-
1
-
-
33645507413
-
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function
-
Artym, V.V., Y. Zhang, F. Seillier-Moiseiwitsch, K.M. Yamada, and S.C. Mueller. 2006. Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res. 66:3034-3043. http://dx.doi .org/10.1158/0008-5472.CAN-05-2177
-
(2006)
Cancer Res
, vol.66
, pp. 3034-3043
-
-
Artym, V.V.1
Zhang, Y.2
Seillier-Moiseiwitsch, F.3
Yamada, K.M.4
Mueller, S.C.5
-
2
-
-
35548963883
-
LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning
-
Asada, N., K. Sanada, and Y. Fukada. 2007. LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning. J. Neurosci. 27:11769-11775. http://dx.doi.org/ 10.1523/JNEUROSCI.1938-07.2007
-
(2007)
J. Neurosci
, vol.27
, pp. 11769-11775
-
-
Asada, N.1
Sanada, K.2
Fukada, Y.3
-
3
-
-
1542777034
-
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
-
Baas, A.F., J. Kuipers, N.N. van der Wel, E. Batlle, H.K. Koerten, P.J. Peters, and H.C. Clevers. 2004. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell. 116:457-466. http://dx.doi.org/10.1016/S0092-8674(04)00114-X
-
(2004)
Cell
, vol.116
, pp. 457-466
-
-
Baas, A.F.1
Kuipers, J.2
van der Wel, N.N.3
Batlle, E.4
Koerten, H.K.5
Peters, P.J.6
Clevers, H.C.7
-
4
-
-
84890070290
-
Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressoractivated NUAK kinases
-
Banerjee, S., S.J. Buhrlage, H.T. Huang, X. Deng, W. Zhou, J. Wang, R. Traynor, A.R. Prescott, D.R. Alessi, and N.S. Gray. 2014. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressoractivated NUAK kinases. Biochem. J. 457:215-225. http://dx.doi.org/10 .1042/BJ20131152
-
(2014)
Biochem. J
, vol.457
, pp. 215-225
-
-
Banerjee, S.1
Buhrlage, S.J.2
Huang, H.T.3
Deng, X.4
Zhou, W.5
Wang, J.6
Traynor, R.7
Prescott, A.R.8
Alessi, D.R.9
Gray, N.S.10
-
5
-
-
0037068461
-
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
-
Bardeesy, N., M. Sinha, A.F. Hezel, S. Signoretti, N.A. Hathaway, N.E. Sharpless, M. Loda, D.R. Carrasco, and R.A. DePinho. 2002. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 419:162-167. http://dx.doi.org/10.1038/nature01045
-
(2002)
Nature
, vol.419
, pp. 162-167
-
-
Bardeesy, N.1
Sinha, M.2
Hezel, A.F.3
Signoretti, S.4
Hathaway, N.A.5
Sharpless, N.E.6
Loda, M.7
Carrasco, D.R.8
DePinho, R.A.9
-
6
-
-
34247511497
-
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
-
Barnes, A.P., B.N. Lilley, Y.A. Pan, L.J. Plummer, A.W. Powell, A.N. Raines, J.R. Sanes, and F. Polleux. 2007. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell. 129:549-563. http://dx.doi.org/10.1016/j.cell.2007.03.025
-
(2007)
Cell
, vol.129
, pp. 549-563
-
-
Barnes, A.P.1
Lilley, B.N.2
Pan, Y.A.3
Plummer, L.J.4
Powell, A.W.5
Raines, A.N.6
Sanes, J.R.7
Polleux, F.8
-
7
-
-
18444389953
-
Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility
-
Bear, J.E., T.M. Svitkina, M. Krause, D.A. Schafer, J.J. Loureiro, G.A. Strasser, I.V. Maly, O.Y. Chaga, J.A. Cooper, G.G. Borisy, and F.B. Gertler. 2002. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell. 109:509-521. http://dx.doi.org/10.1016/ S0092-8674(02)00731-6
-
(2002)
Cell
, vol.109
, pp. 509-521
-
-
Bear, J.E.1
Svitkina, T.M.2
Krause, M.3
Schafer, D.A.4
Loureiro, J.J.5
Strasser, G.A.6
Maly, I.V.7
Chaga, O.Y.8
Cooper, J.A.9
Borisy, G.G.10
Gertler, F.B.11
-
8
-
-
84903822184
-
Automated analysis of invadopodia dynamics in live cells
-
Berginski, M.E., S.J. Creed, S. Cochran, D.W. Roadcap, J.E. Bear, and S.M. Gomez. 2014. Automated analysis of invadopodia dynamics in live cells. PeerJ. 2:e462. http://dx.doi.org/10.7717/peerj.462
-
(2014)
PeerJ
, vol.2
, pp. e462
-
-
Berginski, M.E.1
Creed, S.J.2
Cochran, S.3
Roadcap, D.W.4
Bear, J.E.5
Gomez, S.M.6
-
9
-
-
33745015018
-
Characterization of melanocyte-specific inducible Cre recombinase transgenic mice
-
Bosenberg, M., V. Muthusamy, D.P. Curley, Z. Wang, C. Hobbs, B. Nelson, C. Nogueira, J.W. Horner II, R. Depinho, and L. Chin. 2006. Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis. 44:262-267. http://dx.doi.org/10.1002/dvg.20205
-
(2006)
Genesis
, vol.44
, pp. 262-267
-
-
Bosenberg, M.1
Muthusamy, V.2
Curley, D.P.3
Wang, Z.4
Hobbs, C.5
Nelson, B.6
Nogueira, C.7
Horner II, J.W.8
Depinho, R.9
Chin, L.10
-
10
-
-
33847420825
-
Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge
-
Cai, L., T.W. Marshall, A.C. Uetrecht, D.A. Schafer, and J.E. Bear. 2007. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell. 128:915-929. http://dx.doi.org/10.1016/j.cell.2007.01.031
-
(2007)
Cell
, vol.128
, pp. 915-929
-
-
Cai, L.1
Marshall, T.W.2
Uetrecht, A.C.3
Schafer, D.A.4
Bear, J.E.5
-
11
-
-
52649120304
-
Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia
-
Cai, L., A.M. Makhov, D.A. Schafer, and J.E. Bear. 2008. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cell. 134:828-842. http://dx.doi.org/10.1016/j.cell.2008.06.054
-
(2008)
Cell
, vol.134
, pp. 828-842
-
-
Cai, L.1
Makhov, A.M.2
Schafer, D.A.3
