Endocrine disruptor activity of multiple environmental food chain contaminants

Toxicology in Vitro

Volumn 29, Issue 1, 2015, Pages 211-220

  Wielogorska E ^a,b   Elliott, C T ^a   Danaher, M ^b   Connolly, L ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Teagasc Food Research Centre   (United Kingdom)

Author keywords

Antimicrobial; Endocrine disruptor; Industrial chemical; Personal care product; Preservative; Reporter gene assay

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; ANTIESTROGEN; ANTIINFECTIVE AGENT; ENDOCRINE DISRUPTOR; ESTRADIOL; ESTROGEN RECEPTOR; FLAME RETARDANT; PERFLUOROALKYLATED COMPOUND; PHTHALIC ACID DERIVATIVE; PRESERVATIVE; PYRETHROID; ULTRAVIOLET FILTER; UNCLASSIFIED DRUG; PHTHALIC ACID;

ARTICLE; BIOASSAY; CONTROLLED STUDY; CYTOTOXICITY; FOOD CHAIN; HUMAN; HUMAN CELL; METABOLITE; POLLUTANT; REPORTER GENE; TRANSACTIVATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; FOOD CONTAMINATION; TOXICITY TESTING;

CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; FOOD CHAIN; FOOD CONTAMINATION; GENES, REPORTER; HUMANS; PARABENS; PHTHALIC ACIDS; PYRETHRINS; RECEPTORS, ESTROGEN; TOXICITY TESTS;

EID: 84910156577     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.10.014     Document Type: Article

References (124)

1. Allmyr M., Adolfsson-Erici M., McLachlan M.S., Sandborgh-Englund G. Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products. Sci. Total Environ. 2006, 372:87-93.
2. Allmyr M., McLachlan M.S., Sandborgh-Englund G., Adolfsson-Erici M. Determination of triclosan as its pentafluorobenzoyl ester in human plasma and milk using electron capture negative ionization mass spectrometry. Anal. Chem. 2006, 78:6542-6546.
3. Alonso M.B., Feo M.L., Corcellas C., Vidal L.G., Bertozzi C.P., Marigo J., Secchi E.R., Bassoi M., Azevedo A.F., Dorneles P.R., Torres J.P.M., Lailson-Brito J., Malm O., Eljarrat E., Barceló D. Pyrethroids: a new threat to marine mammals?. Environ. Int. 2012, 47:99-106.
4. Axelstad M., Boberg J., Hougaard K.S., Christiansen S., Jacobsen P.R., Mandrup K.R., Nellemann C., Lund S.P., Hass U. Effects of pre- and postnatal exposure to the UV-filter octyl methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring. Toxicol. Appl. Pharmacol. 2011, 250:278-290.
5. Barse A.V., Chakrabarti T., Ghosh T.K., Pal A.K., Kumar N., Raman R.P., Jadhao S.B. Vitellogenin induction and histo-metabolic changes following exposure of Cyprinus carpio to methyl paraben. Asian-Aust. J. Anim. Sci. 2010, 23:1557-1565.
6. Benninghoff A.D., Bisson W.H., Koch D.C., Ehresman D.J., Kolluri S.K., William D.E. Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro. Toxicol. Sci. 2011, 120:42-58.
7. Berckmans P., Leppens H., Vangenechten C., Witters H. Screening of endocrine disrupting chemicals with MELN cells, an ER-transactivation assay combined with cytotoxicity assessment. Toxicol. In Vitro 2007, 21:1262-1267.
8. Biegel L.B., Liu R.C.M., Hurtt M.E., Cook J.C. Effects of ammonium perfluorooctanoate on leydig-cell function. in vitro, in vivo, and ex vivo studies. Toxicol. Appl. Pharmacol. 1995, 134:18-25.
9. Boberg J., Taxvig C., Christiansen S., Hass U. Possible endocrine disrupting effects of parabens and their metabolites. Reprod. Toxicol. 2010, 30:301-312.
