-
2
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O (1956) On the origin of cancer cells. Science 123: 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
3
-
-
0026619273
-
Deviant energetic metabolism of glycolytic cancer cells
-
Baggetto LG (1992) Deviant energetic metabolism of glycolytic cancer cells. Biochimie 74: 959-974.
-
(1992)
Biochimie
, vol.74
, pp. 959-974
-
-
Baggetto, L.G.1
-
4
-
-
0034856827
-
Glutamine and cancer
-
discussion 2550S-2531S
-
Medina MA (2001) Glutamine and cancer. The Journal of nutrition 131: 2539S-2542S; discussion 2550S-2531S.
-
(2001)
The Journal of Nutrition
, vol.131
, pp. 2539S-2542S
-
-
Medina, M.A.1
-
5
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, et al. (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proceedings of the National Academy of Sciences of the United States of America 104: 19345-19350.
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
-
6
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, et al. (2008) Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proceedings of the National Academy of Sciences of the United States of America 105: 18782-18787.
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
DeBerardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
-
7
-
-
64749116346
-
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, et al. (2009) c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458: 762-765.
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
Lee, Y.S.4
Kita, K.5
-
8
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nature reviews Cancer 4: 891-899.
-
(2004)
Nature Reviews Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
9
-
-
35448964610
-
Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.E., elevated glycolysis in the presence of oxygen
-
Pedersen PL (2007) Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen. Journal of bioenergetics and biomembranes 39: 211-222.
-
(2007)
Journal of Bioenergetics and Biomembranes
, vol.39
, pp. 211-222
-
-
Pedersen, P.L.1
-
10
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
11
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol WH, Bounds PL, Dang CV (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nature reviews Cancer 11: 325-337.
-
(2011)
Nature Reviews Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
14
-
-
84858604270
-
Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
-
Ward PS, Thompson CB (2012) Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer cell 21: 297-308.
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
15
-
-
84863011452
-
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
-
Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, et al. (2012) The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell metabolism 15: 157-170.
-
(2012)
Cell Metabolism
, vol.15
, pp. 157-170
-
-
Yuneva, M.O.1
Fan, T.W.2
Allen, T.D.3
Higashi, R.M.4
Ferraris, D.V.5
-
17
-
-
0021111735
-
Protons and anaerobiosis
-
Hochachka PW, Mommsen TP (1983) Protons and anaerobiosis. Science 219: 1391-1397.
-
(1983)
Science
, vol.219
, pp. 1391-1397
-
-
Hochachka, P.W.1
Mommsen, T.P.2
-
18
-
-
67349275453
-
Metabolic acidosis and the importance of balanced equations
-
Lane AN, Fan TW, Higashi RM (2009) Metabolic acidosis and the importance of balanced equations. Metabolomics 5: 3.
-
(2009)
Metabolomics
, vol.5
, pp. 3
-
-
Lane, A.N.1
Fan, T.W.2
Higashi, R.M.3
-
19
-
-
23944511341
-
Lactate accumulation, proton buffering, and pH change in ischemically exercising muscle
-
author reply R904-910
-
Kemp G (2005) Lactate accumulation, proton buffering, and pH change in ischemically exercising muscle. American journal of physiology Regulatory, integrative and comparative physiology 289: R895-901; author reply R904-910.
-
(2005)
American Journal of Physiology Regulatory, Integrative and Comparative Physiology
, vol.289
, pp. R895-R901
-
-
Kemp, G.1
-
20
-
-
84864045066
-
Glycogen as a fuel: Metabolic interaction between glycogen and ATP catabolism in oxygen-independent muscle contraction
-
Ipata PB, Francesco (2012) Glycogen as a fuel: metabolic interaction between glycogen and ATP catabolism in oxygen-independent muscle contraction. Metabolomics 8.
-
(2012)
Metabolomics
, vol.8
-
-
Ipata, P.B.1
Francesco2
-
21
-
-
77953174044
-
What does glycolysis make and why is it important?
-
Brooks GA (2010) What does glycolysis make and why is it important? Journal of applied physiology 108: 1450-1451.
-
(2010)
Journal of Applied Physiology
, vol.108
, pp. 1450-1451
-
-
Brooks, G.A.1
-
22
-
-
33846317064
-
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
-
Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, et al. (2007) Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292: C125-136.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
, pp. C125-C136
-
-
Wu, M.1
Neilson, A.2
Swift, A.L.3
Moran, R.4
Tamagnine, J.5
-
23
-
-
0142150051
-
Mitochondrial formation of reactive oxygen species
-
Turrens JF (2003) Mitochondrial formation of reactive oxygen species. The Journal of physiology 552: 335-344.