Bear, J.E.4
-
12
-
-
77953238558
-
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors
-
Carretero, J., T. Shimamura, K. Rikova, A.L. Jackson, M.D. Wilkerson, C.L. Borgman, M.S. Buttarazzi, B.A. Sanofsky, K.L. McNamara, K.A. Brandstetter, et al. 2010. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell. 17:547-559. http://dx.doi.org/10.1016/j.ccr.2010.04.026
-
(2010)
Cancer Cell
, vol.17
, pp. 547-559
-
-
Carretero, J.1
Shimamura, T.2
Rikova, K.3
Jackson, A.L.4
Wilkerson, M.D.5
Borgman, C.L.6
Buttarazzi, M.S.7
Sanofsky, B.A.8
McNamara, K.L.9
Brandstetter, K.A.10
-
13
-
-
79953147370
-
A perspective on cancer cell metastasis
-
Chaffer, C.L., and R.A. Weinberg. 2011. A perspective on cancer cell metastasis. Science. 331:1559-1564. http://dx.doi.org/10.1126/science.1203543
-
(2011)
Science
, vol.331
, pp. 1559-1564
-
-
Chaffer, C.L.1
Weinberg, R.A.2
-
14
-
-
0028938832
-
Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains
-
Chapin, S.J., C.M. Lue, M.T. Yu, and J.C. Bulinski. 1995. Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains. Biochemistry. 34:2289-2301. http://dx.doi.org/10.1021/bi00007a025
-
(1995)
Biochemistry
, vol.34
, pp. 2289-2301
-
-
Chapin, S.J.1
Lue, C.M.2
Yu, M.T.3
Bulinski, J.C.4
-
15
-
-
0024414571
-
Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells
-
Chen, W.T. 1989. Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells. J. Exp. Zool. 251:167-185. http://dx.doi.org/10.1002/jez.1402510206
-
(1989)
J. Exp. Zool
, vol.251
, pp. 167-185
-
-
Chen, W.T.1
-
16
-
-
70349565231
-
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
-
Cheng, H., P. Liu, Z.C. Wang, L. Zou, S. Santiago, V. Garbitt, O.V. Gjoerup, J.D. Iglehart, A. Miron, A.L. Richardson, et al. 2009. SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. Sci. Signal. 2:ra35. http://dx.doi.org/10.1126/scisignal.2000369
-
(2009)
Sci. Signal
, vol.2
, pp. ra35
-
-
Cheng, H.1
Liu, P.2
Wang, Z.C.3
Zou, L.4
Santiago, S.5
Garbitt, V.6
Gjoerup, O.V.7
Iglehart, J.D.8
Miron, A.9
Richardson, A.L.10
-
17
-
-
77954362704
-
Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy
-
Chinnakkannu, P., V. Samanna, G. Cheng, Z. Ablonczy, C.F. Baicu, J.R. Bethard, D.R. Menick, D. Kuppuswamy, and G. Cooper IV. 2010. Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy. J. Biol. Chem. 285:21837-21848. http://dx.doi.org/10.1074/jbc.M110.120709
-
(2010)
J. Biol. Chem
, vol.285
, pp. 21837-21848
-
-
Chinnakkannu, P.1
Samanna, V.2
Cheng, G.3
Ablonczy, Z.4
Baicu, C.F.5
Bethard, J.R.6
Menick, D.R.7
Kuppuswamy, D.8
Cooper IV, G.9
-
18
-
-
0034141636
-
LKB1, a novel serine/ threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
-
Collins, S.P., J.L. Reoma, D.M. Gamm, and M.D. Uhler. 2000. LKB1, a novel serine/ threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem. J. 345:673-680. http://dx.doi.org/10.1042/0264-6021:3450673
-
(2000)
Biochem. J
, vol.345
, pp. 673-680
-
-
Collins, S.P.1
Reoma, J.L.2
Gamm, D.M.3
Uhler, M.D.4
-
19
-
-
38849193504
-
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
-
Contreras, C.M., S. Gurumurthy, J.M. Haynie, L.J. Shirley, E.A. Akbay, S.N. Wingo, J.O. Schorge, R.R. Broaddus, K.K. Wong, N. Bardeesy, and D.H. Castrillon. 2008. Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res. 68:759-766. http://dx.doi.org/ 10.1158/0008-5472.CAN-07-5014
-
(2008)
Cancer Res
, vol.68
, pp. 759-766
-
-
Contreras, C.M.1
Gurumurthy, S.2
Haynie, J.M.3
Shirley, L.J.4
Akbay, E.A.5
Wingo, S.N.6
Schorge, J.O.7
Broaddus, R.R.8
Wong, K.K.9
Bardeesy, N.10
Castrillon, D.H.11
-
20
-
-
84879401464
-
Terminal axon branching is regulated by the LKB1- NUAK1 kinase pathway via presynaptic mitochondrial capture
-
Courchet, J., T.L. Lewis Jr., S. Lee, V. Courchet, D.Y. Liou, S. Aizawa, and F. Polleux. 2013. Terminal axon branching is regulated by the LKB1- NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell. 153:1510-1525. http://dx.doi.org/10.1016/j.cell.2013.05.021
-
(2013)
Cell
, vol.153
, pp. 1510-1525
-
-
Courchet, J.1
Lewis Jr., T.L.2
Lee, S.3
Courchet, V.4
Liou, D.Y.5
Aizawa, S.6
Polleux, F.7
-
21
-
-
0027227425
-
Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength
-
DiMilla, P.A., J.A. Stone, J.A. Quinn, S.M. Albelda, and D.A. Lauffenburger. 1993. Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J. Cell Biol. 122:729-737. http://dx.doi.org/10.1083/jcb.122.3.729
-
(1993)
J. Cell Biol
, vol.122
, pp. 729-737
-
-
DiMilla, P.A.1
Stone, J.A.2
Quinn, J.A.3
Albelda, S.M.4
Lauffenburger, D.A.5
-
22
-
-
0030969575
-
MARK, a novel family of protein kinases that phosphorylate microtubule- associated proteins and trigger microtubule disruption
-
Drewes, G., A. Ebneth, U. Preuss, E.M. Mandelkow, and E. Mandelkow. 1997. MARK, a novel family of protein kinases that phosphorylate microtubule- associated proteins and trigger microtubule disruption. Cell. 89:297-308. http://dx.doi.org/10.1016/S0092-8674(00)80208-1
