A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts

Anti-Cancer Agents in Medicinal Chemistry

Volumn 12, Issue 7, 2012, Pages 791-800

  Kawakami, Koshi ^a,b   Hattori, Miho ^a   Inoue, Takatsugu ^c   Maruyama, Yuriko ^c   Ohkanda, Junko ^c   Kato, Nobuo ^c   Tongu, Miki ^a   Yamada, Takaya ^a   Akimoto, Miho ^a   Takenaga, Keizo ^a   Sassa, Takeshi ^d   Suzumiya, Junji ^a,b   Honma, Yoshio ^a  

^a SHIMANE UNIVERSITY   (Japan)

^b School of Medicine   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d YAMAGATA UNIVERSITY   (Japan)

Author keywords

Akt; Combination therapy; Cotylenin; Fusicoccin; Gemcitabine; HIF 1; Hypoxia targeting agent; MIAPaCa 2 cells; Pancreatic cancer; Tumor stem cell; Xenograft

Indexed keywords

CD24 ANTIGEN; CYTOTOXIC AGENT; FUSICOCCIN; GEMCITABINE; HERMES ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISIR 042; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL HYPOXIA; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS CANCER; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; STEM CELL; TUMOR XENOGRAFT;

EID: 84866424022     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/187152012802650264     Document Type: Article

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