Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: Inhibitors with therapeutic potential

Journal of Biological Chemistry

Volumn 286, Issue 48, 2011, Pages 41711-41722

  Timm, Thomas ^a   Von Kries, Jens Peter ^b   Li, Xiaoyu ^a,d   Zempel, Hans ^a,c   Mandelkow, Eckhard ^a,c   Mandelkow, Eva Maria ^a,c  

^a MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY-BASED; ALZHEIMER DISEASE; BRAIN DISEASE; CELL CYCLE CONTROL; CULTURED CELL; DONOR AND ACCEPTOR; FLUORESCENCE LIFETIME IMAGING; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT PROTEIN; GROWTH CONES; INHIBITION EFFICIENCY; INHIBITORY ACTIVITY; INTRACELLULAR SIGNALS; KINASE ACTIVITY; MICROMOLAR RANGE; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULES; PROTEIN KINASE; SCAFFOLD PROTEIN; SPECIFIC INHIBITORS; TARGET SEQUENCES; THERAPEUTIC POTENTIALS; YELLOW FLUORESCENT PROTEINS;

BIOSENSORS; ENZYMES; FLUORESCENCE; LEAD COMPOUNDS; NEURONS; PHOSPHORYLATION; PROTEINS; SIGNAL TRANSDUCTION;

SCAFFOLDS (BIOLOGY);

CYAN FLUORESCENT PROTEIN; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 5; FLUORESCENT DYE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MICROTUBULE AFFINITY REGULATING KINASE; MICROTUBULE AFFINITY REGULATING KINASE 2; MICROTUBULE AFFINITY REGULATING KINASE ACTIVATING KINASE; MICROTUBULE AFFINITY REGULATING KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN 14 3 3; REAGENT; SAD KINASE B; SCAFFOLD PROTEIN; TAU PROTEIN; TEAL FLUORESCENT PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ARTICLE; BIOSENSOR; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS REACTION; ENZYME ACTIVITY; ENZYME LOCALIZATION; FLUORESCENCE LIFETIME MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GROWTH CONE; IC 50; IMAGING SYSTEM; MICROTUBULE; NERVE CELL; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; RAT; SCREENING;

14-3-3 PROTEINS; ANIMALS; BIOSENSING TECHNIQUES; CELL DIFFERENTIATION; CHO CELLS; CRICETINAE; CRICETULUS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GREEN FLUORESCENT PROTEINS; GROWTH CONES; HUMANS; MICROTUBULES; PC12 CELLS; PROTEIN-SERINE-THREONINE KINASES; RATS;

EID: 82355171931     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.257865     Document Type: Article

References (44)