-
(1997)
Cell
, vol.89
, pp. 297-308
-
-
Drewes, G.1
Ebneth, A.2
Preuss, U.3
Mandelkow, E.M.4
Mandelkow, E.5
-
23
-
-
81855169565
-
Cancer invasion and the microenvironment: plasticity and reciprocity
-
Friedl, P., and S. Alexander. 2011. Cancer invasion and the microenvironment: plasticity and reciprocity. Cell. 147:992-1009. http://dx.doi.org/10.1016/ j.cell.2011.11.016
-
(2011)
Cell
, vol.147
, pp. 992-1009
-
-
Friedl, P.1
Alexander, S.2
-
24
-
-
0024336977
-
The E8 subfragment of laminin promotes locomotion of myoblasts over extracellular matrix
-
Goodman, S.L., G. Risse, and K. von der Mark. 1989. The E8 subfragment of laminin promotes locomotion of myoblasts over extracellular matrix. J. Cell Biol. 109:799-809. http://dx.doi.org/10.1083/jcb.109.2.799
-
(1989)
J. Cell Biol
, vol.109
, pp. 799-809
-
-
Goodman, S.L.1
Risse, G.2
von der Mark, K.3
-
25
-
-
84905568827
-
An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential
-
Goodwin, J.M., R.U. Svensson, H.J. Lou, M.M. Winslow, B.E. Turk, and R.J. Shaw. 2014. An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Mol. Cell. 55:436-450. http://dx.doi.org/10.1016/j.molcel.2014.06.021
-
(2014)
Mol. Cell
, vol.55
, pp. 436-450
-
-
Goodwin, J.M.1
Svensson, R.U.2
Lou, H.J.3
Winslow, M.M.4
Turk, B.E.5
Shaw, R.J.6
-
26
-
-
0033522144
-
Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/ STK11, in malignant melanoma
-
Guldberg, P., P. Thor Straten, V. Ahrenkiel, T. Seremet, A.F. Kirkin, and J. Zeuthen. 1999. Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/ STK11, in malignant melanoma. Oncogene. 18:1777-1780. http://dx.doi .org/10.1038/sj.onc.1202486
-
(1999)
Oncogene
, vol.18
, pp. 1777-1780
-
-
Guldberg, P.1
Thor Straten, P.2
Ahrenkiel, V.3
Seremet, T.4
Kirkin, A.F.5
Zeuthen, J.6
-
27
-
-
0029024475
-
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed.
-
Guo, S., and K.J. Kemphues. 1995. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 81:611-620. http://dx.doi.org/10.1016/ 0092-8674(95)90082-9
-
(1995)
Cell
, vol.81
, pp. 611-620
-
-
Guo, S.1
Kemphues, K.J.2
-
28
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D., and R.A. Weinberg. 2000. The hallmarks of cancer. Cell. 100:57- 70. http://dx.doi.org/10.1016/S0092-8674(00)81683-9
-
(2000)
Cell
, vol.100
, pp. 57- 70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
29
-
-
33744782567
-
Frequency and spectrum of cancers in the Peutz-Jeghers syndrome
-
Hearle, N., V. Schumacher, F.H. Menko, S. Olschwang, L.A. Boardman, J.J. Gille, J.J. Keller, A.M. Westerman, R.J. Scott, W. Lim, et al. 2006. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin. Cancer Res. 12:3209-3215. http://dx.doi.org/10.1158/1078-0432.CCR-06-0083
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 3209-3215
-
-
Hearle, N.1
Schumacher, V.2
Menko, F.H.3
Olschwang, S.4
Boardman, L.A.5
Gille, J.J.6
Keller, J.J.7
Westerman, A.M.8
Scott, R.J.9
Lim, W.10
-
30
-
-
0032495530
-
A serine/ threonine kinase gene defective in Peutz-Jeghers syndrome
-
Hemminki, A., D. Markie, I. Tomlinson, E. Avizienyte, S. Roth, A. Loukola, G. Bignell, W. Warren, M. Aminoff, P. Höglund, et al. 1998. A serine/ threonine kinase gene defective in Peutz-Jeghers syndrome. Nature. 391:184-187. http://dx.doi.org/10.1038/34432
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
Bignell, G.7
Warren, W.8
Aminoff, M.9
Höglund, P.10
-
31
-
-
39749194712
-
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
-
Hezel, A.F., S. Gurumurthy, Z. Granot, A. Swisa, G.C. Chu, G. Bailey, Y. Dor, N. Bardeesy, and R.A. Depinho. 2008. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol. Cell. Biol. 28:2414-2425. http://dx.doi.org/10.1128/MCB.01621-07
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 2414-2425
-
-
Hezel, A.F.1
Gurumurthy, S.2
Granot, Z.3
Swisa, A.4
Chu, G.C.5
Bailey, G.6
Dor, Y.7
Bardeesy, N.8
Depinho, R.A.9
-
32
-
-
60849106379
-
Second-harmonic generation in collagen as a potential cancer diagnostic parameter
-
Hompland, T., A. Erikson, M. Lindgren, T. Lindmo, and C. de Lange Davies. 2008. Second-harmonic generation in collagen as a potential cancer diagnostic parameter. J. Biomed. Opt. 13:054050. http://dx.doi.org/10.1117/ 1.2983664
-
(2008)
J. Biomed. Opt
, vol.13
, pp. 054050
-
-
Hompland, T.1
Erikson, A.2
Lindgren, M.3
Lindmo, T.4
de Lange Davies, C.5
-
33
-
-
84892933078
-
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
-
Houde, V.P., M.S. Ritorto, R. Gourlay, J. Varghese, P. Davies, N. Shpiro, K. Sakamoto, and D.R. Alessi. 2014. Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. Biochem. J. 458:41-56. http://dx.doi.org/10.1042/BJ20131324
-
(2014)
Biochem. J
, vol.458
, pp. 41-56
-
-
Houde, V.P.1
Ritorto, M.S.2
Gourlay, R.3
Varghese, J.4
Davies, P.5
Shpiro, N.6
Sakamoto, K.7
Alessi, D.R.8
-
34
-
-
0029965781
-
Phosphorylation of microtubuleassociated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.
