Does acidosis in brain play a role in Alzheimers disease?;Spielt die übersäuerung im gehirn eine zentrale rolle bei Alzheimer?

Neuropsychiatrie

Volumn 23, Issue 3, 2009, Pages 187-192

  Pirchl, Michael ^a   Humpel, Christian ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

amyloid; Acidosis; Alzheimers disease; Cell death; Vascular

Indexed keywords

AMYLOID BETA PROTEIN; CHOLESTEROL; HOMOCYSTEINE; LACTIC ACID; TAU PROTEIN;

ACIDOSIS; ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN ARTERY; BRAIN ISCHEMIA; CELL DEATH; HUMAN; INFLAMMATION; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK FACTOR;

ACIDOSIS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BLOOD-BRAIN BARRIER; BRAIN; BRAIN ISCHEMIA; CELL DEATH; CEREBRAL ARTERIES; CHOLESTEROL; HOMOCYSTEINE; HUMANS; INFLAMMATION; LACTIC ACID; NEURONS; RISK FACTORS; TAU PROTEINS;

EID: 79959346473     PISSN: 09486259     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Atwood CS, Moir RD, Huang X, Scarpa RC; Bacarra ME, Romano DM et al. Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem 1998; 273: 12817-12826. (Pubitemid 28246837)
2. Atwood CS, Obrenovich ME, Liu T, Chan H, Perry G, Smith MA et al. Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β. Brain Res Rev 2003; 43: 1-16. (Pubitemid 37130077)
3. Brewer GJ. Effects of acidosis on the distribution of processing of the β-amyloid prcursor protein in cultured hippocampal neurons. Mol Chem Neuropathol 1997; 31: 171-186.
4. Carrotta R, Manno M, Bulone D, Martotrana V, San Biagio PL. Protofibril formation of amyloid-protein at low pH via a noncooperative elongation mechanism. J Biol Chem 2005; 280: 30001-30008. (Pubitemid 41216175)
5. Erkinjuntti T, Roman G, Gauthier S et al. Emerging therapies for vascular dementia and vascular cognitive impairment. Stroke 2004; 35: 1010-1017. (Pubitemid 38419819)
6. Farkas E, Luiten PG. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol 2001; 64: 575-611. (Pubitemid 32304447)
7. Fillenz M. The role of lactate in brain metabolism. Neurochem Int 2005; 47: 413-417. (Pubitemid 41242622)
8. Hamel E. Cholinergic modulation of the cortical microvascular bed. Prog Brain Res 2004;145: 171-8. (Pubitemid 37442943)
9. Humpel C. "Alzheimer's disease - is it caused by cerebrovascular dysfunction?", Chapter 15, In: "Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging", Kenneth Maise (Editor), Oxford University Press, 2008, 369-402.
10. Humpel C. Cerebrovascular damage: a cause for Alzheimer's disease. Chapter I. In: "Ischemia-Reperfusion Pathways in Alzheimer's disease", Ryszard Pluta (Editor), Nova Science Publishers, p 1- 16, 2007; ISBN: 1-60021-744-3.
11. Humpel C. and Marksteiner J."Cerebrovascular damage as a cause for Alzheimer's disease?" Current Neurovascular Research 2 (2005) 341-347. (Pubitemid 41297371)
12. Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 2004; 5: 347-360. (Pubitemid 38568496)
13. Kalaria RN. The role of cerebral ischemia in Alzheimer's disease. Neurobiol Aging 2000; 21: 321-330. (Pubitemid 30387091)
14. Langa KM, Foster NL, Larson EB. Mixed dementia: Emerging concepts and therapeutic implications. JAMA 2004; 292: 2901-2908. (Pubitemid 39628238)
15. Li PA, Siesjo BK. Role of hyperglycaemia-related acidosis in ischemic brain damage. Acta Physiol Scand 1997; 161: 567-580. (Pubitemid 27515849)
16. Linden T, Skoog I, Fagerberg B et al. Cognitive impairment and dementia 20 months after stroke. Neuroepdemiology 2004; 23: 45-52. (Pubitemid 38142272)
17. Marksteiner J, Humpel C. Beta-amyloid expression, release and extracellular deposition in aged rat brain slices. Molecular Psychiatry 2008; 13: 939-952
18. Matsunaga Y, Fujii A, Yokotani J, Takakura T, Yamada T. Eight residue amyloid β peptides inhibit the aggregation and enzymatic activity of amyloid-β42. Regul Peptides 1994; 120: 227-236.
19. Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM. A dynamic relationship between intracellular and extracellular pools of β-amyloid. Am j Pathol 2006; 168: 184-194. (Pubitemid 43062572)
20. Pirchl M, Marksteiner J, Humpel C. Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance for vascular dementia and Alzheimer's disease. NeurolRes 2006; 28: 657-664. (Pubitemid 44433326)
21. Quast S. Säure-Basen-Haushalt. http://www.qualimedic.de/saeure- basen-haushalt.html 2008.
22. Rehncrona S. Brain acidosis. Ann Emerg Med 1985; 14: 770-776. (Pubitemid 15233320)
23. Siesjö BK. Lactic acidosis in the brain: Occurence, triggering mechanisms and pathophysiological importance. Ciba Found Symp 1982; 87: 77-100.
24. Siesjö BK, von Hanwehr R, Nergelius G, Nevander G, Ingvar M. Extra- and intracellular pH in the brain during seizures and in the recovery period following the arrest of seizure activity. J Cereb Blood Flow Metab 1985; 5: 47-57. (Pubitemid 15146558)
25. Siesjö BK. Acidosis and ischemic brain damage. Neurochem Pathol 1988; 9: 31-88. (Pubitemid 19164797)
26. Tanzi RE, Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 2005; 120: 545-555. (Pubitemid 40269768)
27. Vaucher E, Hamel E. Cholinergic basal fore-brain neurons project to cortical microvessels in the rat: Electron microscopic study with anterogradely transported Phaseolus vulgaris leucoagglutinin and choline acetyltransferase immunocytochemistry. J Neurosci 1995; 15: 7427-7441
28. Wirths O, Multhaup G, Bayer TA. A modified β-amyloid hypothesis: intraneuronal accumulation of β-amyloid peptide - the first step of a fatal cascade. J Neurochem 2004; 91: 513-520. (Pubitemid 39431147)
29. + exchanger Isoform 1 null mutant mouse brain. Neurosci 2003; 122: 37-46.
30. Yip AG, McKee AC, Green RC, Wells J, Young H, Cupples LA et al. APOE, vascular pathology, and the AD brain. Neurology 2005; 65: 259-265. (Pubitemid 41022371)