-
1
-
-
84875436143
-
Inhibition of α-helix-mediated protein-protein interactions using designed molecules
-
V. Azzarito Inhibition of α-helix-mediated protein-protein interactions using designed molecules Nat. Chem. 5 2013 161 173
-
(2013)
Nat. Chem.
, vol.5
, pp. 161-173
-
-
Azzarito, V.1
-
2
-
-
84879784821
-
Targeting protein-protein interactions as an anticancer strategy
-
A.A. Ivanov Targeting protein-protein interactions as an anticancer strategy Trends Pharmacol. Sci. 34 2013 393 400
-
(2013)
Trends Pharmacol. Sci.
, vol.34
, pp. 393-400
-
-
Ivanov, A.A.1
-
3
-
-
37249004920
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
-
J.A. Wells, and C.L. McClendon Reaching for high-hanging fruit in drug discovery at protein-protein interfaces Nature 450 2007 1001 1009
-
(2007)
Nature
, vol.450
, pp. 1001-1009
-
-
Wells, J.A.1
McClendon, C.L.2
-
4
-
-
79953655080
-
Recent advances in the therapeutic perspectives of nutlin-3
-
P. Secchiero Recent advances in the therapeutic perspectives of nutlin-3 Curr. Pharm. Des. 17 2011 569 577
-
(2011)
Curr. Pharm. Des.
, vol.17
, pp. 569-577
-
-
Secchiero, P.1
-
5
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
L.T. Vassilev In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 Science 303 2004 844 848
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
6
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
T. Oltersdorf An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature 435 2005 677 681
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
-
7
-
-
84861482216
-
Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer
-
C.M. Rudin Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer Clin. Cancer Res.: Off. J. Am. Assoc. Cancer Res. 18 2012 3163 3169
-
(2012)
Clin. Cancer Res.: Off. J. Am. Assoc. Cancer Res.
, vol.18
, pp. 3163-3169
-
-
Rudin, C.M.1
-
8
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
C. Tse ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor Cancer Res. 68 2008 3421 3428
-
(2008)
Cancer Res.
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
-
9
-
-
77952553431
-
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
-
F. Christ Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication Nat. Chem. Biol. 6 2010 442 448
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 442-448
-
-
Christ, F.1
-
10
-
-
84878401236
-
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
-
G. Zimmermann Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling Nature 497 2013 638 642
-
(2013)
Nature
, vol.497
, pp. 638-642
-
-
Zimmermann, G.1
-
11
-
-
27744586067
-
Small-molecule inhibition of TNF-α
-
M.M. He Small-molecule inhibition of TNF-α Science 310 2005 1022 1025
-
(2005)
Science
, vol.310
, pp. 1022-1025
-
-
He, M.M.1
-
12
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
P. Filippakopoulos Selective inhibition of BET bromodomains Nature 468 2010 1067 1073
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
-
13
-
-
79961140522
-
Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition
-
L. Von Kleist Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition Cell 146 2011 471 484
-
(2011)
Cell
, vol.146
, pp. 471-484
-
-
Von Kleist, L.1
-
14
-
-
84857509304
-
Small-molecule stabilization of protein-protein interactions: An underestimated concept in drug discovery?
-
P. Thiel Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery? Angew. Chem. Int. Ed. 51 2012 2012 2018
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 2012-2018
-
-
Thiel, P.1
-
15
-
-
0017157814
-
Biological effects of cyclosporin A: A new antilymphocytic agent
-
J.F. Borel Biological effects of cyclosporin A: a new antilymphocytic agent Agents Actions 6 1976 468 475
-
(1976)
Agents Actions
, vol.6
, pp. 468-475
-
-
Borel, J.F.1
-
16
-
-
0023046561
-
Biosynthesis of cyclosporin A: Partial purification and properties of a multifunctional enzyme from Tolypocladium inflatum
-
R. Zocher Biosynthesis of cyclosporin A: partial purification and properties of a multifunctional enzyme from Tolypocladium inflatum Biochemistry 25 1986 550 553
-
(1986)
Biochemistry
, vol.25
, pp. 550-553
-
-
Zocher, R.1
-
17
-
-
0029986277
-
Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: In vitro-in vivo correlation
-
G. Fricker Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation Br. J. Pharmacol. 118 1996 1841 1847
-
(1996)
Br. J. Pharmacol.