10. Bocio A., Llobet J.M., Domingo J.L., Corbella J., Teixido A., Casas C. Polybrominated diphenyl ethers (PBDEs) in foodstuffs: human exposure through the diet. J. Agric. Food Chem. 2003, 51:3191-3195.
11. Bovee T.F.H., Hoogenboom L.A.P. Bioassays for the detection of hormonal activities. Endocrine-Disrupting Chemicals in Food 2009, Woodhead Publishing Limited, Cambridge. I. Shaw (Ed.).
12. Brausch J.M., Rand G.M. A review of personal care products in the aquatic environment: environmental concentrations and toxicity. Chemosphere 2011, 82:1518-1532.
13. Calafat A.M., Ye X., Wong L.Y., Reidy J.A., Needham L.L. Urinary concentrations of Triclosan in the US population: 2003-2004. Environ. Health Perspect. 2008, 116:303-307.
14. Carou M.E., Ponzo O.J., Gutierrez R.P.C., Szwarcfarb B., Deguiz M.L., Reynoso R., Carbone S., Moguilevsky J.A., Scacchi P. Low dose 4-MBC effect on neuroendocrine regulation of reproductive axis in adult male rats. Environ. Toxicol. Pharmacol. 2008, 26:222-224.
15. Connolly L. Endocrine-disrupting chemicals:orgins, fates and transmission into the food chain. Endocrine Disrupting Chemicals in Food 2009, Woodhead Publishing Limited, Cambridge. I. Shaw (Ed.).
16. Covaci A., Harrad S., Abdallah M.A.E., Ali N., Law R.J., Herzke D., de Wit C.A. Novel brominated flame retardants: a review of their analysis, environmental fate and behaviour. Environ. Int. 2011, 37:532-556.
17. Dann A.B., Hontela A. Triclosan: environmental exposure, toxicity and mechanisms of action. J. Appl. Toxicol. 2011, 31:285-311.
18. Darbre P.D., Harvey P.W. Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. J. Appl. Toxicol. 2008, 28:561-578.
19. Diamanti-Kandarakis E., Bourguignon J.P., Giudice L.C., Hauser R., Prins G.S., Soto A.M., Zoeller R.T., Gore A.C. Endocrine-disrupting chemicals: an endocrine society scientific statement. Endocr. Rev. 2009, 30:293-342.
20. Diaz-Cruz M.S., Garcia-Galan M.J., Guerra P., Jelic A., Postigo C., Eljarrat E., Farre M., de Alda M.J.L., Petrovic M., Barcelo D. Analysis of selected emerging contaminants in sewage sludge. TrAC, Trends Anal. Chem. 2009, 28:1263-1275.
21. Dorosh A., Ded L., Elzeinova F., Peknicova J. Assessing oestrogenic effects of brominated flame retardants hexabromocyclododecane and tetrabromobisphenol a on MCF-7 cells. Folia Biol. 2010, 56:35-39.
22. Du G.Z., Shen O.X., Sun H., Fei J., Lu C.C., Song L., Xia Y.K., Wang S.L., Wang X.R. Assessing hormone receptor activities of pyrethroid insecticides and their metabolites in reporter gene assays. Toxicol. Sci. 2010, 116:58-66.
23. Duty S.M., Ackerman R.M., Calafat A.M., Hauser R. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ. Health Perspect. 2005, 113:1530-1535.
24. EFSA Scientific report of the endocrine active substances task force. EFSA J. 2010, 8:59.
25. EU, 1976. Council Directive of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products (76/768/EEC). Official Journal of the EU.
26. EU, 2000. Green Paper. Environmental issues of PVC COM (2000) 469 final, 26 July 2000. UNSPECIFIED.
27. EU, 2002. Commission Decision 2002/657/EC of 12 August 2002, Official Journal of the European Communities, pp. 8-35.
28. EU, 2003. Directive 2003/11/EC of the European Parliament and of the Council of 6 February 2003. Official Journal of the European Union, pp. L 42/45-46.
