Assessing hormone receptor activities of pyrethroid insecticides and their metabolites in reporter gene assays

Toxicological Sciences

Volumn 116, Issue 1, 2010, Pages 58-66

  Du, Guizhen ^a   Shen, Ouxi ^a   Sun, Hong ^b   Fei, Juan ^a   Lu, Chuncheng ^a   Song, Ling ^a   Xia, Yankai ^a   Wang, Shoulin ^a   Wang, Xinru ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

AR; ER; Pyrethroid insecticides; Reporter gene assay; TR

Indexed keywords

3 (2,2 DICHLOROVINYL) 2,2 DIMETHYLCYCLOPROPENE CARBOXYLIC ACID; 3 PHENOXYBENZOIC ACID; ANDROGEN RECEPTOR; CIPERMETHRIN; CYCLOPROTHRIN; CYFLUTHRIN; CYHALOTHRIN; DELTAMETHRIN; ESTROGEN RECEPTOR; ETOFENPROX; FENVALERATE; LUCIFERASE; PERMETHRIN; PYRETHROID; TETRAMETHRIN; THYROID HORMONE RECEPTOR; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; ENDOCRINE DISRUPTOR; HORMONE; INSECTICIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOCRINE SYSTEM; ESTROGEN ACTIVITY; GENITAL SYSTEM; KIDNEY CELL; MOLECULAR INTERACTION; MONKEY; NONHUMAN; PROTEIN FUNCTION; RECEPTOR BINDING; RECEPTOR BLOCKING; REPORTER GENE; TOXICITY TESTING; ANIMAL; CELL LINE; DRUG EFFECTS; METABOLISM; TOXICITY; XENOPUS LAEVIS;

ANIMALS; CELL LINE; ENDOCRINE DISRUPTORS; GENES, REPORTER; HORMONES; INSECTICIDES; PYRETHRINS; RECEPTORS, CELL SURFACE; XENOPUS LAEVIS;

EID: 77954351492     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq120     Document Type: Article

References (43)