, vol.118
, pp. 1841-1847
-
-
Fricker, G.1
-
19
-
-
0026031596
-
Cyclosporine analogues
-
J.R. Jeffery Cyclosporine analogues Clin. Biochem. 24 1991 15 21
-
(1991)
Clin. Biochem.
, vol.24
, pp. 15-21
-
-
Jeffery, J.R.1
-
20
-
-
0141517204
-
Cyclosporin A analogues: Recent advances
-
T. Lazarova, and Z. Weng Cyclosporin A analogues: recent advances Expert Opin. Ther. Pat. 13 2003 1327 1332
-
(2003)
Expert Opin. Ther. Pat.
, vol.13
, pp. 1327-1332
-
-
Lazarova, T.1
Weng, Z.2
-
21
-
-
0029671145
-
The history of cyclosporin A (Sandimmune) revisited: Another point of view
-
H.F. Stähelin The history of cyclosporin A (Sandimmune) revisited: another point of view Experientia 52 1996 5 13
-
(1996)
Experientia
, vol.52
, pp. 5-13
-
-
Stähelin, H.F.1
-
22
-
-
0021159379
-
Cyclophilin: A specific cytosolic binding protein for cyclosporin A
-
R.E. Handschumacher Cyclophilin: a specific cytosolic binding protein for cyclosporin A Science 226 1984 544 547
-
(1984)
Science
, vol.226
, pp. 544-547
-
-
Handschumacher, R.E.1
-
23
-
-
84873978406
-
Profile of alisporivir and its potential in the treatment of hepatitis C
-
P.A. Gallay, and K. Lin Profile of alisporivir and its potential in the treatment of hepatitis C Drug Des. Dev. Ther. 7 2013 105 115
-
(2013)
Drug Des. Dev. Ther.
, vol.7
, pp. 105-115
-
-
Gallay, P.A.1
Lin, K.2
-
24
-
-
0025893168
-
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
-
J. Liu Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes Cell 66 1991 807 815
-
(1991)
Cell
, vol.66
, pp. 807-815
-
-
Liu, J.1
-
25
-
-
0037126026
-
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
-
Q. Huai Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes Proc. Natl. Acad. Sci. U. S. A. 99 2002 12037 12042
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 12037-12042
-
-
Huai, Q.1
-
26
-
-
0023245677
-
FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics
-
T. Kino FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics J. Antibiot. 40 1987 1249 1255
-
(1987)
J. Antibiot.
, vol.40
, pp. 1249-1255
-
-
Kino, T.1
-
27
-
-
0000691667
-
The medicinal chemistry of FK-506
-
M.T. Goulet The medicinal chemistry of FK-506 Perspect. Drug Discov. Des. 2 1994 145 162
-
(1994)
Perspect. Drug Discov. Des.
, vol.2
, pp. 145-162
-
-
Goulet, M.T.1
-
28
-
-
0024442393
-
A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
-
J.J. Siekierka A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin Nature 341 1989 755 757
-
(1989)
Nature
, vol.341
, pp. 755-757
-
-
Siekierka, J.J.1
-
29
-
-
0029133116
-
X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
-
J.P. Griffith X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex Cell 82 1995 507 522
-
(1995)
Cell
, vol.82
, pp. 507-522
-
-
Griffith, J.P.1
-
30
-
-
0016713286
-
Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
S.N. Sehgal Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization J. Antibiot. 28 1975 727 732
-
(1975)
J. Antibiot.
, vol.28
, pp. 727-732
-
-
Sehgal, S.N.1
-
31
-
-
0017362502
-
Inhibition of the immune response by rapamycin, a new antifungal antibiotic
-
R.R. Martel Inhibition of the immune response by rapamycin, a new antifungal antibiotic Can. J. Physiol. Pharmacol. 55 1977 48 51
-
(1977)
Can. J. Physiol. Pharmacol.