-
Illenberger, S., G. Drewes, B. Trinczek, J. Biernat, H.E. Meyer, J.B. Olmsted, E.M. Mandelkow, and E. Mandelkow. 1996. Phosphorylation of microtubuleassociated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics. J. Biol. Chem. 271:10834-10843. http://dx.doi.org/10.1074/jbc.271.18.10834
-
(1996)
J. Biol. Chem
, vol.271
, pp. 10834-10843
-
-
Illenberger, S.1
Drewes, G.2
Trinczek, B.3
Biernat, J.4
Meyer, H.E.5
Olmsted, J.B.6
Mandelkow, E.M.7
Mandelkow, E.8
-
35
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
Jackson, E.L., N. Willis, K. Mercer, R.T. Bronson, D. Crowley, R. Montoya, T. Jacks, and D.A. Tuveson. 2001. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15:3243-3248. http://dx.doi.org/10.1101/gad.943001
-
(2001)
Genes Dev
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
Willis, N.2
Mercer, K.3
Bronson, R.T.4
Crowley, D.5
Montoya, R.6
Jacks, T.7
Tuveson, D.A.8
-
36
-
-
0000152018
-
Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance
-
Jeghers, H., V.A. McKusick, and K.H. Katz. 1949. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. N. Engl. J. Med. 241:1031-1036. http://dx.doi .org/10.1056/NEJM194912292412601
-
(1949)
N. Engl. J. Med
, vol.241
, pp. 1031-1036
-
-
Jeghers, H.1
McKusick, V.A.2
Katz, K.H.3
-
37
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
Ji, H., M.R. Ramsey, D.N. Hayes, C. Fan, K. McNamara, P. Kozlowski, C. Torrice, M.C. Wu, T. Shimamura, S.A. Perera, et al. 2007. LKB1 modulates lung cancer differentiation and metastasis. Nature. 448:807-810. http://dx.doi.org/10.1038/nature06030
-
(2007)
Nature
, vol.448
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
Torrice, C.7
Wu, M.C.8
Shimamura, T.9
Perera, S.A.10
-
38
-
-
0035734285
-
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
-
Jonkers, J., R. Meuwissen, H. van der Gulden, H. Peterse, M. van der Valk, and A. Berns. 2001. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat. Genet. 29:418-425. http://dx.doi.org/10.1038/ng747
-
(2001)
Nat. Genet
, vol.29
, pp. 418-425
-
-
Jonkers, J.1
Meuwissen, R.2
van der Gulden, H.3
Peterse, H.4
van der Valk, M.5
Berns, A.6
-
39
-
-
0024284814
-
Identification of genes required for cytoplasmic localization in early C. elegans embryos.
-
Kemphues, K.J., J.R. Priess, D.G. Morton, and N.S. Cheng. 1988. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell. 52:311-320. http://dx.doi.org/10.1016/S0092-8674(88)80024-2
-
(1988)
Cell
, vol.52
, pp. 311-320
-
-
Kemphues, K.J.1
Priess, J.R.2
Morton, D.G.3
Cheng, N.S.4
-
40
-
-
80052977483
-
Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis
-
Kline, E.R., S. Muller, L. Pan, M. Tighiouart, Z.G. Chen, and A.I. Marcus. 2011. Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis. Head Neck. 33:1501-1512. http://dx.doi.org/10.1002/ hed.21638
-
(2011)
Head Neck
, vol.33
, pp. 1501-1512
-
-
Kline, E.R.1
Muller, S.2
Pan, L.3
Tighiouart, M.4
Chen, Z.G.5
Marcus, A.I.6
-
41
-
-
0042622241
-
Further observations on LKB1/ STK11 status and cancer risk in Peutz-Jeghers syndrome
-
Lim, W., N. Hearle, B. Shah, V. Murday, S.V. Hodgson, A. Lucassen, D. Eccles, I. Talbot, K. Neale, A.G. Lim, et al. 2003. Further observations on LKB1/ STK11 status and cancer risk in Peutz-Jeghers syndrome. Br. J. Cancer. 89:308-313. http://dx.doi.org/10.1038/sj.bjc.6601030
-
(2003)
Br. J. Cancer
, vol.89
, pp. 308-313
-
-
Lim, W.1
Hearle, N.2
Shah, B.3
Murday, V.4
Hodgson, S.V.5
Lucassen, A.6
Eccles, D.7
Talbot, I.8
Neale, K.9
Lim, A.G.10
-
42
-
-
84880920112
-
Clinicopathologic correlations of liver kinase B1, E-cadherin, and N-cadherin expression in non-small cell lung cancer
-
Liu, S., Y. Miao, C. Fan, Y. Liu, J. Yu, Y. Zhang, S. Dai, and E. Wang. 2013. Clinicopathologic correlations of liver kinase B1, E-cadherin, and N-cadherin expression in non-small cell lung cancer. Appl. Immunohistochem. Mol. Morphol. 21:334-340. http://dx.doi.org/10.1097/PAI.0b013e31826b128b
-
(2013)
Appl. Immunohistochem. Mol. Morphol
, vol.21
, pp. 334-340
-
-
Liu, S.1
Miao, Y.2
Fan, C.3
Liu, Y.4
Yu, J.5
Zhang, Y.6
Dai, S.7
Wang, E.8
-
43
-
-
84862119127
-
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma
-