-
(2003)
The Journal of Physiology
, vol.552
, pp. 335-344
-
-
Turrens, J.F.1
-
24
-
-
10344264960
-
Mitochondrial H(+) leak and ROS generation: An odd couple
-
Brookes PS (2005) Mitochondrial H(+) leak and ROS generation: an odd couple. Free radical biology & medicine 38: 12-23.
-
(2005)
Free Radical Biology & Medicine
, vol.38
, pp. 12-23
-
-
Brookes, P.S.1
-
25
-
-
66449103009
-
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
-
Xie H, Valera VA, Merino MJ, Amato AM, Signoretti S, et al. (2009) LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther 8: 626-635.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 626-635
-
-
Xie, H.1
Valera, V.A.2
Merino, M.J.3
Amato, A.M.4
Signoretti, S.5
-
26
-
-
79961215490
-
Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality
-
Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, et al. (2011) Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality. Sci Transl Med 3: 94ra70.
-
(2011)
Sci Transl Med
, vol.3
, pp. 94ra70
-
-
Chan, D.A.1
Sutphin, P.D.2
Nguyen, P.3
Turcotte, S.4
Lai, E.W.5
-
27
-
-
84861019195
-
Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells
-
Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, et al. (2012) Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells. Nat Protoc 7: 1068-1085.
-
(2012)
Nat Protoc
, vol.7
, pp. 1068-1085
-
-
Zhang, J.1
Nuebel, E.2
Wisidagama, D.R.3
Setoguchi, K.4
Hong, J.S.5
-
28
-
-
0000089325
-
Observations on the carbohydrate metabolism of tumours
-
Crabtree HG (1929) Observations on the carbohydrate metabolism of tumours. The Biochemical journal 23: 536-545.
-
(1929)
The Biochemical Journal
, vol.23
, pp. 536-545
-
-
Crabtree, H.G.1
-
29
-
-
68549085318
-
Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
-
Fan TW, Lane AN, Higashi RM, Farag MA, Gao H, et al. (2009) Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Molecular cancer 8: 41.
-
(2009)
Molecular Cancer
, vol.8
, pp. 41
-
-
Fan, T.W.1
Lane, A.N.2
Higashi, R.M.3
Farag, M.A.4
Gao, H.5
-
30
-
-
80053341343
-
Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
-
Pike LS, Smift AL, Croteau NJ, Ferrick DA, Wu M (2010) Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim Biophys Acta.
-
(2010)
Biochim Biophys Acta
-
-
Pike, L.S.1
Smift, A.L.2
Croteau, N.J.3
Ferrick, D.A.4
Wu, M.5
-
31
-
-
49849093594
-
Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells
-
Samudio I, Kurinna S, Ruvolo P, Korchin B, Kantarjian H, et al. (2008) Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells. Molecular cancer therapeutics 7: 1130-1139.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, pp. 1130-1139
-
-
Samudio, I.1
Kurinna, S.2
Ruvolo, P.3
Korchin, B.4
Kantarjian, H.5
-
33
-
-
84867595989
-
Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma
-
Caro P, Kishan AU, Norberg E, Stanley IA, Chapuy B, et al. (2012) Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer cell 22: 547-560.
-
(2012)
Cancer Cell
, vol.22
, pp. 547-560
-
-
Caro, P.1
Kishan, A.U.2
Norberg, E.3
Stanley, I.A.4
Chapuy, B.5
-
34
-
-
79956326256
-
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
-
Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, et al. (2011) Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes & development 25: 1041-1051.
-
(2011)
Genes & Development
, vol.25
, pp. 1041-1051
-
-
Zaugg, K.1
Yao, Y.2
Reilly, P.T.3
Kannan, K.4
Kiarash, R.5
-
35
-
-
0022521626
-
Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma
-
Trent J, Meltzer P, Rosenblum M, Harsh G, Kinzler K, et al. (1986) Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma. Proceedings of the National Academy of Sciences of the United States of America 83: 470-473.