29. EU, 2006. Directive 2006/122/ECOF the European Parliment and of the Council of 12 December 2006. Official Journal of the European Union, pp. L 372/332-334.
30. EU, 2007. Commission Directive 2007/19/EC of 30 March 2007. Official Journal of the European Union, pp. L/19/17-36.
31. FAO, FAOSTAT, p. Resources on pesticide usage in the EU.
32. Fernandez-Alvarez M., Sanchez-Prado L., Lores M., Llompart M., Garcia-Jares C., Cela R. Alternative sample preparation method for photochemical studies based on solid phase microextraction: synthetic pyrethroid photochemistry. J. Chromatogr., A 2007, 1152:156-167.
33. Ferrer E., Santoni E., Vittori S., Font G., Manes J., Sagratini G. Simultaneous determination of bisphenol A, octylphenol, and nonylphenol by pressurised liquid extraction and liquid chromatography-tandem mass spectrometry in powdered milk and infant formulas. Food Chem. 2011, 126:360-367.
34. Fierens T., Servaes K., Van Holderbeke M., Geerts L., De Henauw S., Sioen I., Vanermen G. Analysis of phthalates in food products and packaging materials sold on the Belgian market. Food Chem. Toxicol. 2012, 50:2575-2583.
35. Frederiksen M., Vorkamp K., Thomsen M., Knudsen L.E. Human internal and external exposure to PBDEs - a review of levels and sources. Int. J. Hydrogen Environ. Health 2009, 212:109-134.
36. Fromme H., Tittlemier S.A., Volkel W., Wilhelm M., Twardella D. Perfluorinated compounds - exposure assessment for the general population in western countries. Int. J. Hydrogen Environ. Health 2009, 212:239-270.
37. Gee R.H., Charles A., Taylor N., Darbre P.D. Oestrogenic and androgenic activity of triclosan in breast cancer cells. J. Appl. Toxicol. 2008, 28:78-91.
38. Giesy J.P., Kannan K. Global distribution of perfluorooctane sulfonate in wildlife. Environ. Sci. Technol. 2001, 35:1339-1342.
39. Giokas D.L., Salvador A., Chisvert A. UV filters: from sunscreens to human body and the environment. TrAC, Trends Anal. Chem. 2007, 26:360-374.
40. Guerra P., de la Torre A., Martinez M.A., Eljarrat E., Barcelo D. Identification and trace level determination of brominated flame retardants by liquid chromatography/quadrupole linear ion trap mass spectrometry. Rapid Commun. Mass Spectrom. 2008, 22:916-924.
41. Halden R.U., Paull D.H. Analysis of triclocarban in aquatic samples by liquid chromatography electrospray ionization mass spectrometry. Environ. Sci. Technol. 2004, 38:4849-4855.
42. Hannas B.R., Lambright C.S., Furr J., Howdeshell K.L., Wilson V.S., Gray L.E. Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate. Toxicol. Sci. 2011, 123:206-216.
43. Hites R.A. Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environ. Sci. Technol. 2004, 38:945-956.
44. Hodgson E. A Textbook of Modern Toxicology 2010, John Wiley and Sons.
45. Houtman C.J., Van Oostveen A.M., Brouwer A., Lamoree M.H., Legler J. Identification of estrogenic compounds in fish bile using bioassay-directed fractionation. Environ. Sci. Technol. 2004, 38:6415-6423.
46. Huang P.C., Tien C.J., Sun Y.M., Hsieh C.Y., Lee C.C. Occurrence of phthalates in sediment and biota: relationship to aquatic factors and the biota-sediment accumulation factor. Chemosphere 2008, 73:539-544.
47. IPCS Global assessment of the state-of-the-science of endocrine disruptors. International Programme on Chemical Safety 2002, W.H.O.a.U.N.E.P., Geneva.
