Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells

Ophthalmic Research

Volumn 51, Issue 2, 2014, Pages 59-66

  Weinberger, Andreas W A ^a   Eddahabi, Cordula ^a   Carstesen, Dörthe ^a   Zipfel, Peter F ^b,c   Walter, Peter ^a   Skerka, Christine ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Age related macular degeneration; Factor H; In situ hybridization; Interleukin; Retinal cell culture; Retinal pigment epithelium

Indexed keywords

COMPLEMENT FACTOR H; FACTOR H LIKE PROTEIN 1; INTERLEUKIN 6; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATION; PATHOGENESIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA CELL; RETINA MACULA AGE RELATED DEGENERATION; CELL PROTECTION; COMPLEMENT ACTIVATION; FLUORESCENCE IN SITU HYBRIDIZATION; IMMUNE RESPONSE; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RETINA PIGMENT CELL;

CELL LINE; COMPLEMENT C3B INACTIVATOR PROTEINS; COMPLEMENT FACTOR H; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERLEUKIN-6; MICROSCOPY, FLUORESCENCE; RETINAL PIGMENT EPITHELIUM; TISSUE DONORS;

EID: 84893075958     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000351624     Document Type: Article

References (41)

1. Donoso LA, Kim D, Frost A, Callahan A, Hageman G: The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2006; 51:137-152. (Pubitemid 43269939)
2. Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, Sangiovanni JP, Mane SM, Mayne ST, Bracken MB, Ferris FL, Ott J, Barnstable C, Hoh J: Complement factor H polymorphism in age-related macular degeneration. Science 2005; 308:385-389. (Pubitemid 40530070)
3. Mandal MN, Ayyagari R: Complement factor H: spatial and temporal expression and localization in the eye. Invest Ophthalmol Vis Sci 2006; 47:4091-4097. (Pubitemid 46049518)
4. Fritsche LG, Lauer N, Hartmann A, Stippa S, Keilhauer CN, Oppermann M, Pandey MK, Köhl J, Zipfel PF, Weber BH, Skerka C: An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet 2010; 19:4694-4704.
5. Mihlan M, Stippa S, Józsi M, Zipfel PF: Mo-nomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H. Cell Death Differ 2009; 16:1630-1640.
6. Zareparsi S, Branham KE, Li M, Shah S, Klein RJ, Ott J, Hoh J, Abecasis GR, Swaroop A: Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet 2005; 77:149-153. (Pubitemid 40848046)
7. Zipfel PF, Lauer N, Skerka C: The role of complement in AMD. Adv Exp Med Biol 2010; 703:9-24.
8. Zipfel PF, Skerka C: Complement regulators and inhibitory proteins. Nat Rev Immunol 2009; 9:729-740.
9. Soames CJ, Sim RB: Interactions between human complement components factor H, factor I and C3b. Biochem J 1997; 326:553-561. (Pubitemid 27417236)
10. Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Super-ti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ: Complement factor H binds mal-ondialdehyde epitopes and protects from oxi-dative stress. Nature 2011; 478:76-81.
11. Pangburn MK, Schreiber RD, Muller-Eber-hard HJ: Human complement C3b inactiva-tor: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. J Exp Med 1977; 146:257-270.
12. Friese MA, Hellwage J, Jokiranta TS, Meri S, Peter HH, Eibel H, Zipfel PF: FHL-1/reconec-tin and factor H: two human complement regulators which are encoded by the same gene are differently expressed and regulated. Mol Immunol 1999; 36:809-818. (Pubitemid 30100832)
13. Kuhn S, Skerka C, Zipfel PF: Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1. J Immunol 1995; 155:5663-5670.
14. Kuhn S, Zipfel PF: Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H. Eur J Immunol 1996; 26:2383-2387. (Pubitemid 26340939)
15. Hellwage J, Kuhn S, Zipfel PF: The human complement regulatory factor-H-like protein 1, which represents a truncated form of factor H, displays cell-attachment activity. Biochem J 1997; 326(Pt 2):321-327. (Pubitemid 27417204)
16. Zipfel PF, Hallström T, Hammerschmidt S, Skerka C: The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci. Vaccine 2008; 30;26:I67-I74.
17. Edwards AO, Ritter R 3rd, Abel KJ, Manning A, Panhuysen C, Farrer LA: Complement factor H polymorphism and age-related macular degeneration. Science 2005; 308:421-424. (Pubitemid 40530082)
18. Schlaf G, Demberg T, Beisel N, Schieferdeck-er HL, Götze O: Expression and regulation of complement factors H and I in rat and human cells: some critical notes. Mol Immunol 2001; 38:231-239. (Pubitemid 32786780)
19. Abecasis GR, Yashar BM, Zhao Y, Ghiasvand NM, Zareparsi S, Branham KE, Reddick AC, Trager EH, Yoshida S, Bahling J, Filippova E, Elner S, Johnson MW, Vine AK, Sieving PA, Jacobson SG, Richards JE, Swaroop A: Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease. Am J Hum Genet 2004; 74:482-494. (Pubitemid 38325919)
