Low dose 4-MBC effect on neuroendocrine regulation of reproductive axis in adult male rats

Environmental Toxicology and Pharmacology

Volumn 26, Issue 2, 2008, Pages 222-224

  Carou, Maria E ^a   Ponzo, Osvaldo J ^a   Cardozo Gutierrez, Romina P ^a   Szwarcfarb, Berta ^a   Deguiz, Maria L ^a   Reynoso, Roxana ^a   Carbone, Silvia ^a   Moguilevsky, Jaime A ^b   Scacchi, Pablo ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b FAVALORO UNIVERSITY   (Argentina)

Author keywords

4 MBC; Endocrine disrupters; FSH; GnRH; LH; Male rats

Indexed keywords

4 METHYLBENZYLIDENE CAMPHOR; CAMPHOR DERIVATIVE; ENDOCRINE DISRUPTOR; ESTROGEN RECEPTOR; FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; PROLACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FOLLITROPIN BLOOD LEVEL; GENE EXPRESSION; GONADORELIN RELEASE; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LIGHT ABSORPTION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RAT; REPRODUCTION; ULTRAVIOLET RADIATION;

ANIMALIA; DRYOBALANOPS; RATTUS;

EID: 47849115672     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2008.04.001     Document Type: Article

References (21)

1. Damgaard I.N., Main K.M., Toppari J., and Skakkebaek N.E. Impact of exposure to endocrine disrupters in uterus and in childhood on adult reproductor. Best. Pract. Res. Clin. Endocrinol. Metab. 16 (2002) 289-309
2. Durrer S., Maerkel K., Schlumpf M., and Lichtensteiger W. Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the UV filter 4-methylbenzylidene camphor. Endocrinology 146 (2005) 2130-2139
3. Herbison A.E. Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons. Endocr. Rev. 19 (1998) 302-330
4. Holbech H., Norum U., Korsgaard B., and Poul B. The chemical UV-filter 3-benzylidene camphor causes an oestrogenic effect in an in vivo fish assay. Pharmacol. Toxicol. 91 (2002) 204-208
5. Hrabovszky E., Steinhauser A., Barabas K., Shughrue P.J., Petersen S.L., Merchenthaler I., and Liposits Z. Estrogen receptor beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brain. Endocrinology 142 (2001) 3261-3264
6. Inui M., Adachi T., Takenaka S., Inui H., Nakazawa M., Ueda M., Watanabe H., Mori C., Iguchi T., and Miyatake K. Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes). Toxicology 194 (2003) 43-50
7. Janjua N.R., Mogensen B., Andersson A.M., Petersen J.H., Henriksen M., Skakkebaek N.E., and Wulf H.C. Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. J. Invest. Dermatol. 123 (2004) 57-61
8. Klann A., Levy G., Lutz I., Muller C., Kloas W., and Hildebrandt J.P. Estrogen-like effects of ultraviolet screen 3-(4-methylbenzylidene)-camphor (Eusolex 6300) on cell proliferation and gene induction in mammalian and amphibian cells. Environ. Res. 97 (2005) 274-281
9. Maerkel K., Durrer S., Henseler M., Schlumpf M., and Lichtensteiger W. Sexually dimorphic gene regulation in brain as a target for endocrine disrupters: developmental exposure of rats to 4-methylbenzylidene camphor. Toxicol. Appl. Pharmacol. 218 (2007) 152-165
10. Mueller S.O., Kling M., Arifin Firzani P., Mecky A., Duranti E., Shields-Botella J., Delasorne R., Broschard T., and Kramer P.J. Activation of estrogen receptor alpha and ERbeta by 4-methylbenzylidene camphor in human and rat cells: comparison with phyto and xenoestrogens. Toxicol. Lett. 142 (2003) 89-101
11. Mooradian A.D., Morley J.E., and Korenman S.G. Biological actions of androgens. Endocr. Rev. 8 (1987) 1-28
12. Ramos J.G., Varayoud J., Kass L., Rodríguez H., Costabel L., Muñoz-de-Toro M., and Luque E.H. Bisphenol A induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male rats. Endocrinology 144 (2003) 3206-3215
13. Rochira V., Zirilli L., Genazzani A.D., Balestrieri A., Aranda C., Fabre B., Antunez P., Diazzi C., Carani C., and Maffei L. Hypothalamic-pituitary-gonadal axis in two men with aromatase deficiency: evidence that circulating estrogens are required at the hypothalamic level for the integrity of gonadotropin negative feedback. Eur. J. Endocrinol. 155 (2006) 513-522
14. Roy D., Angelini N.L., and Belsham D.D. Estrogen directly represses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha) and ERbeta-expressing GT1-7 GnRH neurons. Endocrinology 140 (1999) 5045-5053
15. Schlumpf M., Cotton B., Conscience M., Haller V., Steinmann B., and Lichtensteiger W. In vitro and in vivo estrogenicity of UV screens. Environ. Health. Perspect. 109 (2001) 239-244
16. Schlumpf M., Jarry H., Wuttke W., Ma R., and Lichtensteiger W. Estrogenic activity and estrogen receptor beta binding of the UV filter 3-benzylidene camphor. Comparison with 4-methylbenzylidene camphor. Toxicology 199 (2004) 109-120
17. Schlumpf M., Schmid P., Durrer S., Conscience M., Maerkel K., Henseler M., Gruetter M., Herzog I., Reolon S., Ceccatelli R., Faass O., Stutz E., Jarry H., Wuttke W., and Lichtensteiger W. Endocrine activity and developmental toxicity of cosmetic UV filters-an update. Toxicology 205 (2004) 113-122
18. Sharpe R.M. The 'oestrogen hypothesis'-where do we stand now. Int. J. Androl. 26 (2003) 2-15
19. Tinwell H., Lefevre P.A., Moffat G.J., Burns A., Odum J., Spurway T.D., Orphanides G., and Ashby J. Confirmation of uterotrophic activity of 3-(4-methylbenzylidene) camphor in the immature rat. Environ. Health. Perspect. 110 (2002) 533-536
20. Volkel W., Colnot T., Schauer U.M., Broschard T.H., and Dekant W. Toxicokinectis and biotransformation of 3-(4-methylbenzylidene) camphor in rats alter oral administration. Toxicol. Appl. Pharmacol. 216 (2006) 318-331
21. Zhou W., Koldzic-Zivanovic N., Clarke C.H., de Beun R., Wassermann K., Burry P.S., Cunningham K.A., and Thomas M.L. Selective estrogen receptor modulator effects in rat brain. Neuroendocrinology 75 (2002) 24-33