur Arch Psychiatry Clin Neurosci 2005; 255:293-298
46. Lambert EA, Thompson J, Schlaich M, Laude D, Elghozi JL, Esler MD, Lambert GW. Sympathetic and cardiac baroreflex function in panic disorder. J Hypertens 2002;20:2445-2451
47. Lambert E, Hotchkin E, Alvarenga M, Pier C, Richards J, Barton D, Dawood T, Esler M, Lambert G. Single-unit analysis of sympathetic nervous discharges in patients with panic disorder. J Physiol 2006;570: 637-643
48. Yeragani VK, Mallavarapu M, Radhakrishna RK, Tancer M, Uhde T. Linear and nonlinear measures of blood pressure variability: increased chaos of blood pressure time series in patients with panic disorder. Depress Anxiety 2004;19:85-95.
49. Thayer JF, Lane RD. The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol 2007;74:224-242
50. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Patient Edition (SCID-IP, 11/2002 Revision). Washington, DC: American Psychiatric Press; 2002.
51. Novak V, Novak P, De Champlain J, Le Blanc AR, Martin R, Nadeau R. Influence of respiration on heart rate and blood pressure fluctuations. J Appl Physiol 1993;74:617-626
52. Pitzalis MV, Mastropasqua F, Massari F, Passantino A, Colombo R, Mannarini A, Forleo C, Rizzon P. Effect of respiratory rate on the relationships between RR interval and systolic blood pressure fluctuations: a frequency-dependent phenomenon. Cardiovasc Res 1998; 38:332-339
53. Badra LJ, Cooke WH, Hoag JB, Crossman AA, Kuusela TA, Tahvanainen KU, Eckberg DL. Respiratory modulation of human autonomic rhythms. Am J Physiol Heart Circ Physiol 2001;280:H2674-88.
54. Pinna GD, Maestri R, La Rovere MT, Gobbi E, Fanfulla F. Effects of paced breathing on ventilatory and cardiovascular variability parameters during short-term investigation of autonomic function. Am J Physiol Heart Circ Physiol 2006;290:424-433
55. Task force of the European society of cardiology and the North American society of pacing and electrophysiology. Eur Heart J 1996; 17:354-381
56. Guy W. ECDEU Assessment Manual for Psychopharmacology, Revised. DHEW Publication No. ADM 76-338. Washington, DC: U.S. Government Printing Office; 1976.
57. Shear MK, Polan JJ, Harshfield G, Pickering T, Mann JJ, Frances A, James G. Ambulatory monitoring of blood pressure and heart rate in panic patients. J Anxiety Disord 1992;6:213-221
58. Hamilton M. The assessment of anxiety states by rating. Br J Psychiatry 1959;32:50-55
59. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.
60. Chambless DL, Caputo GC, Jasin SE, Gracely EJ, Williams C. The mobility inventory for agoraphobia. Behav Res Ther 1985;23:35-44.
61. Kohn PM, Macdonald JE. The survey of recent life experiences: a decontaminated hassles scale for adults. J Behav Med 1992;15:221-236.
62. Dillon DJ, Gorman JM, Liebowitz MR, Fyer AJ, Klein, DF. Measurement of lactate-induced panic and anxiety. Psychiatry Res 1987;20:97-105.
63. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982;14:377-381
64. Houtman IL, Bakker FC. The anxiety thermometer: a validation study. J Pers Assess 1989;53:575-582
65. Gorman JM, Kent JM, Sullivan GM, Coplan JD. Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 2000;157:493-505.
66. Klein DF. False suffocation alarm, spontaneous panic, and related conditions. An integrative hypothesis. Arch Gen Psychiatry 1993;50:306-317
67. Kawachi I, Sparrow D, Vokonas PS. Symptoms of anxiety and risk of coronary heart disease: the normative aging study. Circulation 1994;90: 2225-2229 (Pubitemid 24354305)