48. Ishibashi H., Ishida H., Matsuoka M., Tominaga N., Arizono K. Estrogenic effects of fluorotelomer alcohols for human estrogen receptor isoforms alpha and beta in vitro. Biol. Pharm. Bull. 2007, 30:1358-1359.
49. Janjua N.R., Kongshoj B., Andersson A.M., Wulf H.C. Sunscreens in human plasma and urine after repeated whole-body topical application. J. Eur. Acad. Dermatol. Venereol. 2008, 22:456-461.
50. Jensen A.A., Leffers H. Emerging endocrine disrupters: perfluoroalkylated substances. Int. J. Androl. 2008, 31:161-169.
51. Jin M.Q., Li L., Xu C., Wen Y.Z., Zhao M.R. Estrogenic activities of two synthetic pyrethroids and their metabolites. J. Environ. Sci. China 2010, 22:290-296.
52. Jogsten I.E., Perello G., Llebaria X., Bigas E., Marti-Cid R., Karrman A., Domingo J.L. Exposure to perfluorinated compounds in Catalonia, Spain, through consumption of various raw and cooked foodstuffs, including packaged food. Food Chem. Toxicol. 2009, 47:1577-1583.
53. Kawamura Y., Ogawa Y., Nishimura T., Kikuchi Y., Nishikawa J., Nishihara T., Tanamoto K. Estrogenic activities of UV stabilizers used in food contact plastics and benzophenone derivatives tested by the yeast two-hybrid assay. J. Health Sci. 2003, 49:205-212.
54. Kelly M.A., Reid A.M., Quinn-Hosey K.M., Fogarty A.M., Roche J.J., Brougham C.A. Investigation of the estrogenic risk to feral male brown trout (Salmo trutta) in the Shannon International River Basin District of Ireland. Ecotoxicol. Environ. Saf. 2010, 73:1658-1665.
55. Kim S.S., Kwack S.J., Lee R.D., Lim K.J., Rhee G.S., Seok J.H., Kim B.H., Won Y.H., Lee G.S., Jeung E.B., Lee B.M., Park K.L. Assessment of estrogenic and androgenic activities of tetramethrin in vitro and in vivo assays. J. Toxicol. Environ. Health, Part A 2005, 68:2277-2289.
56. Kim S.S., Lee R.D., Lim K.J., Kwack S.J., Rhee G.S., Seok J.H., Lee G.S., An B.S., Jeung E.B., Park K.L. Potential estrogenic and antiandrogenic effects of permethrin in rats. J. Reprod. Dev. 2005, 51:201-210.
57. Kim J.W., Ramaswamy B.R., Chang K.H., Isobe T., Tanabe S. Multiresidue analytical method for the determination of antimicrobials, preservatives, benzotriazole UV stabilizers, flame retardants and plasticizers in fish using ultra high performance liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr., A 2011, 1218:3511-3520.
58. Kim Y.J., Kim E.Y., Ryu J.C. Identification of estrogenic genes responding to phthalate esters treatment in human MCF-7 cells. Mol. Cell. Toxicol. 2011, 7:163-170.
59. Kjaerstad M.B., Taxvig C., Andersen H.R., Nellemann C. Mixture effects of endocrine disrupting compounds in vitro. Int. J. Androl. 2010, 33:425-433.
60. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 2002, 36:1202-1211.
61. Kraugerud M., Zimmer K.E., Ropstad E., Verhaegen S. Perfluorinated compounds differentially affect steroidogenesis and viability in the human adrenocortical carcinoma (H295R) in vitro cell assay. Toxicol. Lett. 2011, 205:62-68.
62. Le Grand R., Dulaurent S., Gaulier J.M., Saint-Marcoux F., Moesch C., Lachatre G. Simultaneous determination of five synthetic pyrethroid metabolites in urine by liquid chromatography-tandem mass spectrometry: application to 39 persons without known exposure to pyrethroids. Toxicol. Lett. 2012, 210:248-253.