Liu, W., K.B. Monahan, A.D. Pfefferle, T. Shimamura, J. Sorrentino, K.T. Chan, D.W. Roadcap, D.W. Ollila, N.E. Thomas, D.H. Castrillon, et al. 2012. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell. 21:751-764. http://dx.doi.org/10 .1016/j.ccr.2012.03.048
-
(2012)
Cancer Cell
, vol.21
, pp. 751-764
-
-
Liu, W.1
Monahan, K.B.2
Pfefferle, A.D.3
Shimamura, T.4
Sorrentino, J.5
Chan, K.T.6
Roadcap, D.W.7
Ollila, D.W.8
Thomas, N.E.9
Castrillon, D.H.10
-
44
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano, J.M., O. Göransson, R. Toth, M. Deak, N.A. Morrice, J. Boudeau, S.A. Hawley, L. Udd, T.P. Mäkelä, D.G. Hardie, and D.R. Alessi. 2004. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 23:833-843. http://dx.doi.org/10 .1038/sj.emboj.7600110
-
(2004)
EMBO J
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Göransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Mäkelä, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
45
-
-
84872005418
-
Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
-
Lo, B., G. Strasser, M. Sagolla, C.D. Austin, M. Junttila, and I. Mellman. 2012. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways. J. Cell Biol. 199:1117-1130. http://dx.doi .org/10.1083/jcb.201208080
-
(2012)
J. Cell Biol
, vol.199
, pp. 1117-1130
-
-
Lo, B.1
Strasser, G.2
Sagolla, M.3
Austin, C.D.4
Junttila, M.5
Mellman, I.6
-
46
-
-
84880017102
-
The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells
-
Lucas, E.P., I. Khanal, P. Gaspar, G.C. Fletcher, C. Polesello, N. Tapon, and B.J. Thompson. 2013. The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells. J. Cell Biol. 201:875-885. http://dx.doi.org/10.1083/jcb.201210073
-
(2013)
J. Cell Biol
, vol.201
, pp. 875-885
-
-
Lucas, E.P.1
Khanal, I.2
Gaspar, P.3
Fletcher, G.C.4
Polesello, C.5
Tapon, N.6
Thompson, B.J.7
-
47
-
-
0037442953
-
Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment
-
Magdalena, J., T.H. Millard, and L.M. Machesky. 2003. Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment. J. Cell Sci. 116:743-756. http://dx.doi.org/10.1242/jcs.00288
-
(2003)
J. Cell Sci
, vol.116
, pp. 743-756
-
-
Magdalena, J.1
Millard, T.H.2
Machesky, L.M.3
-
48
-
-
78650465738
-
LKB1 regulated pathways in lung cancer invasion and metastasis
-
Marcus, A.I., and W. Zhou. 2010. LKB1 regulated pathways in lung cancer invasion and metastasis. J. Thorac. Oncol. 5:1883-1886. http://dx.doi.org/ 10.1097/JTO.0b013e3181fbc28a
-
(2010)
J. Thorac. Oncol
, vol.5
, pp. 1883-1886
-
-
Marcus, A.I.1
Zhou, W.2
-
49
-
-
0037461735
-
A role for Drosophila LKB1 in anteriorposterior axis formation and epithelial polarity
-
Martin, S.G., and D. St Johnston. 2003. A role for Drosophila LKB1 in anteriorposterior axis formation and epithelial polarity. Nature. 421:379-384. http://dx.doi.org/10.1038/nature01296
-
(2003)
Nature
, vol.421
, pp. 379-384
-
-
Martin, S.G.1
Johnston St, D.2
-
50
-
-
77953510471
-
Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases
-
Marx, A., C. Nugoor, S. Panneerselvam, and E. Mandelkow. 2010. Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases. FASEB J. 24:1637-1648. http:// dx.doi.org/10.1096/fj.09-148064
-
(2010)
FASEB J
, vol.24
, pp. 1637-1648
-
-
Marx, A.1
Nugoor, C.2
Panneerselvam, S.3
Mandelkow, E.4
-
51
-
-
70350436136
-
Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation
-
McCarthy, A., C.J. Lord, K. Savage, A. Grigoriadis, D.P. Smith, B. Weigelt, J.S. Reis-Filho, and A. Ashworth. 2009. Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J. Pathol. 219:306-316. http://dx.doi.org/10.1002/path.2599
-
(2009)
J. Pathol
, vol.219
, pp. 306-316
-
-
McCarthy, A.1
Lord, C.J.2
Savage, K.3
Grigoriadis, A.4
Smith, D.P.5
Weigelt, B.6
Reis-Filho, J.S.7
Ashworth, A.8
-
52
-
-
83755188070
-
MARK2/Par-1 guides the directionality of neuroblasts migrating to the olfactory bulb
-
Mejia-Gervacio, S., K. Murray, T. Sapir, R. Belvindrah, O. Reiner, and P.M. Lledo. 2012. MARK2/Par-1 guides the directionality of neuroblasts migrating to the olfactory bulb. Mol. Cell. Neurosci. 49:97-103. http:// dx.doi.org/10.1016/j.mcn.2011.10.006
-
(2012)
Mol. Cell. Neurosci
, vol.49
, pp. 97-103
-
-
Mejia-Gervacio, S.1
Murray, K.2
Sapir, T.3
Belvindrah, R.4
Reiner, O.5
Lledo, P.M.6
-
53
-
-
71049143563
-
Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice
-