, vol.55
, pp. 48-51
-
-
Martel, R.R.1
-
32
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
E.J. Brown A mammalian protein targeted by G1-arresting rapamycin-receptor complex Nature 369 1994 756 758
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
-
33
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
J. Choi Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP Science 273 1996 239 242
-
(1996)
Science
, vol.273
, pp. 239-242
-
-
Choi, J.1
-
34
-
-
0029329592
-
Structure-activity studies of rapamycin analogs: Evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface
-
J.I. Luengo Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface Chem. Biol. 2 1995 471 481
-
(1995)
Chem. Biol.
, vol.2
, pp. 471-481
-
-
Luengo, J.I.1
-
35
-
-
30744467675
-
Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity
-
J.H. Bayle Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity Chem. Biol. 13 2006 99 107
-
(2006)
Chem. Biol.
, vol.13
, pp. 99-107
-
-
Bayle, J.H.1
-
36
-
-
80155142474
-
Rapamycin passes the torch: A new generation of mTOR inhibitors
-
D. Benjamin Rapamycin passes the torch: a new generation of mTOR inhibitors Nat. Rev. Drug Discov. 10 2011 868 880
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 868-880
-
-
Benjamin, D.1
-
37
-
-
84892163643
-
Macrocyclic drugs and clinical candidates: What can medicinal chemists learn from their properties?
-
F. Giordanetto, and J. Kihlberg Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties? J. Med. Chem. 57 2014 278 295
-
(2014)
J. Med. Chem.
, vol.57
, pp. 278-295
-
-
Giordanetto, F.1
Kihlberg, J.2
-
38
-
-
49349139162
-
Structures and stereochemistry of new labdane diterpiniods from coleus forskohlii briq
-
S.V. Bhat Structures and stereochemistry of new labdane diterpiniods from coleus forskohlii briq Tetrahedron Lett. 18 1977 1669 1672
-
(1977)
Tetrahedron Lett.
, vol.18
, pp. 1669-1672
-
-
Bhat, S.V.1
-
39
-
-
2342652901
-
Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells
-
K.B. Seamon Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells Proc. Natl. Acad. Sci. U. S. A. 78 1981 3363 3367
-
(1981)
Proc. Natl. Acad. Sci. U. S. A.
, vol.78
, pp. 3363-3367
-
-
Seamon, K.B.1
-
40
-
-
0030612427
-
Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase
-
R.K. Sunahara Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase J. Biol. Chem. 272 1997 22265 22271
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22265-22271
-
-
Sunahara, R.K.1
-
41
-
-
0030901637
-
Structure of the adenylyl cyclase catalytic core
-
G. Zhang Structure of the adenylyl cyclase catalytic core Nature 386 1997 247 253
-
(1997)
Nature
, vol.386
, pp. 247-253
-
-
Zhang, G.1
-
42
-
-
2642689663
-
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS
-
J.J. Tesmer Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS Science 278 1997 1907 1916
-
(1997)
Science
, vol.278
, pp. 1907-1916
-
-
Tesmer, J.J.1
-
43
-
-
0023264534
-
Stimulation of adenylate cyclase by water-soluble analogues of forskolin
-
A. Laurenza Stimulation of adenylate cyclase by water-soluble analogues of forskolin Mol. Pharmacol. 32 1987 133 139
-
(1987)
Mol. Pharmacol.
, vol.32
, pp. 133-139
-
-
Laurenza, A.1
-
44
-
-
12644251058
-
Forskolin derivatives. I. Synthesis, and cardiovascular and adenylate cyclase-stimulating activities of water-soluble forskolins
-
T. Tatee Forskolin derivatives. I. Synthesis, and cardiovascular and adenylate cyclase-stimulating activities of water-soluble forskolins Chem. Pharm. Bull. 44 1996 2274 2279
-
(1996)
Chem. Pharm. Bull.