1. Abd El-Aziz, M.I., Sahlab, A.M., and Abd El-Khalik, M. (1994). Influence of diazinon and deltamethrine on reproductive organs and fertility of male rats. Dtsch. Tieräerztl. Wochenshr. 101, 213-248.
2. Akhtar, N., Kayani, S.A., Ahmad, M.M., and Shahab, M. (1996). Insecticide-induced changes in secretory activity of the thyroid gland in rats. J. Appl. Toxicol. 16, 397-400.
3. Andrade, A.J., Araujo, S., Santana, G.M., Ohi, M., and Dalsenter, P.R. (2002). Screening for in vivo (anti)estrogenic and (anti)androgenic activities of technical and formulated deltamethrin. Regul. Toxicol. Pharmacol. 35, 379-382.
4. Bian, Q., Xu, L.C., Wang, S.L., Xia, Y.K., Tan, L.F., Chen, J.F., Song, L., Chang, H.C., and Wang, X.R. (2004). Study on the relation between occupational fenvalerate exposure and spermatozoa DNA damage of pesticide factory workers. Occup. Environ. Med. 61, 999-1005.
5. Casida, J.E. (1980). Pyrethrum flowers and pyrethroid insecticides. Environ. Health Perspect. 34, 189-202.
6. Chen, H., Xiao, J., Hu, G., Zhou, J., Xiao, H., and Wang, X. (2002). Estrogenicity of organophosphorus and pyrethroid pesticides. J. Toxicol. Environ. Health A 65, 1419-1435.
7. Colborn, T., vom Saal, F.S., and Soto, A.M. (1993). Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 101, 378-384.
8. DeVito, M., Biegel, L., Brouwer, A., Brown, S., Brucker-Davis, F., Cheek, A.O., Christensen, R., Colborn, T., Cooke, P., Crissman, J., et al. (1999). Screening methods for thyroid hormone disruptors. Environ. Health Perspect. 107, 407-415.
9. Diamanti-Kandarakis, E., Bourguignon, J.P., Giudice, L.C., Hauser, R., Prins, G.S., Soto, A.M., Zoeller, R.T., and Gore, A.C. (2009). Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr. Rev. 30, 293-342.
10. Eil, C., and Nisula, B.C. (1990). The binding properties of pyrethroids to human skin fibroblast androgen receptors and to sex hormone binding globulin. J. Steroid Biochem. 35, 409-414.
11. Elbetieha, A., Da'as, S. I., Khamas, W., and Darmani, H. (2001). Evaluation of the toxic potentials of cypermethrin pesticide on some reproductive and fertility parameters in the male rats. Arch. Environ. Contam. Toxicol. 41, 522-528.
12. Erstfeld, K.M. (1999). Environmental fate of synthetic pyrethroids during spray drift and field runoff treatments in aquatic microcosms. Chemosphere 39, 1737-1769.
13. Gaido, K.W., Maness, S.C., McDonnell, D.P., Dehal, S.S., Kupfer, D., and Safe, S. (2000). Interaction of methoxychlor and related compounds with estrogen receptor a and b, and androgen receptor: structure-activity studies. Mol. Pharmacol. 58, 852-858.
14. Gan, J., Lee, S.J., Liu, W.P., Haver, D.L., and Kabashima, J.N. (2005). Distribution and persistence of pyrethroids in runoff sediments. J. Environ. Qual. 34, 836-841.
15. Go, V., Garey, J., Wolff, M.S., and Pogo, B.G. (1999). Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line. Environ. Health Perspect. 107, 173-177.
16. Gould, J.C., Leonard, L.S., Maness, S.C., Wagner, B.L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D.P., and Gaido, K.W. (1998). Bisphenol A interacts with the estrogen receptor a in a distinct manner from estradiol. Mol. Cell Endocrinol. 142, 203-214.
17. Kim, I.Y., Shin, J.H., Kim, H.S., Lee, S.J., Kang, I.H., Kim, T.S., Moon, H.J., Choi, K.S., Moon, A., and Han, S.Y. (2004). Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assays. J. Reprod. Dev. 50, 245-255.
18. Kim, S.S., Lee, R.D., Lim, K.J., Kwack, S.J., Rhee, G.S., Seok, J.H., Lee, G.S., An, B.S., Jeung, E.B., and Park, K.L. (2005). Potential estrogenic and antiandrogenic effects of permethrin in rats. J. Reprod. Dev. 51, 201-210.
19. Kojima, H., Katsura, E., Takeuchi, S., Niiyama, K., and Kobayashi, K. (2004). Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ. Health Perspect. 112, 524-531.
20. Korner, W., Vinggaard, A.M., Terouanne, B., Ma, R., Wieloch, C., Schlumpf, M., Sultan, C., and Soto, A.M. (2004). Interlaboratory comparison of four in vitro assays for assessing androgenic and antiandrogenic activity of environmental chemicals. Environ. Health Perspect. 112, 695-702.
21. Maiti, P.K., and Kar, A. (1998). Is triiodothyronine capable of ameliorating pyrethroid-induced thyroid dysfunction and lipid peroxidation? J. Appl. Toxicol. 18, 125-128.
22. Markovic, M., Cupac, S., Durovic, R., Milinovic, J., and Kljajic, P. (2010). Assessment of heavy metal and pesticide levels in soil and plant products from agricultural area of Belgrade, Serbia. Arch. Environ. Contam. Toxicol. 58, 341-351.