Miyoshi, H., A. Deguchi, M. Nakau, Y. Kojima, A. Mori, M. Oshima, M. Aoki, and M.M. Taketo. 2009. Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice. Cancer Sci. 100:2046-2053. http://dx.doi.org/10.1111/j.1349-7006.2009.01284.x
-
(2009)
Cancer Sci
, vol.100
, pp. 2046-2053
-
-
Miyoshi, H.1
Deguchi, A.2
Nakau, M.3
Kojima, Y.4
Mori, A.5
Oshima, M.6
Aoki, M.7
Taketo, M.M.8
-
54
-
-
84891345748
-
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway
-
Mohseni, M., J. Sun, A. Lau, S. Curtis, J. Goldsmith, V.L. Fox, C. Wei, M. Frazier, O. Samson, K.K. Wong, et al. 2014. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat. Cell Biol. 16:108-117. http://dx.doi.org/10.1038/ncb2884
-
(2014)
Nat. Cell Biol
, vol.16
, pp. 108-117
-
-
Mohseni, M.1
Sun, J.2
Lau, A.3
Curtis, S.4
Goldsmith, J.5
Fox, V.L.6
Wei, C.7
Frazier, M.8
Samson, O.9
Wong, K.K.10
-
55
-
-
78049345763
-
Somatic p16(INK4a) loss accelerates melanomagenesis
-
Monahan, K.B., G.I. Rozenberg, J. Krishnamurthy, S.M. Johnson, W. Liu, M.K. Bradford, J. Horner, R.A. Depinho, and N.E. Sharpless. 2010. Somatic p16(INK4a) loss accelerates melanomagenesis. Oncogene. 29:5809- 5817. http://dx.doi.org/10.1038/onc.2010.314
-
(2010)
Oncogene
, vol.29
, pp. 5809- 5817
-
-
Monahan, K.B.1
Rozenberg, G.I.2
Krishnamurthy, J.3
Johnson, S.M.4
Liu, W.5
Bradford, M.K.6
Horner, J.7
Depinho, R.A.8
Sharpless, N.E.9
-
56
-
-
66349125397
-
Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during plateletderived growth factor-dependent chemotaxis
-
Monypenny, J., D. Zicha, C. Higashida, F. Oceguera-Yanez, S. Narumiya, and N. Watanabe. 2009. Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during plateletderived growth factor-dependent chemotaxis. Mol. Cell. Biol. 29:2730- 2747. http://dx.doi.org/10.1128/MCB.01285-08
-
(2009)
Mol. Cell. Biol
, vol.29
, pp. 2730- 2747
-
-
Monypenny, J.1
Zicha, D.2
Higashida, C.3
Oceguera-Yanez, F.4
Narumiya, S.5
Watanabe, N.6
-
57
-
-
46249106990
-
Mapping and quantifying mammalian transcriptomes by RNA-Seq
-
Mortazavi, A., B.A. Williams, K. McCue, L. Schaeffer, and B. Wold. 2008. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat. Methods. 5:621-628. http://dx.doi.org/10.1038/nmeth.1226
-
(2008)
Nat. Methods
, vol.5
, pp. 621-628
-
-
Mortazavi, A.1
Williams, B.A.2
McCue, K.3
Schaeffer, L.4
Wold, B.5
-
58
-
-
84883488932
-
LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap
-
Nguyen, H.B., J.T. Babcock, C.D. Wells, and L.A. Quilliam. 2013. LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap. Oncogene. 32:4100-4109. http://dx.doi.org/10.1038/onc.2012.431
-
(2013)
Oncogene
, vol.32
, pp. 4100-4109
-
-
Nguyen, H.B.1
Babcock, J.T.2
Wells, C.D.3
Quilliam, L.A.4
-
59
-
-
0034988818
-
Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma
-
Olschwang, S., C. Boisson, and G. Thomas. 2001. Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma. J. Med. Genet. 38:356-360. http://dx.doi.org/10 .1136/jmg.38.6.356
-
(2001)
J. Med. Genet
, vol.38
, pp. 356-360
-
-
Olschwang, S.1
Boisson, C.2
Thomas, G.3
-
60
-
-
84863721162
-
Enhanced antitumor effect of cisplatin in human NSCLC cells by tumor suppressor LKB1
-
Ou, W., S. Ye, W. Yang, Y. Wang, Q. Ma, C. Yu, H. Shi, Z. Yuan, G. Zhong, J. Ren, et al. 2012. Enhanced antitumor effect of cisplatin in human NSCLC cells by tumor suppressor LKB1. Cancer Gene Ther. 19:489- 498. http://dx.doi.org/10.1038/cgt.2012.18
-
(2012)
Cancer Gene Ther
, vol.19
, pp. 489- 498
-
-
Ou, W.1
Ye, S.2
Yang, W.3
Wang, Y.4
Ma, Q.5
Yu, C.6
Shi, H.7
Yuan, Z.8
Zhong, G.9
Ren, J.10
-
61
-
-
84857132136
-
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity
-
Partanen, J.I., T.A. Tervonen, M. Myllynen, E. Lind, M. Imai, P. Katajisto, G.J. Dijkgraaf, P.E. Kovanen, T.P. Mäkelä, Z. Werb, and J. Klefström. 2012. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc. Natl. Acad. Sci. USA. 109:E388- E397. http://dx.doi.org/10.1073/pnas.1120421109
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E388- E397
-
-
Partanen, J.I.1
Tervonen, T.A.2
Myllynen, M.3
Lind, E.4
Imai, M.5
Katajisto, P.6
Dijkgraaf, G.J.7
Kovanen, P.E.8
Mäkelä, T.P.9
Werb, Z.10
Klefström, J.11
-
62
-
-
68049083547
-
Random versus directionally persistent cell migration
-
Petrie, R.J., A.D. Doyle, and K.M. Yamada. 2009. Random versus directionally persistent cell migration. Nat. Rev. Mol. Cell Biol. 10:538-549. http:// dx.doi.org/10.1038/nrm2729