, vol.44
, pp. 2274-2279
-
-
Tatee, T.1
-
45
-
-
0031940268
-
Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase
-
Y. Toya Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase J. Mol. Cell. Cardiol. 30 1998 97 108
-
(1998)
J. Mol. Cell. Cardiol.
, vol.30
, pp. 97-108
-
-
Toya, Y.1
-
46
-
-
41149107453
-
Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs
-
C. Pinto Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs J. Pharmacol. Exp. Ther. 325 2008 27 36
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.325
, pp. 27-36
-
-
Pinto, C.1
-
47
-
-
0000765578
-
Fusicoccin: A new wilting toxin produced by Fusicoccum amygdali Del
-
A. Ballio Fusicoccin: a new wilting toxin produced by Fusicoccum amygdali Del Nature 203 1964 297
-
(1964)
Nature
, vol.203
, pp. 297
-
-
Ballio, A.1
-
48
-
-
36949043322
-
Isolation of a new plant growth substance with cytokinin-like activity
-
T. Sassa Isolation of a new plant growth substance with cytokinin-like activity Nature 227 1970 379
-
(1970)
Nature
, vol.227
, pp. 379
-
-
Sassa, T.1
-
49
-
-
84881493413
-
The phytotoxin fusicoccin, a selective stabilizer of 14-3-3 interactions?
-
L. Camoni The phytotoxin fusicoccin, a selective stabilizer of 14-3-3 interactions? IUBMB Life 65 2013 513 517
-
(2013)
IUBMB Life
, vol.65
, pp. 513-517
-
-
Camoni, L.1
-
50
-
-
84861886597
-
Fusicoccanes: Diterpenes with surprising biological functions
-
A.H. De Boer, and I.J. de Vries-van Leeuwen Fusicoccanes: diterpenes with surprising biological functions Trends Plant Sci. 17 2012 360 368
-
(2012)
Trends Plant Sci.
, vol.17
, pp. 360-368
-
-
De Boer, A.H.1
De Vries-Van Leeuwen, I.J.2
-
51
-
-
84872513683
-
Stabilization and inhibition of protein-protein interactions: The 14-3-3 case study
-
L-G. Milroy Stabilization and inhibition of protein-protein interactions: the 14-3-3 case study ACS Chem. Biol. 8 2013 27 35
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 27-35
-
-
Milroy, L.-G.1
-
52
-
-
77952504491
-
Fusicoccin-A selectively induces apoptosis in tumor cells after interferon-alpha priming
-
I.J. De Vries-van Leeuwen Fusicoccin-A selectively induces apoptosis in tumor cells after interferon-alpha priming Cancer Lett. 293 2010 198 206
-
(2010)
Cancer Lett.
, vol.293
, pp. 198-206
-
-
De Vries-Van Leeuwen, I.J.1
-
53
-
-
79956048261
-
The phytotoxin fusicoccin promotes platelet aggregation via 14-3-3-glycoprotein Ib-IX-V interaction
-
L. Camoni The phytotoxin fusicoccin promotes platelet aggregation via 14-3-3-glycoprotein Ib-IX-V interaction Biochem. J. 436 2011 429 436
-
(2011)
Biochem. J.
, vol.436
, pp. 429-436
-
-
Camoni, L.1
-
54
-
-
84878442899
-
Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface
-
I.J. De Vries-van Leeuwen Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface Proc. Natl. Acad. Sci. U. S. A. 110 2013 8894 8899
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 8894-8899
-
-
De Vries-Van Leeuwen, I.J.1
-
55
-
-
0035992246
-
Cotylenin A - A plant growth regulator as a differentiation-inducing agent against myeloid leukemia
-
Y. Honma Cotylenin A - a plant growth regulator as a differentiation-inducing agent against myeloid leukemia Leuk. Lymphoma 43 2002 1169 1178
-
(2002)
Leuk. Lymphoma
, vol.43
, pp. 1169-1178
-
-
Honma, Y.1
-
56
-
-
34447647615
-
Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts
-
T. Kasukabe Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts Breast Cancer Res. 7 2005 R1097 R1110
-
(2005)
Breast Cancer Res.
, vol.7
, pp. 1097-R1110
-
-
Kasukabe, T.1
-
57
-
-
60149087610
-
A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A
-
C. Ottmann A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A J. Mol. Biol. 386 2009 913 919
-
(2009)
J. Mol. Biol.
, vol.386
, pp. 913-919
-
-
Ottmann, C.1
-
58
-
-
84884654621
-
Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers
-
M. Molzan Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers ACS Chem. Biol. 8 2013 1869 1875
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 1869-1875
-
-
Molzan, M.1
-
59
-
-
84876472566
-
A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
-
C. Anders A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface Chem. Biol. 20 2013 583 593
-
(2013)
Chem. Biol.