-
(1986)
Proceedings of the National Academy of Sciences of the United States of America
, vol.83
, pp. 470-473
-
-
Trent, J.1
Meltzer, P.2
Rosenblum, M.3
Harsh, G.4
Kinzler, K.5
-
36
-
-
65649092131
-
Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: Spare respiratory capacity and stochastic mitochondrial failure
-
Choi SW, Gerencser AA, Nicholls DG (2009) Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure. J Neurochem 109: 1179-1191.
-
(2009)
J Neurochem
, vol.109
, pp. 1179-1191
-
-
Choi, S.W.1
Gerencser, A.A.2
Nicholls, D.G.3
-
37
-
-
70350694223
-
Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal
-
Hill BG, Dranka BP, Zou L, Chatham JC, Darley-Usmar VM (2009) Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. Biochem J 424: 99-107.
-
(2009)
Biochem J
, vol.424
, pp. 99-107
-
-
Hill, B.G.1
Dranka, B.P.2
Zou, L.3
Chatham, J.C.4
Darley-Usmar, V.M.5
-
38
-
-
84864774480
-
Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model
-
Ibrahim-Hashim A, Wojtkowiak JW, Ribeiro MdLC, Estrella V, Bailey KM, et al. (2011) Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model. J Cancer Sci Ther S1.
-
(2011)
J Cancer Sci Ther
, vol.S1
-
-
Ibrahim-Hashim, A.1
Wojtkowiak, J.W.2
Ribeiro, M.3
Estrella, V.4
Bailey, K.M.5
-
39
-
-
0141857820
-
Glycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer
-
Rivenzon-Segal D, Boldin-Adamsky S, Seger D, Seger R, Degani H (2003) Glycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer. International journal of cancer Journal international du cancer 107: 177-182.
-
(2003)
International Journal of Cancer Journal International du Cancer
, vol.107
, pp. 177-182
-
-
Rivenzon-Segal, D.1
Boldin-Adamsky, S.2
Seger, D.3
Seger, R.4
Degani, H.5
-
40
-
-
0032438672
-
Two-compartment model for determination of glycolytic rates of solid tumors by in vivo 13C NMR spectroscopy
-
Artemov D, Bhujwalla ZM, Pilatus U, Glickson JD (1998) Two-compartment model for determination of glycolytic rates of solid tumors by in vivo 13C NMR spectroscopy. NMR in biomedicine 11: 395-404.
-
(1998)
NMR in Biomedicine
, vol.11
, pp. 395-404
-
-
Artemov, D.1
Bhujwalla, Z.M.2
Pilatus, U.3
Glickson, J.D.4
-
41
-
-
0030882879
-
Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53
-
Mathupala SP, Heese C, Pedersen PL (1997) Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. The Journal of biological chemistry 272: 22776-22780.
-
(1997)
The Journal of Biological Chemistry
, vol.272
, pp. 22776-22780
-
-
Mathupala, S.P.1
Heese, C.2
Pedersen, P.L.3
-
42
-
-
84860793042
-
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
-
Ye J, Mancuso A, Tong X, Ward PS, Fan J, et al. (2012) Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 109: 6904-6909.
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 6904-6909
-
-
Ye, J.1
Mancuso, A.2
Tong, X.3
Ward, P.S.4
Fan, J.5
-
43
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, et al. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 25: 460-470.
-
(2011)
Genes Dev
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
Fan, J.4
Strohecker, A.M.5
-
44
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, et al. (2009) Autophagy regulates lipid metabolism. Nature 458: 1131-1135.
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
Kaushik, S.2
Wang, Y.3
Xiang, Y.4
Novak, I.5
-
45
-
-
84910015911
-
KSR1, a molecular scaffold of the Ras-Raf-MEK-ERK kinase cascade that is necessary for H-RasV12-induced oncogenic transformation, is also required for uptake/consumption of glucose and glutamine in mouse embryonic fibroblasts
-
poster
-
Swift AL, Chen D, Pike LS, Fisher K, Winer M, et al. (2011) KSR1, a molecular scaffold of the Ras-Raf-MEK-ERK kinase cascade that is necessary for H-RasV12-induced oncogenic transformation, is also required for uptake/consumption of glucose and glutamine in mouse embryonic fibroblasts. F1000 Posters 2: 52 (poster)
-
(2011)
F1000 Posters
, vol.2
, pp. 52
-
-
Swift, A.L.1
Chen, D.2
Pike, L.S.3
Fisher, K.4
Winer, M.5
|