-
(2009)
Nat. Rev. Mol. Cell Biol
, vol.10
, pp. 538-549
-
-
Petrie, R.J.1
Doyle, A.D.2
Yamada, K.M.3
-
63
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
Pfaffl, M.W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45. http://dx.doi.org/10.1093/ nar/29.9.e45
-
(2001)
Nucleic Acids Res
, vol.29
, pp. e45
-
-
Pfaffl, M.W.1
-
64
-
-
0344305784
-
Cell migration: integrating signals from front to back
-
Ridley, A.J., M.A. Schwartz, K. Burridge, R.A. Firtel, M.H. Ginsberg, G. Borisy, J.T. Parsons, and A.R. Horwitz. 2003. Cell migration: integrating signals from front to back. Science. 302:1704-1709. http://dx.doi.org/ 10.1126/science.1092053
-
(2003)
Science
, vol.302
, pp. 1704-1709
-
-
Ridley, A.J.1
Schwartz, M.A.2
Burridge, K.3
Firtel, R.A.4
Ginsberg, M.H.5
Borisy, G.6
Parsons, J.T.7
Horwitz, A.R.8
-
65
-
-
84869098775
-
Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis
-
Rodríguez-Fraticelli, A.E., M. Auzan, M.A. Alonso, M. Bornens, and F. Martín-Belmonte. 2012. Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis. J. Cell Biol. 198:1011-1023. http://dx.doi.org/10.1083/jcb.201203075
-
(2012)
J. Cell Biol
, vol.198
, pp. 1011-1023
-
-
Rodríguez-Fraticelli, A.E.1
Auzan, M.2
Alonso, M.A.3
Bornens, M.4
Martín-Belmonte, F.5
-
66
-
-
0032908579
-
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas
-
Rowan, A., V. Bataille, R. MacKie, E. Healy, D. Bicknell, W. Bodmer, and I. Tomlinson. 1999. Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas. J. Invest. Dermatol. 112:509- 511. http://dx.doi.org/10.1046/j.1523-1747.1999.00551.x
-
(1999)
J. Invest. Dermatol
, vol.112
, pp. 509- 511
-
-
Rowan, A.1
Bataille, V.2
MacKie, R.3
Healy, E.4
Bicknell, D.5
Bodmer, W.6
Tomlinson, I.7
-
67
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
-
Sanchez-Cespedes, M., P. Parrella, M. Esteller, S. Nomoto, B. Trink, J.M. Engles, W.H. Westra, J.G. Herman, and D. Sidransky. 2002. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res. 62:3659-3662.
-
(2002)
Cancer Res.
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
Westra, W.H.7
Herman, J.G.8
Sidransky, D.9
-
68
-
-
45949103263
-
Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration
-
Sapir, T., S. Sapoznik, T. Levy, D. Finkelshtein, A. Shmueli, T. Timm, E.M. Mandelkow, and O. Reiner. 2008. Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration. J. Neurosci. 28:5710-5720. http://dx.doi.org/10.1523/JNEUROSCI.0911-08.2008
-
(2008)
J. Neurosci
, vol.28
, pp. 5710-5720
-
-
Sapir, T.1
Sapoznik, S.2
Levy, T.3
Finkelshtein, D.4
Shmueli, A.5
Timm, T.6
Mandelkow, E.M.7
Reiner, O.8
-
69
-
-
0035375261
-
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth
-
Sapkota, G.P., A. Kieloch, J.M. Lizcano, S. Lain, J.S. Arthur, M.R. Williams, N. Morrice, M. Deak, and D.R. Alessi. 2001. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J. Biol. Chem. 276:19469-19482. http://dx.doi.org/10.1074/jbc.M009953200
-
(2001)
J. Biol. Chem
, vol.276
, pp. 19469-19482
-
-
Sapkota, G.P.1
Kieloch, A.2
Lizcano, J.M.3
Lain, S.4
Arthur, J.S.5
Williams, M.R.6
Morrice, N.7
Deak, M.8
Alessi, D.R.9
-
70
-
-
47949100705
-
Endothelial cell polarization and chemotaxis in a microfluidic device
-
Shamloo, A., N. Ma, M.M. Poo, L.L. Sohn, and S.C. Heilshorn. 2008. Endothelial cell polarization and chemotaxis in a microfluidic device. Lab Chip. 8:1292-1299. http://dx.doi.org/10.1039/b719788h
-
(2008)
Lab Chip
, vol.8
, pp. 1292-1299
-
-
Shamloo, A.1
Ma, N.2
Poo, M.M.3
Sohn, L.L.4
Heilshorn, S.C.5
-
71
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling.
-
Shaw, R.J., N. Bardeesy, B.D. Manning, L. Lopez, M. Kosmatka, R.A. DePinho, and L.C. Cantley. 2004a. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 6:91-99. http://dx.doi.org/10.1016/ j.ccr.2004.06.007
-
(2004)
Cancer Cell.
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
Cantley, L.C.7
-
72
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
-
Shaw, R.J., M. Kosmatka, N. Bardeesy, R.L. Hurley, L.A. Witters, R.A. DePinho, and L.C. Cantley. 2004b. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. USA. 101:3329-3335. http://dx.doi.org/ 10.1073/pnas.0308061100
-
(2004)
Proc. Natl. Acad. Sci. USA.