, vol.20
, pp. 583-593
-
-
Anders, C.1
-
60
-
-
84866424022
-
A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts
-
K. Kawakami A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts Anticancer Agents Med. Chem. 12 2012 791 800
-
(2012)
Anticancer Agents Med. Chem.
, vol.12
, pp. 791-800
-
-
Kawakami, K.1
-
61
-
-
33847626336
-
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi
-
T. Toyomasu Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi Proc. Natl. Acad. Sci. U. S. A. 104 2007 3084 3088
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 3084-3088
-
-
Toyomasu, T.1
-
62
-
-
84876544204
-
Exploration of biosynthetic access to the shared precursor of the fusicoccane diterpenoid family
-
J. Arens Exploration of biosynthetic access to the shared precursor of the fusicoccane diterpenoid family Chem. Commun. 49 2013 4337 4339
-
(2013)
Chem. Commun.
, vol.49
, pp. 4337-4339
-
-
Arens, J.1
-
63
-
-
80054041183
-
Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome
-
M110.005751
-
C. Johnson Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome Mol. Cell. Proteomics MCP 10 2011 M110.005751
-
(2011)
Mol. Cell. Proteomics
, vol.10 MCP
-
-
Johnson, C.1
-
64
-
-
0036711574
-
The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization
-
M.M. Nalaskowski The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization Biochem. J. 366 2002 549 556
-
(2002)
Biochem. J.
, vol.366
, pp. 549-556
-
-
Nalaskowski, M.M.1
-
65
-
-
13144250167
-
D-Myo-inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways
-
L. Eckmann d-Myo-inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways Proc. Natl. Acad. Sci. U. S. A. 94 1997 14456 14460
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 14456-14460
-
-
Eckmann, L.1
-
66
-
-
84855984763
-
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
-
P.J. Watson Structure of HDAC3 bound to co-repressor and inositol tetraphosphate Nature 481 2012 335 340
-
(2012)
Nature
, vol.481
, pp. 335-340
-
-
Watson, P.J.1
-
67
-
-
0029046736
-
DNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae
-
R. Ishida DNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae Cancer Res. 55 1995 2299 2303
-
(1995)
Cancer Res.
, vol.55
, pp. 2299-2303
-
-
Ishida, R.1
-
69
-
-
0028345406
-
Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp
-
J. Roca Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp Proc. Natl. Acad. Sci. U. S. A. 91 1994 1781 1785
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 1781-1785
-
-
Roca, J.1
-
70
-
-
0141591551
-
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
-
S. Classen Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 Proc. Natl. Acad. Sci. U. S. A. 100 2003 10629 10634
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 10629-10634
-
-
Classen, S.1
-
71
-
-
28244502156
-
Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: A focus on the transthyretin amyloidoses
-
S.M. Johnson Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses Acc. Chem. Res. 38 2005 911 921
-
(2005)
Acc. Chem. Res.
, vol.38
, pp. 911-921
-
-
Johnson, S.M.1
-
72
-
-
77949272212
-
Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses
-
S. Connelly Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses Curr. Opin. Struct. Biol. 20 2010 54 62
-
(2010)
Curr. Opin. Struct. Biol.
, vol.20
, pp. 54-62
-
-
Connelly, S.1
-
73
-
-
10744228786
-
Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action
-
H. Razavi Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action Angew. Chem. Int. Ed. Engl. 42 2003 2758 2761
-
(2003)
Angew. Chem. Int. Ed. Engl.
, vol.42
, pp. 2758-2761
-
-
Razavi, H.1
-
74
-
-
84862234023
-
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
-
C.E. Bulawa Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade Proc. Natl. Acad. Sci. U. S. A. 109 2012 9629 9634
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 9629-9634
-
-
Bulawa, C.E.1
-
75
-
-
38349151537
-
A biosensor of S100A4 metastasis factor activation: Inhibitor screening and cellular activation dynamics
-
S.C. Garrett A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics Biochemistry 47 2008 986 996
-
(2008)
Biochemistry
, vol.47
, pp. 986-996
-
-
Garrett, S.C.1
-
76
-
-
0000496026
-
The chemistry of phenothiazine
-
S.P. Massie The chemistry of phenothiazine Chem. Rev. 54 1954 797 833
-
(1954)
Chem. Rev.