63. Legler J. Determination of the estrogenic potency of phyto- and synthetic estrogens using in vitro bioassays. Natural and Synthetic Estrogens Aspects of the Cellular and Molecular Activity 2002, Research Signpost. E. Dopp, H. Stopper, G.M. Alink (Eds.).
64. Lemini C., Jaimez R., Avila M.E., Franco Y., Larrea F., Lemus A.E. In vivo and in vitro estrogen bioactivities of alkyl parabens. Toxicol. Ind. Health 2003, 19:69-79.
65. Liu A.M.F., New D.C., Lo R.K.H., Wong Y.H. Reporter gene assays. Cell-Based Assays for High Throughput Screening 2009, Human Press. P.A. Clemons, N.J. Tolliday, B.K. Wagner (Eds.).
66. Liu L.P., Bao H.Q., Liu F., Zhang J., Shen H.Q. Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study. Environ. Int. 2012, 42:78-83.
67. Llorca M., Farre M., Pico Y., Barcelo D. Development and validation of a pressurized liquid extraction liquid chromatography-tandem mass spectrometry method for perfluorinated compounds determination in fish. J. Chromatogr., A 2009, 1216:7195-7204.
68. Lopez-Carrillo L., Hernandez-Ramirez R.U., Calafat A.M., Torres-Sanchez L., Galvan-Portillo M., Needham L.L., Ruiz-Ramos R., Cebrian M.E. Exposure to phthalates and breast cancer risk in Northern Mexico. Environ. Health Perspect. 2010, 118:539-544.
69. Maras M., Vanparys C., Muylle F., Robbens J., Berger U., Barber J.L., Blust R., De Coen W. Estrogen-like properties of fluorotelomer alcohols as revealed by MCF-7 breast cancer cell proliferation. Environ. Health Perspect. 2006, 114:100-105.
70. McCarthy A.R., Thomson B.M., Shaw I.C., Abell A.D. Estrogenicity of pyrethroid insecticide metabolites. J. Environ. Monit. 2006, 8:197-202.
71. Mikula P., Kruzikova K., Dobsikova R., Harustiakova D., Svobodova Z. Influence of Propylparaben on Vitellogenesis and Sex Ratio in Juvenile Zebrafish (Danio rerio). Acta Veterinaria Brno 2009, 78:319-326.
72. Molina-Molina J.M., Escande A., Pillon A., Gomez E., Pakdel F., Cavailles V., Olea N., Ait-Aissa S., Balaguer P. Profiling of benzophenone derivatives using fish and human estrogen receptor-specific in vitro bioassays. Toxicol. Appl. Pharmacol. 2008, 232:384-395.
73. Montano M., Bakker E.J., Murk A.J. Meta-analysis of supramaximal effects in in vitro estrogenicity assays. Toxicol. Sci. 2010, 115:462-474.
74. Morohoshi K., Yamamoto H., Kamata R., Shiraishi F., Koda T., Morita M. Estrogenic activity of 37 components of commercial sunscreen lotions evaluated by in vitro assays. Toxicol. In Vitro 2005, 19:457-469.
75. Mortimer R.D., Shields J.B. Total, free, and glucose-conjugated acid metabolites from permethrin and cypermethrin in foods by gas chromatography electron capture detection. J. AOAC Int. 1995, 78:1302-1307.
76. Munshi A.B., Boardman G., Ansari F., Filck G., Smiley J., Lane R.B. Determination of 4-nonylphenol, 2-ethoxy phenol, 4-octyl phenol and other alkylphenols in fish and shellfish by GC-MS. J. Chem. Soc. Pak. 2009, 31:89-96.
77. Okubo T., Yokoyama Y., Kano K., Kano I. ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ER alpha and PR. Food Chem. Toxicol. 2001, 39:1225-1232.