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
73
-
-
34247478454
-
LKB1/ STRAD promotes axon initiation during neuronal polarization
-
Shelly, M., L. Cancedda, S. Heilshorn, G. Sumbre, and M.M. Poo. 2007. LKB1/ STRAD promotes axon initiation during neuronal polarization. Cell. 129:565-577. http://dx.doi.org/10.1016/j.cell.2007.04.012
-
(2007)
Cell
, vol.129
, pp. 565-577
-
-
Shelly, M.1
Cancedda, L.2
Heilshorn, S.3
Sumbre, G.4
Poo, M.M.5
-
74
-
-
0032984141
-
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers
-
Su, G.H., R.H. Hruban, R.K. Bansal, G.S. Bova, D.J. Tang, M.C. Shekher, A.M. Westerman, M.M. Entius, M. Goggins, C.J. Yeo, and S.E. Kern. 1999. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am. J. Pathol. 154:1835-1840. http:// dx.doi.org/10.1016/S0002-9440(10)65440-5
-
(1999)
Am. J. Pathol
, vol.154
, pp. 1835-1840
-
-
Su, G.H.1
Hruban, R.H.2
Bansal, R.K.3
Bova, G.S.4
Tang, D.J.5
Shekher, M.C.6
Westerman, A.M.7
Entius, M.M.8
Goggins, M.9
Yeo, C.J.10
Kern, S.E.11
-
75
-
-
82355171931
-
Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/ fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential
-
Timm, T., J.P. von Kries, X. Li, H. Zempel, E. Mandelkow, and E.M. Mandelkow. 2011. Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/ fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential. J. Biol. Chem. 286:41711-41722. http://dx.doi.org/10 .1074/jbc.M111.257865
-
(2011)
J. Biol. Chem
, vol.286
, pp. 41711-41722
-
-
Timm, T.1
von Kries, J.P.2
Li, X.3
Zempel, H.4
Mandelkow, E.5
Mandelkow, E.M.6
-
76
-
-
38449089459
-
Generation of multicellular tumor spheroids by the hanging-drop method
-
Timmins, N.E., and L.K. Nielsen. 2007. Generation of multicellular tumor spheroids by the hanging-drop method. Methods Mol. Med. 140:141-151. http://dx.doi.org/10.1007/978-1-59745-443-8_8
-
(2007)
Methods Mol. Med
, vol.140
, pp. 141-151
-
-
Timmins, N.E.1
Nielsen, L.K.2
-
77
-
-
65449136284
-
TopHat: discovering splice junctions with RNA-Seq
-
Trapnell, C., L. Pachter, and S.L. Salzberg. 2009. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 25:1105-1111. http://dx.doi.org/ 10.1093/bioinformatics/btp120
-
(2009)
Bioinformatics
, vol.25
, pp. 1105-1111
-
-
Trapnell, C.1
Pachter, L.2
Salzberg, S.L.3
-
78
-
-
0034090975
-
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.
-
Watts, J.L., D.G. Morton, J. Bestman, and K.J. Kemphues. 2000. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development. 127:1467-1475.
-
(2000)
Development.
, vol.127
, pp. 1467-1475
-
-
Watts, J.L.1
Morton, D.G.2
Bestman, J.3
Kemphues, K.J.4
-
79
-
-
64549113040
-
Somatic LKB1 mutations promote cervical cancer progression
-
Wingo, S.N., T.D. Gallardo, E.A. Akbay, M.C. Liang, C.M. Contreras, T. Boren, T. Shimamura, D.S. Miller, N.E. Sharpless, N. Bardeesy, et al. 2009. Somatic LKB1 mutations promote cervical cancer progression. PLoS ONE. 4:e5137. http://dx.doi.org/10.1371/journal.pone.0005137
-
(2009)
PLoS ONE
, vol.4
, pp. e5137
-
-
Wingo, S.N.1
Gallardo, T.D.2
Akbay, E.A.3
Liang, M.C.4
Contreras, C.M.5
Boren, T.6
Shimamura, T.7
Miller, D.S.8
Sharpless, N.E.9
Bardeesy, N.10
-
80
-
-
84863229890
-
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis
-
Wu, C., S.B. Asokan, M.E. Berginski, E.M. Haynes, N.E. Sharpless, J.D. Griffith, S.M. Gomez, and J.E. Bear. 2012. Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell. 148:973-987. http://dx.doi.org/10.1016/j.cell.2011.12.034
-
(2012)
Cell
, vol.148
, pp. 973-987
-
-
Wu, C.1
Asokan, S.B.2
Berginski, M.E.3
Haynes, E.M.4
Sharpless, N.E.5
Griffith, J.D.6
Gomez, S.M.7
Bear, J.E.8
-
81
-
-
18744381001
-
Neutrophil microtubules suppress polarity and enhance directional migration
-
Xu, J., F. Wang, A. Van Keymeulen, M. Rentel, and H.R. Bourne. 2005. Neutrophil microtubules suppress polarity and enhance directional migration. Proc. Natl. Acad. Sci. USA. 102:6884-6889. http://dx.doi.org/10 .1073/pnas.0502106102
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 6884-6889
-
-
Xu, J.1
Wang, F.2
Van Keymeulen, A.3
Rentel, M.4
Bourne, H.R.5
-
82
-
-
13444301091
-
Molecular mechanisms of invadopodium formation: the role of the NWASP- Arp2/3 complex pathway and cofilin
-
Yamaguchi, H., M. Lorenz, S. Kempiak, C. Sarmiento, S. Coniglio, M. Symons, J. Segall, R. Eddy, H. Miki, T. Takenawa, and J. Condeelis. 2005. Molecular mechanisms of invadopodium formation: the role of the NWASP- Arp2/3 complex pathway and cofilin. J. Cell Biol. 168:441-452. http://dx.doi.org/10.1083/jcb.200407076
-
(2005)
J. Cell Biol
, vol.168
, pp. 441-452
-
-
Yamaguchi, H.1
Lorenz, M.2
Kempiak, S.3
Sarmiento, C.4
Coniglio, S.5
Symons, M.6
Segall, J.7
Eddy, R.8
Miki, H.9
Takenawa, T.10
Condeelis, J.11
-
83
-
-
84455161860
-
Polarityregulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoAdependent actin cytoskeletal reorganization
-
Yamahashi, Y., Y. Saito, N. Murata-Kamiya, and M. Hatakeyama. 2011. Polarityregulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoAdependent actin cytoskeletal reorganization. J. Biol. Chem. 286:44576- 44584. http://dx.doi.org/10.1074/jbc.M111.267021
-
(2011)
J. Biol. Chem
, vol.286
, pp. 44576-44584
-
-
Yamahashi, Y.1
Saito, Y.2
Murata-Kamiya, N.3
Hatakeyama, M.4
-
84
-
-
77953653569
-
New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion
-
Zagórska, A., M. Deak, D.G. Campbell, S. Banerjee, M. Hirano, S. Aizawa, A.R. Prescott, and D.R. Alessi. 2010. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci. Signal. 3:ra25. http://dx.doi.org/10.1126/scisignal.2000616
-
(2010)
Sci. Signal
, vol.3
, pp. ra25
-
-
Zagórska, A.1
Deak, M.2
Campbell, D.G.3
Banerjee, S.4
Hirano, M.5
Aizawa, S.6
Prescott, A.R.7
Alessi, D.R.8
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