, vol.54
, pp. 797-833
-
-
Massie, S.P.1
-
77
-
-
84862187466
-
Chemical structure of phenothiazines and their biological activity
-
A. Jaszczyszyn Chemical structure of phenothiazines and their biological activity Pharmacol. Rep. 64 2012 16 23
-
(2012)
Pharmacol. Rep.
, vol.64
, pp. 16-23
-
-
Jaszczyszyn, A.1
-
78
-
-
23844434863
-
History of the discovery and clinical introduction of chlorpromazine
-
F. López-Muñoz History of the discovery and clinical introduction of chlorpromazine Ann. Clin. Psychiatry 17 2005 113 135
-
(2005)
Ann. Clin. Psychiatry
, vol.17
, pp. 113-135
-
-
López-Muñoz, F.1
-
79
-
-
77952724647
-
Phenothiazines inhibit S100A4 function by inducing protein oligomerization
-
V.N. Malashkevich Phenothiazines inhibit S100A4 function by inducing protein oligomerization Proc. Natl. Acad. Sci. U. S. A. 107 2010 8605 8610
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 8605-8610
-
-
Malashkevich, V.N.1
-
80
-
-
31444441789
-
Architecture of ribonucleoprotein complexes in influenza A virus particles
-
T. Noda Architecture of ribonucleoprotein complexes in influenza A virus particles Nature 439 2006 490 492
-
(2006)
Nature
, vol.439
, pp. 490-492
-
-
Noda, T.1
-
81
-
-
77953259427
-
Identification of influenza A nucleoprotein as an antiviral target
-
R.Y. Kao Identification of influenza A nucleoprotein as an antiviral target Nat. Biotechnol. 28 2010 600 605
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 600-605
-
-
Kao, R.Y.1
-
82
-
-
78650606465
-
High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity
-
C.-Y. Su High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity Proc. Natl. Acad. Sci. U. S. A. 107 2010 19151 19156
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 19151-19156
-
-
Su, C.-Y.1
-
83
-
-
80053089237
-
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers
-
S.W. Gerritz Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers Proc. Natl. Acad. Sci. U. S. A. 108 2011 15366 15371
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 15366-15371
-
-
Gerritz, S.W.1
-
84
-
-
77952543499
-
The p53 orchestra: Mdm2 and Mdmx set the tone
-
M. Wade The p53 orchestra: Mdm2 and Mdmx set the tone Trends Cell Biol. 20 2010 299 309
-
(2010)
Trends Cell Biol.
, vol.20
, pp. 299-309
-
-
Wade, M.1
-
85
-
-
70450270900
-
Awakening guardian angels: Drugging the p53 pathway
-
C.J. Brown Awakening guardian angels: drugging the p53 pathway Nat. Rev. Cancer 9 2009 862 873
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 862-873
-
-
Brown, C.J.1
-
86
-
-
58749094954
-
Targeting Mdm2 and Mdmx in cancer therapy: Better living through medicinal chemistry?
-
M. Wade, and G.M. Wahl Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol. Cancer Res. 7 2009 1 11
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 1-11
-
-
Wade, M.1
Wahl, G.M.2
-
87
-
-
84863966819
-
Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
-
B. Graves Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization Proc. Natl. Acad. Sci. U. S. A. 109 2012 11788 11793
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 11788-11793
-
-
Graves, B.1
-
88
-
-
0032189766
-
Mechanism of calcium gating in small-conductance calcium-activated potassium channels
-
X.M. Xia Mechanism of calcium gating in small-conductance calcium-activated potassium channels Nature 395 1998 503 507
-
(1998)
Nature
, vol.395
, pp. 503-507
-
-
Xia, X.M.1
-
89
-
-
77952816888
-
Impairment of endothelial SK(Ca) channels and of downstream hyperpolarizing pathways in mesenteric arteries from spontaneously hypertensive rats
-
A.H. Weston Impairment of endothelial SK(Ca) channels and of downstream hyperpolarizing pathways in mesenteric arteries from spontaneously hypertensive rats Br. J. Pharmacol. 160 2010 836 843
-
(2010)
Br. J. Pharmacol.