1. Kemphues, K. (2000) Cell 101, 345-348
2. Nance, J. (2005) Bioessays 27, 126-135
3. Shulman, J. M., Benton, R., and St. Johnston, D. (2000) Cell 101, 377-388
4. Cohen, D., Brennwald, P. J., Rodriguez-Boulan, E., and Müsch, A. (2004) J. Cell Biol. 164, 717-727
5. Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E. M., and Mandelkow, E. (1997) Cell 89, 297-308
6. Ebneth, A., Drewes, G., Mandelkow, E. M., and Mandelkow, E. (1999) Cell Motil. Cytoskeleton 44, 209-224
7. Schaar, B. T., Kinoshita, K., and McConnell, S. K. (2004) Neuron 41, 203-213
8. Peng, C. Y., Graves, P. R., Ogg, S., Thoma, R. S., Byrnes, M. J., 3rd, Wu, Z., Stephenson, M. T., and Piwnica-Worms, H. (1998) Cell Growth Differ. 9, 197-208
9. Müller, J., Ory, S., Copeland, T., Piwnica-Worms, H., and Morrison, D. K. (2001) Mol. Cell 8, 983-993
10. Matenia, D., and Mandelkow, E. M. (2009) Trends Biochem. Sci. 34, 332-342
11. Sapir, T., Shmueli, A., Levy, T., Timm, T., Elbaum, M., Mandelkow, E. M., and Reiner, O. (2008) J. Neurosci. 28, 13008-13013
12. Mandelkow, E. M., Thies, E., Trinczek, B., Biernat, J., and Mandelkow, E. (2004) J. Cell Biol. 167, 99-110
13. Panneerselvam, S., Marx, A., Mandelkow, E. M., and Mandelkow, E. (2006) Structure 14, 173-183
14. Tochio, N., Koshiba, S., Kobayashi, N., Inoue, M., Yabuki, T., Aoki, M., Seki, E., Matsuda, T., Tomo, Y., Motoda, Y., Kobayashi, A., Tanaka, A., Hayashizaki, Y., Terada, T., Shirouzu, M., Kigawa, T., and Yokoyama, S. (2006) Protein Sci. 15, 2534-2543
15. Manning, G., Whyte, D. B., Martinez, R., Hunter, T., and Sudarsanam, S. (2002) Science 298, 1912-1934
16. Barnes, A. P., Lilley, B. N., Pan, Y. A., Plummer, L. J., Powell, A. W., Raines, A. N., Sanes, J. R., and Polleux, F. (2007) Cell 129, 549-563
17. Timm, T., Li, X. Y., Biernat, J., Jiao, J., Mandelkow, E., Vandekerckhove, J., and Mandelkow, E. M. (2003) EMBO J. 22, 5090-5101
18. Lizcano, J. M., Göransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S. A., Udd, L., Mäkelä, T. P., Hardie, D. G., and Alessi, D. R. (2004) EMBO J. 23, 833-843
19. Timm, T., Balusamy, K., Li, X., Biernat, J., Mandelkow, E., and Mandelkow, E. M. (2008) J. Biol. Chem. 283, 18873-18882
20. Matenia, D., Griesshaber, B., Li, X. Y., Thiessen, A., Johne, C., Jiao, J., Mandelkow, E., and Mandelkow, E. M. (2005) Mol. Biol. Cell 16, 4410-4422
21. Johne, C., Matenia, D., Li, X. Y., Timm, T., Balusamy, K., and Mandelkow, E. M. (2008) Mol. Biol. Cell. 19, 1391-1403
22. Benton, R., Palacios, I. M., and St, Johnston, D. (2002) Dev. Cell 3, 659-671
23. Biernat, J., Wu, Y. Z., Timm, T., Zheng-Fischhöfer, Q., Mandelkow, E., Meijer, L., and Mandelkow, E. M. (2002) Mol. Biol. Cell 13, 4013-4028
24. Stamer, K., Vogel, R., Thies, E., Mandelkow, E., and Mandelkow, E. M. (2002) J. Cell Biol. 156, 1051-1063
25. Augustinack, J. C., Schneider, A., Mandelkow, E. M., and Hyman, B. T. (2002) Acta Neuropath. 103, 26-35
26. Chin, J. Y., Knowles, R. B., Schneider, A., Drewes, G., Mandelkow, E. M., and Hyman, B. T. (2000) J. Neuropath. Exp. Neurol. 59, 966-971
27. Eckermann, K., Mocanu, M. M., Khlistunova, I., Biernat, J., Nissen, A., Hofmann, A., Schönig, K., Bujard, H., Haemisch, A., Mandelkow, E., Zhou, L., Rune, G., and Mandelkow, E. M. (2007) J. Biol. Chem. 282, 31755-31765
28. Mocanu, M. M., Nissen, A., Eckermann, K., Khlistunova, I., Biernat, J., Drexler, D., Petrova, O., Schönig, K., Bujard, H., Mandelkow, E., Zhou, L., Rune, G., and Mandelkow, E. M. (2008) J. Neurosci. 28, 737-748
29. Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., McLauchlan, H., Klevernic, I., Arthur, J. S., Alessi, D. R., and Cohen, P. (2007) Biochem. J. 408, 297-315
30. Lisurek, M., Rupp, B., Wichard, J., Neuenschwander, M., von Kries, J. P., Frank, R., Rademann, J., and Kühne, R. (2010) Mol. Divers. 14, 401-408
31. Esterman, A. L., and Cohen S. P. (2006) Gen. Eng. News 26, 34-36
32. Bright, N. J., Thornton, C., and Carling, D. (2009) Acta Physiol. (Oxf) 196, 15-26
33. Zhang, J., Ma, Y., Taylor, S. S., and Tsien, R. Y. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 14997-15002
34. Hutchins, J. R., and Clarke, P. R. (2004) Cell Cycle 3, 41-45
35. Clegg, R. M., Holub, O., and Gohlke, C. (2003) Methods Enzymol. 360, 509-542
36. Rizzo, M. A., Springer, G. H., Granada, B., and Piston, D. W. (2004) Nat. Biotechnol. 22, 445-449
37. Buée, L., Troquier, L., Burnouf, S., Belarbi, K., Van der Jeugd, A., Ahmed, T., Fernandez-Gomez, F., Caillierez, R., Grosjean, M. E., Begard, S., Barbot, B., Demeyer, D., Obriot, H., Brion, I., Buée-Scherrer, V., Maurage, C. A., Balschun, D., D'hooge, R., Hamdane, M., Blum, D., and Sergeant, N. (2010) Biochem. Soc. Trans. 38, 967-972
38. Holtzman, D. M., Morris, J. C., and Goate, A. M. (2011) Sci. Transl. Med. 3, 77sr1
39. Biernat, J., and Mandelkow, E. M. (1999) Mol. Biol. Cell 10, 727-740
40. Goldstein, B., and Macara, I. G. (2007) Dev. Cell 13, 609-622
41. Meijer, L., Thunnissen, A. M., White, A. W., Garnier, M., Nikolic, M., Tsai, L. H., Walter, J., Cleverley, K. E., Salinas, P. C., Wu, Y. Z., Biernat, J., Mandelkow, E. M., Kim, S. H., and Pettit, G. R. (2000) Chem. Biol. 7, 51-63
42. Thies, E., and Mandelkow, E. M. (2007) J. Neurosci. 27, 2896-2907
43. Ai, H. W., Henderson, J. N., Remington, S. J., and Campbell, R. E. (2006) Biochem. J. 400, 531-540
44. Geraldo, S., and Gordon-Weeks, P. R. (2009) J. Cell Sci. 122, 3595-3604