78. Olsen C.M., Meussen-Elholm E.T.M., Samuelsen M., Holme J.A., Hongslo J.K. Effects of the environmental oestrogens bisphenol A, tetrachlorobisphenol A, tetrabromobisphenol A, 4-hydroxybiphenyl and 4,4'-dihydroxybiphenyl on oestrogen receptor binding, cell proliferation and regulation of oestrogen sensitive proteins in the human breast cancer cell line MCF-7. Pharmacol. Toxicol. 2003, 92:180-188.
79. Page B.D., Lacroix G.M. The occurence of phthalate ester and di-2-ethylhexyl adipate plasticizers in canadian packaging and food samples in 1985-1989 - a survey. Food Addit. Contam. 1995, 12:129-151.
80. Perez-Fuentetaja A., Lupton S., Clapsadl M., Samara F., Gatto L., Biniakewitz R., Aga D.S. PCB and PBDE levels in wild common carp (Cyprinus carpio) from eastern Lake Erie. Chemosphere 2010, 81:541-547.
81. Petro E.M.L., Covaci A., Leroy J., Dirtu A.C., De Coen W., Bols P.E.J. Occurrence of endocrine disrupting compounds in tissues and body fluids of Belgian dairy cows and its implications for the use of the cow as a model to study endocrine disruption. Sci. Total Environ. 2010, 408:5423-5428.
82. Plotan M., Elliott C.T., Oplatowska M., Connolly L. Validation and application of reporter gene assays for the determination of estrogenic and androgenic endocrine disruptor activity in sport supplements. Anal. Bioanal. Chem. 2012, 403:3057-3067.
83. Poiger T., Buser H.R., Balmer M.E., Bergqvist P.A., Muller M.D. Occurrence of UV filter compounds from sunscreens in surface waters: regional mass balance in two Swiss lakes. Chemosphere 2004, 55:951-963.
84. Pugazhendhi D., Pope G.S., Darbre P.D. Oestrogenic activity of p-hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines. J. Appl. Toxicol. 2005, 25:301-309.
85. Ramaswamy B.R., Kim J.W., Isobe T., Chang K.H., Amano A., Miller T.W., Siringan F.P., Tanabe S. Determination of preservative and antimicrobial compounds in fish from Manila Bay, Philippines using ultra high performance liquid chromatography tandem mass spectrometry, and assessment of human dietary exposure. J. Hazard. Mater. 2011, 192:1739-1745.
86. Roosens L., D'Hollander W., Bervoets L., Reynders H., Van Campenhout K., Cornelis C., Van Den Heuvel R., Koppen G., Covaci A. Brominated flame retardants and perfluorinated chemicals, two groups of persistent contaminants in Belgian human blood and milk. Environ. Pollut. 2010, 158:2546-2552.
87. Sabaliunas, D., Webb, S.F., Peeters, S., Eckhoff, W.S., 2010. Environmental concentrations, fate and safety of the organic uv filter octyl methoxycinnamate in surface waters. Poster, 11th. SETAC Europe Annual Congress, Madrid. Available from: http://www.great-er.org/files/webb_OMC.PDF.
88. Sannino A. Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods. J. AOAC Int. 2010, 93:315-322.
89. Schecter A., Colacino J., Patel K., Kannan K., Yun S.H., Haffner D., Harris T.R., Birnbaum L. Polybrominated diphenyl ether levels in foodstuffs collected from three locations from the United States. Toxicol. Appl. Pharmacol. 2010, 243:217-224.
90. Schlumpf M., Cotton B., Conscience M., Haller V., Steinmann B., Lichtensteiger W. In vitro and in vivo estrogenicity of UV screens. Environ. Health Perspect. 2001, 109:239-244.
91. Schlumpf M., Durrer S., Faass O., Ehnes C., Fuetsch M., Gaille C., Henseler M., Hofkamp L., Maerkel K., Reolon S., Timms B., Tresguerres J.A.F., Lichtensteiger W. Developmental toxicity of UV filters and environmental exposure: a review. Int. J. Androl. 2008, 31:144-150.
