Two-compartment model for determination of glycolytic rates of solid tumors by in vivo 13C NMR spectroscopy

NMR in Biomedicine

Volumn 11, Issue 8, 1998, Pages 395-404

  Artemov, Dmitri ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

13C NMR; Glucose metabolism; Glycolysis; Lactate; Metabolic model; Tumor metabolism

Indexed keywords

ALANINE; CARBON 13; GLUTAMIC ACID; GLYCOGEN; LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COMPARTMENT MODEL; DIAGNOSTIC VALUE; FEMALE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; ISOTOPE LABELING; LACTATE BLOOD LEVEL; MATHEMATICAL MODEL; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SOLID TUMOR; STEADY STATE; TUMOR DIFFERENTIATION; TUMOR GROWTH;

ANIMALS; CARBON ISOTOPES; DISEASE MODELS, ANIMAL; FEMALE; FIBROSARCOMA; GLUCOSE; GLYCOLYSIS; LACTIC ACID; MICE; MICE, INBRED C3H; NEOPLASM TRANSPLANTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORUS; PROTONS; SKIN NEOPLASMS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0032438672     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1492(199812)11:8<395::AID-NBM536>3.0.CO;2-R     Document Type: Article

References (4)

1. Baggetto L. G. Deviant energetic metabolism of glycolytic cancer cells. Biochimie 74, 959-974 (1992).
2. Eakin R. T., Morgan L. O., Gregg C. T. and Matwiyoff N. A. Carbon-13 nuclear magnetic resonance of living cells and their metabolism of a specifically labeled 13C substrate. FEES Lett. 28, 259-264 (1972).
3. Constantinidis I., Chatham J. C., Wehrle J. P. and Glickson J. D. In vivo 13C NMR spectroscopy of glucose metabolism of RIF-1 tumors. Magn. Reson. Med. 20, 17-26 (1991).
4. Bhujwalla Z. M., Constantinidis I., Chatham J. C., Wehrle J. P. and Glickson J. D. Energy metabolism, pH changes, and lactate production in RIF-1 tumors following intratumoral injection of glucose. Int. J. Radiat. Oncol. Biol. Phys. 22, 95-101 (1991).