, vol.160
, pp. 836-843
-
-
Weston, A.H.1
-
90
-
-
6544269945
-
Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: A candidate for schizophrenia and bipolar disorder?
-
K.G. Chandy Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? Mol. Psychiatry 3 1998 32 37
-
(1998)
Mol. Psychiatry
, vol.3
, pp. 32-37
-
-
Chandy, K.G.1
-
91
-
-
84866074628
-
Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels
-
M. Zhang Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels Nat. Commun. 3 2012 1021
-
(2012)
Nat. Commun.
, vol.3
, pp. 1021
-
-
Zhang, M.1
-
92
-
-
53849127475
-
Molecular and cellular basis of small - And intermediate - Conductance, calcium-activated potassium channel function in the brain
-
P. Pedarzani, and M. Stocker Molecular and cellular basis of small - and intermediate - conductance, calcium-activated potassium channel function in the brain Cell. Mol. Life Sci. 65 2008 3196 3217
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 3196-3217
-
-
Pedarzani, P.1
Stocker, M.2
-
93
-
-
4644325419
-
Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)
-
D. Strøbæk Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) Biochim. Biophys. Acta - Biomembr. 1665 2004 1 5
-
(2004)
Biochim. Biophys. Acta - Biomembr.
, vol.1665
, pp. 1-5
-
-
Strøbæk, D.1
-
94
-
-
8844262660
-
Principles for modulation of the nuclear receptor superfamily
-
H. Gronemeyer Principles for modulation of the nuclear receptor superfamily Nat. Rev. Drug Discov. 3 2004 950 964
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 950-964
-
-
Gronemeyer, H.1
-
95
-
-
0347627638
-
Asoprisnil (J867): A selective progesterone receptor modulator for gynecological therapy
-
D. DeManno Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy Steroids 68 2003 1019 1032
-
(2003)
Steroids
, vol.68
, pp. 1019-1032
-
-
Demanno, D.1
-
96
-
-
34250894870
-
A structural and in vitro characterization of asoprisnil: A selective progesterone receptor modulator
-
K.P. Madauss A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator Mol. Endocrinol. 21 2007 1066 1081
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 1066-1081
-
-
Madauss, K.P.1
-
97
-
-
65949085164
-
Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists
-
P. Germain Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists Chem. Biol. 16 2009 479 489
-
(2009)
Chem. Biol.
, vol.16
, pp. 479-489
-
-
Germain, P.1
-
98
-
-
77954387100
-
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
-
A. Le Maire A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor Nat. Struct. Mol. Biol. 17 2010 801 807
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 801-807
-
-
Le Maire, A.1
-
99
-
-
77953106214
-
Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions
-
R. Rose Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions Angew. Chem. Int. Ed. Engl. 49 2010 4129 4132
-
(2010)
Angew. Chem. Int. Ed. Engl.
, vol.49
, pp. 4129-4132
-
-
Rose, R.1
-
100
-
-
76149109071
-
Targeting protein-protein interactions for therapeutic intervention: A challenge for the future
-
G. Zinzalla, and D.E. Thurston Targeting protein-protein interactions for therapeutic intervention: a challenge for the future Future Med. Chem. 1 2009 65 93
-
(2009)
Future Med. Chem.
, vol.1
, pp. 65-93
-
-
Zinzalla, G.1
Thurston, D.E.2
-
101
-
-
25144498379
-
A human protein-protein interaction network: A resource for annotating the proteome
-
U. Stelzl A human protein-protein interaction network: a resource for annotating the proteome Cell 122 2005 957 968
-
(2005)
Cell
, vol.122
, pp. 957-968
-
-
Stelzl, U.1
-
102
-
-
77951898121
-
Hub promiscuity in protein-protein interaction networks
-
A. Patil Hub promiscuity in protein-protein interaction networks Int. J. Mol. Sci. 11 2010 1930 1943
-
(2010)
Int. J. Mol. Sci.
, vol.11
, pp. 1930-1943
-
-
Patil, A.1
|