92. Schmitt S., Reifferscheid G., Claus E., Schlusener M., Buchinger S. Effect directed analysis and mixture effects of estrogenic compounds in a sediment of the river Elbe. Environ. Sci. Pollut. Res. 2012, 19:3350-3361.
93. Schreurs R., Sonneveld E., Jansen J.H.J., Seinen W., van der Burg B. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol. Sci. 2005, 83:264-272.
94. Seidlova-Wuttke D., Christoffel J., Rimoldi G., Jarry H., Wuttke W. Comparison of effects of estradiol with those of octylmethoxycinnamate and 4-methylbenzylidene camphor on fat tissue, lipids and pituitary hormones. Toxicol. Appl. Pharmacol. 2006, 214:1-7.
95. Shi Z.M., Zhang H.X., Liu Y., Xu M., Dai J.Y. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Toxicol. Sci. 2007, 98:206-215.
96. Sjodin A., Patterson D.G., Bergman A. A review on human exposure to brominated flame retardants - particularly polybrominated diphenyl ethers. Environ. Int. 2003, 29:829-839.
97. Soeborg T., Ganderup N.C., Kristensen J.H., Bjerregaard P., Pedersen K.L., Bollenc P., Hansen S.H., Halling-Sorensen B. Distribution of the UV filter 3-benzylidene camphor in rat following topical application. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2006, 834:117-121.
98. Sorensen L.K. Determination of phthalates in milk and milk products by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2006, 20:1135-1143.
99. Sotoca A.M., Bovee T.F.H., Brand W., Velikova N., Boeren S., Murk A.J., Vervoort J., Rietjens I. Superinduction of estrogen receptor mediated gene expression in luciferase based reporter gene assays is mediated by a post-transcriptional mechanism. J. Steroid Biochem. Mol. Biol. 2010, 122:204-211.
100. Takeuchi S., Iida M., Kobayashi S., Jin K., Matsuda T., Kojima H. Differential effects of phthalate esters on transcriptional activities via human estrogen receptors alpha and beta, and androgen receptor. Toxicology 2005, 210:223-233.
101. Tao L., Chen M., Collins E., Lu C.S. Simultaneous quantitation of seven pyrethroid metabolites in human urine by capillary gas chromatography-mass spectrometry. J. Sep. Sci. 2013, 36:773-780.
102. Taxvig C., Vinggaard A.M., Hass U., Axelstad M., Boberg J., Hansen P.R., Frederiksen H., Nellemann C. Do parabens have the ability to interfere with steroidogenesis?. Toxicol. Sci. 2008, 106:206-213.
103. Teagasc National Food Residue Database of Ireland 2005, Teagasc Food Research Centre, Ashtown, Ashtown.
104. Terasaki M., Kamata R., Shiraishi F., Makino M. Evaluation of estrogenic activity of parabens and their chlorinated derivatives by using the yeast two-hybrid assay and the enzyme-linked immunosorbent assay. Environ. Toxicol. Chem. 2009, 28:204-208.
105. Teuten E.L., Saquing J.M., Knappe D.R.U., Barlaz M.A., Jonsson S., Bjorn A., Rowland S.J., Thompson R.C., Galloway T.S., Yamashita R., Ochi D., Watanuki Y., Moore C., Pham H.V., Tana T.S., Prudente M., Boonyatumanond R., Zakaria M.P., Akkhavong K., Ogata Y., Hirai H., Iwasa S., Mizukawa K., Hagino Y., Imamura A., Saha M., Takada H. Transport and release of chemicals from plastics to the environment and to wildlife. Philos. Trans. R. Soc. Lond., B 2009, 364:2027-2045.
106. Thomson, B., 2009. Exposure to endocrine-disrupting chemicals in food. In: Shaw, I. (Ed.), Endocrine Disrupting Chemicals in Food. Woodhead Publishing Limited; Cambridge.