23. Meerts, I.A., van Zanden, J.J., Luijks, E.A., van Leeuwen-Bol, I., Marsh, G., Jakobsson, E., Bergman, A., and Brouwer, A. (2000). Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol. Sci. 56, 95-104.
24. Miyamoto, J. (1976). Degradation, metabolism and toxicity of synthetic pyrethroids. Environ. Health Perspect. 14, 15-28.
25. Miyamoto, T., Kakizawa, T., Ichikawa, K., Nishio, S., Takeda, T., Suzuki, S., Kaneko, A., Kumagai, M., Mori, J., and Yamashita, K. (2001). The role of hinge domain in heterodimerization and specific DNA recognition by nuclear receptors. Mol. Cell Endocrinol. 181, 229-238.
26. Moriyama, K., Tagami, T., Akamizu, T., Usui, T., Saijo, M., Kanamoto, N., Hataya, Y., Shimatsu, A., Kuzuya, H., and Nakao, K. (2002). Thyroid hormone action is disrupted by bisphenol A as an antagonist. J. Clin. Endocrinol. Metab. 87, 5185-5190.
27. Moriyama, K., Tagami, T., Usui, T., Naruse, M., Nambu, T., Hataya, Y., Kanamoto, N., Li, Y.S., Yasoda, A., and Arai, H. (2007). Antithyroid drugs inhibit thyroid hormone receptor-mediated transcription. J. Clin. Endocrinol. Metab. 92, 1066-1072.
28. Pine, M.D., Hiney, J.K., Lee, B., and Dees, W.L. (2008). The pyrethroid pesticide esfenvalerate suppresses the afternoon rise of luteinizing hormone and delays puberty in female rats. Environ. Health Perspect. 116, 1243-1247.
29. Saito, K., Tomigahara, Y., Ohe, N., Isobe, N., Nakatsuka, I., and Kaneko, H. (2000). Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms. Toxicol. Sci. 57, 54-60.
30. Sereda, B., Bouwman, H., and Kylin, H. (2009). Comparing water, bovine milk, and indoor residual spraying as possible sources of DDT and pyrethroid residues in breast milk. J. Toxicol. Environ. Health A 72, 842-851.
31. Shen, O., Du, G., Sun, H., Wu, W., Jiang, Y., Song, L., and Wang, X. (2009). Comparison of in vitro hormone activities of selected phthalates using reporter gene assays. Toxicol. Lett. 191, 9-14.
32. Sun, H., Shen, O.X., Wang, X.R., Zhou, L., Zhen, S.Q., and Chen, X.D. (2009). Anti-thyroid hormone activity of bisphenol A, tetrabromobisphenol A and tetrachlorobisphenol A in an improved reporter gene assay. Toxicol. In Vitro 23, 950-954.
33. Sun, H., Xu, X.L., Qu, J.H., Hong, X., Wang, Y.B., Xu, L.C., and Wang, X.R. (2008). 4-Alkylphenols and related chemicals show similar effect on the function of human and rat estrogen receptor alpha in reporter gene assay. Chemosphere 71, 582-588.
34. Tagami, T., Madison, L.D., Nagaya, T., and Jameson, J.L. (1997). Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone. Mol. Cell Biol. 17, 2642-2648.
35. Tone, Y., Collingwood, T.N., Adams, M., and Chatterjee, V.K. (1994). Functional analysis of a transactivation domain in the thyroid hormone beta receptor. J. Biol. Chem. 269, 31157-31161.
36. Tyler, C.R., Beresford, N., van der Woning, M., Sumpter, J.P., and Thorpe, K. (2000). Metabolism and environmental degradation of pyrethroid insecticides produce compounds with endocrine activities. Environ. Toxicol. Chem. 19, 801-809.
37. U.S. Environmental Protection Agency (USEPA). (2008). Technical Review Document for EDSP, Proposed Tier 1 Screening Battery. Available at: http://www.epa.gov/scipoly/sap/meetings/2008/march/technical_review.pdf. Accessed April 27, 2010.
38. Xia, Y., Han, Y., Wu, B., Wang, S., Gu, A., Lu, N., Bo, J., Song, L., Jin, N., and Wang, X. (2008). The relation between urinary metabolite of pyrethroid insecticides and semen quality in humans. Fertil. Steril. 89, 1743-1750.
39. Xu, L.C., Liu, L., Ren, X.M., Zhang, M.R., Cong, N., Xu, A.Q., and Shao, J.H. (2008). Evaluation of androgen receptor transcriptional activities of some pesticides in vitro. Toxicology 243, 59-65.
40. Yousef, M.I., El-Demerdash, F.M., and Al-Salhen, K.S. (2003). Protective role of isoflavones against the toxic effect of cypermethrin on semen quality and testosterone levels of rabbits. J. Environ. Sci. Health B 38, 463-478.
41. Zhang, J., Zhu, W., Zheng, Y., Yang, J., and Zhu, X. (2008). The antiandrogenic activity of pyrethroid pesticides cyfluthrin and beta-cyfluthrin. Reprod. Toxicol. 25, 491-496.
42. Zhang, S.Y., Ito, Y., Yamanoshita, O., Yanagiba, Y., Kobayashi, M., Taya, K., Li, C., Okamura, A., Miyata, M., Ueyama, J., et al. (2007). Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse. Endocrinology 148, 3941-3949.
43. Zhao, M., Zhang, Y., Liu, W., Xu, C., Wang, L., and Gan, J. (2008). Estrogenic activity of lambda-cyhalothrin in the MCF-7 human breast carcinoma cell line. Environ. Toxicol. Chem. 27, 1194-1200.