20. Iyengar SK, Song D, Klein BE, Klein R, Schick JH, Humphrey J, Millard C, Liptak R, Russo K, Jun G, Lee KE, Fijal B, Elston RC: Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet 2004; 74:20-39. (Pubitemid 38085235)
21. Majewski J, Schultz DW, Weleber RG, Schain MB, Edwards AO, Matise TC, Acott TS, Ott J, Klein ML: Age-related macular degeneration-a genome scan in extended families. Am J Hum Genet 2003; 73:540-550. (Pubitemid 37076268)
22. Seddon JM, Santangelo SL, Book K, Chong S, Cote J: A genome-wide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. Am J Hum Genet 2003; 73:780-790. (Pubitemid 37271882)
23. Weeks DE, Conley YP, Tsai HJ, Mah TS, Schmidt S, Postel EA, Aqarwal A, Haines JL, Pericak-Vance MA, Rosenfeld PJ, Paul TO, Eller AW, Morse LS, Dailey JP, Ferrell RE, Gorin MB: Age-related maculopathy: a ge-nomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. Am J Hum Genet 2004; 75: 174-189. (Pubitemid 38943862)
24. Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R: A common haplotype in the complement regulatory gene factor H (HF1/factor H) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 2005; 102:7227-7232. (Pubitemid 40696361)
25. Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, Spencer KL, Kwan SY, Noureddine M, Gilbert JR, Schnetz-Boutaud N, Agarwal A, Postel EA, Pericak-Vance MA: Complement factor H variant increases the risk of age-related macular degeneration. Science 2005; 308:419-421. (Pubitemid 40530081)
26. Skerka C, Lauer N, Weinberger A, Keilhauer CN, Sühnel J, Smith R, Schlötzer-Schrehardt U, Fritsche L, Heinen S, Hartmann A, Weber BH, Zipfel PF: Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration. Mol Immunol 2007; 44:3398-3406. (Pubitemid 46678196)
27. Lauer N, Mihlan M, Hartmann A, Schlötzer-Schrehardt U, Keilhauer C, Scholl HP, Char-bel Issa P, Holz F, Weber BH, Skerka C, Zip-fel PF: Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant. J Immunol 2011; 187: 4374-4383.
28. Febbraio MA, Pedersen BK: Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? Exerc Sport Sci Rev 2005; 33:114-119. (Pubitemid 40994563)
29. Seitsonen S, Lemmelä S, Holopainen J, Tom-mila P, Ranta P, Kotamies A, Moilanen J, Palosaari T, Kaarniranta K, Meri S, Immonen I, Järvelä I: Analysis of variants in the complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degeneration in the Finnish population. Mol Vis 2006; 12:796-801. (Pubitemid 44111652)
30. Skerka C, Zipfel PF: Complement factor H related proteins in immune diseases. Vaccine 2008; 30;26:I9-I14.
31. Laine M, Jarva H, Seitsonen S, Haapasalo K, Lehtinen MJ, Lindeman N, Anderson DH, Johnson PT, Järvelä I, Jokiranta TS, Hageman GS, Immonen I, Meri S: Y402H polymorphism of complement factor H affects binding affinity to C-Reactive Protein. J Immunol 2007; 178:3831-3836. (Pubitemid 46417652)
32. Chen M, Forrester JV, Xu H: Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments. Exp Eye Res 2007; 84:635-645. (Pubitemid 46400631)
33. Kim YH, He S, Kase S, Kitamura M, Ryan SJ, Hinton DR: Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefes Arch Clin Exp Ophthalmol 2009; 247:651-659.
34. Klaver CC, Kliffen M, van Duijn CM, Hofman A, Cruts M, Grobbee DE, van Broeckhoven C, de Jong PT: Genetic association of apolipo-protein E with age-related macular degeneration. Am J Hum Genet 1998; 63:200-206. (Pubitemid 30428336)
35. Zipfel PF, Hellwage J, Friese MA, Hegasy G, Jokiranta ST, Meri S: Factor H and disease: a complement regulator affects vital body functions. Mol Immunol 1999; 36:241-248. (Pubitemid 29281852)
36. Jozsi M, Manuelian T, Heinen S, Oppermann M, Zipfel PF: Attachment of the soluble complement regulator factor H to cell and tissue surfaces: relevance for pathology. Histol His-topathol 2004; 19:251-258. (Pubitemid 38120210)
37. Goodship T: Inherited dysregulation of the complement system. Bull Mem Acad R Med Belg 2004; 159:195-198.
38. Conley YP, Thalamuthu A, Jakobsdottir J, Weeks DE, Mah T, Ferrell RE, Gorin MB: Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology of age-related maculopathy. Hum Mol Genet 2005; 14: 1991-2002. (Pubitemid 41418035)
39. Scholl HP, Issa PC, Walier M, Janzer S, Pol-lok-Kopp B, Börncke F, Fritsche LG, Chong NV, Fimmers R, Wienker T, Holz FG, Weber BH, Oppermann M: Systemic complement activation in age-related macular degeneration. PLoS One 2008; 3:e2593.
40. Huang SJ, Costa DL, Gross NE, Yannuzzi LA: Peripheral drusen in membranoproliferative glomerulonephritis type II. Retina 2003; 23: 429-431. (Pubitemid 36793003)
41. Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Pro-vis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdano-vich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J: DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature 2011; 471:308-309.