107. Tittlemier S.A., Pepper K., Seymour C., Moisey J., Bronson R., Cao X.-L., Dabeka R.W. Dietary exposure of Canadians to perfluorinated carboxylates and perfluorooctane sulfonate via consumption of meat, fish, fast foods, and food items prepared in their packaging. J. Agric. Food Chem. 2007, 55:3203-3210.
108. Tsumura Y., Wada I., Fujiwara Y., Nakamura Y., Tonogai Y., Ito Y. Simultaneous determination of 13 synthetic pyrethroids and their metabolite, 3-phenoxybenzoic acid, in tea by gas-chromatography. J. Agric. Food Chem. 1994, 42:2922-2925.
109. Ueyama J., Saito I., Kamijima M. Analysis and evaluation of pyrethroid exposure in human population based on biological monitoring of urinary pyrethroid metabolites. J. Pestic. Sci. 2010, 35:87-98.
110. UNEP, 2009. Report of the Conference of the Parties of the Stockholm Convention on Persistent Organic Pollutants on the work of its fourth meeting.
111. van Meeuwen J.A., van Son O., Piersma A.H., de Jong P.C., van den Berg M. Aromatase inhibiting and combined estrogenic effects of parabens and estrogenic effects of other additives in cosmetics. Toxicol. Appl. Pharmacol. 2008, 230:372-382.
112. Vanparys C., Depiereux S., Nadzialek S., Robbens J., Blust R., Kestemont P., De Coen W. Performance of the flow cytometric E-screen assay in screening estrogenicity of pure compounds and environmental samples. Sci. Total Environ. 2010, 408:4451-4460.
113. Vo T.T.B., Yoo Y.M., Choi K.C., Jeung E.B. Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model. Reprod. Toxicol. 2010, 29:306-316.
114. White S.S., Fenton S.E., Hines E.P. Endocrine disrupting properties of perfluorooctanoic acid. J. Steroid Biochem. Mol. Biol. 2011, 127:16-26.
115. WHO, UNEP, 2012. State of the Science of Endocrine Disrupting Chemicals 2012.
116. Wielogorska E., Elliott C., Danaher M., Connolly L. Validation and application of a reporter gene assay for the determination of estrogenic endocrine disruptor activity in milk. Food Chem. Toxicol. 2014, 69:260-266.
117. Willemsen P., Scippo M.L., Kausel G., Figueroa J., Maghuin-Rogister G., Martial J.A., Muller M. Use of reporter cell lines for detection of endocrine-disrupter activity. Anal. Bioanal. Chem. 2004, 378:655-663.
118. Willingham E. Endocrine-disrupting compounds and mixtures: unexpected dose-response. Arch. Environ. Contam. Toxicol. 2004, 46:265-269.
119. Withers J.A., Jess S., Kirbas J.M., Matthews D., Kelly T. Pesticide Usage Survey Report 230 2008, Northern Ireland Arable Crops, Agri-Food and Biosciences Institute, Belfast.
120. Witorsch R.J., Thomas J.A. Personal care products and endocrine disruption: a critical review of the literature. Crit. Rev. Toxicol. 2010, 40:1-30.
121. WWF, U.K., 2006. Chain of Contamination - The Food Link., Surrey.
122. Ying G.G., Kookana R.S. Triclosan in wastewaters and biosolids from Australian wastewater treatment plants. Environ. Int. 2007, 33:199-205.
123. Yousef M.I., El-Demerdash F.M., Al-Salhen K.S. Protective role of Isoflavones against the toxic effect of cypermethrin on semen quality and testosterone levels of rabbits. J. Environ. Sci. Health, Part B 2003, 38:463-478.
124. Zhang H., Wang H., Ji Y.L., Zhang Y., Yu T., Ning H., Zhang C., Zhao X.F., Wang Q., Liu P., Xu D.X. Maternal fenvalerate exposure during pregnancy persistently impairs testicular development and spermatogenesis in male offspring. Food Chem. Toxicol. 2010, 48:1160-1169.